DK250084D0 - Spiro-(imidazolidin-4,3'-indolin)-2,2',5-trionforbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer - Google Patents

Spiro-(imidazolidin-4,3'-indolin)-2,2',5-trionforbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer

Info

Publication number: DK250084D0
Authority: DK; Denmark
Prior art keywords: spiro; indoline; compounds; trione; imidazolidine
Prior art date: 1983-05-25

Application number

DK2500/84A

Other languages

English (en)

Other versions

DK163924C (da

DK163924B (da

DK250084A (da

Inventor

Alan Jeffrey Hutchison

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-25

Filing date

1984-05-22

Publication date

1984-05-22

1984-05-22 Application filed by Pfizer filed Critical Pfizer

1984-05-22 Publication of DK250084D0 publication Critical patent/DK250084D0/da

1984-11-26 Publication of DK250084A publication Critical patent/DK250084A/da

1992-04-21 Publication of DK163924B publication Critical patent/DK163924B/da

1992-09-14 Application granted granted Critical

1992-09-14 Publication of DK163924C publication Critical patent/DK163924C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cosmetics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
External Artificial Organs (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fats And Perfumes (AREA)

DK250084A 1983-05-25 1984-05-22 Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer DK163924C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/497,962 US4464380A (en)	1983-05-25	1983-05-25	Imidazolidinedione derivatives
US49796283		1983-05-25

Publications (4)

Publication Number	Publication Date
DK250084D0 true DK250084D0 (da)	1984-05-22
DK250084A DK250084A (da)	1984-11-26
DK163924B DK163924B (da)	1992-04-21
DK163924C DK163924C (da)	1992-09-14

Family

ID=23979057

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK250084A DK163924C (da)	1983-05-25	1984-05-22	Spiro-oeimidazolidin-4,3'-azaindolinaa-2,2',5-trion-forbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer

Country Status (19)

Country	Link
US (1)	US4464380A (da)
EP (1)	EP0127412B1 (da)
JP (1)	JPS604183A (da)
KR (1)	KR860001869B1 (da)
AT (1)	ATE57531T1 (da)
AU (1)	AU543916B2 (da)
CA (1)	CA1266270A (da)
DE (1)	DE3483402D1 (da)
DK (1)	DK163924C (da)
ES (2)	ES8600764A1 (da)
FI (1)	FI78699C (da)
GR (1)	GR82020B (da)
HU (1)	HU190548B (da)
IE (1)	IE57520B1 (da)
IL (1)	IL71904A (da)
PH (1)	PH21151A (da)
PL (3)	PL252850A1 (da)
PT (1)	PT78625A (da)
YU (2)	YU43931B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0172719B1 (en) *	1984-08-20	1988-09-21	Pfizer Inc.	Process for the production as asymmetric hydantoins
US4762839A (en) *	1985-06-06	1988-08-09	Tanabe Seiyaku Co., Ltd.	Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) *	1986-11-21	1988-06-04	Tanabe Seiyaku Co Ltd	キナゾリノン誘導体
US4841079A (en) *	1987-08-07	1989-06-20	Pfizer, Inc.	Process for the production of asymmetric hydantoins
ATE229948T1 (de) *	1995-10-18	2003-01-15	Hoffmann La Roche	Hydroxymethylierung von tocopherolen
NZ512870A (en)	1998-12-19	2003-11-28	Janssen Pharmaceutica Nv	Antihistaminic spiro compounds
EP2013216A2 (en) *	2006-02-07	2009-01-14	AstraZeneca AB	Novel spiro [imidazolidine-4, 3' -indole] 2, 2', 5' (1h) triones for treatment of conditions associated with vanilloid receptor 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
IE50332B1 (en) *	1979-11-13	1986-04-02	Ici Ltd	1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones,processes for their manufacture and pharmaceutical compositions thereof
ZA806623B (en) *	1979-11-13	1981-12-30	Ici Ltd	Substituted indoline-2-one derivatives
US4248882A (en) *	1980-02-12	1981-02-03	Pfizer Inc.	Treating diabetes-associated complications with hydantoin amines
IE52879B1 (en) *	1981-05-12	1988-03-30	Ici Plc	Pharmaceutical spiro-hydantoin derivatives

1983
- 1983-05-25 US US06/497,962 patent/US4464380A/en not_active Expired - Fee Related
1984
- 1984-05-21 DE DE8484303420T patent/DE3483402D1/de not_active Expired - Lifetime
- 1984-05-21 PT PT78625A patent/PT78625A/pt not_active IP Right Cessation
- 1984-05-21 EP EP84303420A patent/EP0127412B1/en not_active Expired - Lifetime
- 1984-05-21 AT AT84303420T patent/ATE57531T1/de not_active IP Right Cessation
- 1984-05-22 DK DK250084A patent/DK163924C/da not_active IP Right Cessation
- 1984-05-23 CA CA000454883A patent/CA1266270A/en not_active Expired - Lifetime
- 1984-05-23 PL PL25285084A patent/PL252850A1/xx unknown
- 1984-05-23 IL IL71904A patent/IL71904A/xx unknown
- 1984-05-23 ES ES532736A patent/ES8600764A1/es not_active Expired
- 1984-05-23 PL PL1984242850A patent/PL143070B1/pl unknown
- 1984-05-23 PH PH30711A patent/PH21151A/en unknown
- 1984-05-23 YU YU897/84A patent/YU43931B/xx unknown
- 1984-05-23 PL PL1984247804A patent/PL143290B1/pl unknown
- 1984-05-24 FI FI842079A patent/FI78699C/fi not_active IP Right Cessation
- 1984-05-24 IE IE1294/84A patent/IE57520B1/en not_active IP Right Cessation
- 1984-05-24 HU HU842021A patent/HU190548B/hu not_active IP Right Cessation
- 1984-05-24 GR GR74816A patent/GR82020B/el unknown
- 1984-05-24 AU AU28563/84A patent/AU543916B2/en not_active Ceased
- 1984-05-24 KR KR1019840002843A patent/KR860001869B1/ko not_active IP Right Cessation
- 1984-05-25 JP JP59106330A patent/JPS604183A/ja active Granted
1985
- 1985-03-01 ES ES540858A patent/ES8607304A1/es not_active Expired
1986
- 1986-12-11 YU YU2122/86A patent/YU43958B/xx unknown

Also Published As

Publication number	Publication date
FI78699B (fi)	1989-05-31
HUT34194A (en)	1985-02-28
EP0127412A2 (en)	1984-12-05
PT78625A (en)	1984-06-01
ES8607304A1 (es)	1986-06-01
FI78699C (fi)	1989-09-11
ATE57531T1 (de)	1990-11-15
EP0127412A3 (en)	1987-09-02
KR840009101A (ko)	1984-12-24
IL71904A0 (en)	1984-09-30
ES532736A0 (es)	1985-10-16
YU89784A (en)	1987-04-30
YU43931B (en)	1989-12-31
DK163924C (da)	1992-09-14
KR860001869B1 (ko)	1986-10-24
YU212286A (en)	1987-10-31
US4464380A (en)	1984-08-07
PL143290B1 (en)	1988-02-29
FI842079A0 (fi)	1984-05-24
PH21151A (en)	1987-07-30
JPS604183A (ja)	1985-01-10
DE3483402D1 (de)	1990-11-22
GR82020B (da)	1984-12-12
YU43958B (en)	1989-12-31
FI842079A (fi)	1984-11-26
ES540858A0 (es)	1986-06-01
IE57520B1 (en)	1993-05-19
DK163924B (da)	1992-04-21
CA1266270A (en)	1990-02-27
AU2856384A (en)	1984-11-29
PL252850A1 (en)	1985-11-19
IE841294L (en)	1984-11-25
AU543916B2 (en)	1985-05-09
HU190548B (en)	1986-09-29
JPH0573754B2 (da)	1993-10-15
DK250084A (da)	1984-11-26
PL247804A1 (en)	1985-08-13
EP0127412B1 (en)	1990-10-17
IL71904A (en)	1988-01-31
ES8600764A1 (es)	1985-10-16
PL143070B1 (en)	1988-01-30

Publication	Publication Date	Title
DK160460C (da)	1991-08-26	Insulinpraeparat til nasal eller rektal administration og anvendelse af et insulinderivat til fremstilling af praeparatet
AU3799789A (en)	1990-01-18	Novel benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
MY102038A (en)	1992-02-29	4-substituted androstendione derivatives and process for their preparation
IS3284A7 (is)	1988-05-22	Aðferð við framleiðslu á N1-súbstitúeruðum bensimidasólafleiðum til að nota við lækningar
DK56581A (da)	1981-08-13	Fremgangsmaade til fremstilling af aminosubstituerede spiro-hydantoin-forbindelser eller farmaceutisk acceptable salte deraf
ATE110071T1 (de)	1994-09-15	Pyridazinon-derivate und diese enthaltende pharmazeutische zubereitungen.
DK250084A (da)	1984-11-26	Spiro-(imidazolidin-4,3'-indolin)-2,2',5-trionforbindelser og farmaceutisk praeparat indeholdende disse til behandling af med diabetes forbundne kroniske komplikationer
AU7767287A (en)	1988-03-17	New imidazolylguanidine derivatives, processes for their preparation and medicaments containing these compounds
NO893909L (no)	1990-04-04	Fremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.
AU1176688A (en)	1988-08-18	Method of treatment comprising transcutaneous administration of prostaglandin E1 derivatives
MY103765A (en)	1993-09-30	Azolidinedione derivatives
IE800672L (en)	1980-10-04	Spiro-quinolone hydantoins
DK451184A (da)	1985-03-24	3-alkyl-7-halogen-2,3-dihydro-spiro(naphthalen-1(4h), 3'-pyrrolidin)-2',4,5'-trioner og farmaceutiske praeparater indeholdende disse
MY101896A (en)	1992-02-15	New tetracyclic indole derivatives
HUT44769A (en)	1988-04-28	Process for producing spiro/benzofuran-2(3h),1'-cycloheptane/ derivatives and pharmaceutical preparations comprising these compounds
UA7042A1 (uk)	1995-03-31	Спосіб одержання похідних імідазола або їх фізіологічно прийнятих солей
NO882279D0 (no)	1988-05-25	Fremgangsmaate for fremstilling av terapeutisk aktive endo-bicyklo (2,2,1) heptyl-adenosin-derivater.

Legal Events

Date	Code	Title	Description
1994-01-24	PBP	Patent lapsed