DK223488A - N-(pyridinyl)-1h-indol-1-aminer, deres fremstilling og anvendelse - Google Patents
N-(pyridinyl)-1h-indol-1-aminer, deres fremstilling og anvendelseInfo
- Publication number
- DK223488A DK223488A DK223488A DK223488A DK223488A DK 223488 A DK223488 A DK 223488A DK 223488 A DK223488 A DK 223488A DK 223488 A DK223488 A DK 223488A DK 223488 A DK223488 A DK 223488A
- Authority
- DK
- Denmark
- Prior art keywords
- loweralkyl
- arylloweralkyl
- sec
- aryl
- halogen
- Prior art date
Links
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
- -1 hydroxy, nitro, amino Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000005239 aroylamino group Chemical group 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004802 cyanophenyl group Chemical group 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000006501 nitrophenyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4207987A | 1987-04-24 | 1987-04-24 | |
| US4207987 | 1987-04-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK223488D0 DK223488D0 (da) | 1988-04-22 |
| DK223488A true DK223488A (da) | 1988-10-25 |
| DK172153B1 DK172153B1 (da) | 1997-12-01 |
Family
ID=21919923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK223488A DK172153B1 (da) | 1987-04-24 | 1988-04-22 | N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0287982B1 (da) |
| JP (1) | JP2683360B2 (da) |
| KR (1) | KR960015003B1 (da) |
| AT (1) | ATE115143T1 (da) |
| AU (1) | AU594876B2 (da) |
| CA (1) | CA1330661C (da) |
| DE (1) | DE3852335T2 (da) |
| DK (1) | DK172153B1 (da) |
| ES (1) | ES2065324T3 (da) |
| FI (1) | FI90978C (da) |
| IE (1) | IE65349B1 (da) |
| IL (1) | IL86154A (da) |
| NO (1) | NO168104C (da) |
| NZ (1) | NZ224338A (da) |
| PH (1) | PH26127A (da) |
| PT (1) | PT87308B (da) |
| ZA (1) | ZA882810B (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| US5179099A (en) * | 1989-08-02 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Incorporated | 2,3-dihydro-1-(pyridinylamino)-indoles |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| US5179119A (en) * | 1989-08-02 | 1993-01-12 | Hoechst-Roussel Pharmaceuticals Incorporated | 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof |
| DK0415103T3 (da) * | 1989-08-02 | 1995-06-19 | Hoechst Roussel Pharma | 2,3-Dihydro-1-(pyridinylamino)-indoler, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler |
| US4983608A (en) | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
| US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
| US5356910A (en) | 1993-07-19 | 1994-10-18 | Hoechst-Roussel Pharmaceuticals Inc. | Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder |
| US5459274A (en) * | 1994-05-13 | 1995-10-17 | Hoechst-Roussel Pharmaceuticals Inc. | Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines |
| US5776955A (en) * | 1995-07-27 | 1998-07-07 | Hoechst Marion Roussel, Inc. | Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents |
| AU696007B2 (en) * | 1995-07-27 | 1998-08-27 | Aventis Pharmaceuticals Inc. | Use of unsubstituted and substituted N-(pyrrol-1-yl) pyridinamines as anticonvulsant agents |
| JP4256937B2 (ja) * | 1996-12-27 | 2009-04-22 | アベンティス・ファーマスーティカルズ・インコーポレイテッド | Ｎ−（ピリジニルアミノ）イソインドリン類および関連化合物 |
| JP4683166B2 (ja) * | 1999-03-10 | 2011-05-11 | 東ソー株式会社 | 含窒素複素環化合物の製造方法 |
| JP4779185B2 (ja) * | 1999-03-10 | 2011-09-28 | 東ソー株式会社 | 含窒素複素環化合物及びその製造方法 |
| DE60016068T2 (de) * | 1999-03-10 | 2005-11-03 | Tosoh Corp., Shinnanyo | Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen |
| GB0119435D0 (en) * | 2001-02-15 | 2001-10-03 | Aventis Pharm Prod Inc | Method of treating of demyelinating diseases or conditions |
| US7538227B2 (en) | 2004-01-13 | 2009-05-26 | Sanofi-Aventis Deutschland Gmbh | Process for stabilizing 4-halopyridines |
| GT200500063A (es) * | 2004-04-01 | 2005-10-14 | Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias | |
| FR2888238B1 (fr) * | 2005-07-07 | 2007-09-07 | Servier Lab | Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent. |
| FR2911780A1 (fr) * | 2007-01-26 | 2008-08-01 | Urogene | Traitement de l'incontinence fecale. |
| WO2008125207A1 (en) * | 2007-04-13 | 2008-10-23 | Sanofi-Aventis | A transition metal catalyzed synthesis of n-aminoindoles |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3242185A (en) * | 1963-10-07 | 1966-03-22 | Merck & Co Inc | Lower aliphatic acids, salts and derivatives thereof |
| DE1670184A1 (de) * | 1967-01-20 | 1971-01-21 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2) |
| CH603581A5 (da) * | 1974-03-29 | 1978-08-31 | Siegfried Ag | |
| US4260767A (en) * | 1979-12-26 | 1981-04-07 | American Cyanamid Company | 2-Pyridylhydrazides |
| US4792562A (en) * | 1985-12-04 | 1988-12-20 | Hoechst-Roussel Pharmaceuticals, Inc. | N-(pyrrol-1-yl)pyridinamines having memory enhancing activity |
-
1988
- 1988-04-18 EP EP88106121A patent/EP0287982B1/en not_active Expired - Lifetime
- 1988-04-18 AT AT88106121T patent/ATE115143T1/de not_active IP Right Cessation
- 1988-04-18 ES ES88106121T patent/ES2065324T3/es not_active Expired - Lifetime
- 1988-04-18 DE DE3852335T patent/DE3852335T2/de not_active Expired - Lifetime
- 1988-04-21 FI FI881874A patent/FI90978C/fi not_active IP Right Cessation
- 1988-04-21 ZA ZA882810A patent/ZA882810B/xx unknown
- 1988-04-22 IE IE121388A patent/IE65349B1/en not_active IP Right Cessation
- 1988-04-22 PT PT87308A patent/PT87308B/pt not_active IP Right Cessation
- 1988-04-22 JP JP63098467A patent/JP2683360B2/ja not_active Expired - Lifetime
- 1988-04-22 NZ NZ224338A patent/NZ224338A/en unknown
- 1988-04-22 AU AU15100/88A patent/AU594876B2/en not_active Expired
- 1988-04-22 CA CA000564923A patent/CA1330661C/en not_active Expired - Lifetime
- 1988-04-22 DK DK223488A patent/DK172153B1/da not_active IP Right Cessation
- 1988-04-22 IL IL86154A patent/IL86154A/xx not_active IP Right Cessation
- 1988-04-22 NO NO881776A patent/NO168104C/no not_active IP Right Cessation
- 1988-04-22 PH PH36833A patent/PH26127A/en unknown
- 1988-04-23 KR KR1019880004605A patent/KR960015003B1/ko not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2065324T3 (es) | 1995-02-16 |
| PH26127A (en) | 1992-02-24 |
| ZA882810B (en) | 1988-10-20 |
| DE3852335D1 (de) | 1995-01-19 |
| EP0287982B1 (en) | 1994-12-07 |
| FI90978C (fi) | 1994-04-25 |
| KR960015003B1 (ko) | 1996-10-23 |
| KR880012591A (ko) | 1988-11-28 |
| FI881874A7 (fi) | 1988-10-25 |
| IL86154A0 (en) | 1988-11-15 |
| NZ224338A (en) | 1991-07-26 |
| PT87308A (pt) | 1988-05-01 |
| JPS63280079A (ja) | 1988-11-17 |
| ATE115143T1 (de) | 1994-12-15 |
| AU594876B2 (en) | 1990-03-15 |
| JP2683360B2 (ja) | 1997-11-26 |
| CA1330661C (en) | 1994-07-12 |
| IL86154A (en) | 1992-03-29 |
| NO168104C (no) | 1992-01-15 |
| FI881874A0 (fi) | 1988-04-21 |
| DE3852335T2 (de) | 1995-05-11 |
| PT87308B (pt) | 1992-08-31 |
| DK223488D0 (da) | 1988-04-22 |
| EP0287982A3 (en) | 1991-03-27 |
| FI90978B (fi) | 1994-01-14 |
| AU1510088A (en) | 1988-10-27 |
| NO881776D0 (no) | 1988-04-22 |
| EP0287982A2 (en) | 1988-10-26 |
| IE65349B1 (en) | 1995-10-18 |
| DK172153B1 (da) | 1997-12-01 |
| NO168104B (no) | 1991-10-07 |
| IE881213L (en) | 1988-10-24 |
| NO881776L (no) | 1988-10-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK223488A (da) | N-(pyridinyl)-1h-indol-1-aminer, deres fremstilling og anvendelse | |
| CS260191A3 (en) | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -oles, process of their preparation and their application as medicaments | |
| AU8121691A (en) | 1-(substituted pyridinylamino)-1h-indole-5-yl substituted carbamates, a process and intermediates for their preparation and their use as medicaments | |
| NO933772D0 (no) | Substituerte (pyridinylamino)-benzisoksazoler og -benzo(b)-tiofener, en fremgangsmaate for fremstilling og deres anvendelse som medikamenter | |
| IL85401A0 (en) | 9-amino-1,4-ethano-1,2,3,4-tetra-hydroacridine and related compounds,process for their preparation and pharmaceutical compositions containing same | |
| DK0471296T3 (da) | 1-(Pyridinylalkyl)-1H-indoler, -indoliner og beslægtede analoge | |
| DK0471298T3 (da) | Carbamoyl-1-(pyridinylalkyl)-1H-indoler, -indoliner og belægtede forbindelser |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |