DK3234152T3 - Svampegenommodificeringssystemer og anvendelsesfremgangsmåder - Google Patents
Svampegenommodificeringssystemer og anvendelsesfremgangsmåder Download PDFInfo
- Publication number
- DK3234152T3 DK3234152T3 DK15823268.6T DK15823268T DK3234152T3 DK 3234152 T3 DK3234152 T3 DK 3234152T3 DK 15823268 T DK15823268 T DK 15823268T DK 3234152 T3 DK3234152 T3 DK 3234152T3
- Authority
- DK
- Denmark
- Prior art keywords
- genomic modification
- application procedures
- modification systems
- fungi
- fungi genomic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014093916 | 2014-12-16 | ||
| CN2014093918 | 2014-12-16 | ||
| CN2014093914 | 2014-12-16 | ||
| PCT/US2015/066195 WO2016100571A1 (en) | 2014-12-16 | 2015-12-16 | Fungal genome modification systems and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3234152T3 true DK3234152T3 (da) | 2021-12-20 |
Family
ID=55083496
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15823254.6T DK3234150T3 (da) | 2014-12-16 | 2015-12-15 | Systemer til svampegenommodificering og fremgangsmåder til anvendelse deraf |
| DK15823267.8T DK3234151T3 (da) | 2014-12-16 | 2015-12-16 | Systemer til svampegenommodificering og fremgangsmåder til anvendelse deraf |
| DK15823268.6T DK3234152T3 (da) | 2014-12-16 | 2015-12-16 | Svampegenommodificeringssystemer og anvendelsesfremgangsmåder |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15823254.6T DK3234150T3 (da) | 2014-12-16 | 2015-12-15 | Systemer til svampegenommodificering og fremgangsmåder til anvendelse deraf |
| DK15823267.8T DK3234151T3 (da) | 2014-12-16 | 2015-12-16 | Systemer til svampegenommodificering og fremgangsmåder til anvendelse deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11427829B2 (da) |
| EP (3) | EP3234150B1 (da) |
| JP (3) | JP6814142B2 (da) |
| KR (3) | KR102350405B1 (da) |
| CN (3) | CN107667171A (da) |
| AU (3) | AU2015362784B2 (da) |
| BR (3) | BR112017012837A2 (da) |
| CA (3) | CA2971187C (da) |
| DK (3) | DK3234150T3 (da) |
| FI (2) | FI3234150T3 (da) |
| MX (3) | MX2017007928A (da) |
| WO (3) | WO2016100272A1 (da) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150166985A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting von willebrand factor point mutations |
| EP3177718B1 (en) | 2014-07-30 | 2022-03-16 | President and Fellows of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016167300A1 (ja) * | 2015-04-13 | 2016-10-20 | 国立大学法人東京大学 | 光依存的に又は薬物存在下でヌクレアーゼ活性若しくはニッカーゼ活性を示す、又は標的遺伝子の発現を抑制若しくは活性化するポリペプチドのセット |
| WO2017019867A1 (en) * | 2015-07-28 | 2017-02-02 | Danisco Us Inc | Genome editing systems and methods of use |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| EP3412765B1 (en) * | 2016-02-04 | 2023-01-18 | Kao Corporation | Method for producing mutant filamentous fungi |
| EP3419992B1 (en) | 2016-02-22 | 2020-11-18 | Danisco US Inc. | Fungal high-level protein production system |
| WO2017191210A1 (en) * | 2016-05-04 | 2017-11-09 | Novozymes A/S | Genome editing by crispr-cas9 in filamentous fungal host cells |
| WO2018015444A1 (en) * | 2016-07-22 | 2018-01-25 | Novozymes A/S | Crispr-cas9 genome editing with multiple guide rnas in filamentous fungi |
| EP3494215A1 (en) | 2016-08-03 | 2019-06-12 | President and Fellows of Harvard College | Adenosine nucleobase editors and uses thereof |
| CN109804066A (zh) | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| US11352647B2 (en) | 2016-08-17 | 2022-06-07 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| WO2018064208A1 (en) | 2016-09-28 | 2018-04-05 | The Broad Institute, Inc. | Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof |
| JP7285780B2 (ja) | 2016-10-04 | 2023-06-02 | ダニスコ・ユーエス・インク | 誘導基質の非存在下における糸状菌細胞内でのタンパク質の産生 |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP6839424B2 (ja) * | 2016-12-27 | 2021-03-10 | 国立大学法人 鹿児島大学 | 真菌におけるタンパク質の選択的分泌技術 |
| CN110662556A (zh) | 2017-03-09 | 2020-01-07 | 哈佛大学的校长及成员们 | 癌症疫苗 |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| WO2018166943A1 (en) | 2017-03-13 | 2018-09-20 | Dsm Ip Assets B.V. | Zinc binuclear cluster transcriptional regulator-deficient strain |
| IL269458B2 (en) | 2017-03-23 | 2024-02-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| WO2018197020A1 (en) * | 2017-04-27 | 2018-11-01 | Novozymes A/S | Genome editing by crispr-cas9 using short donor oligonucleotides |
| US11591601B2 (en) | 2017-05-05 | 2023-02-28 | The Broad Institute, Inc. | Methods for identification and modification of lncRNA associated with target genotypes and phenotypes |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| CA3061984A1 (en) * | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A htp genomic engineering platform for improving fungal strains |
| CA3065813A1 (en) | 2017-06-09 | 2018-12-13 | Editas Medicine, Inc. | Engineered cas9 nucleases |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
| WO2019046703A1 (en) * | 2017-09-01 | 2019-03-07 | Novozymes A/S | METHODS OF ENHANCING GENOME EDITION IN FUNGI |
| WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | USES OF BASIC EDITORS ADENOSINE |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN108085317B (zh) * | 2018-01-17 | 2019-06-21 | 四川大学 | 一种特异性靶向变异链球菌gtfB位点的CRISPR-B基因编辑方法及应用 |
| WO2019209576A1 (en) | 2018-04-24 | 2019-10-31 | Danisco Us Inc | Filamentous fungal strains comprising reduced viscosity phenotypes |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| CN112166180A (zh) | 2018-06-06 | 2021-01-01 | 齐默尔根公司 | 操纵涉及信号转导的基因以控制发酵和生产期间的真菌形态 |
| EP3578658A1 (en) * | 2018-06-08 | 2019-12-11 | Johann Wolfgang Goethe-Universität Frankfurt | Method for generating a gene editing vector with fixed guide rna pairs |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020028126A1 (en) | 2018-07-30 | 2020-02-06 | Danisco Us Inc | Mutant and genetically modified filamentous fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| CN113166754A (zh) | 2018-10-16 | 2021-07-23 | 蓝色等位基因有限责任公司 | 用于将dna靶向插入基因中的方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| EP3874051A1 (en) * | 2018-10-31 | 2021-09-08 | Novozymes A/S | Genome editing by guided endonuclease and single-stranded oligonucleotide |
| KR20210104068A (ko) | 2018-12-14 | 2021-08-24 | 파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 | 게놈 편집을 위한 신규한 crispr-cas 시스템 |
| US12264323B2 (en) | 2018-12-17 | 2025-04-01 | The Broad Institute, Inc. | CRISPR CPF1 direct repeat variants |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| US12215382B2 (en) | 2019-03-01 | 2025-02-04 | The General Hospital Corporation | Liver protective MARC variants and uses thereof |
| US12534714B2 (en) | 2019-03-18 | 2026-01-27 | The Broad Institute, Inc. | Type VII CRISPR proteins and systems |
| AU2020242032A1 (en) | 2019-03-19 | 2021-10-07 | Massachusetts Institute Of Technology | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US20220235340A1 (en) | 2019-05-20 | 2022-07-28 | The Broad Institute, Inc. | Novel crispr-cas systems and uses thereof |
| US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CA3155372A1 (en) | 2019-10-28 | 2021-05-06 | Sharief Barends | Microbial host cells for the production of heterologous cyanuric acid hydrolases and biuret hydrolases |
| EP4055177B1 (en) | 2019-11-08 | 2024-07-31 | Danisco US Inc. | Fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| EP4139332A1 (en) | 2020-04-22 | 2023-03-01 | Danisco US Inc. | Compositions and methods for enhanced protein production in filamentous fungal cells |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート,インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| WO2021242774A1 (en) * | 2020-05-26 | 2021-12-02 | Zymergen Inc. | Methods of transient protein and gene expression in cells |
| US11479779B2 (en) | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
| WO2023003683A2 (en) | 2021-07-19 | 2023-01-26 | Danisco Us Inc. | Compositions and methods for enhanced protein production in fungal cells |
| US20240352499A1 (en) | 2021-08-20 | 2024-10-24 | Danisco Us Inc. | Polynucleotides encoding novel nucleases, compositions thereof and methods thereof for eliminating dna from protein preparations |
| WO2023039358A1 (en) | 2021-09-09 | 2023-03-16 | Dupont Nutrition Biosciences Aps | Over expression of foldases and chaperones improves protein production |
| US20250320512A1 (en) | 2021-12-01 | 2025-10-16 | Danisco Us Inc. | Compositions and methods for enhanced protein production in fungal cells |
| CN114410635B (zh) * | 2022-03-29 | 2022-06-14 | 中国科学院天津工业生物技术研究所 | 威尼斯镰刀菌内源U6启动子及其基于CRISPR/Cas9的基因编辑方法 |
| PE20251180A1 (es) | 2022-07-15 | 2025-04-23 | Int Nandh Denmark Aps | Modificacion enzimatica mejorada de fosfolipidos en alimentos |
| EP4615861A1 (en) | 2022-11-11 | 2025-09-17 | Danisco US Inc. | Filamentous fungal strains comprising enhanced protein productivity phenotypes and methods thereof |
| WO2024122646A1 (ja) * | 2022-12-08 | 2024-06-13 | 学校法人東京理科大学 | ゲノム編集された細胞の作製方法及び交雑促進方法 |
| WO2024137350A2 (en) | 2022-12-19 | 2024-06-27 | Danisco Us Inc. | Recombinant fungal strains and methods thereof for producing consistent proteins |
| CN120769861A (zh) | 2023-02-08 | 2025-10-10 | 丹尼斯科美国公司 | 用于在丝状真菌细胞中生产异源球蛋白的组合物和方法 |
| EP4689096A1 (en) | 2023-03-27 | 2026-02-11 | Danisco US Inc. | Reduced fermentation glycerol and acetate using yeast expressing rubisco from gallionella capsiferriformans |
| KR20250000949A (ko) * | 2023-06-26 | 2025-01-06 | 전북대학교산학협력단 | 시그마-54 및 MmoR을 통한 선택적 메탄 모노옥시게나제의 고효율 생산 방법 |
| WO2025007098A1 (en) | 2023-06-30 | 2025-01-02 | Danisco Us Inc. | Recombinant fungal cells and methods thereof for industrial scale production of lectins |
| CN116769781B (zh) * | 2023-08-16 | 2023-10-24 | 中国科学院天津工业生物技术研究所 | 一种来源于粗壮脉纹孢菌的启动子及其应用 |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025207802A1 (en) | 2024-03-27 | 2025-10-02 | Nutrition & Biosciences USA 4, Inc. | Recombinant microbial strains comprising reduced beta-oxidation phenotypes and methods thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5107065A (en) | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| US5290474A (en) | 1990-10-05 | 1994-03-01 | Genencor International, Inc. | Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp |
| US6436643B1 (en) * | 1997-12-22 | 2002-08-20 | Unilever Patent Holdings Bv | Process for site-directed integration of multiple copies of a gene in a mould |
| CA2525333C (en) | 2003-05-29 | 2016-03-01 | Genencor International, Inc. | Trichoderma genes |
| ATE550424T1 (de) | 2003-11-21 | 2012-04-15 | Danisco Us Inc | Expression granuläre stärke hydrolysierender enzyme in trichoderma und verfahren zur herstellung von glucose aus granulären stärkesubstraten |
| EP1751281A2 (en) | 2004-05-27 | 2007-02-14 | Genencor International, Inc. | Aspergillus kawachi acid-stable alpha amylase and applications in granular starch hydrolysis |
| CA2801799C (en) | 2010-06-03 | 2018-11-20 | Danisco Us Inc. | Filamentous fungal host strains and dna constructs, and methods of use thereof |
| WO2013141680A1 (en) | 2012-03-20 | 2013-09-26 | Vilnius University | RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX |
| CN110066775B (zh) * | 2012-10-23 | 2024-03-19 | 基因工具股份有限公司 | 用于切割靶dna的组合物及其用途 |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP3825401A1 (en) * | 2012-12-12 | 2021-05-26 | The Broad Institute, Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
| CA2913865C (en) * | 2013-05-29 | 2022-07-19 | Cellectis | A method for producing precise dna cleavage using cas9 nickase activity |
| JP6670743B2 (ja) * | 2013-05-29 | 2020-03-25 | セレクティスCellectis | Ii型crisprシステムにおける新規のコンパクトなcas9足場 |
| WO2015054507A1 (en) * | 2013-10-10 | 2015-04-16 | Pronutria, Inc. | Nutritive polypeptide production systems, and methods of manufacture and use thereof |
| AU2014362245A1 (en) * | 2013-12-12 | 2016-06-16 | Massachusetts Institute Of Technology | Compositions and methods of use of CRISPR-Cas systems in nucleotide repeat disorders |
| WO2015138855A1 (en) * | 2014-03-14 | 2015-09-17 | The Regents Of The University Of California | Vectors and methods for fungal genome engineering by crispr-cas9 |
| EP3172333B1 (en) * | 2014-07-21 | 2020-05-13 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| US10513711B2 (en) * | 2014-08-13 | 2019-12-24 | Dupont Us Holding, Llc | Genetic targeting in non-conventional yeast using an RNA-guided endonuclease |
| EP3242950B1 (en) * | 2015-01-06 | 2021-10-06 | DSM IP Assets B.V. | A crispr-cas system for a filamentous fungal host cell |
-
2015
- 2015-12-15 FI FIEP15823254.6T patent/FI3234150T3/fi active
- 2015-12-15 AU AU2015362784A patent/AU2015362784B2/en not_active Ceased
- 2015-12-15 US US15/536,836 patent/US11427829B2/en active Active
- 2015-12-15 DK DK15823254.6T patent/DK3234150T3/da active
- 2015-12-15 CN CN201580076187.6A patent/CN107667171A/zh active Pending
- 2015-12-15 WO PCT/US2015/065693 patent/WO2016100272A1/en not_active Ceased
- 2015-12-15 KR KR1020177019683A patent/KR102350405B1/ko not_active Expired - Fee Related
- 2015-12-15 BR BR112017012837A patent/BR112017012837A2/pt not_active Application Discontinuation
- 2015-12-15 MX MX2017007928A patent/MX2017007928A/es unknown
- 2015-12-15 CA CA2971187A patent/CA2971187C/en active Active
- 2015-12-15 JP JP2017532765A patent/JP6814142B2/ja not_active Expired - Fee Related
- 2015-12-15 EP EP15823254.6A patent/EP3234150B1/en active Active
- 2015-12-16 CA CA2971248A patent/CA2971248C/en active Active
- 2015-12-16 JP JP2017532637A patent/JP6814141B2/ja not_active Expired - Fee Related
- 2015-12-16 WO PCT/US2015/066192 patent/WO2016100568A1/en not_active Ceased
- 2015-12-16 DK DK15823267.8T patent/DK3234151T3/da active
- 2015-12-16 CA CA2971247A patent/CA2971247A1/en active Pending
- 2015-12-16 DK DK15823268.6T patent/DK3234152T3/da active
- 2015-12-16 EP EP15823267.8A patent/EP3234151B1/en active Active
- 2015-12-16 US US15/536,872 patent/US11098314B2/en active Active
- 2015-12-16 FI FIEP15823267.8T patent/FI3234151T3/fi active
- 2015-12-16 JP JP2017532781A patent/JP6814143B2/ja not_active Expired - Fee Related
- 2015-12-16 WO PCT/US2015/066195 patent/WO2016100571A1/en not_active Ceased
- 2015-12-16 MX MX2017007930A patent/MX2017007930A/es unknown
- 2015-12-16 MX MX2017008036A patent/MX2017008036A/es unknown
- 2015-12-16 AU AU2015364632A patent/AU2015364632B2/en not_active Ceased
- 2015-12-16 US US15/536,933 patent/US11401522B2/en active Active
- 2015-12-16 BR BR112017012851A patent/BR112017012851A2/pt not_active Application Discontinuation
- 2015-12-16 KR KR1020177019686A patent/KR102350404B1/ko not_active Expired - Fee Related
- 2015-12-16 BR BR112017012850A patent/BR112017012850A2/pt not_active Application Discontinuation
- 2015-12-16 CN CN201580076199.9A patent/CN107257859A/zh active Pending
- 2015-12-16 EP EP15823268.6A patent/EP3234152B1/en active Active
- 2015-12-16 CN CN201580076181.9A patent/CN107278231A/zh active Pending
- 2015-12-16 AU AU2015364629A patent/AU2015364629B2/en not_active Ceased
- 2015-12-16 KR KR1020177019705A patent/KR102350402B1/ko not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3234152T3 (da) | Svampegenommodificeringssystemer og anvendelsesfremgangsmåder | |
| IL259766A (en) | Relocalization systems and methods | |
| IL258437B (en) | Growing systems and methods | |
| IL256369B (en) | Novel crispr enzymes and systems | |
| DK3374291T3 (da) | Plukningssystemer og -fremgangsmåder | |
| DK3194908T3 (da) | Overvågningssystemer og fremgangsmåder | |
| EP4135127C0 (en) | MICRO-ASSEMBLY STRATEGIES AND DEVICES FOR COMPOUNDS | |
| GB201720065D0 (en) | Systems and methods | |
| DK3218358T3 (da) | Ifluorometyl-aminopyridiner og difluorometyl-aminopyrimidiner | |
| DK3215147T3 (da) | Neurodæmpende norketamin-forbindelser og fremgangsmåder | |
| EP3205103C0 (en) | INTER AND INTRA UNIFICATION BLOCK COPY | |
| DK3103715T3 (da) | Styreindretning og styringsfremgangsmåde dertil | |
| GB201506119D0 (en) | Systems and methods | |
| DK3234160T3 (da) | Sammensætninger og fremgangsmåder til hjælper-stamme-medieret svampegenommodifikation | |
| DK3304394T3 (da) | Fremgangsmåder og systemer til godkendelse | |
| DK3256598T3 (da) | Svampestammer og anvendelsesfremgangsmåder | |
| DK3161139T3 (da) | Tlr-4-specifikke aptamerer og anvendelser heraf | |
| DK3209773T3 (da) | Prolintolerante tripeptidylpeptidaser og anvendelser deraf | |
| IL252224B (en) | Systems and methods for performing electrocardiograms | |
| DK3265641T3 (da) | Stigørenhed og fremgangsmåde | |
| EP3332266C0 (en) | MONITORING SYSTEMS AND METHODS | |
| DK3359773T3 (da) | Datasystemer, anordninger og fremgangsmåder | |
| DK3100886T3 (da) | Køretøj og kraftoverføringssystem deraf | |
| DK3321279T3 (da) | Exenatidmodificeringsmiddel og anvendelse deraf | |
| DK3365321T3 (da) | Solabegron-zwitterion og anvendelser deraf |