[go: up one dir, main page]

DK82087D0 - PYROCATECHAL DERIVATIVES - Google Patents

PYROCATECHAL DERIVATIVES

Info

Publication number
DK82087D0
DK82087D0 DK082087A DK82087A DK82087D0 DK 82087 D0 DK82087 D0 DK 82087D0 DK 082087 A DK082087 A DK 082087A DK 82087 A DK82087 A DK 82087A DK 82087 D0 DK82087 D0 DK 82087D0
Authority
DK
Denmark
Prior art keywords
pyrocatechal
derivatives
pyrocatechal derivatives
Prior art date
Application number
DK082087A
Other languages
Danish (da)
Other versions
DK82087A (en
DK175069B1 (en
Inventor
Karl Bernauer
Janos Borgulya
Hans Bruderer
Prada Mose Da
Gerhard Zuercher
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK82087D0 publication Critical patent/DK82087D0/en
Publication of DK82087A publication Critical patent/DK82087A/en
Application granted granted Critical
Publication of DK175069B1 publication Critical patent/DK175069B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/15—Six-membered rings
    • C07D285/16—Thiadiazines; Hydrogenated thiadiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DK198700820A 1986-03-11 1987-02-18 Pyrocatechol derivatives DK175069B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH98086 1986-03-11
CH98086 1986-03-11
CH6287 1987-01-09
CH6287 1987-01-09

Publications (3)

Publication Number Publication Date
DK82087D0 true DK82087D0 (en) 1987-02-18
DK82087A DK82087A (en) 1987-09-12
DK175069B1 DK175069B1 (en) 2004-05-24

Family

ID=25683401

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700820A DK175069B1 (en) 1986-03-11 1987-02-18 Pyrocatechol derivatives

Country Status (22)

Country Link
EP (1) EP0237929B1 (en)
JP (1) JPH0742254B2 (en)
AR (1) AR245097A1 (en)
AT (1) ATE90072T1 (en)
AU (1) AU603788B2 (en)
CA (1) CA1302418C (en)
CS (1) CS402291A3 (en)
DE (1) DE3786026D1 (en)
DK (1) DK175069B1 (en)
ES (1) ES2056792T3 (en)
FI (1) FI91396C (en)
HK (1) HK165896A (en)
HU (1) HU201900B (en)
IE (1) IE61316B1 (en)
IL (1) IL81791A (en)
LU (1) LU90219I2 (en)
LV (1) LV5742B4 (en)
MC (1) MC1807A1 (en)
NL (1) NL970041I1 (en)
NO (2) NO165959C (en)
NZ (1) NZ219496A (en)
PT (1) PT84449B (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283352A (en) * 1986-11-28 1994-02-01 Orion-Yhtyma Oy Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same
YU213587A (en) * 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives
FI864875A0 (en) * 1986-11-28 1986-11-28 Orion Yhtymae Oy NYA FARMAKOLOGISKT AKTIVA FOERENINGAR, DESSA INNEHAOLLANDE KOMPOSITIONER SAMT FOERFARANDE OCH MELLANPRODUKTER FOER ANVAENDNING VID FRAMSTAELLNING AV DESSA.
US5489614A (en) * 1987-11-27 1996-02-06 Orion-Yhtyma Oy Catechol derivatives, their physiologically acceptable salts, esters and use
MTP1031B (en) * 1987-12-24 1990-10-04 Orion Yhtymae Oy New use of cathecol-o-methyl transferase (comt) inhibitors and their physiologically acceptable salts and esters
GB9113431D0 (en) * 1991-06-20 1991-08-07 Orion Yhytma Oy Method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
GB9419274D0 (en) * 1994-09-23 1994-11-09 Orion Yhtymae Oy New method for the preparation of 3,4-dihydroxy-5-nitrobenzaldehyde
GB9626472D0 (en) 1996-12-20 1997-02-05 Aperia Anita C New use of comt inhibitors
ID19540A (en) * 1997-01-22 1998-07-23 Hoffmann La Roche METHOD OF MAKING BENZOFENON DECREASES
GB9819382D0 (en) 1998-09-04 1998-10-28 Cerebrus Ltd Chemical compounds I
GB2344819A (en) * 1998-12-18 2000-06-21 Portela & Ca Sa 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones
DE19960105A1 (en) * 1999-12-14 2001-06-21 Haarmann & Reimer Gmbh Catechol oximes and their use in cosmetic and dermatological preparations
FI20000635A0 (en) * 2000-03-17 2000-03-17 Orion Yhtymae Oyj Use of COMT inhibitors as an analgesic
WO2001087857A1 (en) * 2000-05-16 2001-11-22 Nippon Soda Co., Ltd. Phenyloxazole compounds and fungicides for agricultural and horticultural use
GB2363792A (en) * 2000-06-21 2002-01-09 Portela & Ca Sa Nitrocatechols
GB0015228D0 (en) * 2000-06-21 2000-08-16 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders
FI20012242A0 (en) * 2001-11-19 2001-11-19 Orion Corp New pharmaceutical compounds
US20060105036A1 (en) 2003-05-12 2006-05-18 Stephen Peroutka Threo-dops controlled release formulation
US8158149B2 (en) 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
CA2563704A1 (en) 2004-05-04 2005-11-24 Children's Medical Center Corporation Methods and compositions for treatment of preeclampsia
DE102004023332A1 (en) * 2004-05-12 2006-01-19 Bayer Cropscience Gmbh Quinoxaline-2-one derivatives, crop protection agents containing them, and processes for their preparation and their use
JP2008519811A (en) 2004-11-10 2008-06-12 オリオン コーポレーション Treatment of restless leg syndrome
PT1907382E (en) 2005-07-26 2015-09-25 Bial Portela & Ca Sa Nitrocatechol derivatives as comt inhibitors
EP1845097A1 (en) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
EP1948155B1 (en) 2006-06-28 2012-03-07 Chelsea Therapeutics Inc. Pharmaceutical compositions comprising droxidopa
US8592166B2 (en) 2006-11-21 2013-11-26 Beth Israel Deaconess Medical Center, Inc. Hypoxia related genes and proteins for the treatment and diagnosis of pregnancy related complications
DK2481410T3 (en) 2007-01-31 2016-10-24 Bial - Portela & Ca S A Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen
CN101657193A (en) 2007-03-09 2010-02-24 切尔西治疗公司 Droxidopa and its pharmaceutical composition for treating fibromyalgia
EP2167066B1 (en) 2007-05-07 2013-06-26 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of attention deficit disorders
JP2009126784A (en) * 2007-11-19 2009-06-11 Mitsubishi Gas Chem Co Inc Method for producing 2-iodo-3,4-dimethoxybenzonitrile
TWI415607B (en) * 2007-12-25 2013-11-21 Kissei Pharmaceutical Novel catechol derivatives, pharmaceutical compositions containing the same and their uses
TW200942531A (en) 2008-03-17 2009-10-16 Bial Portela & Companhia S A Crystal forms of a nitrocatechol
ES2402562T3 (en) 2008-07-04 2013-05-06 Kissei Pharmaceutical Co., Ltd. Catechol derivative and its use
AU2010231961B2 (en) 2009-04-01 2015-05-21 Bial - Portela & Ca., S.A. Pharmaceutical formulations comprising nitrocatechol derivatives and methods of making thereof
JP5529639B2 (en) * 2009-06-18 2014-06-25 キッセイ薬品工業株式会社 Novel catechol-O-methyltransferase inhibitor
JP5707063B2 (en) * 2009-06-18 2015-04-22 キッセイ薬品工業株式会社 Novel catechol derivatives, pharmaceutical compositions containing them, and uses thereof
KR101868326B1 (en) 2010-03-04 2018-06-19 오리온 코포레이션 Use of levodopa, carbidopa and entacapone for treating parkinson's disease
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
JP5880913B2 (en) 2011-05-17 2016-03-09 三郎 佐古田 Treatment for trunk symptoms (postural reflex abnormalities) in Parkinson's disease
BR112014014341A2 (en) 2011-12-13 2017-08-22 Bial Portela & Ca Sa METHYL INTERMEDIATE, ITS PREPARATION METHOD AND USES, AND PHARMACEUTICAL COMPOSITION
BR112014018851A2 (en) 2012-01-31 2017-07-04 Lundbeck Na Ltd improvement of postural stability by administering droxidopa
US9109005B2 (en) * 2012-02-23 2015-08-18 Boehringer Ingelheim International Gmbh Method for manufacturing of ciclesonide
TWI638802B (en) * 2012-05-24 2018-10-21 芬蘭商奧利安公司 Catechol o-methyltransferase activity inhibiting compounds
WO2014147464A2 (en) * 2013-03-20 2014-09-25 Ra Chem Pharma Limited Novel process for the preparation of tolcapone
JP2018500300A (en) 2014-11-28 2018-01-11 ノヴィファーマ，エス．アー． Medicines for delaying Parkinson's disease
NZ743725A (en) 2015-12-24 2024-11-29 Univ California Cftr regulators and methods of use thereof
JP2020158391A (en) * 2017-06-13 2020-10-01 株式会社富士薬品 Novel nitrocatechol derivative
JP7532259B2 (en) * 2018-04-05 2024-08-13 プレックス ファーマスーティカルズ，インク Eye disease treatment drugs
WO2022150962A1 (en) * 2021-01-12 2022-07-21 Westlake Pharmaceutical (Hangzhou) Co., Ltd. Protease inhibitors, preparation, and uses thereof
CN114560771B (en) * 2022-03-07 2023-10-27 中北大学 Method for photocatalytic selective nitration of bromophenol
WO2025016521A1 (en) 2023-07-18 2025-01-23 Universitat Autonoma De Barcelona Compound for the treatment of transthyretin amyloidosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54128542A (en) * 1978-03-27 1979-10-05 Ube Ind Ltd Preparation of 3-cyanocatechol derivative
GB2038819B (en) * 1978-12-21 1983-02-16 Secr Defence Initiatory explosives comprising a lead salt of 3,5-dinitro-catechol
EP0375668A3 (en) * 1983-10-25 1990-10-17 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
DE3406329A1 (en) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt PYRIDONE
CA1339860C (en) * 1985-06-17 1998-05-12 Tsunehiko Soga Derivatives of penem

Also Published As

Publication number Publication date
DK82087A (en) 1987-09-12
EP0237929B1 (en) 1993-06-02
ES2056792T3 (en) 1994-10-16
AR245097A1 (en) 1993-12-30
NZ219496A (en) 1990-12-21
EP0237929A1 (en) 1987-09-23
IL81791A (en) 1992-12-01
NO870984L (en) 1987-09-14
NO870984D0 (en) 1987-03-10
CS402291A3 (en) 1992-12-16
FI91396C (en) 1994-06-27
ATE90072T1 (en) 1993-06-15
JPS62240649A (en) 1987-10-21
LU90219I2 (en) 1998-05-28
HU201900B (en) 1991-01-28
IE61316B1 (en) 1994-11-02
AU6976487A (en) 1987-09-17
FI871041A (en) 1987-09-12
IL81791A0 (en) 1987-10-20
DK175069B1 (en) 2004-05-24
LV5742B4 (en) 1996-12-20
PT84449B (en) 1989-10-04
CA1302418C (en) 1992-06-02
HK165896A (en) 1996-09-13
HUT43804A (en) 1987-12-28
JPH0742254B2 (en) 1995-05-10
NO1998006I1 (en) 1998-01-28
PT84449A (en) 1987-04-01
NO165959C (en) 1991-05-08
NO165959B (en) 1991-01-28
FI871041A0 (en) 1987-03-10
NL970041I1 (en) 1998-02-02
AU603788B2 (en) 1990-11-29
IE870609L (en) 1987-09-11
LV5742A4 (en) 1996-10-20
DE3786026D1 (en) 1993-07-08
FI91396B (en) 1994-03-15
MC1807A1 (en) 1987-12-22

Similar Documents

Publication Publication Date Title
DK263587A (en) IMIDAZOQUINOLINYLETHERY DERIVATIVES
DK82087A (en) PYROCATECHAL DERIVATIVES
ATA312487A (en) TETRAHYDROCARBAZOLONE DERIVATIVES
DK69887D0 (en) DICHLORANILINE DERIVATIVES
AT399804B (en) SPORTSHOE
TR26815A (en) Azolylmethyl-cycropyl derivatives
TR24894A (en) N-FENILPIRAZOL DERIVATIVES
DK507188D0 (en) CHOLECALCIFERAL DERIVATIVES
DK693587D0 (en) ALKANSULPHONANILIDE DERIVATIVES
DK81888D0 (en) DIBENZOXEPIN DERIVATIVES
DK378088D0 (en) ALKENDER DERIVATIVES
DK519787D0 (en) STREAMLEDEFLADE
DK49688A (en) PROPIOLOPHENONE DERIVATIVES
DK691287D0 (en) 5-FLOURURACIL DERIVATIVES
DK210487A (en) SUBSTITUTED BENZIMIDAZOLD DERIVATIVES
DK444687A (en) ALFA-SUBSTITUTED KETONITRON DERIVATIVES
DK271088A (en) TIENOPYRIDINE DERIVATIVES
DK229887D0 (en) ALKENAMIDE DERIVATIVES
DK440687A (en) BICYCLOOCTAN DERIVATIVES
DK619187A (en) ISOINDOLD DERIVATIVES
DK695788A (en) NAPHTALEN DERIVATIVES
AT386436B (en) SHAFTSYSTEM
DK435087A (en) ISOPRENDER DERIVATIVES
DK440787A (en) BICYCLOOCTAN DERIVATIVES
DK71488A (en) DIPENYLETHYLEN DERIVATIVES

Legal Events

Date Code Title Description
ATS Application withdrawn
ATS Application withdrawn
PUP Patent expired