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EA200100391A1 - Новые производные 6-(4-фенилбутокси)гексиламина и способ получения сальметерола - Google Patents

Новые производные 6-(4-фенилбутокси)гексиламина и способ получения сальметерола

Info

Publication number
EA200100391A1
EA200100391A1 EA200100391A EA200100391A EA200100391A1 EA 200100391 A1 EA200100391 A1 EA 200100391A1 EA 200100391 A EA200100391 A EA 200100391A EA 200100391 A EA200100391 A EA 200100391A EA 200100391 A1 EA200100391 A1 EA 200100391A1
Authority
EA
Eurasian Patent Office
Prior art keywords
general formula
phenylbutoxy
hexylamine
group
new derivatives
Prior art date
Application number
EA200100391A
Other languages
English (en)
Other versions
EA003397B1 (ru
Inventor
Хорди Бесса Бельмунт
Пере Далмасес Бархуан
Франсиско Маркильяс Олондрис
Original Assignee
Вита-Инвест, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вита-Инвест, С.А. filed Critical Вита-Инвест, С.А.
Publication of EA200100391A1 publication Critical patent/EA200100391A1/ru
Publication of EA003397B1 publication Critical patent/EA003397B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/40—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the same carbon atom of the carbon skeleton, e.g. amino-ketals, ortho esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Данное изобретение относится к новым производным 6-(4-фенилбутокси)гексиламина общей формулы (I)где R- CHO или CHOROR-группа, где Rи Rнезависимо являются C-C-алкил-, аралкилгруппами или они образуют 5- или 6-членные циклические ацетали, и R- атом водорода, бензил- или алкилоксикарбонил-, арилоксикарбонил-, аралкилоксикарбонил- или ацилгруппа, и способу их получения. Изобретение также относится к новому способу получения Сальметерола или его фармацевтически приемлемых солей, отличающемуся тем, что реакцию органометаллического соединения общей формулы (13) проводят в инертном растворителе при низкой температуре с синтетическим полупродуктом общей формулы (I), где R- CHO-группа и R- алкилоксикарбонил-, арилоксикарбонил-, аралкилоксикарбонил- или ацилгруппа.Отчет о международном поиске был опубликован 2000.07.06.
EA200100391A 1998-09-28 1999-09-20 Производные 6-(4-фенилбутокси)гексиламина и способ получения сальметерола EA003397B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009802014A ES2142771B1 (es) 1998-09-28 1998-09-28 Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol.
PCT/ES1999/000294 WO2000018722A2 (es) 1998-09-28 1999-09-20 Nuevos derivados de la 6-(4-fenilbutoxi)hexilamina y procedimiento para la obtencion de salmeterol

Publications (2)

Publication Number Publication Date
EA200100391A1 true EA200100391A1 (ru) 2001-10-22
EA003397B1 EA003397B1 (ru) 2003-04-24

Family

ID=8305274

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100391A EA003397B1 (ru) 1998-09-28 1999-09-20 Производные 6-(4-фенилбутокси)гексиламина и способ получения сальметерола

Country Status (24)

Country Link
US (1) US6388134B1 (ru)
EP (1) EP1132373B1 (ru)
JP (1) JP3786834B2 (ru)
KR (1) KR100479256B1 (ru)
CN (1) CN1189446C (ru)
AT (1) ATE254596T1 (ru)
AU (1) AU756042B2 (ru)
BR (1) BR9913989A (ru)
CA (1) CA2344647C (ru)
CZ (2) CZ296901B6 (ru)
DE (1) DE69912984D1 (ru)
EA (1) EA003397B1 (ru)
ES (2) ES2142771B1 (ru)
HU (1) HUP0103969A3 (ru)
IL (1) IL141991A (ru)
IS (1) IS2016B (ru)
NO (2) NO327780B1 (ru)
NZ (1) NZ511157A (ru)
OA (1) OA11660A (ru)
PL (1) PL196116B1 (ru)
PT (1) PT1132373E (ru)
SK (1) SK284366B6 (ru)
TR (1) TR200100862T2 (ru)
WO (1) WO2000018722A2 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6835857B2 (en) 2002-03-05 2004-12-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for the manufacture of 4-(6-bromohexyloxy)-butylbenzene
DE10209583B4 (de) * 2002-03-05 2006-01-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von 4-(6-Bromhexyloxy)-butylbenzol
CA2625337C (en) * 2005-10-17 2014-03-18 Vinayak G. Gore Novel process
ES2288114B1 (es) * 2006-04-26 2008-12-01 Quimica Sintetica S.A. Nuevo procedimiento de sintesis de (6-(4-fenilbutoxi)hexil)aminas n-sustituidas y su uso en la sintesis de salmeterol xinafoato.
EP2127641A1 (en) 2008-05-26 2009-12-02 Inke, S.A. Micronisable form of salmeterol xinafoate
CN101712622B (zh) * 2009-11-10 2012-10-03 浙江万里学院 抗哮喘药物沙美特罗的制备方法
CN103435505A (zh) * 2013-09-05 2013-12-11 南京工业大学 一种合成(r)-沙美特罗的方法
US9447067B2 (en) 2014-10-03 2016-09-20 Amphastar Pahmaceuticals, Inc. Method of preparing intermediate of salmeterol
KR20230001708U (ko) 2022-02-17 2023-08-24 유기택 재접착식 슬림 평면형 액자

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW6584A1 (en) * 1983-04-18 1985-04-17 Glaxo Group Ltd Phenethanolamine derivatives
DK173685A (da) * 1984-04-17 1985-10-18 Glaxo Group Ltd Ethanolaminderivater
ES2065269B1 (es) * 1993-05-11 1995-10-01 S A L V A T Lab Sa 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion.

Also Published As

Publication number Publication date
IS5880A (is) 2001-03-08
IS2016B (is) 2005-06-15
NO20011197D0 (no) 2001-03-08
ES2142771B1 (es) 2001-01-01
IL141991A0 (en) 2002-03-10
JP2002525349A (ja) 2002-08-13
DE69912984D1 (de) 2003-12-24
HUP0103969A2 (hu) 2002-05-29
WO2000018722A3 (es) 2000-07-06
IL141991A (en) 2004-03-28
SK284366B6 (sk) 2005-02-04
AU756042B2 (en) 2003-01-02
US6388134B1 (en) 2002-05-14
PL196116B1 (pl) 2007-12-31
NO20084343L (no) 2001-03-28
HUP0103969A3 (en) 2003-05-28
PL348572A1 (en) 2002-06-03
EA003397B1 (ru) 2003-04-24
PT1132373E (pt) 2004-03-31
ES2142771A1 (es) 2000-04-16
CA2344647C (en) 2005-07-05
JP3786834B2 (ja) 2006-06-14
NZ511157A (en) 2002-12-20
TR200100862T2 (tr) 2001-07-23
CZ296901B6 (cs) 2006-07-12
KR20010079948A (ko) 2001-08-22
KR100479256B1 (ko) 2005-03-30
NO327780B1 (no) 2009-09-21
EP1132373B1 (en) 2003-11-19
BR9913989A (pt) 2001-06-19
NO20011197L (no) 2001-03-28
ES2212672T3 (es) 2004-07-16
CZ296902B6 (cs) 2006-07-12
CN1320114A (zh) 2001-10-31
ATE254596T1 (de) 2003-12-15
SK3862001A3 (en) 2002-09-10
CN1189446C (zh) 2005-02-16
EP1132373A2 (en) 2001-09-12
OA11660A (en) 2004-12-08
WO2000018722A2 (es) 2000-04-06
CZ2001958A3 (cs) 2001-08-15
AU5983999A (en) 2000-04-17
CA2344647A1 (en) 2000-04-06

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
PC4A Registration of transfer of a eurasian patent by assignment
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU