DOP2020000145A - Inhibidores de arginasa y sus métodos de uso - Google Patents
Inhibidores de arginasa y sus métodos de usoInfo
- Publication number
- DOP2020000145A DOP2020000145A DO2020000145A DO2020000145A DOP2020000145A DO P2020000145 A DOP2020000145 A DO P2020000145A DO 2020000145 A DO2020000145 A DO 2020000145A DO 2020000145 A DO2020000145 A DO 2020000145A DO P2020000145 A DOP2020000145 A DO P2020000145A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- methods
- compounds
- formula
- arginase inhibitors
- arginase
- Prior art date
Links
- 102000004452 Arginase Human genes 0.000 title abstract 2
- 108700024123 Arginases Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se divulgan compuestos de fórmula (Ia) o una sal farmacéuticamente aceptable de estos, composiciones farmacéuticas que comprenden compuestos de fórmula (Ia) y métodos para utilizarlas en el tratamiento del cáncer o una enfermedad respiratoria inflamatoria y la inhibición de la arginasa: (Ia) donde R1 es -NHR1a; R1a es -H o -C(O)CH(R1b)NHR1c; y R1b se selecciona entre -H, -alquilo (C1-C4) y CH2OR1d y R1c es -H; o R1b y R1c, junto con el átomo al que están unidos, forman un anillo heterocíclico de 5 miembros; y R1d es H o CH3;
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862631659P | 2018-02-17 | 2018-02-17 | |
| US201862671576P | 2018-05-15 | 2018-05-15 | |
| US201862721113P | 2018-08-22 | 2018-08-22 | |
| US201862778002P | 2018-12-11 | 2018-12-11 | |
| PCT/IB2019/051236 WO2019159120A1 (en) | 2018-02-17 | 2019-02-15 | Arginase inhibitors and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2020000145A true DOP2020000145A (es) | 2020-09-15 |
Family
ID=65763693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2020000145A DOP2020000145A (es) | 2018-02-17 | 2020-07-22 | Inhibidores de arginasa y sus métodos de uso |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11420984B2 (es) |
| EP (1) | EP3752251A1 (es) |
| JP (2) | JP7317841B2 (es) |
| KR (1) | KR102657919B1 (es) |
| CN (3) | CN111712302B (es) |
| AU (2) | AU2019221896B2 (es) |
| BR (1) | BR112020015973A2 (es) |
| CA (1) | CA3091365A1 (es) |
| CL (1) | CL2020002096A1 (es) |
| CR (1) | CR20200418A (es) |
| DO (1) | DOP2020000145A (es) |
| EC (1) | ECSP20058183A (es) |
| IL (1) | IL276711B2 (es) |
| JO (1) | JOP20200197A1 (es) |
| MA (1) | MA51837A (es) |
| MX (1) | MX2020008570A (es) |
| NI (1) | NI202000055A (es) |
| PE (1) | PE20210176A1 (es) |
| SG (1) | SG11202007739XA (es) |
| TW (1) | TWI803574B (es) |
| UA (1) | UA129083C2 (es) |
| UY (1) | UY38096A (es) |
| WO (1) | WO2019159120A1 (es) |
| ZA (2) | ZA202305542B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY38096A (es) * | 2018-02-17 | 2019-07-31 | Astrazeneca Ab | Inhibidores de arginasa y sus métodos de uso |
| TWI877770B (zh) | 2018-02-27 | 2025-03-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 |
| TWI723366B (zh) | 2018-03-29 | 2021-04-01 | 波蘭商昂科艾倫迪治療法股份公司 | 二肽哌啶衍生物 |
| JP7391046B2 (ja) | 2018-05-18 | 2023-12-04 | インサイト・コーポレイション | Ａ２ａ／ａ２ｂ阻害剤としての縮合ピリミジン誘導体 |
| BR112021000075A2 (pt) | 2018-07-05 | 2021-04-06 | Incyte Corporation | Derivados de pirazina fundidos como inibidores de a2a/a2b |
| KR102668252B1 (ko) | 2018-08-22 | 2024-05-21 | 아스트라제네카 아베 | 아르기나제 저해제 및 이의 사용 방법 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| US20220106335A1 (en) * | 2019-02-08 | 2022-04-07 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
| EP4054591A1 (en) * | 2019-11-04 | 2022-09-14 | Astrazeneca AB | Combination therapy for treating cancer |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2586219C2 (ru) | 2010-04-22 | 2016-06-10 | Марс, Инкорпорейтед | Ингибиторы аргиназы и их терапевтические применения |
| ES2568680T3 (es) | 2010-10-26 | 2016-05-03 | Mars, Incorporated | Boratos como inhibidores de arginasa |
| RU2695650C2 (ru) | 2010-12-31 | 2019-07-25 | Астразенека Юкей Лимитед | Ингибиторы аргиназы и способы их применения |
| EP2852598B3 (en) | 2012-04-18 | 2016-10-19 | Mars, Incorporated | Ring constrained analogs as arginase inhibitors |
| PL410665A1 (pl) | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| US10143699B2 (en) * | 2015-06-23 | 2018-12-04 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| SG10201911406TA (en) | 2015-10-30 | 2020-01-30 | Calithera Biosciences Inc | Compositions and methods for inhibiting arginase activity |
| PL417066A1 (pl) | 2016-05-04 | 2017-11-06 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| KR20190104521A (ko) | 2016-11-08 | 2019-09-10 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 아르기나제 억제제 병용 요법들 |
| SI3559009T1 (sl) | 2016-12-22 | 2021-08-31 | Calithera Biosciences, Inc. | Sestavki in postopki za zaviranje arginazne dejavnosti |
| WO2019120296A1 (en) | 2017-12-22 | 2019-06-27 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Heterocyclic compounds as arginase inhibitors |
| UY38096A (es) * | 2018-02-17 | 2019-07-31 | Astrazeneca Ab | Inhibidores de arginasa y sus métodos de uso |
| US12215116B2 (en) | 2018-03-13 | 2025-02-04 | Merck Sharp & Dohme Llc | Arginase inhibitors and methods of use |
| CN111770756B (zh) | 2018-04-27 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途 |
| WO2019218904A1 (zh) | 2018-05-18 | 2019-11-21 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、其制备方法及用途 |
| EP3810615A4 (en) | 2018-06-20 | 2022-03-30 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
| US20220106335A1 (en) * | 2019-02-08 | 2022-04-07 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
-
2019
- 2019-02-15 UY UY0001038096A patent/UY38096A/es active IP Right Grant
- 2019-02-15 CN CN201980013045.3A patent/CN111712302B/zh active Active
- 2019-02-15 WO PCT/IB2019/051236 patent/WO2019159120A1/en active IP Right Grant
- 2019-02-15 JP JP2020543307A patent/JP7317841B2/ja active Active
- 2019-02-15 CA CA3091365A patent/CA3091365A1/en active Pending
- 2019-02-15 CR CR20200418A patent/CR20200418A/es unknown
- 2019-02-15 MA MA051837A patent/MA51837A/fr unknown
- 2019-02-15 IL IL276711A patent/IL276711B2/en unknown
- 2019-02-15 KR KR1020207026580A patent/KR102657919B1/ko active Active
- 2019-02-15 EP EP19710796.4A patent/EP3752251A1/en active Pending
- 2019-02-15 UA UAA202005697A patent/UA129083C2/uk unknown
- 2019-02-15 US US16/969,739 patent/US11420984B2/en active Active
- 2019-02-15 AU AU2019221896A patent/AU2019221896B2/en active Active
- 2019-02-15 CN CN202311157009.9A patent/CN117180290A/zh active Pending
- 2019-02-15 CN CN202311155200.XA patent/CN117186134A/zh active Pending
- 2019-02-15 MX MX2020008570A patent/MX2020008570A/es unknown
- 2019-02-15 JO JOP/2020/0197A patent/JOP20200197A1/ar unknown
- 2019-02-15 BR BR112020015973-5A patent/BR112020015973A2/pt unknown
- 2019-02-15 PE PE2020001241A patent/PE20210176A1/es unknown
- 2019-02-15 SG SG11202007739XA patent/SG11202007739XA/en unknown
- 2019-02-15 TW TW108105043A patent/TWI803574B/zh active
-
2020
- 2020-07-22 DO DO2020000145A patent/DOP2020000145A/es unknown
- 2020-08-13 CL CL2020002096A patent/CL2020002096A1/es unknown
- 2020-08-14 NI NI202000055A patent/NI202000055A/es unknown
- 2020-09-16 EC ECSENADI202058183A patent/ECSP20058183A/es unknown
-
2022
- 2022-06-07 AU AU2022203938A patent/AU2022203938B2/en active Active
- 2022-07-15 US US17/812,736 patent/US12195485B2/en active Active
-
2023
- 2023-05-23 ZA ZA2023/05542A patent/ZA202305542B/en unknown
- 2023-07-10 US US18/349,336 patent/US11912727B2/en active Active
- 2023-07-19 JP JP2023117406A patent/JP7699171B2/ja active Active
-
2024
- 2024-10-21 ZA ZA2024/07941A patent/ZA202407941B/en unknown
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