DK84693D0 - Tetracycliske forbindelser - Google Patents

Tetracycliske forbindelser

Info

Publication number: DK84693D0
Authority: DK; Denmark
Prior art keywords: lower alkyl; chem; formula; independently hydrogen; alpha
Prior art date: 1987-04-13

Application number

DK93846A

Other languages

English (en)

Other versions

DK84693A (da

Inventor

Robin D Clark

Original Assignee

Syntax Usa Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-13

Filing date

1993-07-15

Publication date

1993-07-15

1993-07-15 Application filed by Syntax Usa Inc filed Critical Syntax Usa Inc

1993-07-15 Publication of DK84693A publication Critical patent/DK84693A/da

1993-07-15 Publication of DK84693D0 publication Critical patent/DK84693D0/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Anesthesiology (AREA)
Ophthalmology & Optometry (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Compounds Of Unknown Constitution (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK93846A 1987-04-13 1993-07-15 Tetracycliske forbindelser DK84693D0 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/037,320 US4791108A (en)	1987-04-13	1987-04-13	Sulfonyl-decahydro-8H-isoquino[2,1-G][1,6]-naphthyridines and related compounds useful as α2 -blockers

Publications (2)

Publication Number	Publication Date
DK84693A DK84693A (da)	1993-07-15
DK84693D0 true DK84693D0 (da)	1993-07-15

Family

ID=21893706

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK199388A DK171106B1 (da)	1987-04-13	1988-04-12	Sulfonyldecahydro-8H-isoquino-[2,1-g][1,6]-naphthyridiner, anvendelse af disse forbindelser ved fremstilling af et medikament, fremgangsmåde til fremstilling af disse forbindelser, farmaceutisk præparat indeholdende disse forbindelser og farmaceutisk præparat til brug ved behandling af en alfa2-blokker, samt fremgangsmåde til fremstilling af et farmaceutisk præparat
DK93846A DK84693D0 (da)	1987-04-13	1993-07-15	Tetracycliske forbindelser

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK199388A DK171106B1 (da)	1987-04-13	1988-04-12	Sulfonyldecahydro-8H-isoquino-[2,1-g][1,6]-naphthyridiner, anvendelse af disse forbindelser ved fremstilling af et medikament, fremgangsmåde til fremstilling af disse forbindelser, farmaceutisk præparat indeholdende disse forbindelser og farmaceutisk præparat til brug ved behandling af en alfa2-blokker, samt fremgangsmåde til fremstilling af et farmaceutisk præparat

Country Status (20)

Country	Link
US (1)	US4791108A (da)
EP (1)	EP0288196B1 (da)
JP (1)	JP2527784B2 (da)
KR (1)	KR960007864B1 (da)
AT (1)	ATE92066T1 (da)
AU (1)	AU613610B2 (da)
CA (1)	CA1331459C (da)
DE (1)	DE3882571T2 (da)
DK (2)	DK171106B1 (da)
ES (1)	ES2058264T3 (da)
FI (1)	FI88162C (da)
HU (2)	HU199469B (da)
IE (1)	IE60624B1 (da)
IL (1)	IL86039A (da)
MX (1)	MX11083A (da)
NO (1)	NO170805C (da)
NZ (1)	NZ224221A (da)
PH (1)	PH25961A (da)
PT (1)	PT87219B (da)
ZA (1)	ZA882562B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4956365A (en) *	1987-04-13	1990-09-11	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino(2,1-g)(1,6)naphthyridine derivatives and related compounds
US4886798A (en) *	1987-04-13	1989-12-12	Syntex (U.S.A.) Inc.	Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers
US4960891A (en) *	1987-04-13	1990-10-02	Syntex (U.S.A.) Inc.	Process for the preparation of decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives
GB9012469D0 (en) *	1990-06-05	1990-07-25	Glaxo Group Ltd	Medicaments
US5231181A (en) *	1991-03-21	1993-07-27	Syntex (U.S.A.) Inc.	Process for the preparation of (8as,12as,13as)-decahydroisoquino ((2,1-g) (1,6)-naphthyridin-8-one derivatives
CA2074038A1 (en) *	1991-07-17	1993-01-18	Robin D. Clark	Decahydro-8h-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a] pyrrol[2,3-e]quinolizine derivatives
US5229387A (en) *	1991-09-20	1993-07-20	Syntex (U.S.A.) Inc.	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine and decahydrobenzo[a]pyrrolo [2,3-e]quinolizine derivatives
EP1483231A1 (de) *	2002-03-04	2004-12-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Neue salmeterol-zimtsäuresalze, verfahren zu deren herstellung und deren verwendung als arzneimittel
CN103387583B (zh) *	2012-05-09	2018-04-13	中国科学院上海药物研究所	二芳基并[a,g]喹嗪类化合物、其制备方法、药物组合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3953598A (en) *	1972-09-08	1976-04-27	The Upjohn Company	Compounds, compositions and methods of use
GB1513824A (en) *	1975-05-22	1978-06-14	Wyeth John & Brother Ltd	1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
US4353911A (en) *	1979-07-20	1982-10-12	Andre Buzas	Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
CH645653A5 (de) *	1980-08-01	1984-10-15	Ciba Geigy Ag	Quaternaere, copolymere, hochmolekulare ammoniumsalze auf acrylbasis, deren herstellung und verwendung als aktive komponente in kosmetischen mitteln.
US4454139A (en) *	1980-08-28	1984-06-12	John Wyeth & Brother, Limited	α2 -Adrenoceptor antagonistic benzoquinolizines
GB8302499D0 (en) *	1983-01-29	1983-03-02	Wyeth John & Brother Ltd	Benzoquinolizines
US4690928A (en) *	1984-02-02	1987-09-01	Merck & Co., Inc.	Substituted hexahydro arylquinolizines as α2 blockers
US4673680A (en) *	1985-09-18	1987-06-16	Pendleton Robert G	α2 -adrenergic receptor antagonists as modifiers of gastrointestinal motility

1987
- 1987-04-13 US US07/037,320 patent/US4791108A/en not_active Expired - Fee Related
1988
- 1988-04-12 PH PH36784A patent/PH25961A/en unknown
- 1988-04-12 PT PT87219A patent/PT87219B/pt not_active IP Right Cessation
- 1988-04-12 IE IE109788A patent/IE60624B1/en not_active IP Right Cessation
- 1988-04-12 NO NO881574A patent/NO170805C/no unknown
- 1988-04-12 MX MX1108388A patent/MX11083A/es unknown
- 1988-04-12 AU AU14502/88A patent/AU613610B2/en not_active Ceased
- 1988-04-12 ES ES88303271T patent/ES2058264T3/es not_active Expired - Lifetime
- 1988-04-12 HU HU881816A patent/HU199469B/hu not_active IP Right Cessation
- 1988-04-12 NZ NZ224221A patent/NZ224221A/xx unknown
- 1988-04-12 AT AT88303271T patent/ATE92066T1/de not_active IP Right Cessation
- 1988-04-12 EP EP88303271A patent/EP0288196B1/en not_active Expired - Lifetime
- 1988-04-12 KR KR1019880004144A patent/KR960007864B1/ko not_active IP Right Cessation
- 1988-04-12 IL IL86039A patent/IL86039A/xx not_active IP Right Cessation
- 1988-04-12 CA CA000563919A patent/CA1331459C/en not_active Expired - Fee Related
- 1988-04-12 JP JP63090154A patent/JP2527784B2/ja not_active Expired - Lifetime
- 1988-04-12 ZA ZA882562A patent/ZA882562B/xx unknown
- 1988-04-12 DE DE88303271T patent/DE3882571T2/de not_active Expired - Fee Related
- 1988-04-12 DK DK199388A patent/DK171106B1/da not_active IP Right Cessation
- 1988-04-12 FI FI881687A patent/FI88162C/fi not_active IP Right Cessation
1993
- 1993-07-15 DK DK93846A patent/DK84693D0/da not_active Application Discontinuation
1994
- 1994-07-01 HU HU94P/P00005P patent/HU210349A9/hu unknown

Also Published As

Publication number	Publication date
EP0288196B1 (en)	1993-07-28
AU613610B2 (en)	1991-08-08
ZA882562B (en)	1989-12-27
PH25961A (en)	1992-01-13
ES2058264T3 (es)	1994-11-01
PT87219B (pt)	1992-12-31
JP2527784B2 (ja)	1996-08-28
DK84693A (da)	1993-07-15
ATE92066T1 (de)	1993-08-15
PT87219A (pt)	1988-05-01
IL86039A (en)	1993-05-13
NO170805C (no)	1992-12-09
KR960007864B1 (ko)	1996-06-13
DK171106B1 (da)	1996-06-10
DK199388A (da)	1988-10-14
FI88162B (fi)	1992-12-31
DE3882571D1 (de)	1993-09-02
FI88162C (fi)	1993-04-13
DK199388D0 (da)	1988-04-12
HU210349A9 (en)	1995-03-28
IE60624B1 (en)	1994-07-27
DE3882571T2 (de)	1994-01-20
IE881097L (en)	1988-10-13
CA1331459C (en)	1994-08-16
FI881687A0 (fi)	1988-04-12
EP0288196A1 (en)	1988-10-26
AU1450288A (en)	1988-10-13
HU199469B (en)	1990-02-28
IL86039A0 (en)	1988-09-30
FI881687A (fi)	1988-10-14
KR880012601A (ko)	1988-11-28
NO881574D0 (no)	1988-04-12
MX11083A (es)	1993-04-01
NZ224221A (en)	1990-07-26
JPS63277679A (ja)	1988-11-15
NO881574L (no)	1988-10-14
US4791108A (en)	1988-12-13
NO170805B (no)	1992-08-31
HUT47107A (en)	1989-01-30

Publication	Publication Date	Title
IL69912A (en)	1987-03-31	Substituted 1-hydroxyethyltriazolyl derivatives,their preparation and their use as plant protection agents
FI862757A0 (fi)	1986-06-27	Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
ATE93232T1 (de)	1993-09-15	Bis(methylendioxy)biphenyl-verbindungen.
DK84693D0 (da)	1993-07-15	Tetracycliske forbindelser
FI834730A0 (fi)	1983-12-22	1-karboxialkanoylperhydro-indol-2-karboxylsyror och deras derivat
ES2046229T3 (es)	1994-02-01	Composicion antiulcerosa.
ZA858418B (en)	1986-07-30	5-alkyl-1-phenyl-2-piperazinoalkylpyrazoline-3-one compounds and methods for the preparation thereof,intermediates for use in the preparation of said compounds and medicaments containing said compounds
PH23489A (en)	1989-08-16	Novel (4.2.0) bicyclooctane derivatives with valuable therapeutic properties
MX9204194A (es)	1993-08-01	Los compuestos de 1,2,4-oxadiazolil-fenoxialquilisoxazolas y su uso como agentes antivirales
ATE98961T1 (de)	1994-01-15	1,8-benzonaphthyridinderivate und ihre herstellung.
ATE98960T1 (de)	1994-01-15	1,8-benzonaphthyridinderivate, ihre herstellung und diese enthaltende zusammensetzungen.
DE69200862D1 (de)	1995-01-26	N-2-Chlorbenzyl-2-oxo- und N-2-Chlorbenzyl-2,2,-dioxo-1,2,3-Oxathiazolidinderivate, ihre Herstellung und ihre Verwendung in der Synthese von Thieno[3,2-c]pyridinderivaten.
GR3020488T3 (en)	1996-10-31	Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system
EP0364254A3 (en)	1991-08-14	Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives and related compounds
FI883507A (fi)	1989-02-01	Naftotiazepinderivat och deras framstaellning.
GB2071093B (en)	1984-01-18	Benzothiopyrano(2,3-c)pyridines

Legal Events

Date	Code	Title	Description
1993-07-15	A0	Application filed
1997-12-22	AHB	Application shelved due to non-payment