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EA200001036A1 - Способы ингибирования mrp1 - Google Patents

Способы ингибирования mrp1

Info

Publication number
EA200001036A1
EA200001036A1 EA200001036A EA200001036A EA200001036A1 EA 200001036 A1 EA200001036 A1 EA 200001036A1 EA 200001036 A EA200001036 A EA 200001036A EA 200001036 A EA200001036 A EA 200001036A EA 200001036 A1 EA200001036 A1 EA 200001036A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
mrp1
inhibiting mrp1
inhibiting
tumors
Prior art date
Application number
EA200001036A
Other languages
English (en)
Inventor
Джозеф Майкл Грюбер
Брайан Х. Норман
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200001036A1 publication Critical patent/EA200001036A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к соединению формулы (I), которое можно использовать для ингибирования устойчивости новообразований, устойчивость которым частично или полностью придается MRP1.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200001036A 1998-04-08 1999-04-07 Способы ингибирования mrp1 EA200001036A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8107798P 1998-04-08 1998-04-08
PCT/US1999/007343 WO1999051227A1 (en) 1998-04-08 1999-04-07 Methods for inhibiting mrp1

Publications (1)

Publication Number Publication Date
EA200001036A1 true EA200001036A1 (ru) 2001-04-23

Family

ID=22161958

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001036A EA200001036A1 (ru) 1998-04-08 1999-04-07 Способы ингибирования mrp1

Country Status (17)

Country Link
US (1) US6417193B1 (ru)
EP (1) EP1069897A1 (ru)
JP (1) JP2002510624A (ru)
KR (1) KR20010042482A (ru)
CN (1) CN1296408A (ru)
AU (1) AU3468099A (ru)
BR (1) BR9909497A (ru)
CA (1) CA2327706A1 (ru)
EA (1) EA200001036A1 (ru)
HU (1) HUP0101736A3 (ru)
ID (1) ID27048A (ru)
IL (1) IL138391A0 (ru)
NO (1) NO20005042L (ru)
PL (1) PL343312A1 (ru)
SK (1) SK15002000A3 (ru)
TR (1) TR200002803T2 (ru)
WO (1) WO1999051227A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60016039T2 (de) * 1999-12-22 2005-08-11 Eli Lilly And Co., Indianapolis Verfahren und verbindungen für die hemmung von mrp1
US6743794B2 (en) 1999-12-22 2004-06-01 Eli Lilly And Company Methods and compounds for inhibiting MRP1
WO2001096346A1 (en) * 2000-06-14 2001-12-20 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
EP1296953A2 (en) 2000-06-23 2003-04-02 Eli Lilly And Company Methods and compounds for inhibiting mrp1
AU2001294518A1 (en) * 2000-09-22 2002-04-02 Eli Lilly And Company Stereoselective process for preparing cyclohexyl amine derivatives
US7037921B2 (en) 2001-04-09 2006-05-02 Eli Lilly And Company Compounds and methods for inhibiting MRP1
CN1281210C (zh) * 2003-11-29 2006-10-25 胡汛 五味子乙素在制备治疗肿瘤药物中的应用
CN104002843A (zh) * 2014-05-29 2014-08-27 安徽银龙泵阀股份有限公司 一种减震效果好易于放置的双泵移动车

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744485A (en) * 1994-03-25 1998-04-28 Vertex Pharmaceuticals Incorporated Carbamates and ureas as modifiers of multi-drug resistance
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity

Also Published As

Publication number Publication date
WO1999051227A1 (en) 1999-10-14
US6417193B1 (en) 2002-07-09
EP1069897A1 (en) 2001-01-24
NO20005042D0 (no) 2000-10-06
CN1296408A (zh) 2001-05-23
HUP0101736A3 (en) 2002-04-29
SK15002000A3 (sk) 2001-06-11
TR200002803T2 (tr) 2000-12-21
KR20010042482A (ko) 2001-05-25
PL343312A1 (en) 2001-08-13
AU3468099A (en) 1999-10-25
IL138391A0 (en) 2001-10-31
HUP0101736A2 (hu) 2001-11-28
NO20005042L (no) 2000-10-06
JP2002510624A (ja) 2002-04-09
BR9909497A (pt) 2000-12-12
ID27048A (id) 2001-02-22
CA2327706A1 (en) 1999-10-14

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