DK6384D0 - Disubstituerede prolinderivater, fremgangsmade til fremstilling deraf og deres anvendelse - Google Patents

Disubstituerede prolinderivater, fremgangsmade til fremstilling deraf og deres anvendelse

Info

Publication number: DK6384D0
Authority: DK; Denmark
Prior art keywords: procedures; preparing; proline derivatives; disubstituted; disubstituted proline
Prior art date: 1983-01-07

Application number

DK0063/84A

Other languages

English (en)

Other versions

DK6384A (da

DK171641B1 (da

Inventor

Rainer Henning

Hansjoerg Urbach

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-01-07

Filing date

1984-01-06

Publication date

1984-01-06

1984-01-06 Application filed by Hoechst Ag filed Critical Hoechst Ag

1984-01-06 Publication of DK6384D0 publication Critical patent/DK6384D0/da

1984-07-08 Publication of DK6384A publication Critical patent/DK6384A/da

1997-03-03 Application granted granted Critical

1997-03-03 Publication of DK171641B1 publication Critical patent/DK171641B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pyrrole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)
Hydrogenated Pyridines (AREA)
Developing Agents For Electrophotography (AREA)
Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
Glass Compositions (AREA)
Golf Clubs (AREA)
Pyrane Compounds (AREA)

DK006384A 1983-01-07 1984-01-06 Disubstituerede prolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse DK171641B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19833300316 DE3300316A1 (de)	1983-01-07	1983-01-07	Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3300316		1983-01-07

Publications (3)

Publication Number	Publication Date
DK6384D0 true DK6384D0 (da)	1984-01-06
DK6384A DK6384A (da)	1984-07-08
DK171641B1 DK171641B1 (da)	1997-03-03

Family

ID=6187824

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK006384A DK171641B1 (da)	1983-01-07	1984-01-06	Disubstituerede prolinderivater, fremgangsmåde til fremstilling deraf og deres anvendelse
DK033196A DK171642B1 (da)	1983-01-07	1996-03-21	Anvendelse af trisubstituerede prolinderivater til fremstilling af tilsvarende carboxylsyrer og deres derivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK033196A DK171642B1 (da)	1983-01-07	1996-03-21	Anvendelse af trisubstituerede prolinderivater til fremstilling af tilsvarende carboxylsyrer og deres derivater

Country Status (21)

Country	Link
US (1)	US4684662A (da)
EP (1)	EP0115639B1 (da)
JP (3)	JPS59144755A (da)
KR (1)	KR900007216B1 (da)
AT (1)	ATE25677T1 (da)
AU (1)	AU575306B2 (da)
CA (1)	CA1220213A (da)
DE (2)	DE3300316A1 (da)
DK (2)	DK171641B1 (da)
ES (2)	ES8407471A1 (da)
FI (1)	FI81780C (da)
GR (1)	GR79462B (da)
HU (1)	HU190541B (da)
IE (1)	IE56520B1 (da)
IL (1)	IL70618A (da)
MA (1)	MA19996A1 (da)
NO (1)	NO165921C (da)
NZ (1)	NZ206733A (da)
PH (1)	PH19979A (da)
PT (1)	PT77924B (da)
ZA (1)	ZA84113B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3226768A1 (de) *	1981-11-05	1983-05-26	Hoechst Ag, 6230 Frankfurt	Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
IE55867B1 (en) *	1981-12-29	1991-02-14	Hoechst Ag	New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
US5175306A (en) *	1983-01-31	1992-12-29	Hoechst Aktiengesellschaft	Process for the resolution of racemates of optically active bicyclic imino-α-carboxylic esters
DE3333455A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung n-alkylierter dipeptide und deren estern
US5684016A (en) *	1984-04-12	1997-11-04	Hoechst Aktiengesellschaft	Method of treating cardiac insufficiency
DE3413710A1 (de) *	1984-04-12	1985-10-24	Hoechst Ag, 6230 Frankfurt	Verfahren zur behandlung der herzinsuffizienz
DE3431541A1 (de) *	1984-08-28	1986-03-06	Hoechst Ag, 6230 Frankfurt	Cis,endo-2-azabicycloalkan-3-carbonsaeure-derivate, verfahren zu deren herstellung, deren verwendung sowie zwischenprodukte bei deren herstellung
US5231080A (en) *	1985-10-15	1993-07-27	Hoechst Aktiengesellschaft	Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
US5231084A (en) *	1986-03-27	1993-07-27	Hoechst Aktiengesellschaft	Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
DE3633496A1 (de) *	1986-10-02	1988-04-14	Hoechst Ag	Kombination von angiotensin-converting-enzyme-hemmern mit calciumantagonisten sowie deren verwendung in arzneimitteln
DE3639879A1 (de) *	1986-11-21	1988-06-01	Hoechst Ag	Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren, zwischenprodukte dieses verfahrens sowie ein verfahren zu deren herstellung
DE3722007A1 (de) *	1987-07-03	1989-01-12	Hoechst Ag	Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
HU904967D0 (en) *	1988-04-22	1991-01-28	Hoechst Ag	Process for producing new azabicyclo(3.3.o)octane-3-carboxylic acid-octylesther derivatives
US5118811A (en) *	1989-04-13	1992-06-02	Japan Tobacco Inc.	Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
TW492957B (en) *	1996-11-07	2002-07-01	Novartis Ag	N-substituted 2-cyanopyrrolidnes
US20040152745A1 (en) *	1999-11-12	2004-08-05	Guilford Pharmaceuticals, Inc.	Dipeptidyl peptidase IV inhibitors and methods of making and using dipeptidyl peptidase IV inhibitors
JP2003535034A (ja) *	1999-11-12	2003-11-25	ギルフォードファーマシューティカルズインコーポレイテッド	ジペプチジルペプチダーゼｉｖ阻害剤並びにジペプチジルペプチダーゼｉｖ阻害剤の製造及び使用法
EP1615886A1 (en) *	2003-04-15	2006-01-18	Warner-Lambert Company LLC	[c]-fused bicyclic proline derivatives and their use for treating arthritic conditions
BRPI0409560A (pt) *	2003-04-15	2006-04-18	Warner Lambert Co	derivados bicìclicos [b]-condensados de prolina e sua utilização para tratar condições artrìticas
JP2008519063A (ja) *	2004-11-05	2008-06-05	キング・ファーマシューティカルズ・リサーチ・アンド・デベロプメント・インコーポレイティッド	安定化ラミプリル組成物及びその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE315190C (da) *
US4350704A (en) *	1980-10-06	1982-09-21	Warner-Lambert Company	Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4374847A (en) *	1980-10-27	1983-02-22	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
DE3151690A1 (de) *	1981-12-29	1983-07-07	Hoechst Ag, 6230 Frankfurt	"neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"

1983
- 1983-01-07 DE DE19833300316 patent/DE3300316A1/de not_active Withdrawn
- 1983-12-29 DE DE8383113193T patent/DE3369980D1/de not_active Expired
- 1983-12-29 AT AT83113193T patent/ATE25677T1/de not_active IP Right Cessation
- 1983-12-29 EP EP83113193A patent/EP0115639B1/de not_active Expired
1984
- 1984-01-02 HU HU846A patent/HU190541B/hu unknown
- 1984-01-04 GR GR73427A patent/GR79462B/el unknown
- 1984-01-05 KR KR1019840000013A patent/KR900007216B1/ko not_active IP Right Cessation
- 1984-01-05 FI FI840027A patent/FI81780C/fi not_active IP Right Cessation
- 1984-01-05 IL IL70618A patent/IL70618A/xx not_active IP Right Cessation
- 1984-01-05 PH PH30067A patent/PH19979A/en unknown
- 1984-01-05 ES ES528703A patent/ES8407471A1/es not_active Expired
- 1984-01-05 PT PT77924A patent/PT77924B/pt unknown
- 1984-01-05 NZ NZ206733A patent/NZ206733A/en unknown
- 1984-01-05 US US06/568,423 patent/US4684662A/en not_active Expired - Lifetime
- 1984-01-06 ZA ZA84113A patent/ZA84113B/xx unknown
- 1984-01-06 IE IE23/84A patent/IE56520B1/en not_active IP Right Cessation
- 1984-01-06 DK DK006384A patent/DK171641B1/da not_active IP Right Cessation
- 1984-01-06 NO NO840048A patent/NO165921C/no not_active IP Right Cessation
- 1984-01-06 AU AU23146/84A patent/AU575306B2/en not_active Expired
- 1984-01-06 MA MA20217A patent/MA19996A1/fr unknown
- 1984-01-06 CA CA000444858A patent/CA1220213A/en not_active Expired
- 1984-01-06 JP JP59000375A patent/JPS59144755A/ja active Granted
- 1984-03-06 ES ES530311A patent/ES8500900A1/es not_active Expired
1992
- 1992-03-03 JP JP4045560A patent/JPH0610190B2/ja not_active Expired - Lifetime
- 1992-03-03 JP JP4045559A patent/JPH0570423A/ja active Granted
1996
- 1996-03-21 DK DK033196A patent/DK171642B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI81780B (fi)	1990-08-31
AU575306B2 (en)	1988-07-28
IL70618A0 (en)	1984-04-30
ZA84113B (en)	1984-08-29
FI840027A (fi)	1984-07-08
JPH056542B2 (da)	1993-01-26
CA1220213A (en)	1987-04-07
ES530311A0 (es)	1984-11-01
NO165921B (no)	1991-01-21
ATE25677T1 (de)	1987-03-15
NZ206733A (en)	1988-02-29
JPS59144755A (ja)	1984-08-18
DK6384A (da)	1984-07-08
NO840048L (no)	1984-07-09
EP0115639B1 (de)	1987-03-04
DE3369980D1 (en)	1987-04-09
DK33196A (da)	1996-03-21
ES528703A0 (es)	1984-09-16
ES8407471A1 (es)	1984-09-16
JPH0583541B2 (da)	1993-11-26
DK171642B1 (da)	1997-03-03
KR900007216B1 (ko)	1990-10-05
HU190541B (en)	1986-09-29
ES8500900A1 (es)	1984-11-01
IL70618A (en)	1987-10-30
DE3300316A1 (de)	1984-07-12
DK171641B1 (da)	1997-03-03
AU2314684A (en)	1984-07-12
PT77924B (de)	1986-05-30
EP0115639A1 (de)	1984-08-15
FI840027A0 (fi)	1984-01-05
NO165921C (no)	1991-05-02
JPH0578312A (ja)	1993-03-30
FI81780C (fi)	1990-12-10
MA19996A1 (fr)	1984-10-01
PH19979A (en)	1986-08-26
US4684662A (en)	1987-08-04
KR840007583A (ko)	1984-12-08
JPH0570423A (ja)	1993-03-23
IE840023L (en)	1984-07-07
PT77924A (de)	1984-02-01
GR79462B (da)	1984-10-30
JPH0610190B2 (ja)	1994-02-09
IE56520B1 (en)	1991-08-28

Publication	Publication Date	Title
DK6384A (da)	1984-07-08	Disubstituerede prolinderivater, fremgangsmaade til fremstilling deraf og deres anvendelse
ATE12042T1 (de)	1985-03-15	Aminosaeurederivate und ihre therapeutische verwendung.
DK441180A (da)	1981-04-20	2-hydroxyalkyl-3,4,5-trihydroxypiperidiner deres fremstilling og anvendelse
DK204686D0 (da)	1986-05-02	Quinolylglycinamidderivater og fremgangsmaade til fremstilling deraf
DK161319C (da)	1991-12-09	Dihydroxyquinoxalinforbindelser, fremgangsmaade til deres fremstilling og farmaceutiske praeparater, hvori forbindelserne indgaar
DK261482A (da)	1982-12-14	Maettede aminocyclitolderivater og fremgangsmaade til deres fremstilling
DK260180A (da)	1980-12-20	Pseudotrisaccharider deres fremstilling og anvendelse som antibakterielle midler
DK374887D0 (da)	1987-07-17	2-acyloxypropropylamin-derivater, deres fremstilling og anvendelse
DK440987D0 (da)	1987-08-24	Thyroninderivater, deres fremstilling og anvendelse
DK439082A (da)	1983-04-06	4-acylamino-1-aza-adamantan-forbindelser samt fremgangsmaade til fremstilling deraf
DK406587D0 (da)	1987-08-04	1,4-dihydropyridinderivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK484684D0 (da)	1984-10-10	Derivater af 4-alkyl-2-hydroxy-3-methyl-2-phenylmorpholin, fremgangsmaade til deres fremstilling og deres terapeutiske anvendelse
NO870228L (no)	1987-07-21	Benzimidazolderivater, fremgangsmaate til deres fremstilling og anvendelse av forbindelsene fremstilt ved fremgangsmaaten.
DK8187A (da)	1987-07-10	Thyroninderivater, fremgangsmaade til deres fremstilling og deres anvendelse i radioimmunanalyser
DK491481A (da)	1982-05-09	2-(n-aryl-n-1,2,3-thiadiazolylcarbonyl)-aminobutyrolacton og fremgangsmaade til fremstilling heraf
DK104488D0 (da)	1988-02-26	Acetamider afledt af 2,3-dihydro-3-phenyl-2-benzofuranon, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem
DK684888D0 (da)	1988-12-08	Nikotinoylpiperazinderivater, fremgangsmaade til deres fremstilling og deres anvendelse i terapien

Legal Events

Date	Code	Title	Description
1997-03-03	B1	Patent granted (law 1993)
2004-01-26	PUP	Patent expired