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EA200100661A1 - Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана - Google Patents

Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана

Info

Publication number
EA200100661A1
EA200100661A1 EA200100661A EA200100661A EA200100661A1 EA 200100661 A1 EA200100661 A1 EA 200100661A1 EA 200100661 A EA200100661 A EA 200100661A EA 200100661 A EA200100661 A EA 200100661A EA 200100661 A1 EA200100661 A1 EA 200100661A1
Authority
EA
Eurasian Patent Office
Prior art keywords
obtaining
mol
formula
azadhydroxybicyclo
heptana
Prior art date
Application number
EA200100661A
Other languages
English (en)
Inventor
Майкл О'Брайен
Патрик Леон
Дени Ларго
Мэттью Пауэрз
Тьерри Дюран
Original Assignee
Авентис Фармасьютикалз Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Авентис Фармасьютикалз Продактс Инк. filed Critical Авентис Фармасьютикалз Продактс Инк.
Publication of EA200100661A1 publication Critical patent/EA200100661A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложен способ получения производного лактама формулыгде Rи Rнезависимо представляют ацил или ароил или, взятые вместе, образуют необязательно замещенный метилен и Gпредставляет водород или аминозащитную группу, включающий окисление производного бис-O-защищенного 1R-2-азадигидроксибицикло[2.2.1]гептана формулыс помощью RuOили его гидрата, взятых в количестве от около 0,1 мол.% до около 1 мол.% в присутствии около 3 эквивалентов окислителя с образованием производного лактама с энантиомерным избытком более или равным 95%.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100661A 1996-10-16 1997-10-15 Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана EA200100661A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/732,024 US5684159A (en) 1995-05-30 1996-10-16 L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds

Publications (1)

Publication Number Publication Date
EA200100661A1 true EA200100661A1 (ru) 2001-12-24

Family

ID=24941881

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200100661A EA200100661A1 (ru) 1996-10-16 1997-10-15 Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана
EA200100660A EA200100660A1 (ru) 1996-10-16 1997-10-15 Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана
EA199900382A EA002438B1 (ru) 1996-10-16 1997-10-15 Способ получения производных 2-азадигидроксибицикло[2.2.1]гептана и l-виннокислой соли производного

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA200100660A EA200100660A1 (ru) 1996-10-16 1997-10-15 Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана
EA199900382A EA002438B1 (ru) 1996-10-16 1997-10-15 Способ получения производных 2-азадигидроксибицикло[2.2.1]гептана и l-виннокислой соли производного

Country Status (21)

Country Link
US (4) US5684159A (ru)
EP (1) EP0934268A4 (ru)
JP (1) JP2001502329A (ru)
KR (1) KR20000049195A (ru)
CN (2) CN1094927C (ru)
AP (1) AP942A (ru)
AU (1) AU721965B2 (ru)
BG (2) BG64733B1 (ru)
BR (1) BR9711910A (ru)
CA (1) CA2268652A1 (ru)
CZ (1) CZ291387B6 (ru)
EA (3) EA200100661A1 (ru)
HU (1) HUP9903583A3 (ru)
IL (1) IL129231A (ru)
NO (2) NO320332B1 (ru)
OA (1) OA11112A (ru)
PL (1) PL332827A1 (ru)
SK (1) SK43799A3 (ru)
UA (1) UA52702C2 (ru)
WO (1) WO1998016510A1 (ru)
ZA (1) ZA979268B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
ES2216252T3 (es) * 1997-12-25 2004-10-16 Kuraray Co., Ltd. Procedimiento de preparacion y metodo de cristalizacion de 2-azabiciclo (2.2.1) hepta-5-en-3-ona.
TW396337B (en) * 1998-02-13 2000-07-01 Mediatek Inc The automatic regulating device of cdrom optimum focusing spot and the method thereof
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US6057446A (en) 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5986100A (en) 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use
DK1140933T3 (da) 1998-12-31 2004-12-20 Aventis Pharma Inc Fremgangsmåde til fremstilling af N6-substituerede deaza-adenosinderivater
US6387033B1 (en) * 2000-11-22 2002-05-14 Council Of Scientific And Industrial Research Preparation of new layered double hydroxides exchanged with osmate for asymmetric dihydroxylation of olefins to vicinal diols
WO2002091988A2 (en) * 2001-05-10 2002-11-21 Aventis Pharma Deutschland Gmbh Novel processes for the preparation of adenosine compounds and intermediates thereto
EP1574508A1 (de) * 2004-01-30 2005-09-14 Lonza AG Verfahren zur Herstellung von Acetalen und Ketalen von 3-Amino-5-(hydroxymethyl)-cyclopentan-1,2-diolen, sowie deren Derivaten und Salzen
ATE537148T1 (de) * 2006-10-11 2011-12-15 Nippon Soda Co Verfahren zur herstellung eines azabicycloalkanolderivats
CN102311440B (zh) * 2010-07-02 2015-01-07 无锡药明康德生物技术有限公司 1-甲氧羰基-3-苄基-8-叔丁氧羰基-3,8-二氮杂双环[3.2.1]辛烷及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK532575A (da) * 1974-12-13 1976-06-14 Merck & Co Inc Fremgangsmade til racematspaltning af organiske forbindelser
US4508911A (en) * 1982-06-21 1985-04-02 The Upjohn Company Amine intermediates for analgesic compounds
US5284769A (en) * 1989-10-16 1994-02-08 Chiros Ltd. Process for preparing a single enantiomer of a lactam using lactamase
AU641712B2 (en) * 1989-12-13 1993-09-30 Noristan Holdings Limited Polycyclic nitrile compounds and pharmaceutical compositions thereof
JP2891740B2 (ja) * 1990-03-30 1999-05-17 塩野義製薬株式会社 光学活性ノルボルナン系アミン誘導体の製造方法
SG80526A1 (en) * 1990-09-25 2001-05-22 Rhone Poulenc Rorer Int Compounds having antihypertensive and anti- ischemic properies
US5700895A (en) * 1993-08-23 1997-12-23 Sumitomo Chemical Company, Limited Ethylene-α-olefin copolymer and molded article thereof
US5670649A (en) * 1995-05-30 1997-09-23 Rhone-Poulenc Rorer S.A. Derivatives of 2-azabicyclo 2.2.1!heptane, their preparation and their application
US5684159A (en) * 1995-05-30 1997-11-04 Rhone-Poulenc Rorer S.A. L-tartaric acid salt of a (1R) diastereomer of a 2-azadihydroxybicyclo 2.2.1!heptane compound and the preparation of 2-azabicyclo 2.2.1!heptane compounds
FR2734822B1 (fr) * 1995-05-30 1997-07-04 Rhone Poulenc Rorer Sa Nouveaux derives du 2-azabicyclo(2.2.1)heptane, leur preparation et leur application
US5856497A (en) * 1995-12-11 1999-01-05 Boehringer Ingelheim Pharmaceuticals, Inc. Asymmetric synthesis of α-cycloalkylalkyl substituted methanamines

Also Published As

Publication number Publication date
NO20051757L (no) 1999-06-15
HUP9903583A3 (en) 2000-10-30
AP9901486A0 (en) 1999-03-31
EP0934268A4 (en) 2001-04-18
IL129231A0 (en) 2000-02-17
BR9711910A (pt) 1999-08-24
EA200100660A1 (ru) 2001-12-24
EA199900382A1 (ru) 1999-10-28
BG103296A (en) 2000-11-30
US5684159A (en) 1997-11-04
CN1094927C (zh) 2002-11-27
US5831096A (en) 1998-11-03
HK1022475A1 (en) 2000-08-11
JP2001502329A (ja) 2001-02-20
UA52702C2 (ru) 2003-01-15
WO1998016510A1 (en) 1998-04-23
OA11112A (en) 2003-04-04
BG64701B1 (bg) 2005-12-30
CN1233239A (zh) 1999-10-27
KR20000049195A (ko) 2000-07-25
US5808093A (en) 1998-09-15
AU721965B2 (en) 2000-07-20
AP942A (en) 2001-02-16
CZ131299A3 (cs) 2000-06-14
NO991800D0 (no) 1999-04-15
AU4816097A (en) 1998-05-11
EA002438B1 (ru) 2002-04-25
EP0934268A1 (en) 1999-08-11
NO320332B1 (no) 2005-11-21
CN1385422A (zh) 2002-12-18
HUP9903583A2 (hu) 2000-04-28
PL332827A1 (en) 1999-10-11
BG64733B1 (bg) 2006-01-31
SK43799A3 (en) 2000-04-10
CZ291387B6 (cs) 2003-02-12
CA2268652A1 (en) 1998-04-23
NO20051757D0 (no) 2005-04-08
US5886192A (en) 1999-03-23
NO991800L (no) 1999-06-15
ZA979268B (en) 1998-07-27
IL129231A (en) 2003-07-06

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