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DK32684A - Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor - Google Patents

Fremgangsmaade til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herfor Download PDF

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Publication number
DK32684A
DK32684A DK32684A DK32684A DK32684A DK 32684 A DK32684 A DK 32684A DK 32684 A DK32684 A DK 32684A DK 32684 A DK32684 A DK 32684A DK 32684 A DK32684 A DK 32684A
Authority
DK
Denmark
Prior art keywords
1alfa
dihydroxycholesterol
hexafluor
intermediates
preparing
Prior art date
Application number
DK32684A
Other languages
English (en)
Other versions
DK32684D0 (da
DK168539B1 (da
Inventor
Hector F Deluca
Yoko Tanaka
Nobuo Ikekawa
Yoshiro Kobayashi
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Publication of DK32684D0 publication Critical patent/DK32684D0/da
Publication of DK32684A publication Critical patent/DK32684A/da
Application granted granted Critical
Publication of DK168539B1 publication Critical patent/DK168539B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK032684A 1982-05-26 1984-01-25 Speciel fremgangsmåde til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herved DK168539B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/382,055 US4411833A (en) 1982-05-26 1982-05-26 Method for preparing 26,26,26,27,27,27-hexafluoro-1α,25-dihydroxycholesterol
US38205582 1982-05-26
US8300577 1983-04-18
PCT/US1983/000577 WO1983004256A1 (en) 1982-05-26 1983-04-18 METHOD FOR PREPARING 26,26,26,27,27,27-HEXAFLUORO-1alpha,25-DIHYDROXYCHOLESTEROL

Publications (3)

Publication Number Publication Date
DK32684D0 DK32684D0 (da) 1984-01-25
DK32684A true DK32684A (da) 1984-01-25
DK168539B1 DK168539B1 (da) 1994-04-18

Family

ID=23507359

Family Applications (1)

Application Number Title Priority Date Filing Date
DK032684A DK168539B1 (da) 1982-05-26 1984-01-25 Speciel fremgangsmåde til fremstilling af 26,26,26,27,27,27-hexafluor-1alfa,25-dihydroxycholesterol og mellemprodukter til brug herved

Country Status (14)

Country Link
US (1) US4411833A (da)
JP (2) JPH0742305B2 (da)
AU (1) AU561182B2 (da)
BE (1) BE896830A (da)
CH (2) CH663212A5 (da)
DE (1) DE3390016C2 (da)
DK (1) DK168539B1 (da)
FR (2) FR2527615B1 (da)
GB (2) GB2121044B (da)
IE (1) IE55022B1 (da)
IL (1) IL68537A (da)
IT (1) IT1203706B (da)
NL (1) NL8320153A (da)
WO (1) WO1983004256A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613594A (en) * 1984-11-16 1986-09-23 Hoffmann-La Roche Inc. Fluorinated vitamin D3 compounds
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3
JPH0764804B2 (ja) * 1986-04-25 1995-07-12 住友製薬株式会社 活性型ビタミンｄ３のフッ素誘導体
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
WO1990009179A1 (en) * 1989-02-16 1990-08-23 University Of Georgia Research Foundation, Inc. Treatment of tibial dyschondroplasia
JPH08507073A (ja) * 1993-02-19 1996-07-30 ウイスコンシン アラムナイ リサーチ フオンデーシヨン カルシウム代謝障害の治療のための２６，２６，２６，２７，２７，２７−ヘキサフルオロ−１アルファ，２５−ジヒドロキシコレカルシフェロールの使用
US8575136B2 (en) * 2006-04-06 2013-11-05 Wisconsin Alumni Research Foundation 2-methylene-1α-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof
AU2007298673A1 (en) 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
CA2639585A1 (en) * 2006-04-06 2007-10-06 Wisconsin Alumni Research Foundation 2-methylene-1.alpha., 25-dihydroxy-18, 19, 21-trinorvitamin d3 and uses thereof
WO2008035207A2 (en) * 2006-04-06 2008-03-27 Wisconsin Alumni Research Foundation 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof
AU2007291005A1 (en) * 2006-04-06 2008-03-06 Wisconsin Alumni Research Foundation 19-nor-vitamin D analogs with 1,2,or 3,2 heterocyclic ring
AU2007234717B2 (en) * 2006-04-06 2012-04-19 Wisconsin Alumni Research Foundation 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof
MX2008012674A (es) * 2006-04-10 2008-10-15 Wisconsin Alumni Res Found Compuestos de 1 a-hidroxi-2-(3'-hidroxipropiliden)-19-nor-vitamina d con una cadena lateral 1,1-dimetilpropilo.
KR20170096238A (ko) 2009-01-27 2017-08-23 베르그 엘엘씨 화학요법과 연관된 부작용을 경감시키기 위한 비타민 ｄ３ 및 이의 유사물
CN106265695B (zh) 2009-08-14 2021-05-07 博格有限责任公司 用于治疗脱发的维生素d3及其类似物
NZ714801A (en) 2013-05-29 2021-07-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
CN113968888B (zh) * 2020-07-24 2023-06-27 上海医药工业研究院 一种胆甾衍生物的制备方法、其中间体及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183852A (en) * 1977-07-18 1980-01-15 Kaiser Emil T Process for preparing 25-hydroxycholesterol
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
US4217279A (en) * 1978-12-18 1980-08-12 Kaiser Emil T Synthesis of steroids
JPS5598199A (en) * 1979-01-17 1980-07-25 Eisai Co Ltd Preparation of 25-hydroxy cholesta-1,4,6-trien-3-one
US4269777A (en) * 1979-05-21 1981-05-26 Wisconsin Alumni Research Foundation Isotopically labeled vitamin D derivatives and processes for preparing same
IL60270A0 (en) * 1979-06-14 1980-09-16 Diamond Shamrock Corp Preparation of 25-ydroxycholesterol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same

Also Published As

Publication number Publication date
IE831226L (en) 1983-11-26
GB2140016B (en) 1986-01-02
JPH0742306B2 (ja) 1995-05-10
FR2533929A1 (fr) 1984-04-06
GB8415630D0 (en) 1984-07-25
GB2121044B (en) 1986-01-02
IT1203706B (it) 1989-02-15
GB2140016A (en) 1984-11-21
GB8314612D0 (en) 1983-06-29
FR2527615B1 (fr) 1986-05-23
DK32684D0 (da) 1984-01-25
DE3390016C2 (de) 1989-08-10
CH662572A5 (de) 1987-10-15
CH663212A5 (de) 1987-11-30
IT8321261A0 (it) 1983-05-24
DK168539B1 (da) 1994-04-18
FR2527615A1 (fr) 1983-12-02
WO1983004256A1 (en) 1983-12-08
DE3390016T1 (de) 1984-05-17
JPH0578387A (ja) 1993-03-30
BE896830A (fr) 1983-09-16
NL8320153A (nl) 1984-04-02
FR2533929B1 (fr) 1986-10-31
JPH0578388A (ja) 1993-03-30
IL68537A0 (en) 1983-07-31
AU561182B2 (en) 1987-04-30
IL68537A (en) 1986-07-31
JPH0742305B2 (ja) 1995-05-10
US4411833A (en) 1983-10-25
IE55022B1 (en) 1990-04-25
AU1554283A (en) 1983-12-16
GB2121044A (en) 1983-12-14

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)