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EA200001184A1 - Фенилсульфонамидфенилэтиламины, полезные в качестве допаминовых рецепторов - Google Patents

Фенилсульфонамидфенилэтиламины, полезные в качестве допаминовых рецепторов

Info

Publication number
EA200001184A1
EA200001184A1 EA200001184A EA200001184A EA200001184A1 EA 200001184 A1 EA200001184 A1 EA 200001184A1 EA 200001184 A EA200001184 A EA 200001184A EA 200001184 A EA200001184 A EA 200001184A EA 200001184 A1 EA200001184 A1 EA 200001184A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
sulphonamidphenylethylamines
phenyl
useful
dopamine receptors
Prior art date
Application number
EA200001184A
Other languages
English (en)
Other versions
EA002918B1 (ru
Inventor
Артур Гленн Ромеро
Джеффри А. Лейби
Original Assignee
Фармация Энд Апджон Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани filed Critical Фармация Энд Апджон Компани
Publication of EA200001184A1 publication Critical patent/EA200001184A1/ru
Publication of EA002918B1 publication Critical patent/EA002918B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/46—Y being a hydrogen or a carbon atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Раскрываются соединения формулы I и их фармацевтически приемлемые соли, обладающие селективной активностью D3 допаминовых рецепторов, подходящие для лечения расстройств центральной нервной системы. Формула IRнезависимо представляет H или C-Cалкил, включая его изомерные формы;Rпредставляет H, C-Cалкил, галоген, OCH, OCF, CF, CN, SCHили NHCOCH; иRпредставляет H, C-Cалкил, галоген, OCH, OCF, CF, CN, SCHили NHCOCH.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001184A 1998-05-14 1999-05-07 Производные фенилсульфонамидфенилэтиламина и их применение в качестве допаминовых рецепторов EA002918B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8549398P 1998-05-14 1998-05-14
PCT/US1999/007023 WO1999058499A1 (en) 1998-05-14 1999-05-07 Phenylsulfonamide-phenylethylamines useful as dopamine receptors

Publications (2)

Publication Number Publication Date
EA200001184A1 true EA200001184A1 (ru) 2001-04-23
EA002918B1 EA002918B1 (ru) 2002-10-31

Family

ID=22191975

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001184A EA002918B1 (ru) 1998-05-14 1999-05-07 Производные фенилсульфонамидфенилэтиламина и их применение в качестве допаминовых рецепторов

Country Status (25)

Country Link
US (1) US6103766A (ru)
EP (1) EP1077935B1 (ru)
JP (1) JP2002514623A (ru)
KR (1) KR20010043546A (ru)
CN (1) CN1152857C (ru)
AT (1) ATE253045T1 (ru)
AU (1) AU752543B2 (ru)
BR (1) BR9910405A (ru)
CA (1) CA2327345A1 (ru)
DE (1) DE69912419T2 (ru)
DK (1) DK1077935T3 (ru)
EA (1) EA002918B1 (ru)
ES (1) ES2211078T3 (ru)
HK (1) HK1036049A1 (ru)
HU (1) HUP0101746A3 (ru)
IL (1) IL139263A0 (ru)
NO (1) NO20005732L (ru)
NZ (1) NZ508152A (ru)
PL (1) PL343891A1 (ru)
PT (1) PT1077935E (ru)
SK (1) SK16242000A3 (ru)
TR (1) TR200003325T2 (ru)
TW (1) TW450954B (ru)
WO (1) WO1999058499A1 (ru)
ZA (1) ZA200005921B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69839305T2 (de) * 1997-02-27 2009-04-09 Takeda Pharmaceutical Co. Ltd. Aminderivate, ihre herstellung und verwendung als inhibitoren der produktion von amyloid-beta
JP2005508852A (ja) * 2001-05-07 2005-04-07 スミスクライン・ビーチャム・コーポレイション スルホンアミド
EP1399137A4 (en) * 2001-05-07 2005-12-14 Smithkline Beecham Corp SULPHONAMIDES
US8232426B2 (en) 2004-10-14 2012-07-31 Abbott Gmbh & Co. Kg Aminoethylaromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
ATE504566T1 (de) * 2004-10-14 2011-04-15 Abbott Gmbh & Co Kg Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen
CA2583333C (en) 2004-10-14 2013-05-14 Abbott Gmbh & Co. Kg Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor
US8383641B2 (en) 2006-04-14 2013-02-26 Abbott Gmbh & Co. Kg Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
TWI400233B (zh) * 2006-04-14 2013-07-01 Abbott Gmbh & Co Kg 適用於治療對多巴胺ｄ3受體之調節有反應的疾病之芳氧基乙胺化合物
US8497273B2 (en) 2006-04-19 2013-07-30 Abbott Gmbh & Co. Kg Heterocyclic compounds suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor
UY30295A1 (es) 2006-04-19 2007-11-30 Abbott Gmbh & Amp Compuestos heterociclicos apropiados para tratar trastornos que responden a la modulacion del receptor de serotonina 5ht6
WO2008026046A1 (en) * 2006-08-30 2008-03-06 Pfizer Products Inc. Morpholine d3 dopamine antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574741A (en) * 1969-04-14 1971-04-13 Mead Johnson & Co Sulfonamidophenalkylamines
US5451677A (en) * 1993-02-09 1995-09-19 Merck & Co., Inc. Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity
GB9402197D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Compounds
BR9509760A (pt) * 1994-11-23 1998-06-30 Neurogen Corp Composto
AU2897497A (en) * 1996-05-11 1997-12-05 Smithkline Beecham Plc Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors
EP1184370B1 (en) * 1996-07-22 2005-09-14 Novo Nordisk A/S Compounds with growth hormone releasing properties
JPH1180156A (ja) * 1997-09-04 1999-03-26 Hokuriku Seiyaku Co Ltd １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体

Also Published As

Publication number Publication date
EP1077935A1 (en) 2001-02-28
ES2211078T3 (es) 2004-07-01
HK1036049A1 (en) 2001-12-21
US6103766A (en) 2000-08-15
NO20005732D0 (no) 2000-11-13
PT1077935E (pt) 2004-03-31
KR20010043546A (ko) 2001-05-25
BR9910405A (pt) 2001-01-09
DE69912419T2 (de) 2004-07-22
AU3741899A (en) 1999-11-29
DE69912419D1 (de) 2003-12-04
HUP0101746A2 (hu) 2002-03-28
CN1152857C (zh) 2004-06-09
EP1077935B1 (en) 2003-10-29
HUP0101746A3 (en) 2002-10-28
AU752543B2 (en) 2002-09-19
IL139263A0 (en) 2001-11-25
NO20005732L (no) 2000-11-13
ATE253045T1 (de) 2003-11-15
SK16242000A3 (sk) 2001-06-11
PL343891A1 (en) 2001-09-10
TW450954B (en) 2001-08-21
ZA200005921B (en) 2001-11-14
WO1999058499A1 (en) 1999-11-18
JP2002514623A (ja) 2002-05-21
DK1077935T3 (da) 2004-02-16
CN1297431A (zh) 2001-05-30
TR200003325T2 (tr) 2001-04-20
CA2327345A1 (en) 1999-11-18
EA002918B1 (ru) 2002-10-31
NZ508152A (en) 2003-03-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU