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DK3371185T3 - 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer - Google Patents

4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer Download PDF

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Publication number
DK3371185T3
DK3371185T3 DK16793974.3T DK16793974T DK3371185T3 DK 3371185 T3 DK3371185 T3 DK 3371185T3 DK 16793974 T DK16793974 T DK 16793974T DK 3371185 T3 DK3371185 T3 DK 3371185T3
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DK
Denmark
Prior art keywords
chinase
hexahydroimidazo
janus
imidazo
tetrahydro
Prior art date
Application number
DK16793974.3T
Other languages
English (en)
Inventor
Matthew Colin Thor Fyfe
Original Assignee
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1519382.4A external-priority patent/GB201519382D0/en
Application filed by Topivert Pharma Ltd filed Critical Topivert Pharma Ltd
Application granted granted Critical
Publication of DK3371185T3 publication Critical patent/DK3371185T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16793974.3T 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer DK3371185T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1519382.4A GB201519382D0 (en) 2015-11-03 2015-11-03 Kinase inhibitors
GB201606971 2016-04-21
PCT/GB2016/053392 WO2017077288A1 (en) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3371185T3 true DK3371185T3 (da) 2020-11-30

Family

ID=57256357

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16793974.3T DK3371185T3 (da) 2015-11-03 2016-11-02 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridin og 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepinderivater som janus-kinase-inhibitorer

Country Status (8)

Country Link
US (2) US10556901B2 (da)
EP (2) EP3831830A1 (da)
CA (1) CA3037248A1 (da)
DK (1) DK3371185T3 (da)
ES (1) ES2840650T3 (da)
PL (1) PL3371185T3 (da)
PT (1) PT3371185T (da)
WO (1) WO2017077288A1 (da)

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PT3371185T (pt) 2015-11-03 2020-12-28 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
EP3371184A1 (en) 2015-11-03 2018-09-12 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
US10196393B2 (en) * 2017-03-09 2019-02-05 Theravance Biopharma R&D Ip, Llc JAK inhibitors containing a 4-membered heterocyclic amide
WO2018204236A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Crystalline forms of a jak inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
WO2018204233A1 (en) 2017-05-01 2018-11-08 Theravance Biopharma R&D Ip, Llc Methods of treatment using a jak inhibitor compound
CN112638902A (zh) * 2018-09-04 2021-04-09 施万生物制药研发Ip有限责任公司 用于制备jak抑制剂的方法及其中间体
MX2021002484A (es) 2018-09-04 2021-05-12 Theravance Biopharma R&D Ip Llc Amidas heterociclicas de 5 a 7 miembros como inhibidores de jak.
BR112021004052A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc amidas de dimetil-amino azetidina como inibidores de jak
US10968222B2 (en) 2018-10-29 2021-04-06 Theravance Biopharma R&D Ip, Llc 2-azabicyclo hexane JAK inhibitor compound
WO2020154350A1 (en) 2019-01-23 2020-07-30 Theravance Biopharma R&D Ip, Llc Imidazo[1,5-a]pyridine, 1,2,4-triazolo[4,3-a]pyridine and imidazo[1,5-a]pyrazine as jak inhibitors
AU2020228799B2 (en) 2019-02-25 2024-12-05 Henan Medinno Pharmaceutical Technology Co., Ltd. JAK inhibitor compound and use thereof
CN114075199A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
JP2024524214A (ja) 2021-06-25 2024-07-05 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤としてのイミダゾロインダゾール化合物
EP4450492A4 (en) * 2021-12-17 2025-10-15 Daewoong Pharmaceutical Co Ltd NEW ACID ADDITION SALT AND CRYSTALLINE FORM OF (2R,3S)-2-(3-(4,5-DICHLORO-1H-BENZO[D]IMIDAZOL-1-YL)PROPYL)PIPERIDIN-3-OL
JP2025525428A (ja) * 2022-07-04 2025-08-05 メディノ ファーマスーティカル テクノロジー （チューハイ） カンパニー リミテッド Ｔｒｋ阻害剤及び／又はｒｅｔ阻害剤としての化合物及びその使用

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CN108349972B (zh) 2015-11-03 2021-06-08 施万生物制药研发Ip有限责任公司 用于治疗呼吸疾病的jak激酶抑制剂化合物
PT3371185T (pt) 2015-11-03 2020-12-28 Topivert Pharma Ltd Derivados de 4,5,6,7-tetrahidro-1h-imidazo[4,5-c]piridina e 1,4,5,6,7,8-hexahidroimidazo[4,5-d]azepina como inibidores de janus quinase
EP3371184A1 (en) 2015-11-03 2018-09-12 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
TWI703147B (zh) 2015-11-24 2020-09-01 美商施萬生物製藥研發Ｉｐ有限責任公司 用於治療胃腸發炎性疾病之jak抑制劑化合物之前藥
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US10196393B2 (en) * 2017-03-09 2019-02-05 Theravance Biopharma R&D Ip, Llc JAK inhibitors containing a 4-membered heterocyclic amide

Also Published As

Publication number Publication date
EP3371185A1 (en) 2018-09-12
US20200223843A1 (en) 2020-07-16
US20180370963A1 (en) 2018-12-27
PL3371185T3 (pl) 2021-04-06
US10556901B2 (en) 2020-02-11
EP3371185B1 (en) 2020-09-30
EP3831830A1 (en) 2021-06-09
PT3371185T (pt) 2020-12-28
WO2017077288A1 (en) 2017-05-11
US10882859B2 (en) 2021-01-05
ES2840650T3 (es) 2021-07-07
CA3037248A1 (en) 2017-05-11

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