[go: up one dir, main page]

DK3152299T3 - Podekædeprocesser og anvendelser deraf - Google Patents

Podekædeprocesser og anvendelser deraf Download PDF

Info

Publication number
DK3152299T3
DK3152299T3 DK15730933.7T DK15730933T DK3152299T3 DK 3152299 T3 DK3152299 T3 DK 3152299T3 DK 15730933 T DK15730933 T DK 15730933T DK 3152299 T3 DK3152299 T3 DK 3152299T3
Authority
DK
Denmark
Prior art keywords
pood
applications
chain processes
chain
processes
Prior art date
Application number
DK15730933.7T
Other languages
English (en)
Inventor
Michael Bruninghaus
Konstantin Konstantinov
Benjamin Wright
Weichang Zhou
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53477008&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3152299(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of DK3152299T3 publication Critical patent/DK3152299T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
DK15730933.7T 2014-06-09 2015-06-08 Podekædeprocesser og anvendelser deraf DK3152299T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462009553P 2014-06-09 2014-06-09
PCT/US2015/034709 WO2015191462A1 (en) 2014-06-09 2015-06-08 Seed train processes and uses thereof

Publications (1)

Publication Number Publication Date
DK3152299T3 true DK3152299T3 (da) 2020-02-24

Family

ID=53477008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15730933.7T DK3152299T3 (da) 2014-06-09 2015-06-08 Podekædeprocesser og anvendelser deraf

Country Status (18)

Country Link
US (2) US10570367B2 (da)
EP (3) EP3628730A1 (da)
JP (3) JP6784600B2 (da)
KR (2) KR102584375B1 (da)
CN (2) CN111575225B (da)
AU (3) AU2015274897B2 (da)
BR (1) BR112016028891B1 (da)
CA (1) CA2951551C (da)
CY (1) CY1122803T1 (da)
DK (1) DK3152299T3 (da)
ES (1) ES2773630T3 (da)
HU (1) HUE047683T2 (da)
IL (3) IL290096B2 (da)
MX (2) MX373323B (da)
RU (1) RU2694327C2 (da)
SG (1) SG11201610216UA (da)
TW (3) TW202246486A (da)
WO (1) WO2015191462A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014130872A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
WO2014130864A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TW202246486A (zh) 2014-06-09 2022-12-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
IL253071B2 (en) 2014-12-22 2024-04-01 Genzyme Corp Methods for growing mammalian cells
WO2017072201A2 (en) * 2015-10-26 2017-05-04 Lonza Limited A manufacturing facility for the production of biopharmaceuticals
CN110072961B (zh) * 2016-12-22 2022-02-08 东亚合成株式会社 粘合剂组合物以及使用其的覆盖膜、粘合片、覆铜层压板和电磁波屏蔽材料
WO2019055796A1 (en) * 2017-09-15 2019-03-21 Bristol-Myers Squibb Company ONLINE BIOMASS CAPACITY MONITORING DURING LARGE SCALE PRODUCTION OF POLYPEPTIDES OF INTEREST
TWI846694B (zh) * 2018-05-04 2024-07-01 美商健臻公司 具有過濾系統的灌注式生物反應器
US12071607B2 (en) * 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
EP3650528A1 (en) * 2018-11-08 2020-05-13 Aglaris Ltd Cell culture system and method
WO2020152509A1 (en) * 2019-01-25 2020-07-30 Enzene Biosciences Limited Automated integrated continuous system and bioprocess for producing therapeutic protein
CN113439118A (zh) * 2019-02-15 2021-09-24 济世易为生物有限公司 自动化生物制造系统、设备和方法
AU2020283752A1 (en) * 2019-05-24 2021-12-23 Rubius Therapeutics, Inc. Methods of generating enucleated erythroid cells
GB2629063B (en) 2019-06-17 2025-02-12 Deka Products Lp System and method for cell and tissue preparation
GB201908612D0 (en) * 2019-06-17 2019-07-31 Ge Healthcare Bio Sciences Ab A method for separating biomolecules
US20220259554A1 (en) * 2019-07-16 2022-08-18 Innovent Biologics (Suzhou) Co., Ltd. Cell culture method and application thereof based on high-density and continuous inoculation
EP3831924A1 (en) * 2019-12-03 2021-06-09 Sartorius Stedim Data Analytics AB Adapting control of a cell culture in a production scale vessel with regard to a starting medium
AR129727A1 (es) * 2022-06-28 2024-09-25 Amgen Inc Configuraciones flexibles de instalaciones para la fabricación de productos terapéuticos
TW202426622A (zh) * 2022-09-06 2024-07-01 美商安進公司 大型生物反應器系統及方法
WO2024191993A2 (en) * 2023-03-13 2024-09-19 Amgen Inc. Systems and methods for seed train optimization

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
RU2058992C1 (ru) * 1993-07-14 1996-04-27 Антипин Георгий Васильевич Способ получения кормового белка и устройство для его осуществления
DE19612966B4 (de) * 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
RU2215748C2 (ru) * 1999-04-09 2003-11-10 Сентро Де Инмунология Молекулар Способ получения рекомбинантного эритропоэтина человека и полученный эритропоэтин, фармацевтическая композиция
US6585971B1 (en) 1999-11-12 2003-07-01 Harbor-Ucla Research And Education Institute Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof
WO2002050251A2 (en) 2000-12-20 2002-06-27 Bayer Pharmaceuticals Corporation A device and method for seed-train expansion of mammalian cells
JP2005509406A (ja) * 2001-05-09 2005-04-14 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞株のための低温保存袋アセンブリー
ES2357423T3 (es) 2001-08-31 2011-04-26 Bayer Schering Pharma Aktiengesellschaft Unidad y procedimiento para realizar fermentación a alta densidad celular.
BR0212780A (pt) 2001-10-02 2004-10-13 Novo Nordisk Healthcare Ag Métodos para produzir polipeptìdeos em células eucarióticas, para cultivar células eucarióticas e para colher polipeptìdeos produzidos por células eucarióticas
WO2003039459A2 (en) 2001-11-05 2003-05-15 Genvec, Inc. Viral vector production methods and compositions
US6953692B2 (en) * 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US20050019914A1 (en) * 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
US20050186669A1 (en) 2004-02-20 2005-08-25 Cesco Bioengineering Co., Ltd. Apparatus and method for preparing and culturing cells
US7294484B2 (en) * 2004-08-27 2007-11-13 Wyeth Research Ireland Limited Production of polypeptides
JP4914835B2 (ja) 2004-09-16 2012-04-11 ベクトン・ディキンソン・アンド・カンパニー 細胞培養用の潅流バイオリアクタ
PT2550971T (pt) 2004-09-30 2017-10-02 Bayer Healthcare Llc Dispositivos e métodos para fabrico contínuo integrado de moléculas biológicas
DK1891205T3 (da) 2005-06-15 2018-03-19 Zhejiang Jinyishengshi Bioengineering Co Ltd Suspensionskulturbeholdere
WO2006138143A1 (en) 2005-06-15 2006-12-28 Amprotein Corporation Suspension culture vessels
US20080206819A1 (en) 2006-08-21 2008-08-28 Mary Tsao Intensified Perfusion Production Method
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
US8501462B2 (en) 2007-02-27 2013-08-06 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
CA2677925A1 (en) * 2007-03-02 2008-09-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Improvement of protein production comprising increasing the expression or activity of cert
US9012212B2 (en) 2007-04-17 2015-04-21 Xendo Holding B.V. Method and device for continuous membrane adsorption
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
ES2657055T3 (es) * 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
WO2009034186A2 (en) 2007-09-13 2009-03-19 Helmholtz-Zentrum für Infektionsforschung GmbH Process for cell cultivation
US20090233334A1 (en) 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
DE102008019691A1 (de) 2008-04-15 2009-10-29 Technische Universität Ilmenau Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion
US20100076380A1 (en) 2008-06-16 2010-03-25 Amprotein Corporation Bioreactors
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
CA2766902C (en) * 2009-07-06 2021-07-06 Genentech, Inc. Method of culturing eukaryotic cells
BR112013013884A2 (pt) 2010-12-06 2016-09-13 Pall Corp métodos de processamento contínuo para produtos biológicos
ES2890412T3 (es) 2011-01-17 2022-01-19 Hoffmann La Roche Aparato de separación
WO2012152945A1 (en) 2011-05-12 2012-11-15 Probiogen Ag Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase
CA2952347A1 (en) * 2011-07-01 2013-01-10 Amgen Inc. Mammalian cell culture
AR089231A1 (es) * 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
US20150004686A1 (en) 2012-02-02 2015-01-01 Corning Incorporated Automatic continuous perfusion cell culture microplate consumables
CN106399094A (zh) 2012-04-01 2017-02-15 Emd密理博公司 细胞培养和梯度迁移化验方法和装置
SG10201901708SA (en) * 2012-10-23 2019-03-28 Genzyme Corp Perfusion culturing methods and uses thereof
WO2014130864A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
WO2014130872A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
SG11201506775VA (en) 2013-03-08 2015-09-29 Genzyme Corp Continuous purification of therapeutic proteins
TWI656839B (zh) 2013-03-15 2019-04-21 健臻公司 高密度細胞儲存方法
KR102369211B1 (ko) 2013-09-16 2022-03-03 젠자임 코포레이션 세포 배양물을 가공하는 방법 및 시스템
JP2017500017A (ja) * 2013-12-20 2017-01-05 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
EP4372078A3 (en) 2014-06-04 2024-09-04 Amgen Inc. Methods for harvesting mammalian cell cultures
TWI743024B (zh) * 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TW202246486A (zh) 2014-06-09 2022-12-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
CN104450597B (zh) 2014-12-10 2020-07-28 青岛农业大学 一种石油降解菌固体菌剂的制备方法及由其制备的固体菌剂修复石油污染的土壤的方法
IL253071B2 (en) 2014-12-22 2024-04-01 Genzyme Corp Methods for growing mammalian cells

Also Published As

Publication number Publication date
US20150353896A1 (en) 2015-12-10
EP3858983A1 (en) 2021-08-04
EP3628730A1 (en) 2020-04-01
ES2773630T3 (es) 2020-07-13
RU2016151316A (ru) 2018-07-10
KR20220098051A (ko) 2022-07-08
IL281626B (en) 2022-03-01
TW202246486A (zh) 2022-12-01
JP6784600B2 (ja) 2020-11-11
AU2015274897B2 (en) 2021-11-04
IL290096A (en) 2022-03-01
CN106574249A (zh) 2017-04-19
WO2015191462A1 (en) 2015-12-17
AU2023203734A1 (en) 2023-07-06
RU2019119708A (ru) 2019-07-03
MX2020004073A (es) 2020-07-29
MX373323B (es) 2025-03-05
JP2021019621A (ja) 2021-02-18
CN111575225A (zh) 2020-08-25
TW201610148A (zh) 2016-03-16
RU2694327C2 (ru) 2019-07-11
BR112016028891B1 (pt) 2023-04-11
US10570367B2 (en) 2020-02-25
CA2951551C (en) 2023-02-28
RU2016151316A3 (da) 2018-11-15
SG11201610216UA (en) 2017-01-27
JP7360504B2 (ja) 2023-10-12
TWI707949B (zh) 2020-10-21
AU2015274897A1 (en) 2017-01-12
KR102584375B1 (ko) 2023-09-27
AU2021245116B2 (en) 2023-07-27
JP7089000B2 (ja) 2022-06-21
TW202102658A (zh) 2021-01-16
BR112016028891A2 (pt) 2017-08-22
TWI776235B (zh) 2022-09-01
HUE047683T2 (hu) 2020-05-28
IL290096B2 (en) 2024-04-01
IL290096B1 (en) 2023-12-01
KR20170015472A (ko) 2017-02-08
JP2022120031A (ja) 2022-08-17
IL281626A (en) 2021-05-31
CA2951551A1 (en) 2015-12-17
IL249452B (en) 2021-04-29
CY1122803T1 (el) 2021-05-05
AU2021245116A1 (en) 2021-10-28
CN106574249B (zh) 2020-05-08
KR102416402B1 (ko) 2022-07-04
CN111575225B (zh) 2023-09-08
EP3152299B1 (en) 2019-11-20
IL249452A0 (en) 2017-02-28
EP3152299A1 (en) 2017-04-12
MX2016016301A (es) 2017-04-06
US20200377850A1 (en) 2020-12-03
JP2017521057A (ja) 2017-08-03

Similar Documents

Publication Publication Date Title
DK3152299T3 (da) Podekædeprocesser og anvendelser deraf
DK3157552T3 (da) Syntac-polypeptider og anvendelser deraf
IL252126A0 (en) Methods for transduction and cell processing
DK3333191T3 (da) Anti-C10ORF54-antistoffer og anvendelser deraf
DK3126388T3 (da) Anti-EGFRvIII-antistoffer og anvendelser deraf
DK3189081T3 (da) Cd123-bindende midler og anvendelser deraf
DK3350220T3 (da) Anti-pro/latente-myostatin-antistoffer og anvendelser deraf
DK3218358T3 (da) Ifluorometyl-aminopyridiner og difluorometyl-aminopyrimidiner
DK3303395T3 (da) Anti-cd40-antistoffer og anvendelser deraf
DK3215147T3 (da) Neurodæmpende norketamin-forbindelser og fremgangsmåder
DK3265448T3 (da) Riluzol-prodrugs og anvendelse deraf
DK3149042T3 (da) PD-L1-antistoffer og anvendelser deraf
DK3212255T3 (da) Selvorienterende sprøjte og sprøjtegrænseflade
DK3155024T3 (da) Opholdsstrukturer og relaterede fremgangsmåder
DK3209773T3 (da) Prolintolerante tripeptidylpeptidaser og anvendelser deraf
DK3236991T3 (da) Fgf21-derivater og anvendelser deraf
DK3359563T3 (da) Antigenreceptorer og anvendelser deraf
DK3395801T3 (da) Arylazolforbindelse og skadedyrsbekæmpelsesmiddel
DK3161139T3 (da) Tlr-4-specifikke aptamerer og anvendelser heraf
DK3191757T3 (da) Kobling og tætning
DK3110447T3 (da) Anti-EGFR-antistof og anvendelser heraf
DK3231793T3 (da) Dihydropyromidin-2-on-forbindelser og medicinske anvendelser deraf
DK3280405T3 (da) Inhibitorer og anvendelser deraf
DK3365321T3 (da) Solabegron-zwitterion og anvendelser deraf
DK3102613T3 (da) Polymerpartikler og anvendelser deraf