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DK2925391T3 - Kombinationsstempelanordning til blandesprøjter med dobbelt kammer - Google Patents

Kombinationsstempelanordning til blandesprøjter med dobbelt kammer Download PDF

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Publication number
DK2925391T3
DK2925391T3 DK13799451.3T DK13799451T DK2925391T3 DK 2925391 T3 DK2925391 T3 DK 2925391T3 DK 13799451 T DK13799451 T DK 13799451T DK 2925391 T3 DK2925391 T3 DK 2925391T3
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DK
Denmark
Prior art keywords
piston
mixing
plunger
combination
delivery
Prior art date
Application number
DK13799451.3T
Other languages
English (en)
Inventor
Peter J Dungar
Robert E Johannesson
Katlin M Lumme
Molly M Miller
Philip A Weaver
Original Assignee
Unitract Syringe Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unitract Syringe Pty Ltd filed Critical Unitract Syringe Pty Ltd
Application granted granted Critical
Publication of DK2925391T3 publication Critical patent/DK2925391T3/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2093—Containers having several compartments for products to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3148—Means for causing or aiding aspiration or plunger retraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3234—Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/40—Mixers with shaking, oscillating, or vibrating mechanisms with an axially oscillating rotary stirrer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/441—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing a rectilinear reciprocating movement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/50—Movable or transportable mixing devices or plants
    • B01F33/501—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use
    • B01F33/5011—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held
    • B01F33/50112—Movable mixing devices, i.e. readily shifted or displaced from one place to another, e.g. portable during use portable during use, e.g. hand-held of the syringe or cartridge type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/20—Measuring; Control or regulation
    • B01F35/22—Control or regulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/716—Feed mechanisms characterised by the relative arrangement of the containers for feeding or mixing the components
    • B01F35/7162—A container being placed inside the other before contacting the contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3221—Constructional features thereof, e.g. to improve manipulation or functioning
    • A61M2005/3231—Proximal end of needle captured or embedded inside piston head, e.g. by friction or hooks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3234—Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user
    • A61M2005/3235—Fully automatic needle retraction, i.e. in which triggering of the needle does not require a deliberate action by the user triggered by radial deflection of the anchoring parts between needle mount and syringe barrel or needle housing, e.g. spreading of needle mount retaining hooks having slanted surfaces by engagement with correspondingly shaped surfaces on the piston at the end of an injection stroke
    • A61M2005/3238—Trigger provided at the proximal end, i.e. syringe end opposite to needle mounting end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/322—Retractable needles, i.e. disconnected from and withdrawn into the syringe barrel by the piston
    • A61M5/3221—Constructional features thereof, e.g. to improve manipulation or functioning

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Environmental & Geological Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (15)

1. Kombinationsstempel (10) til en sprøjteblandingsanordning (100), der omfatter en første tætning (160) og en afgivelsesstempeltætning (80), hvilket kombinationsstempel (10) omfatter: et blandestempel (30) , der er indrettet til at gå i indgreb med den første tætning (160) for at forårsage aksial bevægelse af den første tætning (160) et afgivelsesstempel (12), der er indrettet til at gå i indgreb med afgivelsesstempeltætningen (80) for at forårsage aksial bevægelse af afgivelsesstempeltætningen (80), og et pillehus (20) med et forspændingselement (21), kendetegnet ved, at blandestemplet (30) og afgivelsestemplet (12) løsbart er i indgreb for at lette koordineret eller synkron aksial bevægelse af blandestemplet (30) og afgivelsestemplet (12) for mindst en del af den aksiale forskydning af kombinationsstemplet (10), således at den aksiale forskydning af afgivelsestemplet (12) forårsager aksial forskydning af blandestemplet (30), og hvori frigørelse af blandestempelet (30) og afgivelsestemplet (12) muliggør særskilt eller uafhængig aksial bevægelse af afgivelsestemplet (12), idet frigørelsen omfatter rotationsmæssig frigørelse af afgivelsesstemplet (12) fra blandestemplet (30).
2. Kombinationsstempel (10) ifølge krav 1, hvori blandestemplet (30) og afgivelsestemplet (12) løsbart er i indgreb for at lette koordineret eller synkron aksial forskydning af blandestemplet (30) og afgivelsestemplet (12) indtil frigørelse af blandestemplet (30) og afgivelsestemplet (12) .
3. Kombinationsstempel (10) ifølge krav 2, hvori blandestemplet (30) omfatter et eller flere forbindelseselementer (33) ved en proksimal ende deraf.
4. Kombinationsstempel (10) ifølge krav 3, hvori afgivelsestemplet (12) omfatter en eller flere forbindelsesudsparinger (14), som løsbart er i indgreb med eller løsbart holdes i indgreb af forbindelseselementerne (33) for blandestemplet (30).
5. Kombinationsstempel (10) ifølge krav 4, hvori det løsbare indgreb mellem forbindelseselementerne (33) og forbindelsesudsparingerne (14) i afgivelsesstemplet (12) muliggør koordineret aksial forskydning af blandestemplet (30) og afgivelsestemplet (12) for i det mindste en del af den aksiale forskydning af kombinationsstemplet (10).
6. Kombinationsstempel (10) ifølge et hvilket som helst af kravene 1-5, der omfatter en eller flere låse eller et eller flere låsesystemer.
7. Kombinationsstempel (10) ifølge krav 6, hvori den ene eller flere låse eller det ene eller flere låsesystemer forhindrer aksial forskydning af blandestemplet (30), alt imens de tillader aksial forskydning af afgivelsesstemplet (12), når blandingen er fuldstændiggjort.
8. Kombinationsstempel (10) ifølge krav 7, hvori det ene eller flere låsesystemer låser blandestemplet (30) til blandeanordningen (100).
9. Kombinationsstempel (10) ifølge et hvilket som helst af de foregående krav, der omfatter et eller flere elementer (31), som i begyndelsen går i indgreb med pillehuset (20) for at opretholde forspændingselementet (21) i en oprindeligt aktiveret tilstand, således at det ved frigørelse af elementet (31) fra pillehuset (20) tillades for forspændingselementet (21) at udvides i en proksimal retning.
10. Kombinationsstempel (10) ifølge krav 9, hvori afgivelsesstemplet (12) er i stand til at gå i indgreb med en nål (410) eller en nåleenhed (400) for at forenkle tilbagetrækning af nålen (410) eller nåleenheden (400).
11. Kombinationsstempel (10) ifølge krav 10, hvori frigivelse af energi fra forspændingselementet (21) muliggør tilbagetrækning af nålen (410) eller nåleenheden (400), når den holdes i indgreb af afgivelsestemplet (12), ind i en sprøj tecylinder.
12. Kombinationsstempel (10) ifølge et hvilket som helst af kravene 9-11, hvori forspændingselementet (21) er en kompressionsfjeder, der i begyndelsen sammenpresses i pillehuset (20) forud for tilbagetrækning af nålen (410) eller nåleenheden (400) .
13. Kombinationsstempel (10) ifølge krav 12, hvori dekompression eller ekspansion af fjederen (21) muliggør tilbagetrækning af nålen (410) eller nåleenheden (400), når den er i indgreb med afgivelsestemplet (12).
14. Kombinationsstempel (10) ifølge et hvilket som helst af de foregående krav, der yderligere omfatter en flangeforbindelse (25) til at forbinde kombinationsstemplet (10) til en eller flere cylindere (110, 120) eller en cylinderudvidelse (126) i blandeanordningen (100).
15. Kombinationsstempel (10) ifølge krav 14, hvori flangeforbindelsen (25) kan gå i indgreb med blandingsanordningens (100) cylinderudvidelse (126).
DK13799451.3T 2012-11-30 2013-11-18 Kombinationsstempelanordning til blandesprøjter med dobbelt kammer DK2925391T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261731972P 2012-11-30 2012-11-30
PCT/US2013/070494 WO2014085118A1 (en) 2012-11-30 2013-11-18 Combination plunger device for a dual chamber mixing syringe

Publications (1)

Publication Number Publication Date
DK2925391T3 true DK2925391T3 (da) 2017-08-28

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ID=49709841

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Application Number Title Priority Date Filing Date
DK13799451.3T DK2925391T3 (da) 2012-11-30 2013-11-18 Kombinationsstempelanordning til blandesprøjter med dobbelt kammer

Country Status (9)

Country Link
US (2) US10130768B2 (da)
EP (1) EP2925391B1 (da)
JP (1) JP6362145B2 (da)
AU (1) AU2013353059B2 (da)
CA (1) CA2892088A1 (da)
DK (1) DK2925391T3 (da)
PT (1) PT2925391T (da)
TW (1) TWI630009B (da)
WO (1) WO2014085118A1 (da)

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US20190217010A1 (en) 2019-07-18
EP2925391B1 (en) 2017-05-03
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CA2892088A1 (en) 2014-06-05
US11191902B2 (en) 2021-12-07
AU2013353059B2 (en) 2018-07-05
US10130768B2 (en) 2018-11-20
JP2015536204A (ja) 2015-12-21
TW201429511A (zh) 2014-08-01
WO2014085118A1 (en) 2014-06-05
US20150320935A1 (en) 2015-11-12
AU2013353059A1 (en) 2015-07-02
EP2925391A1 (en) 2015-10-07
PT2925391T (pt) 2017-08-10

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