DK3269809T3 - MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF - Google Patents
MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF Download PDFInfo
- Publication number
- DK3269809T3 DK3269809T3 DK16764874.0T DK16764874T DK3269809T3 DK 3269809 T3 DK3269809 T3 DK 3269809T3 DK 16764874 T DK16764874 T DK 16764874T DK 3269809 T3 DK3269809 T3 DK 3269809T3
- Authority
- DK
- Denmark
- Prior art keywords
- trna synthetase
- modified aminoacyl
- aminoacyl
- modified
- trna
- Prior art date
Links
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 title 1
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015051202 | 2015-03-13 | ||
| PCT/JP2016/057707 WO2016148044A1 (ja) | 2015-03-13 | 2016-03-11 | 改変アミノアシルｔＲＮＡ合成酵素およびその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3269809T3 true DK3269809T3 (da) | 2022-09-12 |
Family
ID=56918843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16764874.0T DK3269809T3 (da) | 2015-03-13 | 2016-03-11 | MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10815489B2 (da) |
| EP (2) | EP4166664A1 (da) |
| JP (3) | JP7020910B2 (da) |
| DK (1) | DK3269809T3 (da) |
| HU (1) | HUE059925T2 (da) |
| WO (1) | WO2016148044A1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI640541B (zh) | 2011-12-28 | 2018-11-11 | 中外製藥股份有限公司 | Peptide compound having an annular portion and pharmaceutical composition thereof |
| HUE059925T2 (hu) | 2015-03-13 | 2023-01-28 | Chugai Pharmaceutical Co Ltd | Módosított aminoacil-tRNS-szintetáz és alkalmazása |
| JP7187323B2 (ja) | 2017-01-31 | 2022-12-12 | 中外製薬株式会社 | 無細胞翻訳系におけるペプチドの合成方法 |
| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| CN110799520B (zh) | 2017-06-09 | 2024-07-12 | 中外制药株式会社 | 用于合成含有n-取代氨基酸的肽的方法 |
| US11492369B2 (en) | 2017-12-15 | 2022-11-08 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide, and method for processing bases |
| WO2019193416A1 (en) * | 2018-04-03 | 2019-10-10 | The University Of Queensland | Oligonucleotide-mediated sense codon reassignment |
| EP3804759A4 (en) * | 2018-06-06 | 2022-07-20 | Osaka University | METHODS OF TREATMENT OF DANDRUFF OR PREVENTION OF GNASE 1 SECONDARY DISEASES |
| CN112969683B (zh) | 2018-11-07 | 2024-05-14 | 中外制药株式会社 | O-取代的丝氨酸衍生物制备方法 |
| KR20210098476A (ko) | 2018-11-30 | 2021-08-10 | 추가이 세이야쿠 가부시키가이샤 | 펩티드 화합물 또는 아마이드 화합물의 탈보호법 및 고상 반응에 있어서의 탈수지 방법, 및 펩티드 화합물의 제조 방법 |
| CN113454058B (zh) | 2018-12-12 | 2024-03-22 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| WO2020189540A1 (ja) | 2019-03-15 | 2020-09-24 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
| US20220325269A1 (en) * | 2019-08-08 | 2022-10-13 | Brickbio, Inc. | Aminoacyl-trna synthetases and cell lines for site-specific incorporation of unnatural amino acids |
| KR102368948B1 (ko) | 2019-11-07 | 2022-03-02 | 추가이 세이야쿠 가부시키가이샤 | Kras 저해 작용을 갖는 환상 펩티드 화합물 |
| WO2021117848A1 (ja) | 2019-12-12 | 2021-06-17 | 中外製薬株式会社 | 非天然アミノ酸を含むペプチドの製造方法 |
| JPWO2022138892A1 (da) | 2020-12-25 | 2022-06-30 | ||
| AU2023264918A1 (en) | 2022-05-06 | 2025-01-09 | Chugai Seiyaku Kabushiki Kaisha | Cyclic compound having selective kras inhibitory effect on hras and nras |
| CA3268707A1 (en) * | 2022-09-28 | 2024-04-04 | Massachusetts Institute Of Technology | EVOLUTION OF FLUOROGENEOUS SENSORS |
| CN120380162A (zh) | 2022-12-12 | 2025-07-25 | 中外制药株式会社 | 包括用于翻译在特定位置处具有氧原子的氨基酸的步骤的肽生产方法 |
| WO2024214303A1 (ja) | 2023-04-14 | 2024-10-17 | 中外製薬株式会社 | 複数種類の標的分子との複合体を形成し得る目的分子のスクリーニング方法、及び当該スクリーニング方法を含む目的分子の製造方法 |
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| CN110799520B (zh) | 2017-06-09 | 2024-07-12 | 中外制药株式会社 | 用于合成含有n-取代氨基酸的肽的方法 |
| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| US11492369B2 (en) | 2017-12-15 | 2022-11-08 | Chugai Seiyaku Kabushiki Kaisha | Method for producing peptide, and method for processing bases |
| CN112969683B (zh) | 2018-11-07 | 2024-05-14 | 中外制药株式会社 | O-取代的丝氨酸衍生物制备方法 |
| KR20210098476A (ko) | 2018-11-30 | 2021-08-10 | 추가이 세이야쿠 가부시키가이샤 | 펩티드 화합물 또는 아마이드 화합물의 탈보호법 및 고상 반응에 있어서의 탈수지 방법, 및 펩티드 화합물의 제조 방법 |
| CN113454058B (zh) | 2018-12-12 | 2024-03-22 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| CN119080856A (zh) | 2018-12-26 | 2024-12-06 | 中外制药株式会社 | 用于密码子扩展的突变tRNA |
| WO2020189540A1 (ja) | 2019-03-15 | 2020-09-24 | 中外製薬株式会社 | 芳香族アミノ酸誘導体の製造方法 |
| KR102368948B1 (ko) | 2019-11-07 | 2022-03-02 | 추가이 세이야쿠 가부시키가이샤 | Kras 저해 작용을 갖는 환상 펩티드 화합물 |
| WO2021117848A1 (ja) | 2019-12-12 | 2021-06-17 | 中外製薬株式会社 | 非天然アミノ酸を含むペプチドの製造方法 |
| CN114641569A (zh) | 2019-12-26 | 2022-06-17 | 中外制药株式会社 | 翻译用组合物及肽的制备方法 |
| JPWO2021261577A1 (da) | 2020-06-25 | 2021-12-30 | ||
| EP4309741A4 (en) | 2021-05-07 | 2025-05-14 | Chugai Seiyaku Kabushiki Kaisha | CYCLIC COMPOUND WITH SELECTIVE INHIBITORY FOR KRAs BUT NOT FOR HRAS AND NRAS |
-
2016
- 2016-03-11 HU HUE16764874A patent/HUE059925T2/hu unknown
- 2016-03-11 US US15/557,532 patent/US10815489B2/en active Active
- 2016-03-11 WO PCT/JP2016/057707 patent/WO2016148044A1/ja not_active Ceased
- 2016-03-11 EP EP22186980.3A patent/EP4166664A1/en active Pending
- 2016-03-11 DK DK16764874.0T patent/DK3269809T3/da active
- 2016-03-11 EP EP16764874.0A patent/EP3269809B1/en active Active
- 2016-03-11 JP JP2017506512A patent/JP7020910B2/ja active Active
-
2020
- 2020-09-18 US US17/024,944 patent/US12163134B2/en active Active
-
2022
- 2022-01-05 JP JP2022000323A patent/JP7292442B2/ja active Active
-
2023
- 2023-06-06 JP JP2023093365A patent/JP7661399B2/ja active Active
-
2024
- 2024-10-25 US US18/926,665 patent/US20250051784A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12163134B2 (en) | 2024-12-10 |
| WO2016148044A1 (ja) | 2016-09-22 |
| EP3269809A4 (en) | 2018-12-05 |
| EP3269809B1 (en) | 2022-07-27 |
| JP7020910B2 (ja) | 2022-02-16 |
| US20250051784A1 (en) | 2025-02-13 |
| EP3269809A1 (en) | 2018-01-17 |
| JPWO2016148044A1 (ja) | 2017-12-28 |
| EP4166664A1 (en) | 2023-04-19 |
| JP7661399B2 (ja) | 2025-04-14 |
| JP2023116605A (ja) | 2023-08-22 |
| US20210087572A1 (en) | 2021-03-25 |
| US20180127761A1 (en) | 2018-05-10 |
| HUE059925T2 (hu) | 2023-01-28 |
| US10815489B2 (en) | 2020-10-27 |
| JP2022061999A (ja) | 2022-04-19 |
| JP7292442B2 (ja) | 2023-06-16 |
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