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DK2539465T3 - Analytsekventering med nanoporer - Google Patents

Analytsekventering med nanoporer Download PDF

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Publication number
DK2539465T3
DK2539465T3 DK11748022.8T DK11748022T DK2539465T3 DK 2539465 T3 DK2539465 T3 DK 2539465T3 DK 11748022 T DK11748022 T DK 11748022T DK 2539465 T3 DK2539465 T3 DK 2539465T3
Authority
DK
Denmark
Prior art keywords
nanopores
analyte
sequencing
analyte sequencing
Prior art date
Application number
DK11748022.8T
Other languages
English (en)
Inventor
Jens H Gundlach
Ian M Derrington
Marcus D Collins
Original Assignee
Univ Washington
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Publication date
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Publication of DK2539465T3 publication Critical patent/DK2539465T3/da

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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721Investigating individual macromolecules, e.g. by translocation through nanopores
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/924Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Human Computer Interaction (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DK11748022.8T 2010-02-23 2011-02-23 Analytsekventering med nanoporer DK2539465T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30744110P 2010-02-23 2010-02-23
US37570710P 2010-08-20 2010-08-20
PCT/US2011/025963 WO2011106459A2 (en) 2010-02-23 2011-02-23 Analyte sequencing with nanopores

Publications (1)

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DK2539465T3 true DK2539465T3 (da) 2024-03-11

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DK11748021.0T DK2539707T3 (da) 2010-02-23 2011-02-23 Kunstige mycolsyremembraner

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US (5) US9588079B2 (da)
EP (4) EP3933402A1 (da)
CN (2) CN102834716B (da)
CA (5) CA2790666C (da)
DK (2) DK2539465T3 (da)
ES (2) ES2978883T3 (da)
FI (1) FI2539465T3 (da)
WO (2) WO2011106456A2 (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889348B2 (en) 2006-06-07 2014-11-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by nanopore using modified nucleotides
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
DK2539465T3 (da) 2010-02-23 2024-03-11 Univ Washington Analytsekventering med nanoporer
CN107083421A (zh) 2010-12-17 2017-08-22 纽约哥伦比亚大学理事会 使用经修饰的核苷酸和纳米孔检测的dna边合成边测序
WO2012088339A2 (en) 2010-12-22 2012-06-28 Genia Technologies, Inc. Nanopore-based single dna molecule characterization using speed bumps
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
BR112013030529B1 (pt) 2011-05-27 2023-03-07 Oxford Nanopore Technologies Plc Método para determinar a presença, ausência ou características de um analito, método e aparelho para sequenciamento de um analito que é um polinucleotídeo alvo, e, kit
EP2807476A4 (en) * 2012-01-20 2015-12-09 Genia Technologies Inc MOLECULAR DETECTION AND SEQUENCING USING NANOPORES
US8541849B2 (en) * 2012-02-14 2013-09-24 Genia Technologies, Inc. Noise shielding techniques for ultra low current measurements in biochemical applications
CA2866587C (en) 2012-02-16 2022-07-26 Oxford Nanopore Technologies Limited Analysis of measurements of a polymer
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
WO2013154999A2 (en) 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Method of preparation of nanopore and uses thereof
WO2013153359A1 (en) 2012-04-10 2013-10-17 Oxford Nanopore Technologies Limited Mutant lysenin pores
WO2013159042A1 (en) 2012-04-19 2013-10-24 University Of Washington Through Its Center For Commercialization Methods and compositions for generating reference maps for nanopore-based polymer analysis
CN104350162A (zh) 2012-06-15 2015-02-11 吉尼亚科技公司 芯片设置和高精确度核酸测序
EP3511424B1 (en) 2012-08-03 2023-10-18 University Of Washington Through Its Center For Commercialization Compositions and methods for improving nanopore sequencing
CN102867851B (zh) * 2012-09-07 2015-10-28 中国科学院苏州纳米技术与纳米仿生研究所 离子束流信号放大器及其制造方法
WO2014071250A1 (en) * 2012-11-01 2014-05-08 University Of Washington Through Its Center For Commercialization Methods for detecting and mapping modifications to nucleic acid polymers using nanopore systems
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
GB201222928D0 (en) 2012-12-19 2013-01-30 Oxford Nanopore Tech Ltd Analysis of a polynucleotide
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
WO2014130686A2 (en) * 2013-02-20 2014-08-28 Eve Biomedical, Inc. Methods and compositions for nanostructure-based nucleic acid sequencing
WO2014144898A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
CA2921700A1 (en) 2013-08-30 2015-03-05 University Of Washington Through Its Center For Commercialization Selective modification of polymer subunits to improve nanopore-based analysis
WO2015051378A1 (en) * 2013-10-04 2015-04-09 University Of Washington Through Its Center For Commercialization Systems and methods for nanopore-based analysis of nucleic acids
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9567630B2 (en) 2013-10-23 2017-02-14 Genia Technologies, Inc. Methods for forming lipid bilayers on biochips
EP3060918B1 (en) 2013-10-23 2019-09-18 Genia Technologies, Inc. High speed molecular sensing with nanopores
GB201406155D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
JP6749243B2 (ja) 2014-01-22 2020-09-02 オックスフォード ナノポール テクノロジーズ リミテッド 1つまたは複数のポリヌクレオチド結合タンパク質を標的ポリヌクレオチドに付着させる方法
SG10202111841TA (en) 2014-02-19 2021-12-30 Univ Washington Nanopore-based analysis of protein characteristics
WO2015127387A1 (en) * 2014-02-21 2015-08-27 Northeastern University Fluorescence-based analysis of biopolymers using nanopores
WO2015138405A2 (en) * 2014-03-10 2015-09-17 The Board Of Trustees Of The University Of Illinois Detection and quantification of methylation in dna
AU2015236392A1 (en) 2014-03-24 2016-10-20 Genia Technologies, Inc. Chemical methods for producing tagged nucleotides
WO2015150786A1 (en) 2014-04-04 2015-10-08 Oxford Nanopore Technologies Limited Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid
US10781237B2 (en) 2014-04-16 2020-09-22 The Uab Research Foundation MSP nanopores and uses thereof
EP3137627A1 (en) * 2014-05-02 2017-03-08 Oxford Nanopore Technologies Limited Method of improving the movement of a target polynucleotide with respect to a transmembrane pore
ES2846746T3 (es) 2014-06-03 2021-07-29 Illumina Inc Composiciones, sistemas y métodos para detectar acontecimientos usando fijaciones ancladas o adyacentes a nanoporos
SG10201809900PA (en) 2014-07-31 2018-12-28 Illumina Inc Hybrid Nanopore Sensors
CA2959220A1 (en) 2014-09-01 2016-03-10 Vib Vzw Mutant csgg pores
US10266885B2 (en) 2014-10-07 2019-04-23 Oxford Nanopore Technologies Ltd. Mutant pores
EP3207154B1 (en) * 2014-10-16 2022-03-16 Oxford Nanopore Technologies PLC Analysis of a polymer
GB201418469D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Method
US9624537B2 (en) 2014-10-24 2017-04-18 Quantapore, Inc. Efficient optical analysis of polymers using arrays of nanostructures
GB201502810D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Method
GB201502809D0 (en) 2015-02-19 2015-04-08 Oxford Nanopore Tech Ltd Mutant pore
EP3283887B1 (en) 2015-04-14 2021-07-21 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
CN114703264B (zh) 2015-06-03 2024-09-20 亿明达股份有限公司 使用锚定至邻近纳米孔的聚合酶的系链对多核苷酸测序的组合物、系统和方法
WO2017098322A1 (en) 2015-12-08 2017-06-15 Katholieke Universiteit Leuven Ku Leuven Research & Development Modified nanopores, compositions comprising the same, and uses thereof
CN105779279A (zh) * 2016-02-29 2016-07-20 东南大学 一种基于二维层状材料的纳米孔传感器件及其构建方法
WO2017149317A1 (en) 2016-03-02 2017-09-08 Oxford Nanopore Technologies Limited Mutant pore
EP4397970A3 (en) 2016-04-06 2024-10-09 Oxford Nanopore Technologies PLC Mutant pore
US11124827B2 (en) * 2016-06-23 2021-09-21 Roche Sequencing Solutions, Inc. Period-to-period analysis of AC signals from nanopore sequencing
GB201707122D0 (en) 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Pore
WO2018209286A1 (en) * 2017-05-12 2018-11-15 Ust Corporation Method and systems for pulling dna, rna and other biological molecules through nanopores using soft magnetic structures
CN110914290A (zh) 2017-06-30 2020-03-24 弗拉芒区生物技术研究所 新颖蛋白孔
CN111512155B (zh) 2017-12-28 2022-07-05 豪夫迈·罗氏有限公司 测量和去除来自交流信号驱动的纳米孔dna测序系统的随机信号中的噪声
WO2019133756A1 (en) 2017-12-29 2019-07-04 Clear Labs, Inc. Automated priming and library loading device
US11391693B2 (en) 2018-02-16 2022-07-19 Illumina, Inc. Device for sequencing
US12195794B2 (en) * 2018-05-23 2025-01-14 The Regents Of The University Of California Methods of analyzing capped ribonucleic acids
GB201811623D0 (en) 2018-07-16 2018-08-29 Univ Oxford Innovation Ltd Molecular hopper
WO2020043082A1 (en) * 2018-08-28 2020-03-05 Nanjing University Protein nanopore for identifying an analyte
US20220366313A1 (en) * 2019-02-14 2022-11-17 University Of Washington Systems and methods for improved nanopore-based analysis of nucleic acids
CN112831395B (zh) * 2019-11-25 2024-01-16 深圳华大生命科学研究院 用于纳米孔测序的类细胞膜
CN111424075B (zh) * 2020-04-10 2021-01-15 西咸新区予果微码生物科技有限公司 一种基于第三代测序技术的微生物检测方法及系统
ES2999861T3 (en) 2020-08-11 2025-02-27 Hoffmann La Roche Nucleoside-5'-oligophosphates tagged with positively-charged polymers, nanopores incorporating negative charges, and methods and systems using the same
US20240272137A1 (en) * 2021-05-13 2024-08-15 Nanjing University Structural-profiling of analytes by nanopore trapping
WO2022263496A1 (en) 2021-06-17 2022-12-22 F. Hoffmann-La Roche Ag Engineered nanopore with a negatively charged polymer threaded through the channel
CN114199875B (zh) * 2022-02-18 2022-05-20 之江实验室 一种蛋白质多聚体是否可作为力缓冲剂的判断方法及装置

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4307229A (en) 1979-11-07 1981-12-22 Avraham Liav 6,6'-Diesters of trehalose and process for the synthesis thereof
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
DE3248167A1 (de) 1982-12-27 1984-06-28 Wintershall Ag, 3100 Celle Trehaloselipidtetraester
WO1987005606A1 (en) 1986-03-20 1987-09-24 Sawai Pharmaceutical Co., Ltd. alpha, alpha-TREHALOSE TRIMYCOLATE AND MEDICINAL COMPOSITION
US5049664A (en) 1988-08-26 1991-09-17 Sawai Pharmaceutical Co., Ltd. Trehalose derivatives
JPH07248329A (ja) * 1994-03-11 1995-09-26 Nippon Bio Ratsudo Lab Kk 結核感染症検査用膜およびこれを用いる結核感染症関連抗体の検出方法
US5658749A (en) * 1994-04-05 1997-08-19 Corning Clinical Laboratories, Inc. Method for processing mycobacteria
US6171830B1 (en) * 1995-02-22 2001-01-09 Adcock Ingram Limited Method for the isolation and purification of lipid cell-wall components
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) * 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
DE69839782D1 (de) * 1997-03-03 2008-09-04 Adcock Ingram Ltd Eine Zusammensetzung, die eine Trägerkomponente und eine gereinigte mykobakterielle Zellwandkomponente enthält, und ihre Verwendung zur Verhinderung, Behandlung und Diagnose von Erkrankungen
US6406880B1 (en) * 1997-05-02 2002-06-18 Integrated Research Technology, Llc Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US6267872B1 (en) 1998-11-06 2001-07-31 The Regents Of The University Of California Miniature support for thin films containing single channels or nanopores and methods for using same
NO986133D0 (no) 1998-12-23 1998-12-23 Preben Lexow FremgangsmÕte for DNA-sekvensering
WO2000039333A1 (en) 1998-12-23 2000-07-06 Jones Elizabeth Louise Sequencing method using magnifying tags
AU783675B2 (en) 1999-09-07 2005-11-24 Regents Of The University Of California, The Methods of determining the presence of double stranded nucleic acids in a sample
US7713544B2 (en) * 2000-07-28 2010-05-11 Emory University Biological component comprising artificial membrane
US6936433B2 (en) 2000-11-27 2005-08-30 The Regents Of The University Of California Methods and devices for characterizing duplex nucleic acid molecules
US6833249B2 (en) * 2002-03-22 2004-12-21 Council Of Scientific And Industrial Research Quick and sensitive method of quantifying mycolic acid to develop anti-microbial agents and a diagnostic kit thereof
ITMI20022096A1 (it) 2002-10-03 2004-04-04 Garden Ventures S R L Sistema di registrazione di un programma tv impostabile
CA2515213A1 (en) 2003-02-11 2004-08-26 University Of Washington Stimuli-responsive polymer conjugates and related methods
US7444053B2 (en) 2003-06-16 2008-10-28 The Regents Of The University Of California Integrated electrical and optical sensor for biomolecule analysis with single molecule sensitivity
US7594359B2 (en) 2004-03-12 2009-09-29 Gm Global Technology Operations, Inc. Active seal assemblies for sound isolation
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US20070269843A1 (en) * 2004-04-28 2007-11-22 Integrated Research Technology, Llc. Diagnostic Assays That Use Mycobacteriophages
US7749520B2 (en) * 2004-07-07 2010-07-06 Statens Serum Institut Compositions and methods for stabilizing lipid based adjuvant formulations using glycolipids
US7972858B2 (en) * 2004-08-13 2011-07-05 President And Fellows Of Harvard College Ultra high-throughput opti-nanopore DNA readout platform
GB0504184D0 (en) 2005-03-01 2005-04-06 Lingvitae As Method
US7514267B1 (en) 2005-08-19 2009-04-07 Stcunm Detection systems utilizing supported lipid bilayers
US20070190542A1 (en) 2005-10-03 2007-08-16 Ling Xinsheng S Hybridization assisted nanopore sequencing
US8889348B2 (en) * 2006-06-07 2014-11-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by nanopore using modified nucleotides
GB2457851B (en) * 2006-12-14 2011-01-05 Ion Torrent Systems Inc Methods and apparatus for measuring analytes using large scale fet arrays
EP2126588A1 (en) 2007-02-20 2009-12-02 Oxford Nanopore Technologies Limited Formation of lipid bilayers
JP5646987B2 (ja) * 2007-04-04 2014-12-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ナノポアを使用するための組成物、デバイス、システム、及び方法
ES2584871T3 (es) 2007-05-08 2016-09-29 Prionics Ag Método para el diagnóstico de la tuberculosis
GB0807305D0 (en) * 2008-04-22 2008-05-28 Univ Ghent Compounds for use in therapy
EP2344891B1 (en) 2008-09-22 2016-03-16 University Of Washington Msp nanopores and related methods
DK2539465T3 (da) 2010-02-23 2024-03-11 Univ Washington Analytsekventering med nanoporer
US9893808B2 (en) 2016-03-18 2018-02-13 Target Brands, Inc. VLC location data applications in a retail setting

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