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DK577084A - 2,2'iminobisethanol-derivater og fremgangsmaade til fremstilling deraf - Google Patents

2,2'iminobisethanol-derivater og fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK577084A
DK577084A DK577084A DK577084A DK577084A DK 577084 A DK577084 A DK 577084A DK 577084 A DK577084 A DK 577084A DK 577084 A DK577084 A DK 577084A DK 577084 A DK577084 A DK 577084A
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DK
Denmark
Prior art keywords
procedures
preparing
iminobisethanol
derivatives
iminobisethanol derivatives
Prior art date
Application number
DK577084A
Other languages
English (en)
Other versions
DK165112B (da
DK165112C (da
DK577084D0 (da
Inventor
Guy Rasalia Eugene Van Lommen
Marcel Frans Leopold De Bruyn
Marc Francis Josephin Schroven
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK577084D0 publication Critical patent/DK577084D0/da
Publication of DK577084A publication Critical patent/DK577084A/da
Publication of DK165112B publication Critical patent/DK165112B/da
Application granted granted Critical
Publication of DK165112C publication Critical patent/DK165112C/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/92Naphthopyrans; Hydrogenated naphthopyrans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK577084A 1983-12-05 1984-12-04 2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse DK165112C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55808183A 1983-12-05 1983-12-05
US55808183 1983-12-05

Publications (4)

Publication Number Publication Date
DK577084D0 DK577084D0 (da) 1984-12-04
DK577084A true DK577084A (da) 1985-06-06
DK165112B DK165112B (da) 1992-10-12
DK165112C DK165112C (da) 1993-03-01

Family

ID=24228139

Family Applications (2)

Application Number Title Priority Date Filing Date
DK577084A DK165112C (da) 1983-12-05 1984-12-04 2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse
DK011892A DK165321C (da) 1983-12-05 1992-01-31 Oxiranderivater og fremgangsmaade til fremstilling deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK011892A DK165321C (da) 1983-12-05 1992-01-31 Oxiranderivater og fremgangsmaade til fremstilling deraf

Country Status (32)

Country Link
EP (1) EP0145067B1 (da)
JP (1) JPS60132977A (da)
KR (1) KR870000923B1 (da)
AR (1) AR241414A1 (da)
AT (1) ATE40361T1 (da)
AU (1) AU573658B2 (da)
BG (1) BG43866A3 (da)
CA (1) CA1337429C (da)
CS (1) CS250242B2 (da)
CY (1) CY1609A (da)
DD (1) DD235453A5 (da)
DE (1) DE3476388D1 (da)
DK (2) DK165112C (da)
DZ (1) DZ712A1 (da)
ES (1) ES538256A0 (da)
FI (1) FI82460C (da)
GR (1) GR81098B (da)
HK (1) HK52791A (da)
HU (1) HU202219B (da)
IE (1) IE57831B1 (da)
IL (1) IL73706A (da)
MA (1) MA20292A1 (da)
NO (2) NO169839C (da)
NZ (1) NZ210388A (da)
PH (1) PH22432A (da)
PL (1) PL146342B1 (da)
PT (1) PT79609B (da)
RO (1) RO91184B (da)
SG (1) SG47091G (da)
SU (1) SU1428199A3 (da)
ZA (1) ZA849445B (da)
ZW (1) ZW19784A1 (da)

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DE69433401T2 (de) * 1993-08-19 2004-09-16 Janssen Pharmaceutica N.V. Gefässverengende dihydrobenzopyranderivate
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
BR9709556A (pt) * 1996-06-07 1999-08-10 Procter & Gamble Dihidrobenzopirano e compostos a ele relacionados úteis como agentes antiflamatórios
EP1040106B1 (en) * 1997-12-19 2002-08-28 Bayer Corporation Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
US6713651B1 (en) 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
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US6593497B1 (en) 1999-06-02 2003-07-15 Theravance, Inc. β2-adrenergic receptor agonists
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UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
ATE437637T1 (de) 2001-05-02 2009-08-15 Nitromed Inc Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren
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ATE397605T1 (de) * 2004-07-30 2008-06-15 Torrent Pharmaceuticals Ltd Nebivolol und dessen pharmazeutisch unbedenkliche salze, herstellungsverfahren und pharmazeutische zusammensetzungen von nebivolol
DE602004026789D1 (de) * 2004-08-11 2010-06-02 Hetero Drugs Ltd Neues verfahren zur herstellung von nebivololzwischenprodukten
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α,α’-[亚氨基二(亚甲基)]-双-(6-氟-3,4-二氢-2H-1-苯并吡喃-2-甲醇)甲烷磺酸盐的合成方法
AU2006210952B2 (en) * 2005-01-31 2011-08-04 Mylan Laboratories, Inc. Pharmaceutical composition comprising hydroxylated nebivolol
CN101223184B (zh) * 2005-01-31 2012-10-10 麦兰实验室公司 葡糖苷酸化的奈必洛尔
EP1850842A1 (de) * 2005-02-11 2007-11-07 Stada Arzneimittel Ag Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer
AT502220A1 (de) * 2005-07-19 2007-02-15 Pharmacon Forschung & Beratung Verfahren zur herstellung von nebivolol
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7858812B2 (en) 2006-01-18 2010-12-28 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
EP2228374B1 (en) 2006-11-27 2013-06-05 ZaCh System S.p.A. Nebivolol formate
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CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
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IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
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IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
PT2907809T (pt) 2014-02-14 2019-01-16 Corden Pharma Int Gmbh Processo sem base para a preparação de intermediários de cetona utilizáveis para fabrico de nebivolol
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Also Published As

Publication number Publication date
SG47091G (en) 1991-07-26
KR850004485A (ko) 1985-07-15
DK165112B (da) 1992-10-12
DK165112C (da) 1993-03-01
HU202219B (en) 1991-02-28
IE57831B1 (en) 1993-04-21
NO2004007I1 (no) 2004-12-20
ATE40361T1 (de) 1989-02-15
AU3632684A (en) 1985-06-13
EP0145067A3 (en) 1986-03-26
AU573658B2 (en) 1988-06-16
NO2004007I2 (no) 2005-05-09
PT79609B (en) 1986-12-12
DE3476388D1 (en) 1989-03-02
DD235453A5 (de) 1986-05-07
FI82460B (fi) 1990-11-30
IL73706A (en) 1988-07-31
FI844777A0 (fi) 1984-12-04
ZA849445B (en) 1986-07-30
CA1337429C (en) 1995-10-24
CY1609A (en) 1992-04-03
PH22432A (en) 1988-09-12
DK577084D0 (da) 1984-12-04
JPS60132977A (ja) 1985-07-16
PT79609A (en) 1985-01-01
NZ210388A (en) 1987-07-31
HUT37418A (en) 1985-12-28
DK165321B (da) 1992-11-09
NO169839B (no) 1992-05-04
CS250242B2 (en) 1987-04-16
RO91184B (ro) 1987-07-31
ES8603870A1 (es) 1986-01-01
ZW19784A1 (en) 1986-07-02
SU1428199A3 (ru) 1988-09-30
GR81098B (en) 1984-12-17
AR241414A1 (es) 1992-07-31
RO91184A (ro) 1987-07-30
DK165321C (da) 1993-03-29
HK52791A (en) 1991-07-19
BG43866A3 (en) 1988-08-15
EP0145067B1 (en) 1989-01-25
JPH0250114B2 (da) 1990-11-01
FI82460C (fi) 1991-03-11
DZ712A1 (fr) 2004-09-13
NO844845L (no) 1985-06-06
NO169839C (no) 1992-08-12
DK11892A (da) 1992-01-31
FI844777L (fi) 1985-06-06
DK11892D0 (da) 1992-01-31
MA20292A1 (fr) 1985-07-01
ES538256A0 (es) 1986-01-01
EP0145067A2 (en) 1985-06-19
IE843103L (en) 1985-06-05
PL146342B1 (en) 1989-01-31
PL250524A1 (en) 1986-02-25
IL73706A0 (en) 1985-03-31
KR870000923B1 (ko) 1987-05-07

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