[go: up one dir, main page]

DK3592393T3 - Frigørbare konjugater - Google Patents

Frigørbare konjugater Download PDF

Info

Publication number
DK3592393T3
DK3592393T3 DK18713014.1T DK18713014T DK3592393T3 DK 3592393 T3 DK3592393 T3 DK 3592393T3 DK 18713014 T DK18713014 T DK 18713014T DK 3592393 T3 DK3592393 T3 DK 3592393T3
Authority
DK
Denmark
Prior art keywords
releasable conjugates
conjugates
releasable
Prior art date
Application number
DK18713014.1T
Other languages
English (en)
Inventor
Marek Kwiatkowski
Christian Sund
Original Assignee
Quiapeg Pharmaceuticals Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quiapeg Pharmaceuticals Ab filed Critical Quiapeg Pharmaceuticals Ab
Application granted granted Critical
Publication of DK3592393T3 publication Critical patent/DK3592393T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK18713014.1T 2017-03-10 2018-03-10 Frigørbare konjugater DK3592393T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762469989P 2017-03-10 2017-03-10
US201762564820P 2017-09-28 2017-09-28
PCT/IB2018/051579 WO2018163131A1 (en) 2017-03-10 2018-03-10 Releasable conjugates

Publications (1)

Publication Number Publication Date
DK3592393T3 true DK3592393T3 (da) 2022-03-07

Family

ID=61764062

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18713014.1T DK3592393T3 (da) 2017-03-10 2018-03-10 Frigørbare konjugater

Country Status (11)

Country Link
US (2) US11786599B2 (da)
EP (2) EP3592393B1 (da)
JP (2) JP7152408B2 (da)
KR (1) KR20190125310A (da)
CN (1) CN110545850A (da)
AU (2) AU2018231832A1 (da)
BR (1) BR112019017103A2 (da)
CA (1) CA3051173A1 (da)
DK (1) DK3592393T3 (da)
SI (1) SI3592393T1 (da)
WO (1) WO2018163131A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3592393T3 (da) * 2017-03-10 2022-03-07 Quiapeg Pharmaceuticals Ab Frigørbare konjugater
CA3086651C (en) 2018-03-09 2023-01-17 Quiapeg Pharmaceuticals Ab Releasable antibody conjugates
BR112021004689A2 (pt) 2018-09-12 2021-06-08 Quiapeg Pharmaceuticals Ab conjugados glp-1 liberáveis
CN111175387B (zh) * 2018-11-13 2022-06-07 成都康弘药业集团股份有限公司 一种米那普仑异构体的检测方法
US10768173B1 (en) 2019-09-06 2020-09-08 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
CN112168820B (zh) * 2019-07-05 2023-09-29 中国科学院生物物理研究所 SRCAP ATPase抑制剂在结直肠癌治疗中的应用
US11287422B2 (en) 2019-09-23 2022-03-29 Element Biosciences, Inc. Multivalent binding composition for nucleic acid analysis
KR102398574B1 (ko) 2019-10-10 2022-05-13 주식회사 엘지에너지솔루션 전지 모듈 및 이를 포함하는 전지 팩
CN110946844A (zh) * 2019-12-11 2020-04-03 正大制药（青岛）有限公司 一种含有艾地骨化醇的复方控释制剂
AU2021216611A1 (en) * 2020-02-03 2022-08-25 Snoretox Ltd Composition and method
CN113456824B (zh) * 2020-03-31 2023-03-31 四川大学华西医院 一种抗肿瘤载药纳米复合材料
CA3184998A1 (en) 2020-08-05 2022-02-10 Samuel WEISBROD Conjugates comprising reversible linkers and uses thereof
CN112138170B (zh) * 2020-09-28 2022-05-20 广东药科大学 一种预防顺铂药源性聋的缀合物及其制备方法和应用
CN112316156B (zh) * 2020-10-27 2022-03-15 四川大学 具抗氧化和抗菌性的胶原蛋白修复膜、其制备方法及应用
CN112402620A (zh) * 2020-12-07 2021-02-26 南开大学 肿瘤微环境还原响应性的纳米药物及其制备方法
CN112457383B (zh) * 2020-12-16 2022-06-17 阿南达 一种多肽、制备方法及其医药用途
CN112516285B (zh) * 2020-12-18 2022-09-02 中南大学 一种预防或治疗缺血/再灌注损伤的药物组合物及应用
CN112574272B (zh) * 2020-12-25 2021-09-21 中国医学科学院药用植物研究所 一种灵芝酸a衍生物的制备及其应用
CN114478800B (zh) * 2021-02-05 2022-10-11 华南理工大学 基于血清白蛋白的融合蛋白、纳米组装体及其制备方法和应用
CN112999196B (zh) * 2021-03-03 2023-04-28 西安医学院 用于长效稳定释放的吗替麦考酚酯纳米制剂及其制备方法
CN113133989B (zh) * 2021-03-09 2023-04-25 西安医学院 一种用于抗结核药物利福平的长效制剂及制备方法
CN114617876B (zh) * 2022-01-28 2023-04-07 四川大学华西医院 一种抗肿瘤联合用药物
CN114886817B (zh) * 2022-06-02 2023-06-27 杭州配方师科技有限公司 一种弗来歇氏柳叶菜和酵母菌锌发酵复合物、制备方法及应用
WO2023244517A1 (en) * 2022-06-16 2023-12-21 Merck Sharp & Dohme Llc Interleukin-2 prodrugs
CN116333047A (zh) * 2022-12-22 2023-06-27 四川大学华西医院 一种抗菌肽及其制备方法
KR102623104B1 (ko) * 2023-08-23 2024-01-11 에프아이씨씨주식회사 보툴리눔톡신 결합체와 줄기세포 엑소좀 복합체를 유효성분으로 함유하는 피부 재생 및 주름 개선용 화장료 조성물 및 그의 제조 방법
CN118415977B (zh) * 2024-07-03 2024-08-23 山东新时代药业有限公司 一种米力农注射剂及其用途

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US200130A (en) * 1878-02-12 Improvement in joining sheet metal to wire-cloth for the construction of fly-traps
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
DK0563475T3 (da) 1992-03-25 2000-09-18 Immunogen Inc Konjugater af cellebindende midler og derivater af CC-1065
US5395619A (en) 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
WO1996012697A2 (en) 1994-10-21 1996-05-02 Nps Pharmaceuticals, Inc. Calcium receptor-active compounds
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US5817856A (en) 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
US5830600A (en) 1996-05-24 1998-11-03 Sri International Nonflammable/self-extinguishing electrolytes for batteries
JPH10175987A (ja) 1996-12-13 1998-06-30 Nof Corp 重合性基含有有機リン酸エステル化合物およびその製造方法
US6180095B1 (en) 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US5922897A (en) 1998-05-29 1999-07-13 Xerox Corporation Surfactant processes
JP2000212191A (ja) * 1999-01-26 2000-08-02 Sankyo Co Ltd リン酸誘導体
US20030165849A1 (en) 2000-11-28 2003-09-04 Biliang Zhang Methods and reagents for introducing a sulfhydryl group into the 5'-terminus of RNA
US6320041B1 (en) 2001-04-13 2001-11-20 Trilink Biotechnologies, Inc. Pre-activated carbonyl linkers for the modification of oligonucleotides
US6743905B2 (en) 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
CA2446904A1 (en) 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US20100240730A1 (en) 2002-02-20 2010-09-23 Merck Sharp And Dohme Corp. RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2004073620A2 (en) 2003-02-14 2004-09-02 Quanta Biodesign, Ltd The selective and specific preparation of discrete peg compounds
NZ547633A (en) 2003-11-06 2010-08-27 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
US20070276139A1 (en) 2004-02-10 2007-11-29 Quanlai Song Substituted Pixyl Protecting Groups for Oligonucleotide Synthesis
HUE045882T2 (hu) 2004-03-23 2020-01-28 Ascendis Pharma Gmbh Polimer prodrug önmagát lehasító linkerrel
JP2008501765A (ja) 2004-06-11 2008-01-24 ノボ　ノルディスク　アクティーゼルスカブ Ｇｌｐ−１アゴニストを用いた薬剤誘発性肥満の中和
US20060063147A1 (en) 2004-09-21 2006-03-23 Chernov Boris K Omega-amino-PEG-phosphoramidites and conjugates thereof
TW200612993A (en) 2004-10-08 2006-05-01 Alza Corp Lipopolymer conjugates
CA2622210A1 (en) 2005-10-21 2007-04-26 Avigenics, Inc. Glycolated and glycosylated poultry derived therapeutic proteins
US8043833B2 (en) 2005-10-31 2011-10-25 Novo Nordisk A/S Expression of soluble therapeutic proteins
AU2006316903B8 (en) 2005-11-23 2010-10-14 F. Hoffmann-La Roche Ag Polynucleotide labelling reagent
US8293869B2 (en) 2005-12-16 2012-10-23 Nektar Therapeutics Polymer conjugates of GLP-1
JP5140824B2 (ja) 2006-04-19 2013-02-13 国立大学法人 東京大学 リゾホスファチジルスレオニンおよびその誘導体
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
BRPI0718696A2 (pt) 2006-11-09 2013-12-31 Alcon Res Ltd Matriz de polímero insolúvel em água para liberação de fármaco.
US20130195888A1 (en) 2007-11-30 2013-08-01 Abbvie Ultrafiltration and diafiltration formulation methods for protein processing
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
EP3981761A3 (en) 2008-02-01 2022-08-24 Ascendis Pharma A/S Intermediates for prodrugs
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
EP2310440A4 (en) 2008-07-10 2013-06-05 Serina Therapeutics Inc POLYOXAZOLINES WITH INTERNAL END GROUPS, POLYOXAZOLINES MANUFACTURED FROM PROTECTED INITIAL GROUPS AND CORRESPONDING COMPOUNDS
EP2334335A1 (en) 2008-09-19 2011-06-22 Nektar Therapeutics Polymer conjugates of cd-np peptides
EP2432489B1 (en) 2009-05-20 2016-10-05 BioMarin Pharmaceutical Inc. Variants of c-type natriuretic peptide
WO2011012722A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Prodrugs containing an aromatic amine connected by an amido bond to a linker
DK2525830T3 (da) 2010-01-22 2016-08-15 Ascendis Pharma As Dipeptid-baserede prodrug-linkere til alifatiske amin-indeholdende lægemidler
EP2566335B1 (en) 2010-05-05 2016-06-29 Prolynx Llc Controlled release of active compounds from macromolecular conjugates
US9387245B2 (en) 2010-08-06 2016-07-12 University Of Colorado, A Body Corporate Methods and compositions for the inhibition of fructokinase
CA2821411C (en) 2010-12-13 2020-02-25 Marek Kwiatkowski Functionalized polymers
DK2734208T3 (da) * 2011-07-19 2017-06-19 Wave Life Sciences Ltd Fremgangsmåder til syntese af funktionaliserede nukleinsyrer
WO2013024053A1 (en) 2011-08-12 2013-02-21 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
EP2858678B1 (en) 2012-06-12 2019-08-07 QuiaPEG Pharmaceuticals AB Conjugates of biologically active molecules to functionalized polymers
EP2910573B1 (en) 2012-10-19 2020-02-19 Daiichi Sankyo Company, Limited Antibody-drug conjugate produced by binding through linker having hydrophilic structure
KR20220127364A (ko) 2013-12-19 2022-09-19 씨젠 인크. 표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
CA2952834A1 (en) 2014-06-20 2015-12-23 Abgenomics International Inc. Her2 antibody-drug conjugates
JP6369721B2 (ja) 2014-07-04 2018-08-08 国立大学法人 東京大学 リゾホスファチジルセリン誘導体
CN104725628B (zh) 2014-10-01 2018-04-17 厦门赛诺邦格生物科技股份有限公司 一种含可降解基团的单一官能化支化聚乙二醇、制备方法及其生物相关物质
MX2017008915A (es) 2015-01-09 2018-04-26 Ascendis Pharma Growth Disorders As Profarmacos de peptido natriuretico tipo c (cnp).
CN107614020A (zh) 2015-03-18 2018-01-19 免疫生化公司 靶向细胞内肿瘤相关抗原的用于治疗癌症的缀合物
DK3334462T3 (da) 2015-08-14 2022-02-14 Rc Biotechnologies Inc Kovalente linkere i antistof-lægemiddel-konjugater og fremgangsmåder til fremstilling og anvendelse deraf
PL3400019T3 (pl) 2016-01-08 2023-01-23 Ascendis Pharma Growth Disorders A/S Proleki cnp z przyłączeniem nośnika w ugrupowaniu pierścieniowy
JP7051686B2 (ja) 2016-01-08 2022-04-11 アセンディス ファーマ グロース ディスオーダーズ エー／エス 大型のキャリアー部分を有するｃｎｐプロドラッグ
GB201607827D0 (en) 2016-05-04 2016-06-15 Bicycle Therapeutics Ltd Bicyclic peptide-toxin conjugates specific for MT1-MMP
ES2985986T3 (es) 2017-01-06 2024-11-08 Bicyclerd Ltd Conjugado biciclo para tratar el cáncer
DK3592393T3 (da) * 2017-03-10 2022-03-07 Quiapeg Pharmaceuticals Ab Frigørbare konjugater
CA3086651C (en) * 2018-03-09 2023-01-17 Quiapeg Pharmaceuticals Ab Releasable antibody conjugates
BR112021004689A2 (pt) * 2018-09-12 2021-06-08 Quiapeg Pharmaceuticals Ab conjugados glp-1 liberáveis

Also Published As

Publication number Publication date
US20180360974A1 (en) 2018-12-20
JP2022191304A (ja) 2022-12-27
AU2024201279A1 (en) 2024-03-21
AU2018231832A1 (en) 2019-08-08
EP3592393A1 (en) 2020-01-15
EP3592393B1 (en) 2021-12-01
JP7381684B2 (ja) 2023-11-15
BR112019017103A2 (pt) 2020-04-14
WO2018163131A1 (en) 2018-09-13
CN110545850A (zh) 2019-12-06
EP4011396A1 (en) 2022-06-15
US11786599B2 (en) 2023-10-17
KR20190125310A (ko) 2019-11-06
JP2020512302A (ja) 2020-04-23
CA3051173A1 (en) 2018-09-13
SI3592393T1 (sl) 2022-04-29
JP7152408B2 (ja) 2022-10-12
US20230381323A1 (en) 2023-11-30

Similar Documents

Publication Publication Date Title
DK3592393T3 (da) Frigørbare konjugater
DK3579883T3 (da) Pyrrolobenzodiazepin-antistofkonjugater
DK3731771T3 (da) V462033dk00
LT3525830T (lt) Pirolbenzodiazepino konjugatai
EP3484518C0 (en) Antibody adjuvant conjugates
LT3544636T (lt) Pirolobenzodiazepino-antikūno konjugatai
DK3268047T3 (da) Amatoxin/antistof-konjugater
DE202018003363U8 (de) Handgelenkssphygmomanometer
CL2018000524S1 (es) Golilla
DK3612537T3 (da) Pyrrolobenzodiazepinkonjugater
EP3588580A4 (en) SCHOTTKY MOS TRENCH DIODE
EP3634404C0 (en) PYRAZOLE-BASED MAGL INHIBITORS
EP3589248A4 (en) CRYOTHERAPIES
EP3697802A4 (en) TRITERPENIC SAPONIN ANALOGUES
DK3571580T3 (da) Load-logical-and-shift-guarded-instruktion
EP3618836A4 (en) TRITERPENIC SAPONIN ANALOGUES
DK3568655T3 (da) Rekuperator
EP3634397A4 (en) HETEROCYCLYL POLYMETHINE-BASED IR CHROMOPHORES
DK3612237T3 (da) Genterapi
EP3575467A4 (en) NON-WOVEN FABRIC THREADED
EP3654852A4 (en) TOURNIQUET
EP3714787A4 (en) BIOSENSOR
DK3544634T3 (da) MET-antistof-lægemiddelkonjugater
DK3568506T3 (da) Offeranode
EP3569893A4 (en) CHAIN TENSIONER