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EA200100315A1 - Простые тетрагидропиридовые эфиры - Google Patents

Простые тетрагидропиридовые эфиры

Info

Publication number
EA200100315A1
EA200100315A1 EA200100315A EA200100315A EA200100315A1 EA 200100315 A1 EA200100315 A1 EA 200100315A1 EA 200100315 A EA200100315 A EA 200100315A EA 200100315 A EA200100315 A EA 200100315A EA 200100315 A1 EA200100315 A1 EA 200100315A1
Authority
EA
Eurasian Patent Office
Prior art keywords
tetrahydropyride
ethers
international
application
substituents
Prior art date
Application number
EA200100315A
Other languages
English (en)
Other versions
EA005377B1 (ru
Inventor
Штефан Постиус
Вольфганг-Александер Зимон
Герхард Грундлер
Гуидо Ханауер
Райнхард Хубер
Вольфганг Кромер
Эрнст Штурм
Original Assignee
Бык Гульден Ломберг Хемише Фабрик Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бык Гульден Ломберг Хемише Фабрик Гмбх filed Critical Бык Гульден Ломберг Хемише Фабрик Гмбх
Publication of EA200100315A1 publication Critical patent/EA200100315A1/ru
Publication of EA005377B1 publication Critical patent/EA005377B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

В заявке описаны соединения формулы (I)в которых заместители имеют значения, указанные в описании, которые могут применяться для предупреждения и лечения желудочно-кишечных болезней.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100315A 1998-09-23 1999-09-17 ТЕТРАГИДРОИМИДАЗО [1,2-h][1,7] НАФТИРИДИНОВЫЕ СОЕДИНЕНИЯ EA005377B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843504 1998-09-23
EP98117988 1998-09-23
PCT/EP1999/006899 WO2000017200A1 (en) 1998-09-23 1999-09-17 Tetrahydropyridoethers

Publications (2)

Publication Number Publication Date
EA200100315A1 true EA200100315A1 (ru) 2001-10-22
EA005377B1 EA005377B1 (ru) 2005-02-24

Family

ID=26049024

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100315A EA005377B1 (ru) 1998-09-23 1999-09-17 ТЕТРАГИДРОИМИДАЗО [1,2-h][1,7] НАФТИРИДИНОВЫЕ СОЕДИНЕНИЯ

Country Status (31)

Country Link
US (4) US6436953B1 (ru)
EP (1) EP1115725B1 (ru)
JP (1) JP4145492B2 (ru)
KR (1) KR100668400B1 (ru)
CN (2) CN100506821C (ru)
AT (1) ATE231862T1 (ru)
AU (1) AU763463B2 (ru)
BG (1) BG65195B1 (ru)
BR (1) BR9914044A (ru)
CA (1) CA2344251A1 (ru)
CZ (1) CZ292335B6 (ru)
DE (1) DE69905178T2 (ru)
DK (1) DK1115725T3 (ru)
EA (1) EA005377B1 (ru)
EE (1) EE04677B1 (ru)
ES (1) ES2191464T3 (ru)
GE (1) GEP20032926B (ru)
HK (1) HK1038360B (ru)
HR (1) HRP20010224A2 (ru)
HU (1) HUP0102990A3 (ru)
ID (1) ID28896A (ru)
IL (2) IL142063A0 (ru)
NO (1) NO317304B1 (ru)
NZ (1) NZ510610A (ru)
PL (1) PL193616B1 (ru)
PT (1) PT1115725E (ru)
RS (1) RS50145B (ru)
SI (1) SI1115725T1 (ru)
SK (1) SK285165B6 (ru)
TR (1) TR200100805T2 (ru)
WO (1) WO2000017200A1 (ru)

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RS50145B (sr) * 1998-09-23 2009-03-25 Altana Pharma Ag., Tetrahidropiridoetri
DE60002855T2 (de) 1999-04-17 2004-05-06 Altana Pharma Ag Haloalkoxy-imidazonaphthyridine
CA2721484A1 (en) * 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
CN1221553C (zh) * 2000-03-29 2005-10-05 奥坦纳医药公司 三环咪唑并吡啶类化合物及药物组合物
MXPA02009551A (es) * 2000-03-29 2004-05-14 Altana Pharma Ag Profarmacos de derivados de imidazopiridina.
CA2426616A1 (en) * 2000-10-25 2002-05-02 Altana Pharma Ag Polysubstituted imidazopyridines as gastric secretion inhibitors
UA80393C2 (ru) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтическая композиция, которая содержит ингибитор фдэ 4, диспергированный в матрице
WO2002069968A1 (en) * 2001-03-08 2002-09-12 Astrazeneca Ab New use
DE60214004T2 (de) 2001-08-02 2007-02-15 Altana Pharma Ag Tricyclische epoxide
JP2005504048A (ja) * 2001-08-03 2005-02-10 アルタナ　ファルマ　アクチエンゲゼルシャフト 胃腸障害治療用のアルカリ置換されたイミダゾピリジン
WO2003014120A1 (en) * 2001-08-03 2003-02-20 Altana Pharma Ag Amino-substituted imidazopyridines for the treatment of gastrointestinal diseases
KR20040081204A (ko) 2002-02-15 2004-09-20 알타나 파마 아게 트리시클릭 ｎ-아실 화합물
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
CA2484272A1 (en) * 2002-05-07 2003-11-20 Altana Pharma Ag New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders
KR20050086584A (ko) 2002-11-19 2005-08-30 알타나 파마 아게 8-치환 이미다조피리딘
WO2004052374A1 (en) 2002-12-12 2004-06-24 Altana Pharma Ag Combination medicament
RS20050449A (en) * 2002-12-20 2007-11-15 Altana Pharma Ag., 8-trialkysyloxy-2-methyl-9-phenyl- 7oxo-7,8,9,10- tetrahydroimidazo/1,2- h//1,7/naphthyridines
CA2515676A1 (en) * 2003-02-17 2004-08-26 Altana Pharma Ag Imidazopyridines containing combinations and their use in treating gastrointestinal inflammatory disorders
AU2004220357B2 (en) 2003-03-10 2010-09-30 Astrazeneca Ab Novel process for the preparation of roflumilast
TW200503783A (en) * 2003-04-11 2005-02-01 Altana Pharma Ag Oral pharmaceutical preparation for proton pump antagonists
SA04250092B1 (ar) * 2003-05-14 2008-05-04 التانا فاروا ايه جي مركب وسيط جديد لتحضير مركبات إيميدازوبيريدين imidazopyridines فعالة علاجياً
AU2004243444A1 (en) * 2003-05-27 2004-12-09 Altana Pharma Ag Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility
EP1663313A2 (en) * 2003-08-29 2006-06-07 Dynogen Pharmaceuticals Inc. Compositions useful for treating gastrointestinal motility disorders
US8371292B2 (en) 2003-09-16 2013-02-12 Nycomed Gmbh Use of ciclesonide for the treatment of respiratory diseases
WO2005041961A1 (en) * 2003-11-03 2005-05-12 Astrazeneca Ab Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux
EP1697358A1 (en) 2003-12-19 2006-09-06 Altana Pharma AG Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives
AR047605A1 (es) * 2004-02-17 2006-01-25 Altana Pharma Ag Imidazopiridinas triciclicas e intermediarios en la sintesis de las mismas,sus procesos de preparacion,composiciones farmaceuticas que los contienen y usos.
KR100958830B1 (ko) 2004-09-03 2010-05-24 주식회사유한양행 피롤로[2,3-ｃ]피리딘 유도체 및 그의 제조방법
KR100946219B1 (ko) 2004-09-03 2010-03-08 주식회사유한양행 피롤로[3,2-ｃ]피리딘 유도체 및 그의 제조방법
WO2006038773A1 (en) 2004-09-03 2006-04-13 Yuhan Corporation Pyrrolo[3,2-b]pyridine derivatives and processes for the preparation thereof
EP1861074B1 (en) * 2005-03-16 2013-04-24 Takeda GmbH Taste masked dosage form containing roflumilast
EP2080513A1 (en) 2008-01-16 2009-07-22 Schraermeyer, Ulrich, Prof. Dr. rer. nat Tetrahydropyridoethers for treatment of AMD
WO2011004882A1 (ja) * 2009-07-09 2011-01-13 ラクオリア創薬株式会社 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤
WO2012027240A1 (en) * 2010-08-23 2012-03-01 Schering Corporation Fused tricyclic inhibitors of mammalian target of rapamycin
JP6001168B2 (ja) * 2012-06-15 2016-10-05 バイオ‐ファーム ソリューションズ カンパニー リミテッドＢｉｏ‐Ｐｈａｒｍ Ｓｏｌｕｔｉｏｎｓ Ｃｏ．， Ｌｔｄ． フェニルアルキルスルファメート化合物及びこれを含む筋弛緩剤組成物
EP3054949A1 (en) 2013-10-08 2016-08-17 Katairo GmbH Tetrahydropyridoethers for the treatment of stargardt's disease

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US4468400A (en) * 1982-12-20 1984-08-28 Schering Corporation Antiulcer tricyclic imidazo [1,2-a]pyridines
WO1989000570A1 (fr) 1987-07-16 1989-01-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux diazoles
SE9401197D0 (sv) * 1994-04-11 1994-04-11 Astra Ab Active compounds
CA2196076A1 (en) * 1994-07-28 1996-02-08 Gerhard Grundler Acyl imidazopyridines
EP0971922B1 (en) * 1997-03-24 2004-04-28 ALTANA Pharma AG Tetrahydropyrido compounds
IL131407A0 (en) * 1997-03-24 2001-01-28 Byk Gulden Lomberg Chem Fab Tetrahydropyrido compounds medicaments containing the same and the use thereof
RS50145B (sr) 1998-09-23 2009-03-25 Altana Pharma Ag., Tetrahidropiridoetri

Also Published As

Publication number Publication date
EE200100172A (et) 2002-06-17
YU21401A (sh) 2004-03-12
US6436953B1 (en) 2002-08-20
NO20011243L (no) 2001-03-12
HRP20010224A2 (en) 2002-04-30
US6696460B2 (en) 2004-02-24
NO317304B1 (no) 2004-10-04
IL142063A (en) 2007-10-31
BG65195B1 (bg) 2007-06-29
CZ20011082A3 (cs) 2001-09-12
ID28896A (id) 2001-07-12
CZ292335B6 (cs) 2003-09-17
EP1115725B1 (en) 2003-01-29
KR100668400B1 (ko) 2007-01-17
JP2002526499A (ja) 2002-08-20
DK1115725T3 (da) 2003-06-23
ATE231862T1 (de) 2003-02-15
EA005377B1 (ru) 2005-02-24
AU763463B2 (en) 2003-07-24
PT1115725E (pt) 2003-06-30
BR9914044A (pt) 2001-12-04
AU6192099A (en) 2000-04-10
GEP20032926B (en) 2003-03-25
HUP0102990A3 (en) 2002-09-30
HUP0102990A2 (hu) 2002-01-28
DE69905178D1 (de) 2003-03-06
CN1155598C (zh) 2004-06-30
ES2191464T3 (es) 2003-09-01
WO2000017200A1 (en) 2000-03-30
SI1115725T1 (en) 2003-06-30
US20020169320A1 (en) 2002-11-14
PL346617A1 (en) 2002-02-25
SK285165B6 (sk) 2006-07-07
PL193616B1 (pl) 2007-02-28
JP4145492B2 (ja) 2008-09-03
US20040162310A1 (en) 2004-08-19
BG105270A (en) 2001-11-30
US7105676B2 (en) 2006-09-12
NO20011243D0 (no) 2001-03-12
CN1560055A (zh) 2005-01-05
EE04677B1 (et) 2006-08-15
DE69905178T2 (de) 2003-07-17
TR200100805T2 (tr) 2001-08-21
SK3992001A3 (en) 2001-12-03
NZ510610A (en) 2003-07-25
KR20010075223A (ko) 2001-08-09
CA2344251A1 (en) 2000-03-30
EP1115725A1 (en) 2001-07-18
HK1038360B (en) 2003-05-16
RS50145B (sr) 2009-03-25
US7393860B1 (en) 2008-07-01
CN1319101A (zh) 2001-10-24
CN100506821C (zh) 2009-07-01
IL142063A0 (en) 2002-03-10
HK1038360A1 (en) 2002-03-15

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Legal Events

Date Code Title Description
PD1A Registration of transfer to a eurasian application by order of succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU