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EA200100311A1 - Бифункциональные антитела и их применение для прицельной доставки противоопухолевых средств - Google Patents

Бифункциональные антитела и их применение для прицельной доставки противоопухолевых средств

Info

Publication number
EA200100311A1
EA200100311A1 EA200100311A EA200100311A EA200100311A1 EA 200100311 A1 EA200100311 A1 EA 200100311A1 EA 200100311 A EA200100311 A EA 200100311A EA 200100311 A EA200100311 A EA 200100311A EA 200100311 A1 EA200100311 A1 EA 200100311A1
Authority
EA
Eurasian Patent Office
Prior art keywords
application
targeted delivery
antitumor agents
bifunctional antibodies
affinity
Prior art date
Application number
EA200100311A
Other languages
English (en)
Inventor
Питер Джон Харрисон
Original Assignee
Кс Байомедикс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кс Байомедикс Лтд. filed Critical Кс Байомедикс Лтд.
Publication of EA200100311A1 publication Critical patent/EA200100311A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Бифункциональное антитело имеет сродство к месту мишени (опухоли) и сродство к органической молекуле, ковалентно связанной с цитотоксическим веществом или ферментом, способным превращать пролекарство в цитотоксическую форму лекарства. Антитело можно использовать в терапии или диагностике, особенно при лечении опухолей.Отчет о международном поиске был опубликован 2000.11.30.
EA200100311A 1998-09-04 1999-09-06 Бифункциональные антитела и их применение для прицельной доставки противоопухолевых средств EA200100311A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9819411.1A GB9819411D0 (en) 1998-09-04 1998-09-04 Antibodies
PCT/GB1999/002938 WO2000014119A2 (en) 1998-09-04 1999-09-06 Bifunctional antibodies and their use in targeting anti-tumour agents

Publications (1)

Publication Number Publication Date
EA200100311A1 true EA200100311A1 (ru) 2001-08-27

Family

ID=10838416

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100311A EA200100311A1 (ru) 1998-09-04 1999-09-06 Бифункциональные антитела и их применение для прицельной доставки противоопухолевых средств

Country Status (20)

Country Link
EP (1) EP1107995A2 (ru)
JP (1) JP2002524470A (ru)
KR (1) KR20010072988A (ru)
CN (1) CN1315967A (ru)
AU (1) AU5641299A (ru)
BG (1) BG105293A (ru)
BR (1) BR9913429A (ru)
CA (1) CA2341753A1 (ru)
EA (1) EA200100311A1 (ru)
GB (1) GB9819411D0 (ru)
HR (1) HRP20010154A2 (ru)
HU (1) HUP0104091A2 (ru)
ID (1) ID28873A (ru)
IL (1) IL141524A0 (ru)
MX (1) MXPA01002349A (ru)
NO (1) NO20011102L (ru)
PL (1) PL346861A1 (ru)
TR (2) TR200100651T2 (ru)
WO (1) WO2000014119A2 (ru)
ZA (1) ZA200101574B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019227490A1 (en) 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
CN112533952B (zh) 2018-06-01 2023-03-07 大有华夏生物医药集团有限公司 治疗疾病或病况的组合物及其用途
WO2020019232A1 (en) * 2018-07-26 2020-01-30 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
WO2020151572A1 (en) 2019-01-23 2020-07-30 Tayu Huaxia Biotech Medical Group Co., Ltd. Anti-pd-l1 diabodies and the use thereof
CN110811820B (zh) * 2019-12-11 2022-07-12 江西华晨医疗设备有限公司 一种直杆式冲洗吸引电凝切割器

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
IL89491A0 (en) * 1988-11-17 1989-09-10 Hybritech Inc Bifunctional chimeric antibodies
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
EP0505566A1 (en) * 1989-12-15 1992-09-30 Takeda Chemical Industries, Ltd. Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics
JPH05184383A (ja) * 1990-06-19 1993-07-27 Dainabotsuto Kk 二重特異性抗体
EP0981748A4 (en) * 1997-02-26 2002-09-18 Ban-An Khaw IMPROVEMENT OF THE SIGNAL OF A BISPECIFIC POLYMER PROBE FOR IMMUNODAYS

Also Published As

Publication number Publication date
KR20010072988A (ko) 2001-07-31
CA2341753A1 (en) 2000-03-16
WO2000014119A2 (en) 2000-03-16
GB9819411D0 (en) 1998-10-28
NO20011102L (no) 2001-03-05
MXPA01002349A (es) 2003-10-15
IL141524A0 (en) 2002-03-10
BR9913429A (pt) 2001-09-25
BG105293A (bg) 2001-12-29
EP1107995A2 (en) 2001-06-20
HRP20010154A2 (en) 2002-02-28
ZA200101574B (en) 2002-02-26
HUP0104091A2 (hu) 2002-03-28
WO2000014119A3 (en) 2000-11-30
PL346861A1 (en) 2002-03-11
TR200103405T2 (tr) 2002-06-21
JP2002524470A (ja) 2002-08-06
AU5641299A (en) 2000-03-27
ID28873A (id) 2001-07-12
NO20011102D0 (no) 2001-03-02
TR200100651T2 (tr) 2001-07-23
CN1315967A (zh) 2001-10-03

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