DK2439205T3 - Carboxamidforbindelser og deres anvendelse som calpaininhibitorer - Google Patents

Carboxamidforbindelser og deres anvendelse som calpaininhibitorer

Info

Publication number: DK2439205T3
Authority: DK; Denmark
Prior art keywords: carboxamide compounds; calpain inhibitors; calpain; inhibitors; carboxamide
Prior art date: 2006-12-29

Application number

DK11195099.4T

Other languages

English (en)

Inventor

Andreas Kling

Wilfried Hornberger

Helmut Mack

Achim Moeller

Volker Nimmrich

Dietmar Seemann

Wilfried Lubisch

Original Assignee

Abbvie Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-29

Filing date

2007-12-28

Publication date

2015-06-22

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39226751&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2439205(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-12-28 Application filed by Abbvie Deutschland filed Critical Abbvie Deutschland

2015-06-22 Application granted granted Critical

2015-06-22 Publication of DK2439205T3 publication Critical patent/DK2439205T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
AIDS & HIV (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK11195099.4T 2006-12-29 2007-12-28 Carboxamidforbindelser og deres anvendelse som calpaininhibitorer DK2439205T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06127369		2006-12-29
EP07866322A EP2121653B1 (en)	2006-12-29	2007-12-28	Carboxamide compounds and their use as calpain inhibitors

Publications (1)

Publication Number	Publication Date
DK2439205T3 true DK2439205T3 (da)	2015-06-22

Family

ID=39226751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK11195099.4T DK2439205T3 (da)	2006-12-29	2007-12-28	Carboxamidforbindelser og deres anvendelse som calpaininhibitorer

Country Status (29)

Country	Link
US (4)	US8436034B2 (da)
EP (2)	EP2121653B1 (da)
JP (1)	JP5295976B2 (da)
KR (3)	KR20150090282A (da)
CN (1)	CN101616908B (da)
AR (2)	AR064693A1 (da)
AT (1)	ATE544758T1 (da)
AU (1)	AU2007341232B2 (da)
BR (1)	BRPI0721298A2 (da)
CA (1)	CA2673580C (da)
CL (1)	CL2007003879A1 (da)
CO (1)	CO6190617A2 (da)
DK (1)	DK2439205T3 (da)
EC (1)	ECSP099476A (da)
ES (2)	ES2381879T3 (da)
GT (1)	GT200900186A (da)
HK (1)	HK1138833A1 (da)
IL (2)	IL199447A (da)
MX (1)	MX2009007050A (da)
MY (1)	MY147780A (da)
NZ (2)	NZ577719A (da)
PE (1)	PE20081609A1 (da)
PL (1)	PL2439205T3 (da)
PT (1)	PT2439205E (da)
RU (2)	RU2485114C2 (da)
TW (1)	TWI405571B (da)
UA (1)	UA100501C2 (da)
UY (1)	UY30850A1 (da)
WO (1)	WO2008080969A1 (da)

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US11180484B2 (en)	2016-05-31	2021-11-23	Kalvista Pharmaceuticals Limited	Pyrazole derivatives as plasma kallikrein inhibitors
GB201609607D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
EP3481835A4 (en)	2016-07-05	2020-02-26	Blade Therapeutics, Inc.	CALPAIN MODULATORS AND THEIR THERAPEUTIC USES
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BRPI0308208B8 (pt) *	2002-03-05	2021-05-25	Axys Pharm Inc	compostos inibidores de catepsina cisteína protease e composições farmacêuticas compreendendo os mesmos
EP1610263A1 (en)	2004-06-18	2005-12-28	Sicpa Holding S.A.	Item carrying at least two data storage elements
WO2006080439A1 (ja)	2005-01-28	2006-08-03	Taisho Pharmaceutical Co., Ltd.	三環性化合物
JP5295976B2 (ja) *	2006-12-29	2013-09-18	アボットゲーエムベーハーウントカンパニーカーゲー	カルボキサミド化合物およびカルパイン阻害剤としてのこれらの使用
TWI453019B (zh) *	2007-12-28	2014-09-21	Abbvie Deutschland	甲醯胺化合物

2007
- 2007-12-28 JP JP2009543479A patent/JP5295976B2/ja not_active Expired - Fee Related
- 2007-12-28 US US11/990,652 patent/US8436034B2/en active Active
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Also Published As

Publication number	Publication date
AR064693A1 (es)	2009-04-22
NZ577719A (en)	2012-06-29
EP2121653B1 (en)	2012-02-08
JP2010514738A (ja)	2010-05-06
ATE544758T1 (de)	2012-02-15
BRPI0721298A2 (pt)	2014-03-25
US7728012B2 (en)	2010-06-01
WO2008080969A1 (en)	2008-07-10
CL2007003879A1 (es)	2008-07-04
KR20150090281A (ko)	2015-08-05
ES2536626T3 (es)	2015-05-27
EP2121653A1 (en)	2009-11-25
EP2439205A1 (en)	2012-04-11
US8436034B2 (en)	2013-05-07
EP2439205B1 (en)	2015-03-11
TWI405571B (zh)	2013-08-21
PT2439205E (pt)	2015-07-16
AU2007341232B2 (en)	2013-01-31
RU2009129119A (ru)	2011-02-10
MY147780A (en)	2013-01-31
US20080234330A1 (en)	2008-09-25
NZ599860A (en)	2013-09-27
RU2485114C2 (ru)	2013-06-20
ECSP099476A (es)	2009-07-31
CA2673580C (en)	2015-11-24
CN101616908A (zh)	2009-12-30
ES2381879T3 (es)	2012-06-01
IL231463A0 (en)	2014-04-30
IL199447A (en)	2014-04-30
AU2007341232A1 (en)	2008-07-10
RU2013104459A (ru)	2014-08-10
UA100501C2 (uk)	2013-01-10
PE20081609A1 (es)	2008-11-12
MX2009007050A (es)	2009-09-23
UY30850A1 (es)	2008-07-31
CN101616908B (zh)	2014-09-10
GT200900186A (es)	2012-03-16
TW200845979A (en)	2008-12-01
US20100298326A1 (en)	2010-11-25
KR20090097205A (ko)	2009-09-15
PL2439205T3 (pl)	2015-08-31
CA2673580A1 (en)	2008-07-10
KR20150090282A (ko)	2015-08-05
JP5295976B2 (ja)	2013-09-18
CO6190617A2 (es)	2010-08-19
KR101578674B1 (ko)	2015-12-18
US9139557B2 (en)	2015-09-22
IL231463A (en)	2016-02-29
US20080234329A1 (en)	2008-09-25
US20130245003A1 (en)	2013-09-19
US7799809B2 (en)	2010-09-21
HK1138833A1 (en)	2010-09-03
AR077477A2 (es)	2011-08-31

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