DK516583A - Tricycliske aminosyrer eller salte deraf, deres fremstilling og anvendelse samt mellemprodukter og disses fremstilling - Google Patents

Tricycliske aminosyrer eller salte deraf, deres fremstilling og anvendelse samt mellemprodukter og disses fremstilling Download PDF

Info

Publication number: DK516583A
Authority: DK; Denmark
Prior art keywords: preparation; intermediates; salts; amino acids; tricyclic amino
Prior art date: 1982-11-13

Application number

DK516583A

Other languages

English (en)

Other versions

DK160983C (da

DK160983B (da

DK516583D0 (da

Inventor

Hansjoerg Urbach

Rainer Henning

Reinhard Becker

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-13

Filing date

1983-11-11

Publication date

1984-05-14

1983-11-11 Application filed by Hoechst Ag filed Critical Hoechst Ag

1983-11-11 Publication of DK516583D0 publication Critical patent/DK516583D0/da

1984-05-14 Publication of DK516583A publication Critical patent/DK516583A/da

1991-05-13 Publication of DK160983B publication Critical patent/DK160983B/da

1991-10-28 Application granted granted Critical

1991-10-28 Publication of DK160983C publication Critical patent/DK160983C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK516583A 1982-11-13 1983-11-11 Analogifremgangsmaade til fremstilling af tricycliske aminosyrer eller deres fysiologisk acceptable salte samt derved anvendelige mellemprodukter DK160983C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19823242151 DE3242151A1 (de)	1982-11-13	1982-11-13	Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3242151		1982-11-13

Publications (4)

Publication Number	Publication Date
DK516583D0 DK516583D0 (da)	1983-11-11
DK516583A true DK516583A (da)	1984-05-14
DK160983B DK160983B (da)	1991-05-13
DK160983C DK160983C (da)	1991-10-28

Family

ID=6178144

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK516583A DK160983C (da)	1982-11-13	1983-11-11	Analogifremgangsmaade til fremstilling af tricycliske aminosyrer eller deres fysiologisk acceptable salte samt derved anvendelige mellemprodukter

Country Status (22)

Country	Link
US (2)	US4558065A (da)
EP (1)	EP0109020B1 (da)
JP (1)	JPS59101463A (da)
KR (1)	KR910000255B1 (da)
AR (2)	AR241474A1 (da)
AT (1)	ATE29889T1 (da)
AU (2)	AU565264B2 (da)
CA (1)	CA1246554A (da)
DE (2)	DE3242151A1 (da)
DK (1)	DK160983C (da)
ES (3)	ES527182A0 (da)
FI (1)	FI79116C (da)
GR (1)	GR78734B (da)
HU (1)	HU188978B (da)
IE (1)	IE56230B1 (da)
IL (1)	IL70207A (da)
MA (1)	MA19951A1 (da)
NO (1)	NO165148C (da)
NZ (1)	NZ206236A (da)
PH (1)	PH19675A (da)
PT (1)	PT77652B (da)
ZA (1)	ZA838378B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3226768A1 (de) *	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) *	1981-12-29	1991-02-14	Hoechst Ag	New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
DE3242151A1 (de) *	1982-11-13	1984-05-17	Hoechst Ag, 6230 Frankfurt	Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
US5175306A (en) *	1983-01-31	1992-12-29	Hoechst Aktiengesellschaft	Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3303344A1 (de)	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten aminosaeuren und deren estern
DE3333455A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung n-alkylierter dipeptide und deren estern
DE3413710A1 (de) *	1984-04-12	1985-10-24	Hoechst Ag, 6230 Frankfurt	Verfahren zur behandlung der herzinsuffizienz
US5684016A (en) *	1984-04-12	1997-11-04	Hoechst Aktiengesellschaft	Method of treating cardiac insufficiency
DE3431541A1 (de) *	1984-08-28	1986-03-06	Hoechst Ag, 6230 Frankfurt	Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US4678802A (en) *	1985-07-09	1987-07-07	Pfizer Inc.	1-acylcarbamoyloxindole-3-carboxamides as antiinflammatory agents
US5231080A (en) *	1985-10-15	1993-07-27	Hoechst Aktiengesellschaft	Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) *	1986-03-27	1993-07-27	Hoechst Aktiengesellschaft	Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) *	1986-10-02	1988-04-14	Hoechst Ag	Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) *	1986-11-21	1988-06-01	Hoechst Ag	Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) *	1987-07-03	1989-01-12	Hoechst Ag	Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) *	1988-04-22	1991-01-28	Hoechst Ag	Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
DD284030A5 (de)	1988-11-24	1990-10-31	Hoechst Ag,De	Verfahren zur herstellung von peptiden mit bradykinin-antagonistischer wirkung
LT3872B (en)	1993-12-06	1996-04-25	Hoechst Ag	Novel peptides and pharmaceutical compositions containing them
FR2746394B1 (fr)	1996-03-20	1998-05-29	Roussel Uclaf	Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
PT796855E (pt)	1996-03-20	2002-07-31	Hoechst Ag	Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
DE19653647A1 (de)	1996-12-20	1998-06-25	Hoechst Ag	Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19741235A1 (de)	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) *	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de)	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
EP1615886A1 (en) *	2003-04-15	2006-01-18	Warner-Lambert Company LLC	[c]-fused bicyclic proline derivatives and their use for treating arthritic conditions
BRPI0409560A (pt) *	2003-04-15	2006-04-18	Warner Lambert Co	derivados bicìclicos [b]-condensados de prolina e sua utilização para tratar condições artrìticas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4060626A (en) *	1972-01-26	1977-11-29	Boehringer Mannheim G.M.B.H.	Indole-carboxylic carbon compounds and pharmaceutical compositions containing them
FR2491469A1 (fr) *	1980-10-02	1982-04-09	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3118191A1 (de) *	1981-05-08	1982-11-25	Hoechst Ag, 6000 Frankfurt	Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3174844D1 (en) *	1980-10-23	1986-07-24	Schering Corp	Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4431645A (en) *	1982-03-08	1984-02-14	Schering Corporation	Antihypertensive agents
US4431644A (en) *	1982-03-08	1984-02-14	Schering Corporation	Antihypertensive agents
DE3360065D1 (en) *	1982-03-08	1985-03-28	Schering Corp	Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
DE3242151A1 (de) *	1982-11-13	1984-05-17	Hoechst Ag, 6230 Frankfurt	Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung

1982
- 1982-11-13 DE DE19823242151 patent/DE3242151A1/de not_active Withdrawn
1983
- 1983-11-07 DE DE8383111079T patent/DE3373818D1/de not_active Expired
- 1983-11-07 EP EP83111079A patent/EP0109020B1/de not_active Expired
- 1983-11-07 AT AT83111079T patent/ATE29889T1/de not_active IP Right Cessation
- 1983-11-08 HU HU833828A patent/HU188978B/hu not_active IP Right Cessation
- 1983-11-10 ZA ZA838378A patent/ZA838378B/xx unknown
- 1983-11-10 US US06/550,531 patent/US4558065A/en not_active Expired - Lifetime
- 1983-11-10 FI FI834131A patent/FI79116C/fi not_active IP Right Cessation
- 1983-11-11 PT PT77652A patent/PT77652B/pt not_active IP Right Cessation
- 1983-11-11 NZ NZ206236A patent/NZ206236A/en unknown
- 1983-11-11 KR KR1019830005346A patent/KR910000255B1/ko not_active IP Right Cessation
- 1983-11-11 IE IE2633/83A patent/IE56230B1/en not_active IP Right Cessation
- 1983-11-11 AR AR83294785A patent/AR241474A1/es active
- 1983-11-11 NO NO834128A patent/NO165148C/no not_active IP Right Cessation
- 1983-11-11 JP JP58211141A patent/JPS59101463A/ja active Granted
- 1983-11-11 ES ES527182A patent/ES527182A0/es active Granted
- 1983-11-11 PH PH29818A patent/PH19675A/en unknown
- 1983-11-11 DK DK516583A patent/DK160983C/da active
- 1983-11-11 MA MA20172A patent/MA19951A1/fr unknown
- 1983-11-11 AU AU21197/83A patent/AU565264B2/en not_active Ceased
- 1983-11-11 IL IL70207A patent/IL70207A/xx not_active IP Right Cessation
- 1983-11-11 GR GR72949A patent/GR78734B/el unknown
- 1983-11-14 CA CA000441040A patent/CA1246554A/en not_active Expired
1984
- 1984-01-20 ES ES529037A patent/ES529037A0/es active Granted
- 1984-01-20 ES ES529030A patent/ES529030A0/es active Granted
1985
- 1985-05-17 AR AR85300427A patent/AR243506A1/es active
- 1985-09-06 US US06/773,077 patent/US4614805A/en not_active Expired - Lifetime
1987
- 1987-02-06 AU AU68597/87A patent/AU584273B2/en not_active Ceased

Also Published As

Publication number	Publication date
AU6859787A (en)	1987-05-07
IL70207A (en)	1988-12-30
FI834131A (fi)	1984-05-14
KR910000255B1 (ko)	1991-01-23
EP0109020A3 (en)	1985-07-17
US4558065A (en)	1985-12-10
ATE29889T1 (de)	1987-10-15
PT77652A (de)	1983-12-01
DK160983C (da)	1991-10-28
ES8500230A1 (es)	1984-10-01
AU584273B2 (en)	1989-05-18
NO165148C (no)	1991-01-09
PH19675A (en)	1986-06-09
ES8406438A1 (es)	1984-08-01
CA1246554A (en)	1988-12-13
AR243506A1 (es)	1993-08-31
AU565264B2 (en)	1987-09-10
IL70207A0 (en)	1984-02-29
EP0109020B1 (de)	1987-09-23
ES8500229A1 (es)	1984-10-01
US4614805A (en)	1986-09-30
DE3242151A1 (de)	1984-05-17
ES529030A0 (es)	1984-10-01
HU188978B (en)	1986-05-28
NO165148B (no)	1990-09-24
JPS59101463A (ja)	1984-06-12
ES527182A0 (es)	1984-08-01
PT77652B (de)	1986-04-17
KR840006623A (ko)	1984-12-01
FI79116B (fi)	1989-07-31
AU2119783A (en)	1984-05-17
DK160983B (da)	1991-05-13
IE56230B1 (en)	1991-05-22
EP0109020A2 (de)	1984-05-23
ES529037A0 (es)	1984-10-01
NZ206236A (en)	1988-03-30
FI834131A0 (fi)	1983-11-10
GR78734B (da)	1984-10-02
AR241474A1 (es)	1992-07-31
DE3373818D1 (en)	1987-10-29
ZA838378B (en)	1984-06-27
MA19951A1 (fr)	1984-07-01
FI79116C (fi)	1989-11-10
IE832633L (en)	1984-05-13
NO834128L (no)	1984-05-14
DK516583D0 (da)	1983-11-11
JPH0472839B2 (da)	1992-11-19

Publication	Publication Date	Title
DK516583A (da)	1984-05-14	Tricycliske aminosyrer eller salte deraf, deres fremstilling og anvendelse samt mellemprodukter og disses fremstilling
DK58184A (da)	1984-08-11	3-amino-1-benzazepin-2-on-1-alkansyrer og salte deraf samt deres fremstilling og anvendelse
DK61887D0 (da)	1987-02-06	Substituerede 5-amino-4-hydroxy-valerylderivater og salte deraf samt deres fremstilling og anvendelse
DK217787A (da)	1987-10-31	Substituerede 2,4-diamino-5-cyano-pyrimidiner og salte deraf samt deres fremstilling og anvendelse
DK525581A (da)	1982-05-29	Imidazolylphenylamidiner eller salte deraf fremgangsmaade til deres fremstilling deres anvendelse samt mellemprodukter til deres fremstilling
DK426083A (da)	1984-03-21	Pteriner, fremgangsmaader til deres fremstilling samt deres anvendelse
DK43685D0 (da)	1985-01-31	Benzobicycliske lactamsyrer og derivater deraf, fremgangsmaade til deres fremstilling samt deres anvendelse
DK197684D0 (da)	1984-04-17	Substituerede indeno-pyridazinoner og salte deraf,fremgangsmaade til deres fremstilling samt deres anvendelse
DK291485D0 (da)	1985-06-27	Usymmetriske aliphatiske thioethere og salte deraf samt deres fremstilling og anvendelse
DK375684D0 (da)	1984-08-02	Cyclopeptider med immunstimulerende virkning eller salte deraf, deres femstilling og anvendelse samt forstadier dertil og disses fremstilling
FI862357A (fi)	1987-01-17	Kaerl eller kanna med loestagbart svaenglock.
DK586283A (da)	1984-06-22	Substituerede azabicycloalkaner og salte deraf samt deres fremstilling og anvendelse
DK125583A (da)	1983-09-20	Benzensulfonylurinstoffer eller salte deraf, deres fremstilling og anvendelse
DK541085A (da)	1986-05-24	Substituerede benzamider og salte deraf samt deres fremstilling og anvendelse
DK222384D0 (da)	1984-05-04	2-aminolavalkyl-2-penem-forbindelser og salte deraf samt deres fremstilling og anvendelse
DK256484D0 (da)	1984-05-24	Aryloxycycloalkanolaminoalkylenarylketoner eller salte deraf,deres fremstilling og mellemprodukter hertil
DK247884A (da)	1984-11-22	Substituerede tetrahydrothiopyran-3,5-dion-4-carboxamider, fremgangsmaade til deres fremstilling og deres anvendelse samt mellemprodukter til fremstillingen
DK87682A (da)	1982-08-28	Aminoacridin-alfa,beta-(d)- eller -(l)-n-glycosid-derivater eller salte deraf,deres fremstilling og anvendelse som antisvulstmidler
DK167785D0 (da)	1985-04-12	Substituerede 1-aminoalkylamino-4-aryloxypiperidiner eller farmaceutisk acceptable salte deraf, deres fremstilling og mellemprodukter hertil samt deres anvendelse som analgetika
DK368483D0 (da)	1983-08-12	Imidazolderivater eller salte deraf, fremgangsmade til deres fremstilling samt deres anvendelse
FI871049A0 (fi)	1987-03-10	Reglersystem foer propeller med reglerbar propellerstigning.
DK415686D0 (da)	1986-09-01	Phenylalaninderivater eller salte deraf samt deres anvendelse
DK268487A (da)	1987-11-28	Alkoxyalkyl- og alkylmercaptoalkylsubstituerede, bicycliske benzofuroisoquinoliner eller syreadditionssalte deraf og deres anvendelse
DK72887D0 (da)	1987-02-13	2-aminoacyloxymethyl-2-penem-forbindelser og salte deraf samt deres fremstilling og anvendelse
DK325687A (da)	1987-12-27	Hydrogenerede 1-phenoxyalkylpyridin-3-carboxylsyreforbindelser og salte deraf samt deres fremstilling og anvendelse