DK429780A - 1,2,4-oxadiazolin-5-on-derivater eller syreadditionssalte eller kvaternaere salte deraf og deres fremstilling - Google Patents

1,2,4-oxadiazolin-5-on-derivater eller syreadditionssalte eller kvaternaere salte deraf og deres fremstilling

Info

Publication number: DK429780A
Authority: DK; Denmark
Prior art keywords: salts; oxadiazoline; derivatives; preparation; acid additional
Prior art date: 1979-10-11

Application number

DK429780A

Other languages

English (en)

Other versions

DK149854C (da

DK149854B (da

Inventor

K Takacs

I Kiss

A Simay

P Literati

M Hetyey

M Ecsery

L Szekeres

G Papp

S Viragh

E Udvardy

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-11

Filing date

1980-10-10

Publication date

1981-04-12

1980-10-10 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1981-04-12 Publication of DK429780A publication Critical patent/DK429780A/da

1986-10-13 Publication of DK149854B publication Critical patent/DK149854B/da

1987-04-21 Application granted granted Critical

1987-04-21 Publication of DK149854C publication Critical patent/DK149854C/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- C07D273/04—Six-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK429780A 1979-10-11 1980-10-10 Analogifremgangsmaade til fremstilling af 1,2,4-oxadiazolin-5-oner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf samt mellemprodukter til anvendelse ved fremstillingen DK149854C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU79CI1973A HU179951B (en)	1979-10-11	1979-10-11	Process for preparing 1,2,4-oxadiazolin-5-one derivatives and pharmaceutical compositions containing thereof
HUCI001973		1979-10-11

Publications (3)

Publication Number	Publication Date
DK429780A true DK429780A (da)	1981-04-12
DK149854B DK149854B (da)	1986-10-13
DK149854C DK149854C (da)	1987-04-21

Family

ID=10994764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK429780A DK149854C (da)	1979-10-11	1980-10-10	Analogifremgangsmaade til fremstilling af 1,2,4-oxadiazolin-5-oner eller farmaceutisk acceptable syreadditionssalte eller kvaternaere salte deraf samt mellemprodukter til anvendelse ved fremstillingen

Country Status (23)

Country	Link
US (1)	US4365064A (da)
JP (1)	JPS5661375A (da)
AT (1)	AT375369B (da)
BE (1)	BE885633A (da)
CA (1)	CA1154019A (da)
CH (1)	CH649547A5 (da)
CS (1)	CS241032B2 (da)
DD (1)	DD153550A5 (da)
DE (1)	DE3037432A1 (da)
DK (1)	DK149854C (da)
ES (1)	ES8106725A1 (da)
FI (2)	FI71932C (da)
FR (1)	FR2467203A1 (da)
GB (1)	GB2059967B (da)
HU (1)	HU179951B (da)
IL (1)	IL61175A (da)
IT (1)	IT1129305B (da)
NL (1)	NL8005586A (da)
NO (1)	NO154795C (da)
PL (3)	PL131375B1 (da)
SE (1)	SE452158B (da)
SU (1)	SU1087519A1 (da)
YU (1)	YU41738B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU180708B (en) *	1979-10-11	1983-04-29	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 1,2,4-oxadiazine derivatives
US6887872B2 (en) *	2000-03-20	2005-05-03	N-Gene Research Laboratiories Inc.	Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
US9365555B2 (en) *	2012-12-21	2016-06-14	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
LT2935222T (lt)	2012-12-21	2018-12-27	Epizyme, Inc.	Prmt5 slopikliai ir jų panaudojimas
US10118918B2 (en)	2012-12-21	2018-11-06	Epizyme, Inc.	PRMT5 inhibitors and uses thereof
CA2894126A1 (en)	2012-12-21	2014-06-26	Epizyme, Inc.	Prmt5 inhibitors and uses thereof
EP2935243B1 (en)	2012-12-21	2018-03-14	Epizyme, Inc.	Prmt5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
JP2017530940A (ja)	2014-08-04	2017-10-19	エピザイム，インコーポレイティド	Ｐｒｍｔ５阻害剤およびその使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1529700A (fr) *	1967-04-11	1968-06-21	Dausse Sa Lab	Tertioaminoalcoyl oxadiazolinones et leur procédé de préparation
FR1575552A (da) *	1967-12-07	1969-07-25
US4038279A (en) *	1972-12-23	1977-07-26	Boehringer Ingelheim Gmbh	N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
US3994891A (en) *	1974-12-20	1976-11-30	Armour Pharmaceutical Company	Tetrahydroisoquinoline compounds
US4187220A (en) *	1977-08-30	1980-02-05	Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T.	New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same
HU180708B (en) *	1979-10-11	1983-04-29	Chinoin Gyogyszer Es Vegyeszet	Process for preparing new 1,2,4-oxadiazine derivatives

1979
- 1979-10-11 HU HU79CI1973A patent/HU179951B/hu not_active IP Right Cessation
1980
- 1980-09-30 IL IL61175A patent/IL61175A/xx unknown
- 1980-10-03 DE DE19803037432 patent/DE3037432A1/de not_active Withdrawn
- 1980-10-06 CS CS806737A patent/CS241032B2/cs unknown
- 1980-10-07 SE SE8007025A patent/SE452158B/sv not_active IP Right Cessation
- 1980-10-09 JP JP14066880A patent/JPS5661375A/ja active Pending
- 1980-10-09 IT IT68555/80A patent/IT1129305B/it active
- 1980-10-09 FR FR8021624A patent/FR2467203A1/fr active Granted
- 1980-10-09 NL NL8005586A patent/NL8005586A/nl not_active Application Discontinuation
- 1980-10-09 AT AT0501380A patent/AT375369B/de not_active IP Right Cessation
- 1980-10-10 BE BE0/202406A patent/BE885633A/fr not_active IP Right Cessation
- 1980-10-10 CA CA000362217A patent/CA1154019A/en not_active Expired
- 1980-10-10 PL PL1980227209A patent/PL131375B1/pl unknown
- 1980-10-10 YU YU2594/80A patent/YU41738B/xx unknown
- 1980-10-10 CH CH7599/80A patent/CH649547A5/de not_active IP Right Cessation
- 1980-10-10 DK DK429780A patent/DK149854C/da not_active IP Right Cessation
- 1980-10-10 ES ES495819A patent/ES8106725A1/es not_active Expired
- 1980-10-10 PL PL1980232292A patent/PL131451B1/pl unknown
- 1980-10-10 PL PL1980232293A patent/PL132131B1/pl unknown
- 1980-10-10 FI FI803220A patent/FI71932C/fi not_active IP Right Cessation
- 1980-10-10 FI FI803219A patent/FI71318C/fi not_active IP Right Cessation
- 1980-10-10 GB GB8032828A patent/GB2059967B/en not_active Expired
- 1980-10-10 NO NO803044A patent/NO154795C/no unknown
- 1980-10-10 DD DD80224478A patent/DD153550A5/de not_active IP Right Cessation
- 1980-10-10 SU SU802993201A patent/SU1087519A1/ru active
- 1980-10-14 US US06/196,583 patent/US4365064A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI71318C (fi)	1986-12-19
NO154795B (no)	1986-09-15
GB2059967A (en)	1981-04-29
FI71318B (fi)	1986-09-09
DK149854C (da)	1987-04-21
SE452158B (sv)	1987-11-16
YU259480A (en)	1984-02-29
PL131375B1 (en)	1984-11-30
IL61175A0 (en)	1980-11-30
FI803219L (fi)	1981-04-12
PL131451B1 (en)	1984-11-30
NO154795C (no)	1986-12-29
NO803044L (no)	1981-04-13
US4365064A (en)	1982-12-21
BE885633A (fr)	1981-02-02
SU1087519A1 (ru)	1984-04-23
IL61175A (en)	1984-08-31
FR2467203B1 (da)	1985-03-22
DE3037432A1 (de)	1981-05-27
FI803220L (fi)	1981-04-12
PL232292A1 (da)	1982-04-26
PL132131B1 (en)	1985-02-28
HU179951B (en)	1983-01-28
GB2059967B (en)	1983-06-02
DD153550A5 (de)	1982-01-13
CA1154019A (en)	1983-09-20
FI71932C (fi)	1987-03-09
PL232293A1 (da)	1982-04-26
SE8007025L (sv)	1981-04-12
FR2467203A1 (fr)	1981-04-17
IT1129305B (it)	1986-06-04
ES495819A0 (es)	1981-09-16
CH649547A5 (de)	1985-05-31
CS673780A2 (en)	1985-06-13
JPS5661375A (en)	1981-05-26
YU41738B (en)	1987-12-31
NL8005586A (nl)	1981-04-14
ES8106725A1 (es)	1981-09-16
CS241032B2 (en)	1986-03-13
FI71932B (fi)	1986-11-28
ATA501380A (de)	1983-12-15
AT375369B (de)	1984-07-25
PL227209A1 (da)	1981-12-11
IT8068555A0 (it)	1980-10-09
DK149854B (da)	1986-10-13

Publication	Publication Date	Title
DK23981A (da)	1982-04-08	Agmatinderivater og salte deraf deres fremstilling og anvendelse
DK513480A (da)	1981-07-09	N-adamantansubstituerede tetrapeptidamider eller farmakologisk acceptable salte deraf og fremgangsmaade til deres fremstilling
DK61887A (da)	1987-08-08	Substituerede 5-amino-4-hydroxy-valerylderivater og salte deraf samt deres fremstilling og anvendelse
DK217787A (da)	1987-10-31	Substituerede 2,4-diamino-5-cyano-pyrimidiner og salte deraf samt deres fremstilling og anvendelse
DK404180A (da)	1981-03-26	Polyetherpolyaminer og salte deraf deres fremstilling og anvendelse
DK323981A (da)	1982-01-22	4,5-diaryl-alfa-polyfluoralkyl-1h-imidazol-2-methanaminer eller syreadditionssalte deraf deres fremstilling og anvendelse som antiinflammatoriske midler
DK567983A (da)	1984-06-11	2-hydroxymethyl-3-carbamoyl-1,4-dihydro-pyridin-forbindelser og salte deraf samt deres fremstilling og anvendelse
DK192788A (da)	1988-10-11	Substituerede anilidderivater eller syreadditionssalte deraf, deres fremstilling og anvendelse
DK429780A (da)	1981-04-12	1,2,4-oxadiazolin-5-on-derivater eller syreadditionssalte eller kvaternaere salte deraf og deres fremstilling
DK504680A (da)	1981-05-29	4,5-umaettede 16-hydroxyprostansyrederivater og deres fremstilling samt mellemprodukter hertil og disses fremstilling
DK38587D0 (da)	1987-01-23	Mono- og disaccharidylderivater og salte deraf samt deres fremstilling og anvendelse
DK43679A (da)	1979-08-03	4-(cycloalkyl-eller cycloalkenyl-substitueret) amino-,alkylamino-eller alkenylaminobenzoesyrer samt salte og derivater deraf samt deres fremstilling og anvendelse
DK162882A (da)	1982-10-14	Imidazolderivater eller syreadditionssalte deraf,deres fremstilling og anvendelse
DK194280A (da)	1980-11-04	Bis-(4-dimethoxydaunorubicin)-dihydrazoner eller salte deraf samt deres fremstilling
DK125583D0 (da)	1983-03-18	Benzensulfonylurinstoffer eller salte deraf, deres fremstilling og anvendelse
DK254983A (da)	1983-12-05	4-aryl-2-methyl-1,2,3,4-tetrahydroisoquinolinderivater eller syreadditionssalte deraf og fremgangsmaade til deres fremstilling
DK429680A (da)	1981-04-12	1,2,4-oxadiazinderivater eller syreadditionssalte eller kvaternaere salte deraf deres fremstilling og anvendelse
DK154586A (da)	1986-10-06	Alkanoylanilider eller salte deraf, deres fremstilling og anvendelse som insekticider og arachmicider
DK256484D0 (da)	1984-05-24	Aryloxycycloalkanolaminoalkylenarylketoner eller salte deraf,deres fremstilling og mellemprodukter hertil
DK317184A (da)	1984-12-30	2-azabicyclo(2,2,2)octanderivater eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika
DK204780A (da)	1980-11-12	3-substituerede hexahydropyrimido (1,2-a) azepiner eller salte deraf deres fremstilling og anvendelse
DK440880A (da)	1981-04-20	Benzimidazolderivater eller salte deraf og fremgangsmaade til deres fr&mstilling
DK92582A (da)	1982-09-05	Alkylendiaminderivater n-oxider eller syreadditionssalte deraf deres fremstilling og anvendelse som antiarytmiske laegemidler
DK364582A (da)	1983-02-15	5(6)-phenylsulfonyloxy-benzimidazolderivater, deres fremstilling og anvendelse
DK111581A (da)	1981-09-13	Steroid-spiro-oxathiazolinderivater eller salte deraf deres fremstilling og anvendelse

Legal Events

Date	Code	Title	Description
1994-06-20	PBP	Patent lapsed