EA200000146A1 - Лиганды, включая антитела, проявляющие реактивность в отношении эндокринных клеток - Google Patents
Лиганды, включая антитела, проявляющие реактивность в отношении эндокринных клетокInfo
- Publication number
- EA200000146A1 EA200000146A1 EA200000146A EA200000146A EA200000146A1 EA 200000146 A1 EA200000146 A1 EA 200000146A1 EA 200000146 A EA200000146 A EA 200000146A EA 200000146 A EA200000146 A EA 200000146A EA 200000146 A1 EA200000146 A1 EA 200000146A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibodies
- ligands
- endocrine cells
- including antibodies
- reactivity against
- Prior art date
Links
- 210000003890 endocrine cell Anatomy 0.000 title 1
- 230000001747 exhibiting effect Effects 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 230000009257 reactivity Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 208000023275 Autoimmune disease Diseases 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 230000008482 dysregulation Effects 0.000 abstract 1
- 230000003054 hormonal effect Effects 0.000 abstract 1
- 230000035879 hyperinsulinaemia Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 210000002955 secretory cell Anatomy 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
Abstract
Настоящее изобретение представляет моноклональные и поликлональные антитела, распознающие молекулы на секреторных клетках различных тканей, являющихся мишенями аутоиммунных заболеваний, обеспечивающих унификацию способа профилактики и лечения аутоиммунных заболеваний и других состояний, в которые вовлечены нарушения гормональной регуляции, гиперинсулинемия и инсулиновая невосприимчивость. Также представляется способ выявления сходных антител в сыворотке человека или других жидкостях тела, которые могут быть использованы в диагностических наборах реактивов. Способы лечения, вытекающие из настоящего изобретения, включают введение препаратов антител, их молекул-мишеней и векторов, включающих последовательности, кодирующие эти антитела и их молекулы-мишени.Отчет о международном поиске был опубликован 1999.06.10.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9715281A GB2327423B (en) | 1997-07-21 | 1997-07-21 | Ligands, including antibodies, showing reactivity against endocrine cells for use in therapy and diagnosis |
| GBGB9810676.8A GB9810676D0 (en) | 1998-05-18 | 1998-05-18 | Ligands including antibodies showing reactivity against endocrine cells for use in therapy and diagnosis |
| PCT/GB1998/002151 WO1999005175A2 (en) | 1997-07-21 | 1998-07-20 | Diagnosis and treatment of diseases using anti-anti-t-cell receptor vbeta anti-bodies or peptides which are recognized by said antibodies, and endocrine secretion regulatory protein i (esrp1) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200000146A1 true EA200000146A1 (ru) | 2000-10-30 |
| EA003131B1 EA003131B1 (ru) | 2003-02-27 |
Family
ID=26311906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200000146A EA003131B1 (ru) | 1997-07-21 | 1998-07-20 | Лиганды, включая антитела, проявляющие реактивность в отношении эндокринных клеток |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6689359B1 (ru) |
| EP (2) | EP1595951A1 (ru) |
| JP (1) | JP2002511765A (ru) |
| KR (2) | KR100567277B1 (ru) |
| CN (1) | CN1330754C (ru) |
| AT (1) | ATE297983T1 (ru) |
| AU (1) | AU758455B2 (ru) |
| BR (1) | BR9810118A (ru) |
| CA (1) | CA2296842C (ru) |
| CU (1) | CU23412A3 (ru) |
| DE (1) | DE69830588T2 (ru) |
| DK (1) | DK0998556T3 (ru) |
| EA (1) | EA003131B1 (ru) |
| ES (1) | ES2245034T3 (ru) |
| IL (3) | IL133277A0 (ru) |
| NZ (1) | NZ501424A (ru) |
| PL (1) | PL204503B1 (ru) |
| PT (1) | PT998556E (ru) |
| SI (1) | SI0998556T1 (ru) |
| TR (1) | TR200000181T2 (ru) |
| WO (1) | WO1999005175A2 (ru) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2385879A1 (en) * | 1999-09-23 | 2001-03-29 | Rigel Pharmaceuticals, Inc. | Traf4 associated cell cycle proteins, compositions and methods of use |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| EA015629B1 (ru) * | 2005-08-11 | 2011-10-31 | Арпи Матоссиан-Роджерс | Пептиды, используемые для лечения и диагностики аутоиммунных заболеваний |
| AU2012244244B2 (en) * | 2005-08-11 | 2015-08-27 | Arpi Matossian-Rogers | TCR-V-beta related peptides for treatment and diagnosis of autoimmune disease |
| DK1954718T3 (en) | 2005-11-30 | 2014-12-15 | Abbvie Inc | Anti-A-globulomer antibodies antigenbindingsgrupper thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods for producing said antibodies, |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US20100311767A1 (en) | 2007-02-27 | 2010-12-09 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| DK2238166T3 (da) | 2007-10-05 | 2014-01-27 | Ac Immune Sa | Anvendelse af et anti-amyloid-beta-antistof ved øjensygdomme |
| MX360403B (es) | 2010-04-15 | 2018-10-31 | Abbvie Inc | Proteinas de union a amiloide beta. |
| CA2806909C (en) | 2010-07-30 | 2019-12-17 | Ac Immune S.A. | Safe and functional humanized antibodies |
| JP6147665B2 (ja) | 2010-08-14 | 2017-06-14 | アッヴィ・インコーポレイテッド | アミロイドベータ結合タンパク質 |
| US9217172B2 (en) * | 2011-09-29 | 2015-12-22 | Cellsnap, Llc | Compositions and methods for toxigenicity testing |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2072356A1 (en) * | 1989-12-29 | 1991-06-30 | James L. Urban | Diagnosis and treatment of diseases |
| US5216132A (en) * | 1990-01-12 | 1993-06-01 | Protein Design Labs, Inc. | Soluble t-cell antigen receptor chimeric antigens |
| JPH06507384A (ja) * | 1991-01-22 | 1994-08-25 | ザ イミューン レスポンス コーポレイション | 特定のｔ細胞群による病理的応答により生じる疾患に対するワクチン投与および方法 |
| US5480895A (en) * | 1991-09-27 | 1996-01-02 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Method of producing antibodies to a restricted population of T lymphocytes, antibodies produced therefrom and methods of use thereof |
| US5891623A (en) * | 1992-11-09 | 1999-04-06 | Consorzio Per Le Biotecnologie | Diagnosis and treatment of AIDS onset |
| US5595721A (en) * | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| US5589328A (en) * | 1994-08-04 | 1996-12-31 | Mahant; Vijay K. | Chemiluminescence assays based on indoxyl substrates, thioindoxyl substrates and other substrates |
-
1998
- 1998-07-20 TR TR2000/00181T patent/TR200000181T2/xx unknown
- 1998-07-20 EP EP05076378A patent/EP1595951A1/en not_active Withdrawn
- 1998-07-20 WO PCT/GB1998/002151 patent/WO1999005175A2/en active IP Right Grant
- 1998-07-20 EA EA200000146A patent/EA003131B1/ru not_active IP Right Cessation
- 1998-07-20 US US09/463,158 patent/US6689359B1/en not_active Expired - Fee Related
- 1998-07-20 AU AU84517/98A patent/AU758455B2/en not_active Ceased
- 1998-07-20 KR KR1020007000632A patent/KR100567277B1/ko not_active Expired - Fee Related
- 1998-07-20 PL PL338449A patent/PL204503B1/pl not_active IP Right Cessation
- 1998-07-20 IL IL13327798A patent/IL133277A0/xx active IP Right Grant
- 1998-07-20 DK DK98935160T patent/DK0998556T3/da active
- 1998-07-20 PT PT98935160T patent/PT998556E/pt unknown
- 1998-07-20 AT AT98935160T patent/ATE297983T1/de active
- 1998-07-20 ES ES98935160T patent/ES2245034T3/es not_active Expired - Lifetime
- 1998-07-20 BR BR9810118-8A patent/BR9810118A/pt not_active Application Discontinuation
- 1998-07-20 NZ NZ501424A patent/NZ501424A/en not_active IP Right Cessation
- 1998-07-20 JP JP50949099A patent/JP2002511765A/ja not_active Ceased
- 1998-07-20 KR KR1020057007380A patent/KR100670070B1/ko not_active Expired - Fee Related
- 1998-07-20 SI SI9830782T patent/SI0998556T1/xx unknown
- 1998-07-20 EP EP98935160A patent/EP0998556B1/en not_active Expired - Lifetime
- 1998-07-20 CA CA2296842A patent/CA2296842C/en not_active Expired - Fee Related
- 1998-07-20 DE DE69830588T patent/DE69830588T2/de not_active Expired - Lifetime
- 1998-07-20 CN CNB988073803A patent/CN1330754C/zh not_active Expired - Fee Related
-
1999
- 1999-12-02 IL IL133277A patent/IL133277A/en not_active IP Right Cessation
-
2000
- 2000-01-18 CU CU20000009A patent/CU23412A3/es not_active IP Right Cessation
-
2003
- 2003-10-01 US US10/674,433 patent/US20050100541A1/en not_active Abandoned
-
2006
- 2006-05-31 IL IL176076A patent/IL176076A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AZ KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM BY RU |