DK2698166T3 - Komplementærhæmning for bedre nerveregeneration - Google Patents
Komplementærhæmning for bedre nerveregeneration Download PDFInfo
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- DK2698166T3 DK2698166T3 DK13181901.3T DK13181901T DK2698166T3 DK 2698166 T3 DK2698166 T3 DK 2698166T3 DK 13181901 T DK13181901 T DK 13181901T DK 2698166 T3 DK2698166 T3 DK 2698166T3
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- antibody
- nerve
- complement
- nerves
- injury
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Claims (14)
1. Antistof eller antistoffragment, der blokerer en komplementærkomponent, til anvendelse i behandling af sygdom eller læsion af PNS eller CNS ved at fremme axonal regeneration hos et individ.
2. Antistof eller antistoffragment til anvendelse ifølge krav 1, hvor antistoffet er udvalgt fra gruppen bestående af: - et antistof, der blokerer én eller flere af C6, C5, C7, C8 og C9, og - et antistof, der blokerer C3-convertase og/eller et membranangrebskompleks assembly.
3. Antistof eller antistoffragment til anvendelse ifølge krav 1 eller 2, hvor antistoffet blokerer C6.
4. Antistof eller antistoffragment til anvendelse ifølge krav 1 eller 2, hvor antistoffet blokerer C5.
5. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-4, hvor antistoffet er et kimært, deimmuniseret, humant eller humaniseret antistof.
6. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-5, hvor antistoffet er et monoklonalt antistof.
7. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-6, hvor antistoffet er et enkeltkæde-antistof, et Fab-fragment, et heavychain-antistof eller et VHH-domæne.
8. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-7, hvor antistoffet eller antistoffragmentet er beregnet til anvendelse ved genvinding af sensorisk eller motorisk funktion.
9. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-8, hvor antistoffet eller antistoffragmentet er beregnet til anvendelse i fremme af regeneration af nerver, der er degenererede på grund af en neurodegenerativ lidelse i det perifere eller centrale nervesystem.
10. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-9, hvor antistoffet eller antistofffagmentet er beregnet til anvendelse ved fremme af regeneration af nerver efter en fysisk læsion af en perifer nerve.
11. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-10, hvor antistoffet eller antistoffragmentet er beregnet til anvendelse ved fremme af regeneration af nerver efter læsion af PNS eller CNS.
12. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-11, hvor antistoffet eller antistoffragmentet er beregnet til anvendelse ved fremme af regeneration af nerver efter et nervetraume som følge af en immun-medieret inflammatorisk lidelse eller læsion og/eller en progressiv neurodegenerativ lidelse.
13. Antistof eller antistoffragment til anvendelse ifølge krav 11, hvor læsionen indbefatter kirurgiske læsioner, rygmarvslæsioner, traumatiske sår på perifere nerver, herunder læsioner fra kollisioner, biluheld, skudsår, frakturer, forvridninger og flænger.
14. Antistof eller antistoffragment til anvendelse ifølge et hvilket som helst af kravene 1-13, hvor antistoffet eller antistoffragmentet er beregnet til anvendelse inden for 24, 12, 6, 3, 2 timer eller 1 time, mere fortrinsvis inden for 45, 30, 20 eller 10 minutter efter forekomst af en nervelæsion.
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| AU2014200822B2 (en) * | 2006-10-10 | 2016-01-28 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
| NZ591057A (en) | 2008-07-10 | 2012-11-30 | Az Univ Amsterdam | Complement antagonists and uses thereof |
| CA2734866A1 (en) * | 2008-08-20 | 2010-02-25 | The Trustees Of The University Of Pennsylvania | Complement inhibitors for treatment of injury from intracerebral hemorrhage |
| WO2011105901A2 (en) | 2010-02-23 | 2011-09-01 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Antagonists of complement component 9 (c9) and uses thereof |
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| WO2011105902A2 (en) | 2010-02-23 | 2011-09-01 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Antagonists of complement component 8-beta (c8-beta) and uses thereof |
| PT2734552T (pt) | 2011-07-22 | 2025-01-29 | Csl Behring Gmbh | Anticorpos monoclonais inibidores do fator xii/xiia e suas utilizações |
| EP2623110A1 (en) * | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
| JP6538561B2 (ja) | 2012-10-25 | 2019-07-03 | バイオベラティブ・ユーエスエイ・インコーポレイテッド | 抗補体Ｃ１ｓ抗体とそれらの用途 |
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| DK3233912T3 (da) | 2014-12-19 | 2021-08-02 | Regenesance B V | Antistoffer, der binder human c6, og anvendelser deraf |
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