DK2121691T3 - Spirocykliske cyklohexanderivater - Google Patents

Spirocykliske cyklohexanderivater

Info

Publication number: DK2121691T3
Authority: DK; Denmark
Prior art keywords: spirocyclic cyclohexane; cyclohexane compounds; cyclohexane derivatives; spirocyclic; compounds
Prior art date: 2007-02-22

Application number

DK08715856.4T

Other languages

English (en)

Inventor

Stefan Schunk

Derek Saunders

Stephanie Harlfinger

Sonja Steufmehl

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-22

Filing date

2008-02-19

Publication date

2012-07-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39531427&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2121691(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-02-19 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2012-07-02 Application granted granted Critical

2012-07-02 Publication of DK2121691T3 publication Critical patent/DK2121691T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Obesity (AREA)
Dermatology (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

DK08715856.4T 2007-02-22 2008-02-19 Spirocykliske cyklohexanderivater DK2121691T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102007009319A DE102007009319A1 (de)	2007-02-22	2007-02-22	Spirocyclische Cyclohexan-Derivate
PCT/EP2008/001271 WO2008101660A1 (de)	2007-02-22	2008-02-19	Spirocyclische cyclohexan-derivate

Publications (1)

Publication Number	Publication Date
DK2121691T3 true DK2121691T3 (da)	2012-07-02

Family

ID=39531427

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08715856.4T DK2121691T3 (da)	2007-02-22	2008-02-19	Spirocykliske cyklohexanderivater

Country Status (26)

Country	Link
US (1)	US7960404B2 (da)
EP (1)	EP2121691B1 (da)
JP (1)	JP5514556B2 (da)
KR (1)	KR101517748B1 (da)
CN (1)	CN101622256B (da)
AT (1)	ATE554089T1 (da)
AU (1)	AU2008217277B2 (da)
BR (1)	BRPI0806794A2 (da)
CA (1)	CA2679173C (da)
CO (1)	CO6220948A2 (da)
CY (1)	CY1112725T1 (da)
DE (1)	DE102007009319A1 (da)
DK (1)	DK2121691T3 (da)
EC (1)	ECSP099621A (da)
ES (1)	ES2386387T3 (da)
HK (1)	HK1136827A1 (da)
HR (1)	HRP20120511T1 (da)
IL (1)	IL200496A (da)
MX (1)	MX2009007387A (da)
NZ (1)	NZ578589A (da)
PL (1)	PL2121691T3 (da)
PT (1)	PT2121691E (da)
RU (1)	RU2470933C2 (da)
SI (1)	SI2121691T1 (da)
WO (1)	WO2008101660A1 (da)
ZA (1)	ZA200906584B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006033114A1 (de) *	2006-07-18	2008-01-24	Grünenthal GmbH	Spirocyclische Azaindol-Derivate
NZ586120A (en)	2008-01-11	2012-07-27	Albany Molecular Res Inc	(1-azinone) -substituted pyridoindoles as mch antagonists
CN103183630A (zh)	2008-03-27	2013-07-03	格吕伦塔尔有限公司	取代的4-氨基环己烷衍生物
CL2009000732A1 (es)	2008-03-27	2009-05-15	Gruenethal Gmbh	Compuestos derivados de hidroximetil ciclohexilaminas sustituidos; composicion farmaceutica que contiene a dicho compuesto y sus uso como moduladores del receptor de opiodes u y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso del alcohol, hipertension, anorexia, obesidad y diarrea.
RU2497824C2 (ru)	2008-03-27	2013-11-10	Грюненталь Гмбх	Производные замещенного спироциклического циклогексана
AU2009228648B2 (en)	2008-03-27	2013-07-11	Grunenthal Gmbh	Substituted cyclohexyldiamines
PL2257526T3 (pl)	2008-03-27	2012-05-31	Gruenenthal Gmbh	Pochodne spiro (5.5) undekanu
WO2011003021A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
EP2448585B1 (en)	2009-07-01	2014-01-01	Albany Molecular Research, Inc.	Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2011003012A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof
US8658827B2 (en)	2010-12-08	2014-02-25	Gruenenthal Gmbh	Method for synthesizing substituted aminocyclohexanone compounds
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
SI2797925T1 (sl) *	2011-12-12	2016-07-29	Gruenenthal Gmbh	Postopek za pripravo (1r,4r)-6'-fluoro(N,N-dimetil- in N-metil)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano-(3,4,b) indol)-4-amina
ES2658193T3 (es)	2013-03-15	2018-03-08	Grünenthal GmbH	Cis-(E)-4-(3-fluorofenil)-2',3',4',9'-tetrahidro-N,N-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclohexano-1,1'[1H]-pirido[3,4-b]indol]-4-amina cristalina
TW201607923A (zh)	2014-07-15	2016-03-01	歌林達有限公司	被取代之氮螺環（４．５）癸烷衍生物
CA2955071A1 (en)	2014-07-15	2016-01-21	Grunenthal Gmbh	Substituted azaspiro(4.5)decane derivatives
DK3247352T3 (da) *	2015-01-23	2020-09-07	Gruenenthal Gmbh	Cebranopadol til behandling af smerter hos individer med forringet lever- og/eller forringet nyrefunktion
CN107383027A (zh) *	2017-07-24	2017-11-24	扬州大学	一种四氢螺类化合物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2426730C2 (ru) *	2001-04-18	2011-08-20	Эро-Селтик, С.А.	Аналоги ноцицептина
DE10252667A1 (de)	2002-11-11	2004-05-27	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) *	2003-12-23	2005-07-28	Grünenthal GmbH	Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de)	2005-04-11	2006-10-19	Grünenthal GmbH	Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102006046745A1 (de)	2006-09-29	2008-04-03	Grünenthal GmbH	Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz

2007
- 2007-02-22 DE DE102007009319A patent/DE102007009319A1/de not_active Withdrawn
2008
- 2008-02-19 DK DK08715856.4T patent/DK2121691T3/da active
- 2008-02-19 SI SI200830635T patent/SI2121691T1/sl unknown
- 2008-02-19 ES ES08715856T patent/ES2386387T3/es active Active
- 2008-02-19 MX MX2009007387A patent/MX2009007387A/es active IP Right Grant
- 2008-02-19 AT AT08715856T patent/ATE554089T1/de active
- 2008-02-19 RU RU2009135070/04A patent/RU2470933C2/ru not_active IP Right Cessation
- 2008-02-19 NZ NZ578589A patent/NZ578589A/en not_active IP Right Cessation
- 2008-02-19 CN CN200880006055.6A patent/CN101622256B/zh not_active Expired - Fee Related
- 2008-02-19 AU AU2008217277A patent/AU2008217277B2/en not_active Ceased
- 2008-02-19 PL PL08715856T patent/PL2121691T3/pl unknown
- 2008-02-19 BR BRPI0806794-5A patent/BRPI0806794A2/pt not_active IP Right Cessation
- 2008-02-19 KR KR1020097019738A patent/KR101517748B1/ko not_active Expired - Fee Related
- 2008-02-19 WO PCT/EP2008/001271 patent/WO2008101660A1/de active Application Filing
- 2008-02-19 PT PT08715856T patent/PT2121691E/pt unknown
- 2008-02-19 EP EP08715856A patent/EP2121691B1/de not_active Not-in-force
- 2008-02-19 JP JP2009550672A patent/JP5514556B2/ja not_active Expired - Fee Related
- 2008-02-19 CA CA2679173A patent/CA2679173C/en not_active Expired - Fee Related
2009
- 2009-08-19 CO CO09086728A patent/CO6220948A2/es active IP Right Grant
- 2009-08-20 IL IL200496A patent/IL200496A/en active IP Right Grant
- 2009-08-21 US US12/545,261 patent/US7960404B2/en not_active Expired - Fee Related
- 2009-09-09 EC EC2009009621A patent/ECSP099621A/es unknown
- 2009-09-21 ZA ZA200906584A patent/ZA200906584B/xx unknown
2010
- 2010-04-13 HK HK10103563.9A patent/HK1136827A1/xx not_active IP Right Cessation
2012
- 2012-05-11 CY CY20121100445T patent/CY1112725T1/el unknown
- 2012-06-19 HR HRP20120511AT patent/HRP20120511T1/hr unknown

Also Published As

Publication number	Publication date
WO2008101660A1 (de)	2008-08-28
AU2008217277A1 (en)	2008-08-28
ATE554089T1 (de)	2012-05-15
CY1112725T1 (el)	2016-02-10
IL200496A0 (en)	2010-04-29
DE102007009319A1 (de)	2008-08-28
IL200496A (en)	2014-02-27
BRPI0806794A2 (pt)	2011-09-13
RU2470933C2 (ru)	2012-12-27
AU2008217277B2 (en)	2012-09-06
JP2010519265A (ja)	2010-06-03
ZA200906584B (en)	2010-06-30
MX2009007387A (es)	2009-07-17
NZ578589A (en)	2012-02-24
EP2121691A1 (de)	2009-11-25
KR20090114470A (ko)	2009-11-03
ES2386387T3 (es)	2012-08-20
CA2679173C (en)	2015-11-24
ECSP099621A (es)	2009-10-30
CN101622256A (zh)	2010-01-06
SI2121691T1 (sl)	2012-06-29
RU2009135070A (ru)	2011-03-27
PL2121691T3 (pl)	2012-09-28
PT2121691E (pt)	2012-05-25
EP2121691B1 (de)	2012-04-18
CO6220948A2 (es)	2010-11-19
HK1136827A1 (en)	2010-07-09
CA2679173A1 (en)	2008-08-28
CN101622256B (zh)	2015-07-22
US20100048553A1 (en)	2010-02-25
HRP20120511T1 (hr)	2012-07-31
US7960404B2 (en)	2011-06-14
KR101517748B1 (ko)	2015-05-06
JP5514556B2 (ja)	2014-06-04

Publication	Publication Date	Title
DK2121691T3 (da)	2012-07-02	Spirocykliske cyklohexanderivater
PL2150530T3 (pl)	2012-03-30	Podstawione pochodne sulfonamidu
MY149731A (en)	2013-10-14	Compounds
EA201390381A1 (ru)	2013-08-30	Триазиноксадиазолы
EA200971143A1 (ru)	2010-06-30	Бензамидные mglur5 позитивные аллостерические модуляторы и способы их получения и применения
CY1108794T1 (el)	2014-04-09	Σπειροκυκλικα παραγωγα κυκλοεξανιου
EA200900023A1 (ru)	2009-06-30	Применение замещенных 2-аминотетралинов для изготовления лекарственного средства для предупреждения, облегчения и/или лечения разных видов боли
HK1136828A1 (en)	2010-07-09	Spirocyclic cyclohexane derivatives
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