DK3269809T3 - MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF - Google Patents
MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF Download PDFInfo
- Publication number
- DK3269809T3 DK3269809T3 DK16764874.0T DK16764874T DK3269809T3 DK 3269809 T3 DK3269809 T3 DK 3269809T3 DK 16764874 T DK16764874 T DK 16764874T DK 3269809 T3 DK3269809 T3 DK 3269809T3
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- DK
- Denmark
- Prior art keywords
- trna synthetase
- modified aminoacyl
- aminoacyl
- modified
- trna
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015051202 | 2015-03-13 | ||
| PCT/JP2016/057707 WO2016148044A1 (ja) | 2015-03-13 | 2016-03-11 | 改変アミノアシルｔＲＮＡ合成酵素およびその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3269809T3 true DK3269809T3 (da) | 2022-09-12 |
Family
ID=56918843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16764874.0T DK3269809T3 (da) | 2015-03-13 | 2016-03-11 | MODIFICERET AMINOACYL-tRNA-SYNTETASE OG ANVENDELSE DERAF |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US10815489B2 (da) |
| EP (2) | EP4166664A1 (da) |
| JP (3) | JP7020910B2 (da) |
| DK (1) | DK3269809T3 (da) |
| HU (1) | HUE059925T2 (da) |
| WO (1) | WO2016148044A1 (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013100132A1 (ja) | 2011-12-28 | 2013-07-04 | 中外製薬株式会社 | ペプチド化合物の環化方法 |
| JP7020910B2 (ja) | 2015-03-13 | 2022-02-16 | 中外製薬株式会社 | 改変アミノアシルｔＲＮＡ合成酵素およびその用途 |
| JP7232758B2 (ja) | 2017-06-09 | 2023-03-06 | 中外製薬株式会社 | 膜透過性の高い環状ペプチド化合物、及びこれを含むライブラリ |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| EP3725796A4 (en) | 2017-12-15 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR MANUFACTURING PEPTIDE AND METHOD FOR PROCESSING BASES |
| EP3775216A4 (en) * | 2018-04-03 | 2022-04-13 | The University of Queensland | Oligonucleotide-mediated sense codon reassignment |
| WO2019235581A1 (ja) * | 2018-06-06 | 2019-12-12 | 国立大学法人大阪大学 | Ｒｅｇｎａｓｅ－１が関与する疾患の治療および／または予防方法 |
| EP3889164A4 (en) | 2018-11-30 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR DEPROTECTION AND METHOD FOR RESIN REMOVAL IN A SOLID PHASE REACTION OF A PEPTIDE COMPOUND OR AN AMIDE COMPOUND, AND METHOD FOR PRODUCTION OF A PEPTIDE COMPOUND |
| CN118184532A (zh) | 2018-12-12 | 2024-06-14 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| KR20210139366A (ko) | 2019-03-15 | 2021-11-22 | 추가이 세이야쿠 가부시키가이샤 | 방향족 아미노산 유도체의 제조 방법 |
| EP4051786A4 (en) * | 2019-08-08 | 2024-04-03 | Brickbio, Inc. | AMINOACYL-TRNA SYNTHETASES AND CELL LINES FOR THE SITE-SPECIFIC INCORPORATION OF UNNATURAL AMINO ACIDS |
| EP4074829A4 (en) | 2019-12-12 | 2024-01-10 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING PEPTIDE CONTAINING NON-NATURAL AMINO ACID |
| WO2022138892A1 (ja) | 2020-12-25 | 2022-06-30 | 中外製薬株式会社 | 複数の標的分子と共に複合体を形成し得る候補分子のスクリーニング方法 |
| WO2024073568A2 (en) * | 2022-09-28 | 2024-04-04 | President And Fellows Of Harvard College | Evolution of fluorogenic sensors |
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| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| EP3725796A4 (en) | 2017-12-15 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR MANUFACTURING PEPTIDE AND METHOD FOR PROCESSING BASES |
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| EP3889164A4 (en) | 2018-11-30 | 2022-11-02 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR DEPROTECTION AND METHOD FOR RESIN REMOVAL IN A SOLID PHASE REACTION OF A PEPTIDE COMPOUND OR AN AMIDE COMPOUND, AND METHOD FOR PRODUCTION OF A PEPTIDE COMPOUND |
| CN118184532A (zh) | 2018-12-12 | 2024-06-14 | 中外制药株式会社 | 具有能形成分子内氢键的官能团的氨基酸、包含该氨基酸的肽化合物、及其制备方法 |
| EP3904568A4 (en) | 2018-12-26 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | ARNT MUTATED FOR CODON EXPANSION |
| KR20210139366A (ko) | 2019-03-15 | 2021-11-22 | 추가이 세이야쿠 가부시키가이샤 | 방향족 아미노산 유도체의 제조 방법 |
| AR120394A1 (es) | 2019-11-07 | 2022-02-09 | Chugai Pharmaceutical Co Ltd | Compuesto de péptido cíclico que tiene acción inhibitoria de kras |
| EP4074829A4 (en) | 2019-12-12 | 2024-01-10 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING PEPTIDE CONTAINING NON-NATURAL AMINO ACID |
| WO2021132546A1 (ja) | 2019-12-26 | 2021-07-01 | 中外製薬株式会社 | 翻訳用組成物及びペプチドの製造方法 |
| EP4166675A1 (en) | 2020-06-25 | 2023-04-19 | Chugai Seiyaku Kabushiki Kaisha | Translation system provided with modified genetic code table |
| US20240158446A1 (en) | 2021-05-07 | 2024-05-16 | Chugai Seiyaku Kabushiki Kaisha | Cyclic compound having selective inhibitory action on kras over hras and nras |
-
2016
- 2016-03-11 JP JP2017506512A patent/JP7020910B2/ja active Active
- 2016-03-11 HU HUE16764874A patent/HUE059925T2/hu unknown
- 2016-03-11 EP EP22186980.3A patent/EP4166664A1/en active Pending
- 2016-03-11 EP EP16764874.0A patent/EP3269809B1/en active Active
- 2016-03-11 US US15/557,532 patent/US10815489B2/en active Active
- 2016-03-11 WO PCT/JP2016/057707 patent/WO2016148044A1/ja active Application Filing
- 2016-03-11 DK DK16764874.0T patent/DK3269809T3/da active
-
2020
- 2020-09-18 US US17/024,944 patent/US12163134B2/en active Active
-
2022
- 2022-01-05 JP JP2022000323A patent/JP7292442B2/ja active Active
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2023
- 2023-06-06 JP JP2023093365A patent/JP2023116605A/ja active Pending
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2024
- 2024-10-25 US US18/926,665 patent/US20250051784A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12163134B2 (en) | 2024-12-10 |
| JP2022061999A (ja) | 2022-04-19 |
| WO2016148044A1 (ja) | 2016-09-22 |
| US10815489B2 (en) | 2020-10-27 |
| EP4166664A1 (en) | 2023-04-19 |
| US20210087572A1 (en) | 2021-03-25 |
| JPWO2016148044A1 (ja) | 2017-12-28 |
| US20180127761A1 (en) | 2018-05-10 |
| JP7292442B2 (ja) | 2023-06-16 |
| JP2023116605A (ja) | 2023-08-22 |
| HUE059925T2 (hu) | 2023-01-28 |
| EP3269809A4 (en) | 2018-12-05 |
| EP3269809B1 (en) | 2022-07-27 |
| US20250051784A1 (en) | 2025-02-13 |
| EP3269809A1 (en) | 2018-01-17 |
| JP7020910B2 (ja) | 2022-02-16 |
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