DK2285765T3 - Fremgangsmåde til fremstilling af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre - Google Patents

Fremgangsmåde til fremstilling af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre

Info

Publication number: DK2285765T3
Authority: DK; Denmark
Prior art keywords: halobiphenyl; derivatives; preparation; carboxylic acid; cyclopropane carboxylic
Prior art date: 2008-06-11

Application number

DK09761360.8T

Other languages

English (en)

Inventor

Benoit Folleas

Hubert Botte

Thomas Delacroix

Fausto Pivetti

Original Assignee

Chiesi Farma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-11

Filing date

2009-05-08

Publication date

2012-06-04

2009-05-08 Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa

2012-06-04 Application granted granted Critical

2012-06-04 Publication of DK2285765T3 publication Critical patent/DK2285765T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK09761360.8T 2008-06-11 2009-05-08 Fremgangsmåde til fremstilling af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre DK2285765T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08158022A EP2133322A1 (en)	2008-06-11	2008-06-11	Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
PCT/EP2009/003288 WO2009149797A1 (en)	2008-06-11	2009-05-08	Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Publications (1)

Publication Number	Publication Date
DK2285765T3 true DK2285765T3 (da)	2012-06-04

Family

ID=40120119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK09761360.8T DK2285765T3 (da)	2008-06-11	2009-05-08	Fremgangsmåde til fremstilling af derivater af 1-(2-halobiphenyl-4-yl)-cyclopropancarboxylsyre

Country Status (28)

Country	Link
US (1)	US8076505B2 (da)
EP (2)	EP2133322A1 (da)
JP (1)	JP5642067B2 (da)
KR (1)	KR101257217B1 (da)
CN (1)	CN102046576B (da)
AT (1)	ATE552230T1 (da)
AU (1)	AU2009256959B2 (da)
BR (1)	BRPI0909560A2 (da)
CA (1)	CA2723878C (da)
CO (1)	CO6331461A2 (da)
DK (1)	DK2285765T3 (da)
ES (1)	ES2384368T3 (da)
GE (1)	GEP20135800B (da)
HK (1)	HK1152292A1 (da)
HR (1)	HRP20120517T1 (da)
IL (1)	IL209209A (da)
MA (1)	MA32297B1 (da)
ME (1)	ME01160B (da)
MX (1)	MX2010012285A (da)
MY (1)	MY150280A (da)
NZ (1)	NZ589087A (da)
PL (1)	PL2285765T3 (da)
PT (1)	PT2285765E (da)
RU (1)	RU2502721C2 (da)
SI (1)	SI2285765T1 (da)
UA (1)	UA101835C2 (da)
WO (1)	WO2009149797A1 (da)
ZA (1)	ZA201007977B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7662995B2 (en) *	2003-02-21	2010-02-16	Chiesi Farmaceutici S.P.A.	1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases
SG178239A1 (en) *	2009-08-04	2012-03-29	Chiesi Farma Spa	Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
CA2794940A1 (en) *	2010-04-01	2011-10-06	Chiesi Farmaceutici S.P.A.	Novel polymorphs and salts
CN102844290B (zh) *	2010-04-21	2015-06-17	奇斯药制品公司	用于治疗转甲状腺素蛋白淀粉样变性的1-(2-氟联苯-4-基)-烷基羧酸衍生物
EP2575797A1 (en)	2010-06-04	2013-04-10	Chiesi Farmaceutici S.p.A.	1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the therapy of prion diseases
US9592210B2 (en)	2011-12-22	2017-03-14	Chiesi Farmaceutici S.P.A.	1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
RU2014139971A (ru)	2012-04-04	2016-04-20	КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А.	Производные 1-(2-галогенобифенил-4-ил) алканкарбоновых кислот для лечения нейродегенеративных заболеваний
EP2818460A1 (en)	2013-06-24	2014-12-31	ZaCh System S.p.A.	Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
KR20160021772A (ko)	2013-06-24	2016-02-26	키에시 파르마슈티시 엣스. 피. 에이.	1-(2-플루오로［1,1′-비페닐］-4-일)-시클로프로판카복실산의 유도체의 개선된 제조 방법
US20150335596A1 (en)	2014-05-26	2015-11-26	Chiesi Farmaceutici S.P.A.	1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
CN107698462A (zh) *	2017-10-10	2018-02-16	重庆科脉生物化工有限公司	一种1‑氨基‑1‑环丙腈盐酸盐的制备方法
IL310956A (en)	2021-08-31	2024-04-01	Cerespir Incorporated	common crystal

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4507294B2 (ja) *	1999-05-27	2010-07-21	チッソ株式会社	ビアリール誘導体の製造方法
JP4502293B2 (ja) *	1999-06-04	2010-07-14	長瀬産業株式会社	軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用
JP2004091342A (ja) *	2002-08-29	2004-03-25	Matsushita Electric Ind Co Ltd	芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子
ITMI20030311A1 (it) *	2003-02-21	2004-08-22	Chiesi Farma Spa	Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
US7662995B2 (en) *	2003-02-21	2010-02-16	Chiesi Farmaceutici S.P.A.	1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases
EP1650183A1 (en) *	2004-10-21	2006-04-26	Cellzome Ag	(Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
US7524870B2 (en) *	2004-12-03	2009-04-28	Hoffmann-La Roche Inc.	Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
EP1893562A4 (en) *	2005-06-14	2010-04-28	Merck Frosst Canada Ltd	REVERSIBLE INHIBITORS OF MONOAMINES OXIDASES A AND B
JP5272345B2 (ja) *	2006-08-28	2013-08-28	東ソー株式会社	ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法
SG178239A1 (en) *	2009-08-04	2012-03-29	Chiesi Farma Spa	Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

2008
- 2008-06-11 EP EP08158022A patent/EP2133322A1/en not_active Withdrawn
2009
- 2009-05-08 PL PL09761360T patent/PL2285765T3/pl unknown
- 2009-05-08 UA UAA201013287A patent/UA101835C2/uk unknown
- 2009-05-08 NZ NZ589087A patent/NZ589087A/en not_active IP Right Cessation
- 2009-05-08 DK DK09761360.8T patent/DK2285765T3/da active
- 2009-05-08 CN CN2009801196647A patent/CN102046576B/zh not_active Expired - Fee Related
- 2009-05-08 MX MX2010012285A patent/MX2010012285A/es active IP Right Grant
- 2009-05-08 RU RU2010146299/04A patent/RU2502721C2/ru not_active IP Right Cessation
- 2009-05-08 GE GEAP200911997A patent/GEP20135800B/en unknown
- 2009-05-08 SI SI200930272T patent/SI2285765T1/sl unknown
- 2009-05-08 ES ES09761360T patent/ES2384368T3/es active Active
- 2009-05-08 WO PCT/EP2009/003288 patent/WO2009149797A1/en active Application Filing
- 2009-05-08 CA CA2723878A patent/CA2723878C/en active Active
- 2009-05-08 AT AT09761360T patent/ATE552230T1/de active
- 2009-05-08 MY MYPI2010005220A patent/MY150280A/en unknown
- 2009-05-08 JP JP2011512846A patent/JP5642067B2/ja not_active Expired - Fee Related
- 2009-05-08 BR BRPI0909560A patent/BRPI0909560A2/pt not_active IP Right Cessation
- 2009-05-08 KR KR1020107027903A patent/KR101257217B1/ko not_active IP Right Cessation
- 2009-05-08 AU AU2009256959A patent/AU2009256959B2/en not_active Ceased
- 2009-05-08 ME MEP-2010-200A patent/ME01160B/me unknown
- 2009-05-08 EP EP09761360A patent/EP2285765B1/en active Active
- 2009-05-08 PT PT09761360T patent/PT2285765E/pt unknown
- 2009-05-15 US US12/466,660 patent/US8076505B2/en active Active
2010
- 2010-11-08 ZA ZA2010/07977A patent/ZA201007977B/en unknown
- 2010-11-09 IL IL209209A patent/IL209209A/en not_active IP Right Cessation
- 2010-11-11 MA MA33338A patent/MA32297B1/fr unknown
- 2010-11-16 CO CO10143043A patent/CO6331461A2/es active IP Right Grant
2011
- 2011-06-21 HK HK11106325.0A patent/HK1152292A1/xx not_active IP Right Cessation
2012
- 2012-06-20 HR HRP20120517AT patent/HRP20120517T1/hr unknown

Also Published As

Publication number	Publication date
MY150280A (en)	2013-12-31
SI2285765T1 (sl)	2012-08-31
ES2384368T3 (es)	2012-07-04
JP5642067B2 (ja)	2014-12-17
US20090312426A1 (en)	2009-12-17
EP2285765B1 (en)	2012-04-04
HRP20120517T1 (hr)	2012-07-31
WO2009149797A1 (en)	2009-12-17
MX2010012285A (es)	2010-12-01
UA101835C2 (uk)	2013-05-13
US8076505B2 (en)	2011-12-13
NZ589087A (en)	2012-03-30
EP2285765A1 (en)	2011-02-23
PT2285765E (pt)	2012-06-21
CA2723878A1 (en)	2009-12-17
AU2009256959A1 (en)	2009-12-17
ZA201007977B (en)	2012-02-29
CN102046576B (zh)	2013-08-21
JP2011523953A (ja)	2011-08-25
CA2723878C (en)	2016-06-28
IL209209A (en)	2014-05-28
RU2502721C2 (ru)	2013-12-27
AU2009256959B2 (en)	2014-03-27
CN102046576A (zh)	2011-05-04
KR20110010633A (ko)	2011-02-01
IL209209A0 (en)	2011-01-31
ATE552230T1 (de)	2012-04-15
MA32297B1 (fr)	2011-05-02
PL2285765T3 (pl)	2012-08-31
KR101257217B1 (ko)	2013-04-22
ME01160B (me)	2013-03-20
BRPI0909560A2 (pt)	2015-09-22
CO6331461A2 (es)	2011-10-20
EP2133322A1 (en)	2009-12-16
GEP20135800B (en)	2013-04-10
RU2010146299A (ru)	2012-07-20
HK1152292A1 (en)	2012-02-24

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