DK3319987T3 - Nye p450-bm3-varianter med forbedret aktivitet - Google Patents
Nye p450-bm3-varianter med forbedret aktivitet Download PDFInfo
- Publication number
- DK3319987T3 DK3319987T3 DK16821779.2T DK16821779T DK3319987T3 DK 3319987 T3 DK3319987 T3 DK 3319987T3 DK 16821779 T DK16821779 T DK 16821779T DK 3319987 T3 DK3319987 T3 DK 3319987T3
- Authority
- DK
- Denmark
- Prior art keywords
- variants
- new
- improved activity
- activity
- improved
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)
- C12Y114/14001—Unspecific monooxygenase (1.14.14.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189281P | 2015-07-07 | 2015-07-07 | |
| PCT/US2016/035399 WO2017007547A1 (en) | 2015-07-07 | 2016-06-02 | Novel p450-bm3 variants with improved activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3319987T3 true DK3319987T3 (da) | 2021-06-21 |
Family
ID=57686072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16821779.2T DK3319987T3 (da) | 2015-07-07 | 2016-06-02 | Nye p450-bm3-varianter med forbedret aktivitet |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US9683220B2 (da) |
| EP (1) | EP3319987B1 (da) |
| JP (1) | JP6691558B2 (da) |
| CN (1) | CN108271374B (da) |
| CA (1) | CA2991195C (da) |
| DK (1) | DK3319987T3 (da) |
| IL (1) | IL256441B (da) |
| WO (1) | WO2017007547A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
| DK3319987T3 (da) | 2015-07-07 | 2021-06-21 | Codexis Inc | Nye p450-bm3-varianter med forbedret aktivitet |
| LT3370733T (lt) * | 2015-11-02 | 2021-10-25 | Board Of Regents, The University Of Texas System | Cd40 aktyvinimo ir imuninės kontrolės taškų blokados būdai |
| US11591627B2 (en) | 2018-03-21 | 2023-02-28 | University Of Florida Research Foundation, Incorporated | Modified bacteria for production of nitroaromatics |
| WO2024112781A1 (en) * | 2022-11-22 | 2024-05-30 | Codexis, Inc. | P450-bm3 variants with improved activity |
| WO2024196434A1 (en) * | 2023-03-20 | 2024-09-26 | Codexis, Inc. | P450-bm3 variants with improved activity |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US6995017B1 (en) | 1994-02-17 | 2006-02-07 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US20060257890A1 (en) | 1996-05-20 | 2006-11-16 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
| PT765394E (pt) | 1994-06-03 | 2002-03-28 | Novozymes Biotech Inc | Lacases myceliophthora purificadas e acidos nucleicos que as codificam |
| AU2705895A (en) | 1994-06-30 | 1996-01-25 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein |
| US5483345A (en) | 1994-09-06 | 1996-01-09 | Mrs Technology, Inc. | Alignment system for use in lithography utilizing a spherical reflector having a centered etched-on projection object |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| WO1997016553A1 (en) * | 1995-11-01 | 1997-05-09 | Bg Plc | MUTANT MONO-OXYGENASE CYTOCHROME P450cam |
| US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
| US6506602B1 (en) | 1996-03-25 | 2003-01-14 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| DE69835360T2 (de) | 1997-01-17 | 2007-08-16 | Maxygen, Inc., Redwood City | EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION |
| US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
| EP1036198B1 (en) | 1997-12-08 | 2012-09-26 | California Institute Of Technology | Method for creating polynucleotide and polypeptide sequences |
| US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
| JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
| US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US6917882B2 (en) | 1999-01-19 | 2005-07-12 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
| US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
| EP1072010B1 (en) | 1999-01-19 | 2010-04-21 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
| US7702464B1 (en) | 2001-08-21 | 2010-04-20 | Maxygen, Inc. | Method and apparatus for codon determining |
| US6961664B2 (en) | 1999-01-19 | 2005-11-01 | Maxygen | Methods of populating data structures for use in evolutionary simulations |
| EP1165757A1 (en) | 1999-03-05 | 2002-01-02 | Maxygen, Inc. | Encryption of traits using split gene sequences |
| US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
| US6519065B1 (en) | 1999-11-05 | 2003-02-11 | Jds Fitel Inc. | Chromatic dispersion compensation device |
| WO2001075767A2 (en) | 2000-03-30 | 2001-10-11 | Maxygen, Inc. | In silico cross-over site selection |
| US20050084907A1 (en) | 2002-03-01 | 2005-04-21 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US7783428B2 (en) | 2002-03-01 | 2010-08-24 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| US7747391B2 (en) | 2002-03-01 | 2010-06-29 | Maxygen, Inc. | Methods, systems, and software for identifying functional biomolecules |
| WO2003078583A2 (en) | 2002-03-09 | 2003-09-25 | Maxygen, Inc. | Optimization of crossover points for directed evolution |
| US7524664B2 (en) * | 2003-06-17 | 2009-04-28 | California Institute Of Technology | Regio- and enantioselective alkane hydroxylation with modified cytochrome P450 |
| GB0403992D0 (en) * | 2004-02-23 | 2004-03-31 | Isis Innovation | Oxidation by hydrogen peroxide |
| CN1273585C (zh) * | 2004-11-29 | 2006-09-06 | 浙江大学 | 细胞色素 p450bm－3 单加氧酶变体基因及其用途 |
| US20070225217A1 (en) | 2005-11-09 | 2007-09-27 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| CA2662977A1 (en) | 2006-09-22 | 2008-03-27 | Novartis Ag | Method of optimizing the treatment of philadelphia-positive leukemia with abl tyrosine kinase inhibitors |
| EA016267B1 (ru) | 2006-09-29 | 2012-03-30 | Айденикс Фармасьютикалз, Инк. | Энантиомерно чистые фосфоиндолы в качестве ингибиторов hiv |
| WO2008073498A2 (en) | 2006-12-12 | 2008-06-19 | The Regents Of The University Of California | Artemisinic epoxide and methods for producing same |
| US20080268517A1 (en) * | 2007-02-08 | 2008-10-30 | The California Institute Of Technology | Stable, functional chimeric cytochrome p450 holoenzymes |
| US8802401B2 (en) * | 2007-06-18 | 2014-08-12 | The California Institute Of Technology | Methods and compositions for preparation of selectively protected carbohydrates |
| GB0719620D0 (en) * | 2007-10-08 | 2007-11-14 | Isis Innovation | Mutant Enzymes |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| CA2726850C (en) | 2008-06-13 | 2015-06-02 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
| EP2426198A1 (en) * | 2010-09-03 | 2012-03-07 | B.R.A.I.N. Biotechnology Research And Information Network AG | Cytochrome P450 monooxygenase variants |
| WO2012109586A2 (en) * | 2011-02-11 | 2012-08-16 | University Of Rochester | Methods and systems for evaluating and predicting the reactivity of monooxygenase enzymes |
| WO2013076258A2 (en) * | 2011-11-23 | 2013-05-30 | Dsm Ip Assets B.V. | P450 bm3 mutants and their use for regio- and stereoselective hydroxylation of alpha-and beta-ionone |
| CN102757944A (zh) * | 2012-07-24 | 2012-10-31 | 浙江大学宁波理工学院 | 细胞色素p450bm-3(d168l/e435t)变体酶及其编码基因和用途 |
| WO2014058744A2 (en) * | 2012-10-09 | 2014-04-17 | California Institute Of Technology | In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes |
| US9708587B2 (en) | 2014-07-09 | 2017-07-18 | Codexis, Inc. | P450-BM3 variants with improved activity |
| DK3319987T3 (da) * | 2015-07-07 | 2021-06-21 | Codexis Inc | Nye p450-bm3-varianter med forbedret aktivitet |
-
2016
- 2016-06-02 DK DK16821779.2T patent/DK3319987T3/da active
- 2016-06-02 EP EP16821779.2A patent/EP3319987B1/en active Active
- 2016-06-02 US US15/171,116 patent/US9683220B2/en active Active
- 2016-06-02 CA CA2991195A patent/CA2991195C/en active Active
- 2016-06-02 JP JP2017567368A patent/JP6691558B2/ja active Active
- 2016-06-02 WO PCT/US2016/035399 patent/WO2017007547A1/en active Application Filing
- 2016-06-02 CN CN201680040014.3A patent/CN108271374B/zh active Active
-
2017
- 2017-05-10 US US15/591,816 patent/US10113153B2/en active Active
- 2017-12-20 IL IL256441A patent/IL256441B/en active IP Right Grant
-
2018
- 2018-10-05 US US16/152,709 patent/US10450550B2/en active Active
-
2019
- 2019-09-06 US US16/562,673 patent/US10704030B2/en active Active
-
2020
- 2020-06-02 US US16/890,408 patent/US10982197B2/en active Active
-
2021
- 2021-03-16 US US17/203,421 patent/US11591578B2/en active Active
-
2023
- 2023-01-12 US US18/153,620 patent/US20230250403A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230250403A1 (en) | 2023-08-10 |
| US10982197B2 (en) | 2021-04-20 |
| US20170009213A1 (en) | 2017-01-12 |
| IL256441A (en) | 2018-02-28 |
| US11591578B2 (en) | 2023-02-28 |
| CA2991195C (en) | 2021-06-29 |
| IL256441B (en) | 2020-02-27 |
| EP3319987A4 (en) | 2018-12-19 |
| US20200291365A1 (en) | 2020-09-17 |
| CA2991195A1 (en) | 2017-01-12 |
| US9683220B2 (en) | 2017-06-20 |
| US20170247667A1 (en) | 2017-08-31 |
| JP2018520674A (ja) | 2018-08-02 |
| US20210214694A1 (en) | 2021-07-15 |
| WO2017007547A1 (en) | 2017-01-12 |
| US10113153B2 (en) | 2018-10-30 |
| US20190024059A1 (en) | 2019-01-24 |
| US20200002685A1 (en) | 2020-01-02 |
| US10450550B2 (en) | 2019-10-22 |
| JP6691558B2 (ja) | 2020-04-28 |
| CN108271374B (zh) | 2021-09-21 |
| CN108271374A (zh) | 2018-07-10 |
| EP3319987A1 (en) | 2018-05-16 |
| US10704030B2 (en) | 2020-07-07 |
| EP3319987B1 (en) | 2021-05-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY2024015I1 (el) | Ρυθμιση δραστικοτητας συμπληρωματος | |
| DK3240773T3 (da) | Picolinamidforbindelser med fungicid aktivitet | |
| IL250320B (en) | Compounds active toward bromodomains | |
| FIC20240025I1 (fi) | Momelotinibi, mukaanlukien momelotinibidihydrokloridimonohydraatti | |
| DK3190923T3 (da) | Hovedstøtte | |
| HK1257845A1 (zh) | 糖靶向治療劑 | |
| DK3174483T3 (da) | Hyporørkonstruktion | |
| FR3019749B1 (fr) | Autoinjecteur | |
| KR20180084915A (ko) | 구조체 | |
| DK3167052T3 (da) | P450-bm3-varianter med forbedret aktivitet | |
| DK3337795T3 (da) | Piperidinobenzodiazepinforbindelser med anti-proliferativ aktivitet | |
| DK3203834T3 (da) | Hovbehandlingsarrangement | |
| DK3110442T3 (da) | Modificerede meningokok-fhbp-polypeptider | |
| DK3319987T3 (da) | Nye p450-bm3-varianter med forbedret aktivitet | |
| DK3310914T3 (da) | Chymosinvarianter med forbedrede egenskaber | |
| EP3341117C0 (en) | Reactor | |
| DK3298022T3 (da) | Nye annelerede phenoxyacetamider | |
| FI20145185A (fi) | Liikkeenrajoitinrakenne | |
| HK1243700A1 (zh) | 具有抗腫瘤活性的化合物 | |
| EP3384016A4 (en) | MANIPULATED PHAGEMIDES | |
| EP3367914A4 (en) | ECHOGENIC NEEDLE | |
| DK3380552T3 (da) | BCHPC med reduceret brændhastighed | |
| DK3193936T3 (da) | Antimikrobielle midler med forøget virkning | |
| DK3097084T3 (da) | Nye kallikrein 7-hæmmere | |
| DK3313999T3 (da) | Polypeptider med demethyleringsaktivitet |