DK379787A - Hetrazepiner og fremgangsmaade til deres fremstilling - Google Patents

Hetrazepiner og fremgangsmaade til deres fremstilling

Info

Publication number: DK379787A
Authority: DK; Denmark
Prior art keywords: hetrazepines; procedures; preparation; paf; platelet
Prior art date: 1986-07-22

Application number

DK379787A

Other languages

Danish (da)

English (en)

Other versions

DK379787D0 (da

Inventor

Karl-Heinz Weber

Albrecht Harreus

Werner Stransky

Gerhard Walther

Jorge Casals Stenzel

Gojko Muacevic

Hubert Heuer

Wolf-Dietrich Bechtel

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-22

Filing date

1987-07-21

Publication date

1988-01-23

1987-07-21 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1987-07-21 Publication of DK379787D0 publication Critical patent/DK379787D0/da

1988-01-23 Publication of DK379787A publication Critical patent/DK379787A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/66—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK379787A 1986-07-22 1987-07-21 Hetrazepiner og fremgangsmaade til deres fremstilling DK379787A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3624647		1986-07-22

Publications (2)

Publication Number	Publication Date
DK379787D0 DK379787D0 (da)	1987-07-21
DK379787A true DK379787A (da)	1988-01-23

Family

ID=6305650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK379787A DK379787A (da)	1986-07-22	1987-07-21	Hetrazepiner og fremgangsmaade til deres fremstilling

Country Status (26)

Country	Link
US (1)	US5532233A (no)
EP (1)	EP0254245B1 (no)
JP (1)	JPH085895B2 (no)
KR (1)	KR950013564B1 (no)
AT (1)	ATE112280T1 (no)
AU (1)	AU609408B2 (no)
CA (1)	CA1338287C (no)
CS (3)	CS274456B2 (no)
CZ (1)	CZ284052B6 (no)
DD (1)	DD281389A5 (no)
DE (1)	DE3750599D1 (no)
DK (1)	DK379787A (no)
ES (1)	ES2061452T3 (no)
FI (1)	FI873180A (no)
HU (1)	HU203354B (no)
IE (1)	IE65111B1 (no)
IL (1)	IL83270A0 (no)
MX (1)	MX7463A (no)
NO (1)	NO166942C (no)
NZ (1)	NZ221153A (no)
PH (1)	PH30676A (no)
PL (2)	PL157209B1 (no)
PT (1)	PT85373B (no)
SU (1)	SU1738089A3 (no)
YU (1)	YU136187A (no)
ZA (1)	ZA875333B (no)

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JPS60219955A (ja) *	1984-04-16	1985-11-02	Matsushita Electric Works Ltd	ステツプモ−タ
ES2037013T3 (es) *	1986-01-21	1993-06-16	Boehringer Ingelheim Kg	Procedimiento para preparar tieno-1,4-diazepinas.
US5895785A (en) *	1987-10-20	1999-04-20	Ruth Korth	Treatment and prevention of disorders mediated by LA-paf or endothelial cells
US4959361A (en) *	1987-12-18	1990-09-25	Hoffmann-La Roche Inc.	Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
CA1324863C (en) *	1988-01-30	1993-11-30	Minoru Moriwaki	Thienotriazolodiazepine compounds and pharmaceutical uses thereof
DE3810848A1 (de) *	1988-03-30	1989-10-19	Boehringer Ingelheim Kg	Neue 2,3,4-substituierte imidazole und 3,4,5-substituierte 1,2,4-triazole, ihre herstellung und verwendung
CA1322367C (en) *	1988-05-17	1993-09-21	Yoshitomi Pharmaceutical Industries Ltd.	Thienotriazolodiazepine compounds and pharmaceutical uses thereof
IL91386A0 (en) *	1988-08-24	1990-04-29	Boehringer Ingelheim Kg	Method for treating autoimmune diseases by using a paf antagonist and pharmaceutical compositions comprising it
US5304553A (en) *	1988-10-31	1994-04-19	Eisai Co., Ltd.	1,4-diazepine derivative and its pharmaceutical use
FI95708C (fi)	1988-10-31	1996-03-11	Eisai Co Ltd	Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
US5382579A (en) *	1988-10-31	1995-01-17	Eisai Co., Ltd.	Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
US5221671A (en) *	1988-10-31	1993-06-22	Eisai Co., Ltd.	Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
RU2117670C1 (ru) *	1988-10-31	1998-08-20	Эйсай Ко., Лтд.	Производные триазоло[1,4]диазепина и способы их получения
US5468740A (en) *	1988-10-31	1995-11-21	Eisai Co., Ltd.	1,4-diazepine derivative and its pharmaceutical use
EP0384421A3 (de) *	1989-02-23	1992-02-12	Boehringer Ingelheim Kg	Verwendung von PAF-Antagonisten zur Behandlung von pathologischen Blutgasveränderungen
AT394562B (de) *	1989-03-31	1992-05-11	Scras	Verfahren zur herstellung neuer thieno-triazolodiazepine
GB8907257D0 (en) *	1989-03-31	1989-05-17	Rech Et D Applic Scient Scras	New derivatives of hetrazepine as anti-paf and anti-ischemic agents
GB8907256D0 (en) *	1989-03-31	1989-05-17	Rech Et D Applic Scient Scras	New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
GB8911030D0 (en) *	1989-05-13	1989-06-28	Scras	Hetrazepine derivatives
GR1000393B (el) *	1990-03-08	1992-06-30	Sod Conseils Rech Applic	Μεθοδος παρασκευης νεων θειενο-τριαζολο-διαζεπινων.
NL9000627A (nl) *	1990-03-29	1991-10-16	Scras	Werkwijze ter bereiding van nieuwe thienotriazolo-diazepines.
DE4010528A1 (de) *	1990-04-02	1991-10-17	Boehringer Ingelheim Kg	Praeparativ chromatographisches trennverfahren zur herstellung enantiomerenreiner hetrazepine
OA09202A (fr) *	1990-04-02	1992-06-30	Sod Conseils Rech Applic	Procédé de préparation des nouveaux dérivés de la thiéno-triazolo-diazépine.
GR1000348B (el) *	1990-04-27	1992-06-25	Sod Conseils Rech Applic	Μεθοδος παρασκευης θειενο-τριαζολο-διαζεπινο-παραγωγων.
AT394563B (de) *	1990-05-09	1992-05-11	Scras	Verfahren zur herstellung von thieno-triazolodiazepinderivaten
DE4027470A1 (de) *	1990-08-30	1992-03-05	Boehringer Ingelheim Kg	Neue hetrazepinoide amide
DE4107521A1 (de) *	1991-03-08	1992-09-10	Boehringer Ingelheim Kg	Neue acylaminosubstituierte hetrazepine
DE4128579A1 (de) *	1991-08-28	1993-03-04	Boehringer Ingelheim Kg	Verwendung von 4-(2-chlorphenyl)-9-methyl-2-(3(4-morpholinyl)-3-propanon-1-y1)-6h-thieno-(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin zur behandlung der allergischen rhinitis
ES2181665T3 (es) *	1991-11-04	2003-03-01	Ruth-Maria Korth	Tratamiento y prevencion de enfermedades mentales, acompañadas por unos elevados niveles de liso paf, con los antagonistas de paf.
WO1995032963A1 (fr) *	1994-06-01	1995-12-07	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de thienylazole et compose de thienotriazolodiazepine
US5714262A (en) *	1995-12-22	1998-02-03	E. I. Du Pont De Nemours And Company	Production of poly(ethylene terephthalate)
AU6517398A (en) *	1997-03-27	1998-10-22	Kyowa Hakko Kogyo Co. Ltd.	Therapeutic agent for autoimmune diseases
CA2297815A1 (en) *	1997-07-31	1999-02-11	Ube Industries, Ltd.	N-acylamino acid amide compounds and intermediates for preparation thereof
US5939432A (en) *	1997-10-29	1999-08-17	Medco Research, Inc.	Thiophenes useful for modulating the adenosine receptor
US6727258B2 (en) *	1997-10-29	2004-04-27	King Pharmaceutical Research & Development, Inc.	Allosteric adenosine receptor modulators
US6323214B1 (en)	1997-10-29	2001-11-27	Medco Research, Inc	Allosteric adenosine receptor modulators
US20060165700A1 (en) *	2002-09-04	2006-07-27	Ostroff Gary R	Cancer therapy using whole glucan particles and antibodies
CN111560025A (zh)	2009-12-04	2020-08-21	桑诺维恩药品公司	多环化合物及其使用方法
SG10202100751YA (en)	2016-07-29	2021-03-30	Sunovion Pharmaceuticals Inc	Compounds and compositions and uses thereof
EA201990400A1 (ru)	2016-07-29	2019-07-31	Суновион Фармасьютикалз, Инк.	Соединения и композиции и их применение
IL268694B2 (en)	2017-02-16	2023-10-01	Sunovion Pharmaceuticals Inc	Treatment of schizophrenia
SG11202000669VA (en)	2017-08-02	2020-02-27	Sunovion Pharmaceuticals Inc	Isochroman compounds and uses thereof
CN112135827B (zh)	2018-02-16	2024-01-12	赛诺维信制药公司	盐、晶型及其制备方法
CA3130849A1 (en)	2019-03-14	2020-09-17	Sunovion Pharmaceuticals Inc.	Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
CN115380034A (zh)	2020-03-31	2022-11-22	豪夫迈·罗氏有限公司	作为GABA Aγ1 PAM的苯并二氮杂䓬衍生物
JP2023523569A (ja)	2020-04-14	2023-06-06	サノビオンファーマシューティカルズインク	神経学的および精神障害の治療方法
US11766443B2 (en)	2020-11-16	2023-09-26	Boehringer Ingelheim International Gmbh	Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists
US11992494B2 (en)	2021-12-22	2024-05-28	Boehringer Ingelheim International Gmbh	Cyclopentathiophene carboxamide derivatives as platelet activating factor receptor antagonists

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ES393101A1 (es) *	1971-07-09	1974-05-16	Made Labor Sa	Procedimiento para la preparacion de derivados de tieno- diazepina.
JPS5438116B2 (no) *	1972-03-22	1979-11-19
JPS5116063B2 (no) *	1972-05-30	1976-05-21
JPS5342400B2 (no) *	1973-05-30	1978-11-10
US3902679A (en) *	1974-01-07	1975-09-02	Charles H Bost	Wire dispenser
JPS50100096A (no) *	1974-01-08	1975-08-08
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AT338799B (de) *	1974-03-02	1977-09-12	Boehringer Sohn Ingelheim	Verfahren zur herstellung neuer substituierter 6-aryl-4h-s-triazolo-(3,4c)-thieno-(2,3e)-1,4-diazepine und ihrer salze
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DE3502392A1 (de) *	1985-01-25	1986-07-31	Boehringer Ingelheim KG, 6507 Ingelheim	Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) *	1986-01-21	1993-06-16	Boehringer Ingelheim Kg	Procedimiento para preparar tieno-1,4-diazepinas.
DE3610848A1 (de) *	1986-04-01	1987-10-15	Boehringer Ingelheim Kg	Neue 1,4-diazepine
ES2039408T3 (es) *	1986-11-17	1993-10-01	Yoshitomi Pharmaceutical Industries, Ltd.	Un procedimiento para preparar un compuesto de tienotriazolodiazepina.
EP0315698B1 (en) *	1987-05-28	1993-03-03	Yoshitomi Pharmaceutical Industries, Ltd.	Thieno(triazolo)diazepine compounds and medicinal application of the same
US5028603A (en) *	1987-06-08	1991-07-02	Yoshitomi Pharmaceutical Industries, Ltd.	Ester-substituted thienotriazolodiazepine compounds and pharmaceutical uses thereof
DE3735525C2 (de) *	1987-10-20	1997-02-20	Korth Ruth Maria	Verfahren zur Bestimmung der Wirksamkeit von paf-Acether-Rezeptor-Antagonisten
MC1999A1 (fr) *	1987-12-18	1990-01-26	Hoffmann La Roche	Composes tricycliques
CA1324863C (en) *	1988-01-30	1993-11-30	Minoru Moriwaki	Thienotriazolodiazepine compounds and pharmaceutical uses thereof
EP0338993A1 (en) *	1988-04-21	1989-10-25	Sandoz Ag	6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines
WO1989010143A1 (en) *	1988-04-27	1989-11-02	Schering Corporation	Certain paf antagonist antihistamine combinations and methods
CA1322367C (en) *	1988-05-17	1993-09-21	Yoshitomi Pharmaceutical Industries Ltd.	Thienotriazolodiazepine compounds and pharmaceutical uses thereof
FI95708C (fi) *	1988-10-31	1996-03-11	Eisai Co Ltd	Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi
GB8907256D0 (en) *	1989-03-31	1989-05-17	Rech Et D Applic Scient Scras	New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors

1987
- 1987-07-10 PH PH35522A patent/PH30676A/en unknown
- 1987-07-18 EP EP87110443A patent/EP0254245B1/de not_active Expired - Lifetime
- 1987-07-18 AT AT87110443T patent/ATE112280T1/de not_active IP Right Cessation
- 1987-07-18 ES ES87110443T patent/ES2061452T3/es not_active Expired - Lifetime
- 1987-07-18 DE DE3750599T patent/DE3750599D1/de not_active Expired - Fee Related
- 1987-07-20 PL PL1987287349A patent/PL157209B1/pl unknown
- 1987-07-20 FI FI873180A patent/FI873180A/fi not_active Application Discontinuation
- 1987-07-20 YU YU01361/87A patent/YU136187A/xx unknown
- 1987-07-20 PL PL1987266884A patent/PL153970B1/pl unknown
- 1987-07-21 DD DD87305190A patent/DD281389A5/de not_active IP Right Cessation
- 1987-07-21 CS CS550887A patent/CS274456B2/cs not_active IP Right Cessation
- 1987-07-21 HU HU873355A patent/HU203354B/hu not_active IP Right Cessation
- 1987-07-21 PT PT85373A patent/PT85373B/pt not_active IP Right Cessation
- 1987-07-21 NO NO873041A patent/NO166942C/no not_active IP Right Cessation
- 1987-07-21 CS CS891931A patent/CS277446B6/cs not_active IP Right Cessation
- 1987-07-21 JP JP62182121A patent/JPH085895B2/ja not_active Expired - Lifetime
- 1987-07-21 IL IL83270A patent/IL83270A0/xx not_active IP Right Cessation
- 1987-07-21 ZA ZA875333A patent/ZA875333B/xx unknown
- 1987-07-21 DK DK379787A patent/DK379787A/da not_active Application Discontinuation
- 1987-07-21 CS CS891930A patent/CS277445B6/cs not_active IP Right Cessation
- 1987-07-22 MX MX746387A patent/MX7463A/es unknown
- 1987-07-22 NZ NZ221153A patent/NZ221153A/xx unknown
- 1987-07-22 CA CA000542748A patent/CA1338287C/en not_active Expired - Fee Related
- 1987-07-22 KR KR87007939A patent/KR950013564B1/ko not_active IP Right Cessation
- 1987-07-22 IE IE198387A patent/IE65111B1/en not_active IP Right Cessation
- 1987-07-22 AU AU76015/87A patent/AU609408B2/en not_active Ceased
1989
- 1989-04-10 CZ CS892206A patent/CZ284052B6/cs unknown
- 1989-08-17 SU SU894614791A patent/SU1738089A3/ru active
1994
- 1994-09-08 US US08/302,578 patent/US5532233A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IE65111B1 (en)	1995-10-04
PL266884A1 (en)	1988-09-15
CS277446B6 (en)	1993-03-17
IL83270A0 (en)	1987-12-31
ZA875333B (en)	1989-03-29
EP0254245A1 (de)	1988-01-27
NO873041L (no)	1988-01-25
KR950013564B1 (en)	1995-11-09
JPS6333382A (ja)	1988-02-13
US5532233A (en)	1996-07-02
EP0254245B1 (de)	1994-09-28
PL157209B1 (pl)	1992-05-29
AU7601587A (en)	1988-01-28
ES2061452T3 (es)	1994-12-16
CZ284052B6 (cs)	1998-08-12
PH30676A (en)	1997-09-16
HU203354B (en)	1991-07-29
CS277445B6 (en)	1993-02-17
FI873180A (fi)	1988-01-23
YU136187A (en)	1991-06-30
NO873041D0 (no)	1987-07-21
JPH085895B2 (ja)	1996-01-24
AU609408B2 (en)	1991-05-02
PT85373A (de)	1987-08-01
KR880001663A (ko)	1988-04-26
HUT50830A (en)	1990-03-28
CS550887A2 (en)	1990-09-12
CA1338287C (en)	1996-04-30
DK379787D0 (da)	1987-07-21
DD281389A5 (de)	1990-08-08
PL153970B1 (en)	1991-06-28
FI873180A0 (fi)	1987-07-20
NO166942C (no)	1991-09-18
IE871983L (en)	1988-01-22
NO166942B (no)	1991-06-10
SU1738089A3 (ru)	1992-05-30
MX7463A (es)	1993-10-01
CS274456B2 (en)	1991-04-11
DE3750599D1 (de)	1994-11-03
ATE112280T1 (de)	1994-10-15
PT85373B (pt)	1990-04-30
NZ221153A (en)	1990-07-26

Publication	Publication Date	Title
DK379787A (da)	1988-01-23	Hetrazepiner og fremgangsmaade til deres fremstilling
ATE45942T1 (de)	1989-09-15	Diarylacetylene, ihre herstellung und verwendung.
ATE50763T1 (de)	1990-03-15	Tetralin-derivate, ihre herstellung und verwendung.
DK353385D0 (da)	1985-08-02	Fremstilling af 3-acylamino-1-hydroxy-2-azetidinoner og herved forekommende n-hydroxybeskyttelsesgrupper
NO861366L (no)	1986-10-27	N-indolyletylsulfonsyreamider og fremgangsmaater til fremstilling derav.
DK163287D0 (da)	1987-03-31	1,4-diazepiner og farmaceutiske midler med indhold af saadanne forbindelser
SE8503207D0 (sv)	1985-06-27	Pharmacologically active substituted benzamides
DK6384D0 (da)	1984-01-06	Disubstituerede prolinderivater, fremgangsmade til fremstilling deraf og deres anvendelse
DK306385A (da)	1986-01-12	Phenylnaphthyridiner samt deres fremstilling og anvendelse
ATE30152T1 (de)	1987-10-15	1-methyl-5-nitro-imidazolin-derivate und diese enthaltende therapeutische zusammensetzungen.
NO167978C (no)	1992-01-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-benzotiazoler.
DK8187A (da)	1987-07-10	Thyroninderivater, fremgangsmaade til deres fremstilling og deres anvendelse i radioimmunanalyser
MX174372B (es)	1994-05-11	Compuestos de trifendioxazina hidrosolubles, compuestos intermediarios empleados en la sintesis de los mismos y procedimiento para preparar los mismos
ATE98232T1 (de)	1993-12-15	0-(1,2,4-triazolyl-1)-0-phenyl-acetale und diese enthaltende fungizide.

Legal Events

Date	Code	Title	Description
2003-02-24	AHB	Application shelved due to non-payment