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DK2794665T3 - Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf - Google Patents

Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf

Info

Publication number
DK2794665T3
DK2794665T3 DK12858809.2T DK12858809T DK2794665T3 DK 2794665 T3 DK2794665 T3 DK 2794665T3 DK 12858809 T DK12858809 T DK 12858809T DK 2794665 T3 DK2794665 T3 DK 2794665T3
Authority
DK
Denmark
Prior art keywords
disaccharid
glycosaminoglycanes
anticoagulative
comprehensive
repeating unit
Prior art date
Application number
DK12858809.2T
Other languages
English (en)
Inventor
Hans-Peter Ekre
Per-Olov Eriksson
Ulf Lindahl
Erik Holmer
Original Assignee
Dilafor Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48668970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2794665(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dilafor Ab filed Critical Dilafor Ab
Application granted granted Critical
Publication of DK2794665T3 publication Critical patent/DK2794665T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK12858809.2T 2011-12-19 2012-12-19 Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf DK2794665T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161577223P 2011-12-19 2011-12-19
PCT/SE2012/051433 WO2013095279A1 (en) 2011-12-19 2012-12-19 Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use

Publications (1)

Publication Number Publication Date
DK2794665T3 true DK2794665T3 (da) 2018-01-29

Family

ID=48668970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12858809.2T DK2794665T3 (da) 2011-12-19 2012-12-19 Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf

Country Status (29)

Country Link
US (1) US9475888B2 (da)
EP (1) EP2794665B1 (da)
JP (2) JP6543467B2 (da)
KR (1) KR102135485B1 (da)
CN (1) CN104144950B (da)
AU (1) AU2012354229B2 (da)
BR (1) BR112014014454B1 (da)
CA (1) CA2856492C (da)
CL (1) CL2014001651A1 (da)
CO (1) CO7061069A2 (da)
CY (1) CY1119899T1 (da)
DK (1) DK2794665T3 (da)
ES (1) ES2656613T3 (da)
HK (1) HK1202883A1 (da)
HR (1) HRP20180124T1 (da)
HU (1) HUE036523T2 (da)
IL (1) IL232905A (da)
LT (1) LT2794665T (da)
ME (1) ME02994B (da)
MX (1) MX351104B (da)
NO (1) NO2904345T3 (da)
PL (1) PL2794665T3 (da)
PT (1) PT2794665T (da)
RS (1) RS56874B1 (da)
RU (1) RU2617764C2 (da)
SI (1) SI2794665T1 (da)
SM (1) SMT201800143T1 (da)
WO (1) WO2013095279A1 (da)
ZA (1) ZA201403640B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
NZ631279A (en) * 2012-03-26 2016-06-24 Dilafor Ab Method for treatment of labor arrest
SG11201406119WA (en) * 2012-03-26 2014-11-27 Dilafor Ab Combination treatment comprising sulphated glycosaminoglycans for inducing labor
MY192330A (en) * 2012-05-08 2022-08-17 Dilafor Ab Treatment of postpartum haemorrhage with chemically modified heapin or heparan sulphate and a uterotonic agent
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
CN103788222B (zh) * 2014-01-08 2016-08-31 中国科学院昆明植物研究所 Fuc3S4S取代的低聚糖胺聚糖及其制备方法
US10596296B2 (en) * 2014-04-30 2020-03-24 Agency For Science, Technology And Research Heparan sulphates
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
IL295184A (en) 2020-02-17 2022-09-01 Dilafor Ab Tafoxiparin for the treatment of preeclampsia
EP4272749A1 (en) 2022-05-03 2023-11-08 Dilafor AB New medical use of tafoxiparin
AR129190A1 (es) 2022-05-03 2024-07-31 Dilafor Ab Nuevo uso médico de la tafoxiparina

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
JPS63246396A (ja) * 1987-03-31 1988-10-13 Shiseido Co Ltd モノクロ−ナル抗体
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
SE9002550D0 (sv) 1990-08-01 1990-08-01 Kabivitrum Ab Heparinfragment
SE9003181D0 (sv) 1990-10-04 1990-10-04 Kabivitrum Ab Use of heparin fraction
US5250519A (en) 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
US5280016A (en) 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
JPH0532703A (ja) * 1991-07-26 1993-02-09 Terumo Corp 低分子量ヘパリン誘導体の製造法
WO1994008595A1 (en) 1992-10-13 1994-04-28 Virginia Commonwealth University Use of non-anticoagulant heparin for treating ischemia/reperfusion injury
US5527785A (en) 1993-05-14 1996-06-18 The Regents Of The University Of California Selectin receptor modulating compositions
GB2299998B (en) * 1995-03-31 1997-03-26 Hamilton Civic Hospitals Res Compositions for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5993810A (en) 1996-03-15 1999-11-30 Lebovitz; Shamir Israel Method of softening or ripening the cervix of a female mammal using collagenase
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
WO1998016559A1 (fr) 1996-10-15 1998-04-23 Toray Industries, Inc. Agent de maturation des canaux cervicaux
GB9711443D0 (en) 1997-06-03 1997-07-30 Leo Pharm Prod Ltd Chemical suppositions
US6569840B1 (en) * 1997-11-20 2003-05-27 Ikuo Yamashina Low-molecular heparin modification and remedy for skin ulcer
US6596705B1 (en) 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin
EP1059304B1 (en) 1998-02-26 2006-04-26 Seikagaku Corporation Novel polysaccharide derivatives, process for the production thereof and medicinal compositions containing the same as the active ingredient
US6028061A (en) 1998-06-18 2000-02-22 Children's Medical Center Corp Angiogenesis inhibitors and use thereof
US6492503B1 (en) * 1998-07-31 2002-12-10 Seikagaku Corporation Glycosaminoglycan and drug compositions containing the same
MXPA01002022A (es) * 1998-08-26 2002-04-24 Collaborative Group Ltd Receptor para beta-(1,3-)glucano soluble acuoso, no derivado.
CN1371391A (zh) * 1999-06-30 2002-09-25 汉密尔顿市医院研究发展有限公司 抑制凝血相关凝血因子的肝素成分
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
CA2422059C (en) * 2000-09-12 2012-05-15 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
SE521676C2 (sv) 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
AU2003230985A1 (en) 2002-04-18 2003-11-03 Stephen H. Embury Method and composition for preventing pain in sickle cell patients
US8071569B2 (en) 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
JP2005106694A (ja) * 2003-09-30 2005-04-21 Mochida Pharmaceut Co Ltd 敗血症早期検出及び重篤度評価
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
US20060040896A1 (en) * 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
US7741311B2 (en) 2005-01-03 2010-06-22 Shaker Mousa Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing
MX2008000974A (es) * 2005-07-22 2008-03-27 Univ California Composiciones de heparina e inhibicion de selectina.
EP1906975A4 (en) 2005-07-22 2010-10-06 Trf Pharma Inc METHOD FOR THE TREATMENT OF SICKLE CELL DISEASE AND CONSEQUENCES OF SICKLE CELL DISEASE
JP2009536727A (ja) * 2006-04-04 2009-10-15 シングレックス，インコーポレイテッド 高感度のマーカー分析および分子検出のための方法および組成物
CA2652205A1 (en) * 2006-05-25 2007-12-06 Mallik Sundaram Low molecular weight heparin composition and uses thereof
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
MY151984A (en) * 2007-11-02 2014-07-31 Momenta Pharmaceuticals Inc Non-anticoagulant polysaccharide compositions
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2205642B1 (en) 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009073184A1 (en) 2007-12-03 2009-06-11 Florida State University Research Foundation, Inc. Compositions for inducing labor and associated methods
JP5758797B2 (ja) 2008-04-04 2015-08-05 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション アルキル化半合成グリコサミノグリカンエーテルならびにその製造および使用方法
JP2012522074A (ja) * 2009-03-27 2012-09-20 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー ポリグリセロールアルデヒド
WO2010121196A1 (en) 2009-04-16 2010-10-21 Momenta Pharmaceuticals, Inc. Methods of assessing activity of a polysaccharide composition
US20120108538A1 (en) 2009-06-30 2012-05-03 James Beeson Sulfated polysaccharides having antiplasmodial activity and methods and products for identifying antiplasmodial activity
PE20121643A1 (es) * 2009-07-31 2012-11-25 Bayer Healthcare Llc Polipeptidos del factor ix modificados y usos de los mismos
EP2515957B1 (en) * 2009-12-22 2015-07-29 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
SG11201406119WA (en) 2012-03-26 2014-11-27 Dilafor Ab Combination treatment comprising sulphated glycosaminoglycans for inducing labor
NZ631279A (en) 2012-03-26 2016-06-24 Dilafor Ab Method for treatment of labor arrest

Also Published As

Publication number Publication date
ZA201403640B (en) 2017-06-28
CA2856492A1 (en) 2013-06-27
EP2794665A4 (en) 2015-08-26
WO2013095279A1 (en) 2013-06-27
RU2617764C2 (ru) 2017-04-26
RU2014129816A (ru) 2016-02-20
US20150011505A1 (en) 2015-01-08
JP2018111825A (ja) 2018-07-19
CL2014001651A1 (es) 2014-10-10
CN104144950A (zh) 2014-11-12
CY1119899T1 (el) 2018-06-27
AU2012354229B2 (en) 2016-12-01
HK1202883A1 (en) 2015-10-09
BR112014014454A2 (pt) 2017-06-13
JP2015500388A (ja) 2015-01-05
PT2794665T (pt) 2018-01-24
MX2014007122A (es) 2015-03-05
MX351104B (es) 2017-10-02
KR102135485B1 (ko) 2020-07-17
SI2794665T1 (en) 2018-03-30
HUE036523T2 (hu) 2018-07-30
JP6543467B2 (ja) 2019-07-10
ME02994B (me) 2018-10-20
KR20140113652A (ko) 2014-09-24
IL232905A0 (en) 2014-07-31
RS56874B1 (sr) 2018-04-30
PL2794665T3 (pl) 2018-04-30
HRP20180124T1 (hr) 2018-02-23
LT2794665T (lt) 2017-12-27
IL232905A (en) 2017-02-28
CO7061069A2 (es) 2014-09-19
CN104144950B (zh) 2017-09-05
US9475888B2 (en) 2016-10-25
EP2794665A1 (en) 2014-10-29
ES2656613T3 (es) 2018-02-27
NO2904345T3 (da) 2018-07-21
EP2794665B1 (en) 2017-11-22
BR112014014454B1 (pt) 2021-03-09
SMT201800143T1 (it) 2018-05-02
AU2012354229A1 (en) 2014-06-05
CA2856492C (en) 2017-01-10

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