DK428478A - Fremgangsmaade til fremstilling af cyclopeptider af somatostatintypen samt syreadditionssalte og komplekser deraf - Google Patents

Fremgangsmaade til fremstilling af cyclopeptider af somatostatintypen samt syreadditionssalte og komplekser deraf

Info

Publication number: DK428478A
Authority: DK; Denmark
Prior art keywords: cyclope; complex; preparation; additional salts; acid additional
Prior art date: 1977-09-28

Application number

DK428478A

Other languages

English (en)

Other versions

DK151034C (da

DK151034B (da

Inventor

H Rink

B Kamber

P Sieber

Original Assignee

Ciba Geigy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-09-28

Filing date

1978-09-27

Publication date

1979-03-29

1978-09-27 Application filed by Ciba Geigy filed Critical Ciba Geigy

1979-03-29 Publication of DK428478A publication Critical patent/DK428478A/da

1987-10-12 Publication of DK151034B publication Critical patent/DK151034B/da

1988-02-22 Application granted granted Critical

1988-02-22 Publication of DK151034C publication Critical patent/DK151034C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK428478A 1977-09-28 1978-09-27 Analogifremgangsmaade til fremstilling af somatostatinanaloge cyclopeptider eller fysiologisk taalelige syreadditionssalte eller komplekser deraf DK151034C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
LU78191		1977-09-28
LU78191A LU78191A1 (de)	1977-09-28	1977-09-28	Verfahren zur herstellung von neuen cyclopeptiden

Publications (3)

Publication Number	Publication Date
DK428478A true DK428478A (da)	1979-03-29
DK151034B DK151034B (da)	1987-10-12
DK151034C DK151034C (da)	1988-02-22

Family

ID=19728716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK428478A DK151034C (da)	1977-09-28	1978-09-27	Analogifremgangsmaade til fremstilling af somatostatinanaloge cyclopeptider eller fysiologisk taalelige syreadditionssalte eller komplekser deraf

Country Status (18)

Country	Link
US (1)	US4238481A (da)
EP (1)	EP0001295B1 (da)
JP (1)	JPS5459293A (da)
AT (1)	AT370090B (da)
AU (1)	AU523050B2 (da)
CA (1)	CA1111841A (da)
DD (1)	DD140142A5 (da)
DE (1)	DE2861672D1 (da)
DK (1)	DK151034C (da)
ES (1)	ES473677A1 (da)
FI (1)	FI68246C (da)
HU (1)	HU184612B (da)
IE (1)	IE47380B1 (da)
IL (1)	IL55643A (da)
LU (1)	LU78191A1 (da)
NO (1)	NO148957C (da)
NZ (1)	NZ188517A (da)
ZA (1)	ZA785488B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4328214A (en) *	1979-07-04	1982-05-04	Ciba-Geigy Corporation	Cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture
NZ195303A (en) *	1979-10-31	1984-10-19	Merck & Co Inc	Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4369179A (en) *	1979-12-14	1983-01-18	Ciba-Geigy Corporation	Acylpeptides
EP0031303A3 (de) *	1979-12-21	1981-11-04	Ciba-Geigy Ag	Cyclooctapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung
US4360516A (en) *	1981-04-13	1982-11-23	Merck & Co., Inc.	Modified D-retro cyclic hexapeptide somatostatin analogs
EP0083305B1 (de) *	1981-12-24	1985-07-10	Ciba-Geigy Ag	Cyclische Octapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung
HUT42101A (en) *	1985-01-07	1987-06-29	Sandoz Ag	Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4798821A (en) *	1987-03-02	1989-01-17	Merck & Co., Inc.	Antihypertensive therapy for diabetics
DE3822557C2 (de) *	1987-07-10	1998-07-02	Ciba Geigy Ag	Arzneimittel, enthaltend Somatostatine
US5633263A (en) *	1989-04-26	1997-05-27	The Administrators Of The Tulane Educational Fund	Linear somatostatin analogs
HU217636B (hu) *	1989-04-26	2000-03-28	Administrators Of The Tulane Educational Fund	Szomatosztatin analógok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
PT981363E (pt)	1997-05-13	2003-12-31	Conseils De Rec Appl Scient S	Somatostatina e agonistas da somatostatina para reduzir o peso corporal
WO1998051330A1 (en) *	1997-05-13	1998-11-19	Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.)	Method and compositions for treating hyperlipidemia and other conditions
DE69822810T2 (de) *	1997-05-13	2005-02-03	Société de Conseils de Recherches et d'Applications Scientifiques S.A.S.	Somatostatin und somatostatin agoniste zur behandlung der insulinsunempfindlichkeit und syndrome x
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
MXPA03011321A (es)	2001-06-08	2004-12-06	Conseils De Rech S Et D Aplica	Analogos quimericos de somatostatina-dopamina.
DE602004001727T2 (de) *	2003-04-07	2007-08-02	Novetide Ltd.	Verfahren zur herstellung cyclischer peptide
MXPA05011233A (es)	2003-04-22	2005-12-14	Conseils De Rech S Et D Aplica	Vectores peptidicos.
JP5799397B2 (ja)	2008-06-12	2015-10-28	イプセン・バイオイノベーション・リミテッドＩｐｓｅｎＢｉｏｉｎｎｏｖａｔｉｏｎＬｉｍｉｔｅｄ	癌の抑制
BRPI0915888E2 (pt)	2008-06-12	2020-09-01	Syntaxin Ltd	polipetídeo, seu método de ativação, sequência de ácido nucléico codificando o mesmo e seu uso
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
EP2654772B1 (en)	2010-12-22	2018-09-26	The Salk Institute for Biological Studies	Cyclic crf antagonist peptides
CA2918787A1 (en)	2013-06-13	2014-12-18	George Tachas	Combination therapy

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4011182A (en) *	1975-03-21	1977-03-08	American Home Products Corporation	Cyclic undecapeptide analogs of somatostatin and intermediates
US4000259A (en) *	1975-06-16	1976-12-28	American Home Products Corporation	Cyclic dodecapeptide analogs of somatostatin and intermediates
NL7607987A (nl) *	1975-08-08	1977-02-10	Merck & Co Inc	Werkwijze voor het bereiden van peptiden.
US3988304A (en) *	1975-08-25	1976-10-26	American Home Products Corporation	Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4133805A (en) *	1975-12-16	1979-01-09	American Home Products Corporation	Cyclic undecapeptides related to somatostatin and intermediates therefor
US4054558A (en) *	1976-05-24	1977-10-18	American Home Products Corporation	Cyclic dodecapeptide and intermediates therefor
EP0000053B1 (en) *	1977-06-08	1981-05-27	Merck & Co. Inc.	Somatostatin analogs, process for their preparation and pharmaceutical compositions containing them
US4115554A (en) *	1977-08-29	1978-09-19	Merck & Co., Inc.	Somatostatin analogs

1977
- 1977-09-28 LU LU78191A patent/LU78191A1/de unknown
1978
- 1978-09-15 US US05/942,565 patent/US4238481A/en not_active Expired - Lifetime
- 1978-09-25 DD DD78208064A patent/DD140142A5/de unknown
- 1978-09-25 FI FI782907A patent/FI68246C/fi not_active IP Right Cessation
- 1978-09-26 EP EP78100994A patent/EP0001295B1/de not_active Expired
- 1978-09-26 ES ES473677A patent/ES473677A1/es not_active Expired
- 1978-09-26 IL IL55643A patent/IL55643A/xx unknown
- 1978-09-26 DE DE7878100994T patent/DE2861672D1/de not_active Expired
- 1978-09-26 CA CA312,129A patent/CA1111841A/en not_active Expired
- 1978-09-27 AU AU40229/78A patent/AU523050B2/en not_active Expired
- 1978-09-27 NZ NZ188517A patent/NZ188517A/xx unknown
- 1978-09-27 NO NO783268A patent/NO148957C/no unknown
- 1978-09-27 HU HU78CI1860A patent/HU184612B/hu unknown
- 1978-09-27 AT AT0698278A patent/AT370090B/de not_active IP Right Cessation
- 1978-09-27 ZA ZA00785488A patent/ZA785488B/xx unknown
- 1978-09-27 IE IE1931/78A patent/IE47380B1/en unknown
- 1978-09-27 DK DK428478A patent/DK151034C/da not_active IP Right Cessation
- 1978-09-28 JP JP11983978A patent/JPS5459293A/ja active Granted

Also Published As

Publication number	Publication date
IL55643A0 (en)	1978-12-17
AT370090B (de)	1983-02-25
FI68246B (fi)	1985-04-30
ZA785488B (en)	1979-09-26
DE2861672D1 (en)	1982-04-15
US4238481A (en)	1980-12-09
NO148957C (no)	1984-01-18
NO148957B (no)	1983-10-10
LU78191A1 (de)	1979-05-25
EP0001295A2 (de)	1979-04-04
EP0001295B1 (de)	1982-03-17
AU523050B2 (en)	1982-07-08
NO783268L (no)	1979-03-29
CA1111841A (en)	1981-11-03
IE781931L (en)	1979-03-28
JPS6218560B2 (da)	1987-04-23
DK151034C (da)	1988-02-22
DD140142A5 (de)	1980-02-13
NZ188517A (en)	1981-04-24
IL55643A (en)	1981-12-31
FI782907A (fi)	1979-03-29
JPS5459293A (en)	1979-05-12
FI68246C (fi)	1985-08-12
IE47380B1 (en)	1984-03-07
ES473677A1 (es)	1980-05-16
EP0001295A3 (en)	1979-06-13
DK151034B (da)	1987-10-12
AU4022978A (en)	1980-04-03
HU184612B (en)	1984-09-28
ATA698278A (de)	1982-07-15

Publication	Publication Date	Title
DK428478A (da)	1979-03-29	Fremgangsmaade til fremstilling af cyclopeptider af somatostatintypen samt syreadditionssalte og komplekser deraf
DK347077A (da)	1978-02-05	Fremgangsmade til fremstilling af d (-)-3-hydroxysmorsyre
DK145260C (da)	1983-03-14	Analogifremgangsmaade til fremstilling af 4-acylamino-phenyl-ethanolaminer eller syreadditionssalte heraf
DK360278A (da)	1979-02-17	Fremgangsmaade til fremstilling af cycloalkylidenmethylhylphenyleddikesyrederivater
DK274178A (da)	1979-01-20	Lyofiliseret gammaglobulinpraeparat samt fremgangsmaade til fremstilling deraf
DK251677A (da)	1977-12-10	N-phosphonomethylen-monoaminoalkanmono- og-polyphosphonsyrer og n-phosphomethylendiaminoalkan-polyphosphonsyrer samt fremgangsmade til fremstilling deraf
DK272778A (da)	1978-12-19	Hexahydropyrimidiner fremgangsmaade til femstilling deraf og syreadditionssalte deraf
DK353577A (da)	1978-08-12	7-acylamido-3-cephem-4-carboxylsyrederivater samt fremgangsmaade til fremstilling deraf
DK496977A (da)	1978-05-10	Fremgangsmaade til fremstilling af 0-alkylerede hydroxylaminer og syreadditionssalte deraf
DK136478A (da)	1978-09-30	N-sulfoalkan-aminoalkanphosphonsyrer alkalimetalsalte deraf samt en fremgangsmaade til fremstilling af disse forbindelser
DK158670C (da)	1991-01-07	Fremgangsmaade til fremstilling af 6beta-halogensubstituerede penicillansyrederivater
DK149231C (da)	1986-08-18	Analogifremgangsmaade til fremstilling af enkephalin-analoge tetrapeptidamider eller syreadditionssalte deraf
DK359577A (da)	1978-02-15	Fremgangsmade til fremstilling af 2-phenylaminoimidazolin-(2) og syreadditionssalte
DK537677A (da)	1978-06-04	Propionsyrederivater samt fremgangsmaade til deres fremstilling
DK540578A (da)	1979-07-01	Fremgangsmaade til fremstilling af aliphatiske diperoxydicarboxylsyrer
DK567778A (da)	1979-07-31	Fremgangsmaade til fremstilling af kvaternaere ammoniumsalte af phenylpropylaminer og phenylbutylaminer
DK142578C (da)	1981-07-20	Analogifremgangsmaade til fremstilling af 2,4-diamino-5-benzylpyrimidiner og syreadditionssalte deraf
DK319178A (da)	1979-01-19	Fremgangsmaade til fremstilling af acylamido-2-cephem-4-carboxylsyreforbindelser og salte
DK240678A (da)	1978-12-02	Fremgangsmaade til fremstilling af di og trifluormethylaminosyrer
DK149628C (da)	1987-02-02	Analogifremgangsmaade til fremstilling af 8-substitueret-4ae-amino-makrolider eller syreadditionssalte deraf
DK143273C (da)	1981-11-30	Analogifremgangsmaade til fremstilling af amidinobenzyloyrimidiner og syreadditionssalte heraf
DK333279A (da)	1980-02-11	Fremgangsmaade til fremstilling af thiosubstitituerede diazacycloalkener og salte deraf
DK62878A (da)	1978-08-12	Fremgangsmaade til fremstilling af benzoheterocyclylglyoxylsyrederivater samt salte deraf
DK512978A (da)	1979-05-19	Fremgangsmaade til fremstilling af 2,5-diketogluconsyre
DK320578A (da)	1979-01-20	Mellemprodukt til fremstilling af hidtil ukendte oximderivater af 7-aminothiazolylacctamidocephalosporansyre samt fremgangsmaade til fremstilling af mellemprodukter

Legal Events

Date	Code	Title	Description
1991-05-27	PBP	Patent lapsed