DK3294865T3 - Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider - Google Patents
Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider Download PDFInfo
- Publication number
- DK3294865T3 DK3294865T3 DK16793332.4T DK16793332T DK3294865T3 DK 3294865 T3 DK3294865 T3 DK 3294865T3 DK 16793332 T DK16793332 T DK 16793332T DK 3294865 T3 DK3294865 T3 DK 3294865T3
- Authority
- DK
- Denmark
- Prior art keywords
- epimerases
- processes
- production
- benzylisoquinoline alkaloids
- benzylisoquinoline
- Prior art date
Links
- 102000004879 Racemases and epimerases Human genes 0.000 title 1
- 108090001066 Racemases and epimerases Proteins 0.000 title 1
- 229930015408 benzyl-isoquinoline alkaloid Natural products 0.000 title 1
- 150000005516 benzylisoquinolines Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
- C12Y501/99—Racemaces and epimerases (5.1) acting on other compounds (5.1.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01247—Codeinone reductase (NADPH) (1.1.1.247)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y501/00—Racemaces and epimerases (5.1)
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159122P | 2015-05-08 | 2015-05-08 | |
| US201562174475P | 2015-06-11 | 2015-06-11 | |
| PCT/US2016/031506 WO2016183023A1 (en) | 2015-05-08 | 2016-05-09 | Methods of producing epimerases and benzylisoquinoline alkaloids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3294865T3 true DK3294865T3 (da) | 2023-05-08 |
Family
ID=57248432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16793332.4T DK3294865T3 (da) | 2015-05-08 | 2016-05-09 | Fremgangsmåder til fremstilling af epimeraser og benzylisoquinolinalkaloider |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11859225B2 (da) |
| EP (2) | EP3294865B1 (da) |
| JP (3) | JP7266966B2 (da) |
| KR (1) | KR20180016396A (da) |
| CN (1) | CN107960102A (da) |
| AU (3) | AU2016261490B2 (da) |
| CA (1) | CA2983445A1 (da) |
| DK (1) | DK3294865T3 (da) |
| ES (1) | ES2945359T3 (da) |
| GB (1) | GB2555044B (da) |
| HK (1) | HK1246354A1 (da) |
| IL (1) | IL255136B2 (da) |
| WO (1) | WO2016183023A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11124814B2 (en) | 2013-11-04 | 2021-09-21 | The Board Of Trustees Of The Leland Stanford Junior University | Benzylisoquinoline alkaloid (BIA) precursor producing microbes, and methods of making and using the same |
| KR102491060B1 (ko) | 2013-12-04 | 2023-01-20 | 에피메론 인코포레이티드 | (r)-레티큘린 및 그 전구체를 제조하기 위한 조성물 및 방법 |
| CN107002103B (zh) * | 2014-11-17 | 2022-01-28 | 小利兰.斯坦福大学托管委员会 | 产生类诺斯卡品的微生物以及其制备和使用方法 |
| EP3497212A1 (en) | 2016-08-09 | 2019-06-19 | River Stone Biotech, LLC | Biosynthesis of benzylisoquinoline alkaloids and benzylisoquinoline alkaloid precursors |
| CN110494560A (zh) * | 2017-02-06 | 2019-11-22 | 齐默尔根公司 | 通过发酵产生酪胺的经改造的生物合成途径 |
| GB2579940B (en) * | 2017-08-03 | 2022-11-30 | Antheia Inc | Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids |
| AU2018329823A1 (en) * | 2017-09-08 | 2020-04-23 | Eleszto Genetika, Inc. | Microorganisms and methods in the fermentation of benzylisoquinoline alkaloids |
| US11560578B2 (en) | 2017-12-05 | 2023-01-24 | Antheia, Inc. | Neopinone isomerase and methods of using |
| CN111971390A (zh) * | 2018-02-08 | 2020-11-20 | 安思雅公司 | 产生吗啡喃生物碱及衍生物的方法 |
| CN112261942A (zh) | 2018-04-19 | 2021-01-22 | 艾伯维公司 | 治疗重度月经出血的方法 |
| WO2019243624A1 (en) | 2018-06-22 | 2019-12-26 | Valorbec, Limited Partnership | Production of benzylisoquinoline alkaloids in recombinant hosts |
| CN109468351B (zh) * | 2018-11-27 | 2020-07-14 | 湖南美可达生物资源股份有限公司 | 高效酶催化合成血根碱与白屈菜红碱的方法 |
| WO2020198373A1 (en) * | 2019-03-26 | 2020-10-01 | Antheia, Inc. | Methods of improving production of morphinan alkaloids and derivatives |
| CN112516143B (zh) * | 2020-11-30 | 2023-03-21 | 重庆医科大学 | 双苄四氢异喹啉衍生物在制备抗冠状病毒药物中的应用 |
| WO2024100063A1 (en) | 2022-11-08 | 2024-05-16 | River Stone Biotech Aps | Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression |
| CN116536285B (zh) * | 2023-05-26 | 2024-09-17 | 浙江中医药大学 | 一种粉防己乌药碱氮甲基转移酶cnmt及应用 |
| CN119432631A (zh) * | 2023-08-04 | 2025-02-14 | 陈云 | 一种重组菌及其在生产苯骈菲啶生物碱中的应用 |
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2016
- 2016-05-09 DK DK16793332.4T patent/DK3294865T3/da active
- 2016-05-09 US US15/567,358 patent/US11859225B2/en active Active
- 2016-05-09 KR KR1020177035395A patent/KR20180016396A/ko not_active Application Discontinuation
- 2016-05-09 JP JP2017558387A patent/JP7266966B2/ja active Active
- 2016-05-09 GB GB1719939.9A patent/GB2555044B/en active Active
- 2016-05-09 EP EP16793332.4A patent/EP3294865B1/en active Active
- 2016-05-09 AU AU2016261490A patent/AU2016261490B2/en active Active
- 2016-05-09 WO PCT/US2016/031506 patent/WO2016183023A1/en active Application Filing
- 2016-05-09 EP EP23167022.5A patent/EP4253525A3/en active Pending
- 2016-05-09 CN CN201680038252.0A patent/CN107960102A/zh active Pending
- 2016-05-09 ES ES16793332T patent/ES2945359T3/es active Active
- 2016-05-09 CA CA2983445A patent/CA2983445A1/en active Pending
- 2016-05-09 IL IL255136A patent/IL255136B2/en unknown
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2018
- 2018-05-04 HK HK18105781.2A patent/HK1246354A1/zh unknown
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2019
- 2019-10-11 AU AU2019246920A patent/AU2019246920B2/en active Active
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2021
- 2021-05-26 JP JP2021088222A patent/JP2021129587A/ja active Pending
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2022
- 2022-08-12 AU AU2022215268A patent/AU2022215268A1/en active Pending
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2023
- 2023-10-23 US US18/382,850 patent/US20240218408A1/en active Pending
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2024
- 2024-01-29 JP JP2024010647A patent/JP2024038497A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2019246920A1 (en) | 2019-11-14 |
| BR112017023816A2 (pt) | 2018-07-31 |
| EP3294865A1 (en) | 2018-03-21 |
| EP4253525A2 (en) | 2023-10-04 |
| GB2555044A (en) | 2018-04-18 |
| IL255136A0 (en) | 2017-12-31 |
| CN107960102A (zh) | 2018-04-24 |
| WO2016183023A1 (en) | 2016-11-17 |
| US20180163241A1 (en) | 2018-06-14 |
| IL255136B2 (en) | 2023-09-01 |
| CA2983445A1 (en) | 2016-11-17 |
| US11859225B2 (en) | 2024-01-02 |
| US20240218408A1 (en) | 2024-07-04 |
| GB2555044B (en) | 2021-03-17 |
| HK1246354A1 (zh) | 2018-09-07 |
| EP4253525A3 (en) | 2023-10-18 |
| IL255136B1 (en) | 2023-05-01 |
| EP3294865A4 (en) | 2019-06-26 |
| EP3294865B1 (en) | 2023-04-12 |
| JP2018515093A (ja) | 2018-06-14 |
| JP2021129587A (ja) | 2021-09-09 |
| JP2024038497A (ja) | 2024-03-19 |
| AU2022215268A1 (en) | 2022-09-01 |
| KR20180016396A (ko) | 2018-02-14 |
| ES2945359T3 (es) | 2023-06-30 |
| AU2016261490A1 (en) | 2017-11-09 |
| JP7266966B2 (ja) | 2023-05-01 |
| GB201719939D0 (en) | 2018-01-17 |
| AU2016261490B2 (en) | 2019-10-31 |
| AU2019246920B2 (en) | 2022-05-12 |
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