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DK2640728T3 - Nye monensinderivater til behandlingen og forebyggelse af protozoale infektioner - Google Patents

Nye monensinderivater til behandlingen og forebyggelse af protozoale infektioner Download PDF

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Publication number
DK2640728T3
DK2640728T3 DK11791699.9T DK11791699T DK2640728T3 DK 2640728 T3 DK2640728 T3 DK 2640728T3 DK 11791699 T DK11791699 T DK 11791699T DK 2640728 T3 DK2640728 T3 DK 2640728T3
Authority
DK
Denmark
Prior art keywords
compound
monensin
mmol
compounds
ppm
Prior art date
Application number
DK11791699.9T
Other languages
English (en)
Inventor
Jean Delaveau
Marc Lemaire
Stéphane Pellet-Rostaing
Bruno Andrioletti
Emilie Vialle
Original Assignee
Merial Inc
Univ Claude Bernard Lyon
Centre Nat De La Rech Scient (Cnrs)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial Inc, Univ Claude Bernard Lyon, Centre Nat De La Rech Scient (Cnrs) filed Critical Merial Inc
Application granted granted Critical
Publication of DK2640728T3 publication Critical patent/DK2640728T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Claims (15)

1. Forbindelse valgt fra følgende:
eller et veterinært eller farmaceutisk acceptabelt salt deraf.
2. Veterinær eller farmaceutisk sammensætning omfattende en parasitisk effektiv mængde af en forbindelse ifølge krav 1 i kombination med en veterinær eller farmaceutisk acceptabel bærer eller fortyndingsmiddel.
3. Forbindelse ifølge krav 1 til anvendelse som et medikament.
4. Forbindelse ifølge krav 1 til anvendelse i behandling eller forebyggelse af coccidiose i et dyr, hvor dyret er en fugl.
5. Forbindelse til anvendelse ifølge krav 4, hvor forbindelsen er til oral administration via drikkevand eller som additiv til foderstof.
6. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 3 til 5 hvor forbindelsen er til administration i mængden på 0,1 til 10 mg/kg af dyrets kropsvægt.
7. Forbindelse til anvendelse ifølge et hvilket som helst af kravene 3 til 6, hvor forbindelsen er til administration med en effektiv mængde af en vaccine der er effektiv i beskyttelse af fugle mod protozoale infestationer.
8. Forbindelse ifølge krav 1, til anvendelse i nedsættelse eller eliminering af babesiose hos kvæg.
9. Forbindelse ifølge krav 1 til anvendelse i nedsættelse, forebyggelse, eller eliminering af protozoale infestationer hos mennesker eller ikke-humane dyr.
10. Forbindelse ifølge krav 1 til anvendelse i nedsættelse, forebyggelse, eller eliminering af malaria hos mennesker.
11. Forbindelse ifølge krav 1 til anvendelse i behandling af coccidiose i et bovint dyr hvor forbindelsen er til administration når kliniske tegn på coccidiose-infektion eksisterer.
12. Forbindelsen til anvendelse ifølge krav 11 hvor forbindelsen er til administration i en mængde der øger vægtforøgelse i det bovine dyr.
13. Forbindelsen til anvendelse ifølge krav 11 eller 12, hvor coccidiosen stammer fra infektion fra Eimeria bovis, E. aubemensis, eller Eimeria zuemii.
14. Forbindelsen til anvendelse ifølge et hvilket som helst af kravene 11 til 13, hvor forbindelsen også er til anvendelse i reducering af diarré og/eller Eimeria oocyte fældning hos dette dyr.
15. Forbindelse med formel (7):
til anvendelse til kontrol af endoparasitter af slægten Eimeria spp.
DK11791699.9T 2010-11-16 2011-11-16 Nye monensinderivater til behandlingen og forebyggelse af protozoale infektioner DK2640728T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41423410P 2010-11-16 2010-11-16
PCT/US2011/060913 WO2012068202A1 (en) 2010-11-16 2011-11-16 Novel monensin derivatives for the treatment and prevention of protozoal infections

Publications (1)

Publication Number Publication Date
DK2640728T3 true DK2640728T3 (da) 2016-11-28

Family

ID=45099195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK11791699.9T DK2640728T3 (da) 2010-11-16 2011-11-16 Nye monensinderivater til behandlingen og forebyggelse af protozoale infektioner

Country Status (12)

Country Link
US (1) US8822528B2 (da)
EP (1) EP2640728B1 (da)
AU (1) AU2011328948B2 (da)
CA (1) CA2818563C (da)
DK (1) DK2640728T3 (da)
HR (1) HRP20161635T1 (da)
HU (1) HUE031125T2 (da)
LT (1) LT2640728T (da)
MX (1) MX2013005414A (da)
NZ (1) NZ610547A (da)
SI (1) SI2640728T1 (da)
WO (1) WO2012068202A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6437523B2 (ja) * 2013-04-04 2018-12-12 プレジデント アンド フェローズ オブ ハーバード カレッジ マクロライドならびにそれらの調製および使用の方法
CN110078749B (zh) * 2019-06-04 2021-01-01 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 3a，3a′-双呋喃[2,3-b]吲哚啉类化合物、制备方法、药物组合物及应用
RU2750707C1 (ru) * 2020-07-22 2021-07-01 Федеральное государственное бюджетное учреждение науки Сибирский федеральный научный центр агробиотехнологий Российской академии наук (СФНЦА РАН) Способ профилактики эймериоза кур
WO2024006531A1 (en) 2022-07-01 2024-01-04 Arkea Bio Corp. Compositions and methods for reducing deleterious atmospheric gas emissions from flooded ecosystems

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Also Published As

Publication number Publication date
AU2011328948B2 (en) 2016-08-04
CA2818563A1 (en) 2012-05-24
US8822528B2 (en) 2014-09-02
LT2640728T (lt) 2017-03-27
AU2011328948A1 (en) 2013-06-06
SI2640728T1 (sl) 2017-03-31
EP2640728B1 (en) 2016-09-07
HRP20161635T1 (hr) 2017-02-24
WO2012068202A1 (en) 2012-05-24
NZ610547A (en) 2015-07-31
EP2640728A1 (en) 2013-09-25
MX2013005414A (es) 2013-08-29
HUE031125T2 (en) 2017-07-28
US20120128722A1 (en) 2012-05-24
CA2818563C (en) 2019-11-12

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