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DK313985A - 1-HYDROXY CYTORHODINES, A MICROBIOLOGICAL PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS CYTOSTATICS - Google Patents

1-HYDROXY CYTORHODINES, A MICROBIOLOGICAL PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS CYTOSTATICS Download PDF

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Publication number
DK313985A
DK313985A DK313985A DK313985A DK313985A DK 313985 A DK313985 A DK 313985A DK 313985 A DK313985 A DK 313985A DK 313985 A DK313985 A DK 313985A DK 313985 A DK313985 A DK 313985A
Authority
DK
Denmark
Prior art keywords
rod
roa
sugar combination
representing
acu
Prior art date
Application number
DK313985A
Other languages
Danish (da)
Other versions
DK313985D0 (en
Inventor
Werner Aretz
Hans Gerd Berscheid
Hans-Wolfram Fehlhaber
Dirk Boettger
Hans Peter Kraemer
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK313985D0 publication Critical patent/DK313985D0/en
Publication of DK313985A publication Critical patent/DK313985A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds of the formula I see diagramm : EP0167954,P12,F1 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod and their physiologically acceptable acid addition salts. 1. Claims for the Contracting State : AT A process for the preparation of a compound of the formula I see diagramm : EP0167954,P12,F2 wherein a) R1 and R2 are identical and each represent the sugar combination Roa-Rod-Rod or Roa-dF=CinB, or b) R1 and R2 are different and each represent the sugar combination Roa-Rod-Rod and Roa-dF-Rod, or c) R1 and R2 are different, R1 representing the sugar combination Roa-dF-CinA and R2 representing the sugar combination Roa-Rod-Rod or Roa-Rod-Acu, or R1 representing the sugar combination Roa-Rod-Acu and R2 representing the sugar combination Roa-Rod-Rod, and their physiologically acceptable acid addition salts, which comprises fermenting the microorganism Streptomyces purpurascens (DSM 2658) in the presence of a nutrient medium with an elevated oxygen supply, otherwise in a customary manner under aerobic conditions, and isolating the compounds formed from the culture liquid and the mycelium by extraction with organic solvents followed by chromatography or partition in a customary manner.
DK313985A 1984-07-10 1985-07-09 1-HYDROXY CYTORHODINES, A MICROBIOLOGICAL PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS CYTOSTATICS DK313985A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843425357 DE3425357A1 (en) 1984-07-10 1984-07-10 1-HYDROXY-CYTORHODINE, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Publications (2)

Publication Number Publication Date
DK313985D0 DK313985D0 (en) 1985-07-09
DK313985A true DK313985A (en) 1986-01-11

Family

ID=6240265

Family Applications (1)

Application Number Title Priority Date Filing Date
DK313985A DK313985A (en) 1984-07-10 1985-07-09 1-HYDROXY CYTORHODINES, A MICROBIOLOGICAL PROCEDURE FOR THEIR PREPARATION AND THEIR USE AS CYTOSTATICS

Country Status (15)

Country Link
EP (1) EP0167954B1 (en)
JP (1) JPS6144841A (en)
KR (1) KR860001190A (en)
AT (1) ATE46701T1 (en)
AU (1) AU586977B2 (en)
DE (2) DE3425357A1 (en)
DK (1) DK313985A (en)
ES (1) ES8609356A1 (en)
FI (1) FI81608C (en)
GR (1) GR851682B (en)
HU (1) HUT42134A (en)
IL (1) IL75748A0 (en)
NO (1) NO852758L (en)
PT (1) PT80790B (en)
ZA (1) ZA855154B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic
JPS62238298A (en) * 1986-04-08 1987-10-19 Sanraku Inc Novel anthracycline antibiotic substance dcp-1 and 2
DE3709337A1 (en) * 1987-03-21 1988-10-13 Hoechst Ag NEW ANTHRACYCLINE GLYCOSIDES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
DE3712350A1 (en) * 1987-04-11 1988-10-20 Behringwerke Ag SEMISYNTHETIC RHODOMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD122069A1 (en) * 1974-04-29 1976-09-12
JPS6023679B2 (en) * 1979-07-13 1985-06-08 メルシャン株式会社 Rhodomycin group antibiotics and their production method
DE3168154D1 (en) * 1980-10-27 1985-02-21 Hoffmann La Roche Process for anthracycline glycosides
DE3325957A1 (en) * 1983-07-19 1985-02-07 Hoechst Ag, 6230 Frankfurt ANTHRACYCLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A CYTOSTATIKA
JPS61236792A (en) * 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic

Also Published As

Publication number Publication date
FI852696L (en) 1986-01-11
DE3425357A1 (en) 1986-01-23
FI81608B (en) 1990-07-31
PT80790B (en) 1987-10-20
AU4473485A (en) 1986-01-16
FI852696A0 (en) 1985-07-08
GR851682B (en) 1985-11-26
IL75748A0 (en) 1985-11-29
ES544960A0 (en) 1986-08-01
EP0167954A3 (en) 1986-11-20
DK313985D0 (en) 1985-07-09
HUT42134A (en) 1987-06-29
ES8609356A1 (en) 1986-08-01
DE3573263D1 (en) 1989-11-02
EP0167954B1 (en) 1989-09-27
EP0167954A2 (en) 1986-01-15
AU586977B2 (en) 1989-08-03
KR860001190A (en) 1986-02-24
ATE46701T1 (en) 1989-10-15
FI81608C (en) 1990-11-12
JPS6144841A (en) 1986-03-04
ZA855154B (en) 1986-02-26
NO852758L (en) 1986-01-13
PT80790A (en) 1985-08-01

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