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AR114420A1 - Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos - Google Patents

Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos

Info

Publication number
AR114420A1
AR114420A1 ARP190100506A ARP190100506A AR114420A1 AR 114420 A1 AR114420 A1 AR 114420A1 AR P190100506 A ARP190100506 A AR P190100506A AR P190100506 A ARP190100506 A AR P190100506A AR 114420 A1 AR114420 A1 AR 114420A1
Authority
AR
Argentina
Prior art keywords
methyl
hydrogen
deuterium
cyclopropyl
fluoro
Prior art date
Application number
ARP190100506A
Other languages
English (en)
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of AR114420A1 publication Critical patent/AR114420A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente solicitud se refiere a derivados de quinazolina, a procesos para su preparación, a composiciones farmacéuticas y a usos médicos de los mismos. Reivindicación 1: Un compuesto de fórmula (1) o una sal, solvato o polimorfo farmacéuticamente aceptable del mismo, en donde R¹ es un alquilo C₃₋₈, opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor, hidroxilo, amino, nitrilo, éster, amida, alquilo C₁₋₃ o alcoxi C₁₋₃, el carbono de R¹ unido a la amina en la posición 4 de la quinazolina se encuentra en la configuración (R); R² es hidrógeno, deuterio, flúor, cloro, metilo, metoxi, ciclopropilo, trifluorometilo o amida carboxílica, en donde cada uno de metilo, metoxi y ciclopropilo está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor y nitrilo; R³ es hidrógeno o deuterio; R⁴ es hidrógeno, deuterio, flúor, metilo, éster carboxílico, amida carboxílica, nitrilo, ciclopropilo, heterociclo C₄₋₇ o un grupo heteroarilo de 5 miembros, en donde cada uno de metilo, ciclopropilo, heterociclo C₄₋₇ y grupo heteroarilo de 5 miembros está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor, hidroxilo o metilo; y R⁵ es hidrógeno, deuterio, flúor, cloro, metilo o metoxi; a condición de que al menos uno de R², R³, R⁴ y R⁵ no sea hidrógeno.
ARP190100506A 2018-03-01 2019-02-28 Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos AR114420A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18159583 2018-03-01

Publications (1)

Publication Number Publication Date
AR114420A1 true AR114420A1 (es) 2020-09-02

Family

ID=61557126

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190100506A AR114420A1 (es) 2018-03-01 2019-02-28 Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos

Country Status (32)

Country Link
US (2) US11597704B2 (es)
EP (2) EP3759083B1 (es)
JP (1) JP2021514981A (es)
KR (1) KR20200128394A (es)
CN (1) CN111868040A (es)
AR (1) AR114420A1 (es)
AU (1) AU2019226342B2 (es)
BR (1) BR112020017702A2 (es)
CA (1) CA3091076A1 (es)
CL (3) CL2020002253A1 (es)
DK (1) DK3759083T3 (es)
EA (1) EA202092052A1 (es)
ES (1) ES2923579T3 (es)
HR (1) HRP20220781T1 (es)
HU (1) HUE059149T2 (es)
IL (2) IL305388A (es)
JO (1) JOP20200208A1 (es)
LT (1) LT3759083T (es)
MA (1) MA52411B1 (es)
MD (1) MD3759083T2 (es)
MX (2) MX2020009071A (es)
NZ (1) NZ768393A (es)
PH (1) PH12020551345A1 (es)
PL (1) PL3759083T3 (es)
PT (1) PT3759083T (es)
RS (1) RS63401B1 (es)
SG (1) SG11202008293YA (es)
SI (1) SI3759083T1 (es)
SM (1) SMT202200315T1 (es)
TW (2) TW202415645A (es)
UA (1) UA127590C2 (es)
WO (1) WO2019166532A1 (es)

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Publication number Priority date Publication date Assignee Title
EP3332007A4 (en) 2015-08-07 2019-07-17 Arrowhead Pharmaceuticals, Inc. RNAi Therapy Against Infection with Hepatitis B Virus
JOP20170161A1 (ar) 2016-08-04 2019-01-30 Arrowhead Pharmaceuticals Inc عوامل RNAi للعدوى بفيروس التهاب الكبد ب
TW202415645A (zh) * 2018-03-01 2024-04-16 愛爾蘭商健生科學愛爾蘭無限公司 ２，４－二胺基喹唑啉衍生物及其醫學用途
JP7373571B2 (ja) * 2019-01-14 2023-11-02 イネイト・テューマー・イミュニティ・インコーポレイテッド がん治療に用いるためのｎｌｒｐ３モジュレーターとしての置換キナゾリン
CA3140707A1 (en) * 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
KR102766465B1 (ko) * 2019-08-19 2025-02-10 상하이 지멍 바이오파마 아이엔씨 2-아미노피리미딘 화합물 및 이의 약학적 조성물 및 용도
WO2021114691A1 (zh) * 2019-12-13 2021-06-17 四川科伦博泰生物医药股份有限公司 含氮并环化合物、其制备方法及用途
KR20220123437A (ko) * 2020-01-02 2022-09-06 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 피리도피리미딘 유도체의 결정형 및 이의 제조 방법

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