DK2099826T3 - Anti-beta-amyloid-antistof og anvendelser deraf - Google Patents
Anti-beta-amyloid-antistof og anvendelser derafInfo
- Publication number
- DK2099826T3 DK2099826T3 DK08700998.1T DK08700998T DK2099826T3 DK 2099826 T3 DK2099826 T3 DK 2099826T3 DK 08700998 T DK08700998 T DK 08700998T DK 2099826 T3 DK2099826 T3 DK 2099826T3
- Authority
- DK
- Denmark
- Prior art keywords
- applications
- beta amyloid
- amyloid antibody
- antibody
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87883107P | 2007-01-05 | 2007-01-05 | |
| EP07000211 | 2007-01-05 | ||
| US93429107P | 2007-06-11 | 2007-06-11 | |
| EP07020341 | 2007-10-17 | ||
| PCT/EP2008/000053 WO2008081008A1 (en) | 2007-01-05 | 2008-01-07 | Method of providing disease-specific binding molecules and targets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2099826T3 true DK2099826T3 (da) | 2014-01-20 |
Family
ID=39186163
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08700998.1T DK2099826T3 (da) | 2007-01-05 | 2008-01-07 | Anti-beta-amyloid-antistof og anvendelser deraf |
| DK11185486.5T DK2436696T3 (da) | 2007-01-05 | 2008-01-07 | Anti-beta-amyloid-antistof og anvendelser deraf |
| DK11184418.9T DK2426143T3 (da) | 2007-01-05 | 2008-01-07 | Fremgangsmåde til tilvejebringelse af sygdomsspecifikke bindingsmolekyler og mål |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11185486.5T DK2436696T3 (da) | 2007-01-05 | 2008-01-07 | Anti-beta-amyloid-antistof og anvendelser deraf |
| DK11184418.9T DK2426143T3 (da) | 2007-01-05 | 2008-01-07 | Fremgangsmåde til tilvejebringelse af sygdomsspecifikke bindingsmolekyler og mål |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8906367B2 (da) |
| EP (5) | EP3239175A1 (da) |
| JP (1) | JP5398545B2 (da) |
| KR (4) | KR20090114388A (da) |
| CN (3) | CN103408661B (da) |
| AU (1) | AU2008203703C1 (da) |
| BR (1) | BRPI0806328B8 (da) |
| CA (2) | CA2674140C (da) |
| CY (1) | CY1119197T1 (da) |
| DK (3) | DK2099826T3 (da) |
| EA (2) | EA017611B1 (da) |
| ES (3) | ES2641897T3 (da) |
| HU (2) | HUE034512T2 (da) |
| LT (1) | LT2436696T (da) |
| MX (1) | MX2009007136A (da) |
| PL (3) | PL2436696T3 (da) |
| PT (3) | PT2099826E (da) |
| SG (1) | SG177954A1 (da) |
| SI (2) | SI2099826T1 (da) |
| WO (1) | WO2008081008A1 (da) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2099826T3 (da) * | 2007-01-05 | 2014-01-20 | Univ Zuerich | Anti-beta-amyloid-antistof og anvendelser deraf |
| HRP20140049T1 (hr) | 2007-01-05 | 2014-02-28 | University Of Zürich | Anti beta-amiloid antitijela i njihova upotreba |
| PT2457928T (pt) | 2007-03-13 | 2017-08-17 | Univ Zuerich | Anticorpo monoclonal humano específico de tumores |
| WO2010004434A2 (en) * | 2008-07-09 | 2010-01-14 | University Of Zurich | Method of promoting neurogenesis |
| EP2186827A1 (en) | 2008-11-14 | 2010-05-19 | HS LifeSciences Ltd. | Surrogate marker directed cDNA cloning of selectively induced mRNAs |
| AU2009328505B2 (en) | 2008-12-19 | 2014-11-27 | Panima Pharmaceuticals Ag | Human anti-alpha-synuclein autoantibodies |
| FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| EP2609211A1 (en) | 2010-08-27 | 2013-07-03 | University of Zurich | A novel diagnostic and therapeutic target in inflammatory and/or cardiovascular diseases |
| US9034333B2 (en) | 2010-08-27 | 2015-05-19 | University Of Zurich | Method for target and drug validation in inflammatory and/or cardiovascular diseases |
| LT2627672T (lt) | 2010-10-11 | 2018-12-10 | Biogen International Neuroscience Gmbh | Žmogaus antikūnai prieš tau baltymą |
| TWI761912B (zh) | 2010-11-30 | 2022-04-21 | 日商中外製藥股份有限公司 | 具有鈣依存性的抗原結合能力之抗體 |
| CA2818781C (en) | 2010-12-17 | 2019-10-08 | Neurimmune Holding Ag | Human anti-sod1 antibodies |
| US20140044644A1 (en) | 2011-02-21 | 2014-02-13 | University Of Zurich | Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders |
| AU2012233313C1 (en) | 2011-03-30 | 2017-08-03 | Chugai Seiyaku Kabushiki Kaisha | Method for altering plasma retention and immunogenicity of antigen-binding molecule |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| EA030777B9 (ru) | 2011-06-23 | 2019-02-28 | Байоджен Интернэшнл Нейросайенз Гмбх | Анти-альфа-синуклеинсвязывающие молекулы |
| TW201945034A (zh) | 2011-09-30 | 2019-12-01 | 日商中外製藥股份有限公司 | 包含依離子濃度之條件對抗原之結合活性會改變之抗原結合分域、及於pH中性之條件下對FcRn有結合活性之FcRn結合分域、且誘導對標的抗原的免疫反應之抗原結合分子 |
| TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
| CN110639014A (zh) | 2011-09-30 | 2020-01-03 | 中外制药株式会社 | 促进抗原消除的抗原结合分子 |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| US20150299313A1 (en) | 2011-10-05 | 2015-10-22 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting clearance from plasma of antigen comprising suger chain receptor-binding domain |
| WO2013055922A1 (en) * | 2011-10-11 | 2013-04-18 | Vaccinex, Inc. | Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability |
| EP2771030A4 (en) * | 2011-10-24 | 2015-07-22 | Intellect Neurosciences Inc | COMPOSITIONS AND METHOD FOR THE TREATMENT OF PROTEINOPATHIES |
| CA2853412C (en) * | 2011-10-28 | 2021-05-04 | University Of Zurich | Tdp-43 specific binding molecules |
| BR112014010664A2 (pt) | 2011-11-02 | 2017-04-25 | Biogen Idec Int Neuroscience Gmbh | uso de um anticorpo anti-alfa-sinucleína para diagnosticar um nível elevado de alfa-sinucleína no cérebro |
| JP6124800B2 (ja) | 2011-11-30 | 2017-05-10 | 中外製薬株式会社 | 免疫複合体を形成する細胞内への運搬体(キャリア)を含む医薬 |
| DE102011057019A1 (de) * | 2011-12-23 | 2013-06-27 | Forschungszentrum Jülich GmbH | Standard zur Quantifizierung von pathogenen Aggregaten aus körpereigenen Proteinen |
| TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
| US10131709B2 (en) | 2011-12-28 | 2018-11-20 | Immunoqure Ag | Nucleic acid molecules encoding monoclonal antibodies specific for IL-22 |
| US9957319B2 (en) | 2011-12-28 | 2018-05-01 | Immunoqure Ag | Method of isolating human antibodies |
| CN108517010A (zh) * | 2012-01-27 | 2018-09-11 | 普罗典娜生物科学有限公司 | 识别α-突触核蛋白的人源化抗体 |
| EP2813568B1 (en) | 2012-02-09 | 2025-04-23 | Chugai Seiyaku Kabushiki Kaisha | Modified fc region of antibody |
| TWI617577B (zh) | 2012-02-24 | 2018-03-11 | 中外製藥股份有限公司 | 經FcγRIIB促進抗原消失之抗原結合分子 |
| CA2874721A1 (en) | 2012-05-30 | 2013-12-05 | Tomoyuki Igawa | Target tissue-specific antigen-binding molecule |
| ES2856272T3 (es) | 2012-05-30 | 2021-09-27 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígenos para eliminar antígenos agregados |
| EP2928494A4 (en) * | 2012-12-07 | 2016-11-02 | Biogen Internat Neuroscience Gmbh | METHOD FOR REDUCING AMYLOIDER PLAQUE OF BRAIN WITH ANTI-ASS ANTIBODIES |
| EP3792278A3 (en) | 2012-12-21 | 2021-05-26 | Biogen MA Inc. | Human anti-tau antibodies |
| EP2970378B1 (en) | 2013-03-15 | 2021-05-26 | Biogen MA Inc. | Hydrophobic interaction protein chromatography under no-salt conditions |
| MX2015017852A (es) | 2013-06-24 | 2016-08-11 | Chugai Pharmaceutical Co Ltd | Agente terapeutico que comprende el anticuerpo anti-epirregulina humanizado con ingrediente activo contra el carcinoma de pulmon de celulas no pequeñas excluyendo el adenocarcinoma. |
| JP6389880B2 (ja) * | 2013-07-03 | 2018-09-12 | ソウル大学校産学協力団Seoul National University R&Db Foundation | システインで変形された鶏の抗体およびこれを用いた部位特異的接合 |
| EP3019629A4 (en) * | 2013-07-12 | 2017-01-18 | Biogen International Neuroscience GmbH | Genetic and image biomarkers associated with decline in cognitive measures and brain glucose metabolism in populations with alzheimer's disease or those susceptible to developing alzheimer's disease |
| US20160229922A1 (en) | 2013-09-20 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Treatment for hemorrhagic diseases by anti-protein-c antibody |
| RU2718990C1 (ru) * | 2013-11-21 | 2020-04-15 | Ф. Хоффманн-Ля Рош Аг | Антитела к альфа-синуклеину и способы применения |
| BR112016012094A2 (pt) | 2013-12-04 | 2017-09-26 | Chugai Pharmaceutical Co Ltd | moléculas de ligação a antígeno, cuja atividade de ligação a antígeno varia de acordo com a concentração de compostos e bibliotecas das ditas moléculas |
| RS60774B1 (sr) * | 2013-12-20 | 2020-10-30 | Neurimmune Holding Ag | Lečenje transtiretinske (ttr) amiloidoze na bazi antitela i odgovarajuća antitela humanog porekla |
| ZA201608812B (en) * | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
| JP6641305B2 (ja) * | 2014-06-26 | 2020-02-05 | ヤンセン ファッシンズ アンド プリベンション ベーフェーJanssen Vaccines & Prevention B.V. | 微小管結合タンパク質タウに特異的に結合する抗体及び抗原結合断片 |
| AU2015295441B2 (en) * | 2014-07-29 | 2020-05-14 | Neurimmune Holding Ag | Human-derived anti-huntingtin (HTT) antibodies and uses thereof |
| BR112017006598A2 (en) | 2014-09-30 | 2018-04-17 | Neurimmune Holding Ag | human derived antidipeptide repeat antibody (dprs) |
| MA41115A (fr) | 2014-12-02 | 2017-10-10 | Biogen Int Neuroscience Gmbh | Procédé de traitement de la maladie d'alzheimer |
| CA2987730C (en) | 2015-04-08 | 2020-02-18 | Nantomics, Llc | Cancer neoepitopes |
| CA2988388C (en) | 2015-04-23 | 2022-11-22 | Nantomics, Llc | Cancer neoepitopes |
| WO2017066290A1 (en) | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Viral neoepitopes and uses thereof |
| WO2017066357A1 (en) | 2015-10-12 | 2017-04-20 | Nantomics, Llc | Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors |
| DK3430397T3 (da) | 2016-03-14 | 2022-05-02 | Biogen Int Neuroscience Gmbh | Antistofafhængig cellemedieret fagocytoseassay til pålidelig måling af optagelse af aggregerede proteiner |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| EP3448874A4 (en) | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| US10906964B2 (en) | 2016-05-02 | 2021-02-02 | Prothena Biosciences Limited | Antibodies recognizing tau |
| UA124148C2 (uk) | 2016-05-02 | 2021-07-28 | Протена Біосайенсіс Лімітед | Антитіла, що розпізнають тау |
| AU2017276656A1 (en) | 2016-06-07 | 2018-12-13 | Biogen International Neuroscience Gmbh | Methods for treating alzheimer's disease |
| KR20230109776A (ko) * | 2016-06-29 | 2023-07-20 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 알파-시누클레인 응집의 구조-기반 펩타이드 저해제 |
| JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag | 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用 |
| EP3487880A1 (en) | 2016-07-25 | 2019-05-29 | Biogen MA Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
| US10662226B2 (en) | 2016-10-28 | 2020-05-26 | The Regents of the University of Caiifomia | Synthetic beta-amyloid peptides capable of forming stable antigenic oligomers |
| MA47163A (fr) | 2016-12-16 | 2019-11-06 | Biogen Ma Inc | Facteur 11 de différenciation de croissance activé protéolytiquement stabilisé |
| AU2018221049A1 (en) | 2017-02-17 | 2019-09-19 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
| KR101989383B1 (ko) * | 2017-04-04 | 2019-06-14 | 조선대학교산학협력단 | 알츠하이머성 치매의 조기진단을 위한 펩타이드 프로브 |
| MX2019013045A (es) | 2017-05-02 | 2020-02-12 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau. |
| CN109201128A (zh) * | 2017-07-05 | 2019-01-15 | 京东方科技集团股份有限公司 | 微流控芯片、化学发光免疫分析系统和分析方法 |
| PL3672631T3 (pl) * | 2017-08-22 | 2023-06-26 | Biogen Ma Inc. | Kompozycje farmaceutyczne zawierające przeciwciała przeciw beta-amyloidowi |
| CN108484761B (zh) * | 2018-03-10 | 2021-04-30 | 吉林大学 | 一种特异性识别并诱导Aβ42的寡聚体及原纤维解聚的单链抗体、单链抗体基因及其应用 |
| CN108874749B (zh) * | 2018-06-22 | 2022-10-14 | 西南科技大学 | 一种高考志愿录取概率模型的建立方法 |
| EP3819311A4 (en) | 2018-07-17 | 2022-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | ANTI-ABETA ANTIBODIES, ANTIGEN-BINDING FRAGMENT THEREOF AND USE THEREOF |
| US12259395B2 (en) | 2018-08-17 | 2025-03-25 | Ab Studio Inc. | Catabodies and methods of use thereof |
| IL281979B2 (en) * | 2018-10-04 | 2025-09-01 | Georg August Universit?T G?Ttingen Stiftung ?Ffentlichen Rechts Universit?Tsmedizin | Human antibodies that bind amyloid peptides |
| AU2019371814A1 (en) | 2018-10-29 | 2021-06-17 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
| CN111518205B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| CN111518207B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| CN111518206B (zh) * | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| KR102135130B1 (ko) * | 2019-02-15 | 2020-07-17 | 충북대학교 산학협력단 | 트랜스타이레틴 단백질에 특이적으로 결합하는 dna 앱타머 및 이의 용도 |
| CN113544149B (zh) | 2019-03-03 | 2024-11-15 | 普罗塞纳生物科学有限公司 | 识别tau的抗体 |
| US11851487B2 (en) * | 2019-04-01 | 2023-12-26 | Rensselaer Polytechnic Institute | Methods and systems for detecting peptide aggregates |
| CA3158513A1 (en) | 2019-10-22 | 2021-04-29 | Biogen Ma Inc. | Methods for treating alzheimer's disease |
| IL292385A (en) | 2019-10-24 | 2022-06-01 | Novago Therapeutics Ag | New anti-nogo-a antibodies |
| EP4069295A4 (en) * | 2019-12-03 | 2024-02-14 | The University of Queensland | TREATMENT OF NEURODEGENERATIVE DISEASES USING ULTRASOUND AND ANTI-AMYLOID BETA ANTIBODIES |
| KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
| WO2021168274A1 (en) | 2020-02-21 | 2021-08-26 | Silverback Therapeutics, Inc. | Nectin-4 antibody conjugates and uses thereof |
| EP4153210A4 (en) | 2020-05-19 | 2024-11-13 | Othair Prothena Limited | MULTIPLE EPITOPE VACCINES FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| US20230242624A1 (en) | 2020-06-02 | 2023-08-03 | Neurimmune Ag | HUMAN ANTIBODIES AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS-2 (SARS-CoV-2) |
| CN116249717A (zh) | 2020-06-24 | 2023-06-09 | 普罗塞纳生物科学有限公司 | 识别分拣蛋白的抗体 |
| IL299508A (en) | 2020-07-01 | 2023-02-01 | Ars Pharmaceuticals Inc | Anti-asgr1 antibody conjugates and uses thereof |
| CN116348487A (zh) | 2020-07-23 | 2023-06-27 | 欧萨尔普罗席纳有限公司 | 抗淀粉样β抗体 |
| JP2023536995A (ja) | 2020-08-07 | 2023-08-30 | オター プロシーナ リミテッド | アルツハイマー病を処置するためのマルチエピトープワクチン |
| CN114252607A (zh) * | 2020-09-24 | 2022-03-29 | 首都医科大学附属北京世纪坛医院 | 尿液v-atpase亚基s1及其多肽片段在过敏性疾病中的应用 |
| CN114252628A (zh) * | 2020-09-24 | 2022-03-29 | 首都医科大学附属北京世纪坛医院 | 尿液再生蛋白及其多肽片段在过敏性疾病中的应用 |
| EP4271708A1 (en) | 2020-12-29 | 2023-11-08 | Neurimmune AG | Human anti-tau antibodies |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| KR20240028975A (ko) * | 2021-04-08 | 2024-03-05 | 사나 바이오테크놀로지, 인크. | Cd8-특이적 항체 구조체들 및 이의 조성물 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| IL309208A (en) | 2021-06-11 | 2024-02-01 | Sage Therapeutics Inc | Neuroactive steroid for the treatment of alzheimer's disease |
| CA3239708A1 (en) | 2021-12-03 | 2023-06-08 | Aubin MICHALON | Novel potency assay for antibody-based drugs and useful means therefor |
| CN117586388A (zh) * | 2022-08-09 | 2024-02-23 | 深圳智源生物医药有限公司 | 改进的β淀粉样蛋白寡聚体特异性结合抗体 |
| CN117157527A (zh) * | 2023-02-28 | 2023-12-01 | 湖南乾康科技有限公司 | 一种用于定量检测尿液淀粉样前体蛋白片段的酶联免疫检测方法 |
| TW202508603A (zh) | 2023-05-02 | 2025-03-01 | 美商賽吉醫療公司 | 神經活性類固醇調配物及其使用方法 |
| WO2025064824A1 (en) | 2023-09-22 | 2025-03-27 | Biogen Ma Inc. | Methods for treating alzheimer's disease |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
| US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US4694778A (en) | 1984-05-04 | 1987-09-22 | Anicon, Inc. | Chemical vapor deposition wafer boat |
| WO1986005807A1 (en) | 1985-04-01 | 1986-10-09 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| ATE120761T1 (de) | 1987-05-21 | 1995-04-15 | Creative Biomolecules Inc | Multifunktionelle proteine mit vorbestimmter zielsetzung. |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| AU631545B2 (en) | 1988-04-15 | 1992-12-03 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
| ATE120454T1 (de) | 1988-06-14 | 1995-04-15 | Cetus Oncology Corp | Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus. |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| IE63847B1 (en) | 1989-05-05 | 1995-06-14 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DK0463151T3 (da) | 1990-01-12 | 1996-07-01 | Cell Genesys Inc | Frembringelse af xenogene antistoffer |
| US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
| AU654811B2 (en) | 1990-03-20 | 1994-11-24 | Trustees Of Columbia University In The City Of New York, The | Chimeric antibodies with receptor binding ligands in place of their constant region |
| GB9020282D0 (en) | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
| ES2178635T3 (es) | 1990-11-09 | 2003-01-01 | Stephen D Gillies | Inmunoconjugados de citoquinas. |
| IE922437A1 (en) | 1991-07-25 | 1993-01-27 | Idec Pharma Corp | Recombinant antibodies for human therapy |
| EP0652950B1 (en) | 1992-07-24 | 2007-12-19 | Amgen Fremont Inc. | Generation of xenogeneic antibodies |
| ATE173016T1 (de) | 1992-08-21 | 1998-11-15 | Biogen Inc | Von tat abgeleitete transportpolypeptide |
| DE69232604T2 (de) | 1992-11-04 | 2002-11-07 | City Of Hope Duarte | Antikörperkonstrukte |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| ATE236987T1 (de) | 1992-11-13 | 2003-04-15 | Idec Pharma Corp | Konsensus-kozak-sequenzen zur säugetier- exprimierung |
| US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| KR100654645B1 (ko) | 1995-04-27 | 2007-04-04 | 아브게닉스, 인크. | 면역화된 제노마우스 유래의 인간 항체 |
| AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5875396A (en) * | 1995-11-13 | 1999-02-23 | Wytec, Incorporated | Multichannel radio frequency transmission system to deliver wideband digital data into independent sectorized service areas |
| GB9524973D0 (en) | 1995-12-06 | 1996-02-07 | Lynxvale Ltd | Viral vectors |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| US6420140B1 (en) | 1996-10-11 | 2002-07-16 | Abgenix, Inc. | Production of multimeric protein by cell fusion method |
| JP4215172B2 (ja) | 1996-12-03 | 2009-01-28 | アムジェン フレモント インク. | 複数のV▲下H▼およびV▲下κ▼領域を含むヒトIg遺伝子座を有するトランスジェニック哺乳動物、ならびにそれから産生される抗体 |
| AU737155B2 (en) | 1997-03-14 | 2001-08-09 | Biogen Idec Inc. | Method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same |
| DK0994728T3 (da) | 1997-04-09 | 2008-12-01 | Intellect Neurosciences Inc | Rekombinante antistoffer, som er specifikke for beta-amyloide ender, DNA, der koder derfor, samt fremgangsmåder til anvendelse heraf |
| US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| US20020086847A1 (en) * | 1997-04-09 | 2002-07-04 | Mindset Biopharmaceuticals (Usa) | Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof |
| ES2172149T3 (es) | 1997-04-14 | 2002-09-16 | Micromet Ag | Nuevo metodo para la produccion de receptores de antigeno anti-humano y sus usos. |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| JP2002512624A (ja) | 1997-05-21 | 2002-04-23 | バイオベーション リミテッド | 非免疫原性タンパク質の製造方法 |
| US6703015B1 (en) * | 1999-09-03 | 2004-03-09 | Ramot At Tel-Aviv University Ltd. | Filamentous bacteriophage displaying an β-amyloid epitope |
| US6761888B1 (en) * | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US6750324B1 (en) * | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6710226B1 (en) | 1997-12-02 | 2004-03-23 | Neuralab Limited | Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics |
| US7964192B1 (en) * | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7462605B2 (en) * | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| WO2000011208A1 (en) | 1998-08-25 | 2000-03-02 | University Of Washington | Rapid quantitative analysis of proteins or protein function in complex mixtures |
| AU1631700A (en) | 1998-11-23 | 2000-06-13 | Idec Pharmaceuticals Corporation | Tumor antigen-specific antibody-gp39 chimeric protein constructs |
| ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| US6361973B1 (en) * | 1999-03-22 | 2002-03-26 | Novozymes Biotech, Inc. | Promoters for expressing genes in a fungal cell |
| US6787637B1 (en) * | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| DE19932958C2 (de) | 1999-07-14 | 2003-08-07 | Walter Schubert | Vorrichtung zur Bindung von Molekülen, Molekülgruppen, Molekülteilen und/oder Zellen |
| ATE461996T1 (de) | 1999-09-03 | 2010-04-15 | Univ Ramot | Verbindungen, zusammensetzungen und verfahren zur behandlung oder vorsorge von alzheimer erkrankung |
| US6713058B2 (en) * | 1999-09-14 | 2004-03-30 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with neuropathic conditions comprising administration of low levels of antibodies |
| US6294171B2 (en) * | 1999-09-14 | 2001-09-25 | Milkhaus Laboratory, Inc. | Methods for treating disease states comprising administration of low levels of antibodies |
| US6436401B1 (en) * | 1999-09-14 | 2002-08-20 | Milkhaus Laboratory, Inc. | Methods for alleviating symptoms associated with diabetes and diabetic neuropathy comprising administration of low levels of antibodies |
| US6187309B1 (en) * | 1999-09-14 | 2001-02-13 | Milkaus Laboratory, Inc. | Method for treatment of symptoms of central nervous system disorders |
| EP2082749A3 (en) * | 2000-07-07 | 2010-06-30 | Bioarctic Neuroscience AB | Prevention and treatment of Alzheimer's disease |
| EP1172378A1 (en) * | 2000-07-12 | 2002-01-16 | Richard Dr. Dodel | Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease |
| ATE352040T1 (de) | 2000-11-17 | 2007-02-15 | Univ Rochester | In-vitro verfahren zur herstellung und identifizierung von immunglobulin moleküle in eukaryotischen zellen |
| US7700751B2 (en) * | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| US6716226B2 (en) * | 2001-06-25 | 2004-04-06 | Inscope Development, Llc | Surgical clip |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| AU2002327164A1 (en) | 2001-01-29 | 2002-12-09 | Idec Pharmaceuticals Corporation | Engineered tetravalent antibodies and methods of use |
| CN1494553A (zh) | 2001-01-29 | 2004-05-05 | IDECҩ�﹫˾ | 改变的抗体及其使用方法 |
| AU2002329775C1 (en) * | 2001-08-17 | 2011-04-07 | Eli Lilly And Company | Assay method for alzheimer's disease |
| US20030157641A1 (en) | 2001-11-16 | 2003-08-21 | Idec Pharmaceuticals Corporation | Polycistronic expression of antibodies |
| US7390885B2 (en) * | 2001-11-26 | 2008-06-24 | Cell Matrix, Inc. | Humanized collagen antibodies and related methods |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| US20110200609A1 (en) * | 2002-09-12 | 2011-08-18 | The Regents Of The University Of California | Monoclonal antibodies specific for pathological amyloid aggregates common to amyloids formed from proteins of differing sequence |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| TW200509968A (en) * | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| JP4690046B2 (ja) * | 2002-11-22 | 2011-06-01 | 中外製薬株式会社 | 病巣組織に対する抗体 |
| EP1597280B2 (en) | 2003-02-26 | 2016-08-24 | Institute for Research in Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
| AU2003276107A1 (en) | 2003-04-24 | 2004-11-19 | Universitat Zurich | Method of monitoring immunotherapy |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| WO2005018424A2 (en) * | 2003-08-18 | 2005-03-03 | Research Foundation For Mental Hygiene, Inc. | Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits |
| EP2502935B1 (en) | 2003-08-22 | 2017-03-29 | Biogen MA Inc. | Improved antibodies having altered effector function and methods for making the same |
| UA93181C2 (ru) * | 2004-02-23 | 2011-01-25 | Эли Лилли Энд Компани | СПОСОБ ПОЛУЧЕНИЯ АНТИТЕЛА K Ab ПЕПТИДУ |
| EP1741783A4 (en) | 2004-04-27 | 2009-05-27 | Chemo Sero Therapeut Res Inst | HUMAN ANTIAMYLOID BETA PEPTIDE ANTIBODY AND ANTIBODY FRAGMENT THEREOF |
| EP1766396B1 (en) | 2004-06-07 | 2010-08-11 | Ramot at Tel-Aviv University Ltd. | Method of passive immunization against disease or disorder characterized by amyloid aggregation with diminished risk of neuroinflammation |
| SE0401601D0 (sv) * | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| EA013752B1 (ru) | 2004-08-09 | 2010-06-30 | Элан Фармасьютикалз, Инк. | Предупреждение и лечение синуклеинопатических и амилоидогенных заболеваний |
| WO2006050041A2 (en) | 2004-10-28 | 2006-05-11 | Ramot At Tel Aviv University Ltd. | Methods for reducing or inhibiting brain inflammation or for promoting neurogenesis |
| AR051800A1 (es) * | 2004-12-15 | 2007-02-07 | Wyeth Corp | Anticuerpos a beta usados en mejorar la cognicion |
| DE602006012459D1 (de) | 2005-03-05 | 2010-04-08 | Abbott Gmbh & Co Kg | Screening-verfahren, verfahren zur aufreinigung nichtdiffundierbarer a-beta-oligomere, selektive antikörper gegen diese nichtdiffundierbaren a-beta-oligomere und verfahren zur herstellung dieser antikörper |
| JP2006265189A (ja) * | 2005-03-24 | 2006-10-05 | Kyoto Univ | βアミロイドペプチド、及びそれを用いたアルツハイマー病治療薬又は予防薬のスクリーニング方法 |
| ES2318918B1 (es) * | 2005-04-01 | 2010-02-16 | Biotherapix Molecular Medicines, S.L.U. | Anticuerpos humanos con capacidad de union al peptido beta-amiloide y sus aplicaciones. |
| PE20061323A1 (es) * | 2005-04-29 | 2007-02-09 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos |
| CA2630964A1 (en) * | 2005-11-22 | 2007-05-31 | The Trustees Of The University Of Pennsylvania | Antibody treatment of alzheimer's and related diseases |
| WO2007064917A2 (en) * | 2005-11-30 | 2007-06-07 | Abbott Laboratories | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins |
| KR20140087058A (ko) * | 2005-11-30 | 2014-07-08 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
| AU2006319358B2 (en) * | 2005-11-30 | 2012-01-19 | AbbVie Deutschland GmbH & Co. KG | Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
| NZ568012A (en) | 2005-12-12 | 2012-07-27 | Ac Immune Sa | A beta 1-42 specific monoclonal antibodies with therapeutic properties |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US8455626B2 (en) * | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| DK2099826T3 (da) * | 2007-01-05 | 2014-01-20 | Univ Zuerich | Anti-beta-amyloid-antistof og anvendelser deraf |
| PL2583978T3 (pl) | 2007-02-23 | 2016-07-29 | Prothena Biosciences Ltd Co | Profilaktyka i leczenie chorób synukleinopatycznych i amyloidogennych |
| CN101970000A (zh) * | 2007-04-18 | 2011-02-09 | 杨森阿尔茨海默氏症免疫治疗公司 | 脑淀粉样血管病的预防和治疗 |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| DK2182983T3 (da) * | 2007-07-27 | 2014-07-14 | Janssen Alzheimer Immunotherap | Behandling af amyloidogene sygdomme med humaniserede anti-abeta antistoffer |
| EP2185160B1 (en) * | 2007-08-31 | 2019-02-13 | Neurimmune Holding AG | Method of providing patient specific immune response in amyloidoses and protein aggregation disorders |
| US20100239570A1 (en) | 2007-09-13 | 2010-09-23 | Roger Nitsch | Moncolonal amyloid beta (abeta) - specific antibody and uses thereof |
| AU2008307144B2 (en) * | 2007-10-02 | 2012-12-20 | Csl Limited | Therapeutic antibody purification method and method of use |
| EP2210901A4 (en) | 2007-10-19 | 2012-04-25 | Immunas Pharma Inc | FOR THE SPECIFIC BINDING TO AN OLIGOMICALLY ABLE ANTIBODY AND ITS USE |
| GB0720912D0 (en) * | 2007-10-25 | 2007-12-05 | Univ Cardiff | Monoclonal Anitbody for APP |
| UY31433A1 (es) * | 2007-10-29 | 2009-05-29 | Nuevos anticuerpos especificos de los peptidos - amiloides y sus usos como agentes de diagnostico o drogas | |
| KR101377535B1 (ko) * | 2007-11-16 | 2014-03-27 | 더 락커펠러 유니버시티 | 원섬유 형태의 베타아밀로이드 단백질에 대해 특이적인 항체 |
| EP3121277B1 (en) * | 2008-02-08 | 2018-04-11 | Immunas Pharma, Inc. | Antibody capable of binding specifically to ab-oligomer, and use thereof |
| WO2010004434A2 (en) * | 2008-07-09 | 2010-01-14 | University Of Zurich | Method of promoting neurogenesis |
| ES2543987T3 (es) * | 2008-11-13 | 2015-08-26 | Modgene, Llc | Reducción de la carga de amiloide beta en tejido no cerebral |
| WO2010119704A1 (en) * | 2009-04-17 | 2010-10-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
| JP5769316B2 (ja) * | 2009-08-06 | 2015-08-26 | イムナス・ファーマ株式会社 | Aβオリゴマーに特異的に結合する抗体およびその利用 |
| EP2462162B1 (en) * | 2009-08-06 | 2016-10-12 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
-
2008
- 2008-01-07 DK DK08700998.1T patent/DK2099826T3/da active
- 2008-01-07 PL PL11185486T patent/PL2436696T3/pl unknown
- 2008-01-07 ES ES11184418.9T patent/ES2641897T3/es active Active
- 2008-01-07 PT PT87009981T patent/PT2099826E/pt unknown
- 2008-01-07 KR KR1020097016340A patent/KR20090114388A/ko not_active Withdrawn
- 2008-01-07 PT PT111854865T patent/PT2436696T/pt unknown
- 2008-01-07 DK DK11185486.5T patent/DK2436696T3/da active
- 2008-01-07 JP JP2009544399A patent/JP5398545B2/ja active Active
- 2008-01-07 PL PL08700998T patent/PL2099826T3/pl unknown
- 2008-01-07 HU HUE11184418A patent/HUE034512T2/en unknown
- 2008-01-07 PT PT111844189T patent/PT2426143T/pt unknown
- 2008-01-07 CN CN201310282725.XA patent/CN103408661B/zh active Active
- 2008-01-07 SG SG2012000758A patent/SG177954A1/en unknown
- 2008-01-07 HU HUE11185486A patent/HUE033325T2/en unknown
- 2008-01-07 SI SI200831130T patent/SI2099826T1/sl unknown
- 2008-01-07 CA CA2674140A patent/CA2674140C/en active Active
- 2008-01-07 ES ES11185486.5T patent/ES2635317T3/es active Active
- 2008-01-07 SI SI200831845T patent/SI2436696T1/sl unknown
- 2008-01-07 LT LTEP11185486.5T patent/LT2436696T/lt unknown
- 2008-01-07 CN CN2008800062941A patent/CN101622275B/zh active Active
- 2008-01-07 BR BRPI0806328A patent/BRPI0806328B8/pt active IP Right Grant
- 2008-01-07 EA EA200900954A patent/EA017611B1/ru not_active IP Right Cessation
- 2008-01-07 CN CN2012100468084A patent/CN102603893A/zh active Pending
- 2008-01-07 EP EP17174176.2A patent/EP3239175A1/en not_active Withdrawn
- 2008-01-07 EP EP17169749.3A patent/EP3239174A1/en not_active Withdrawn
- 2008-01-07 US US12/522,031 patent/US8906367B2/en active Active
- 2008-01-07 KR KR1020167002281A patent/KR101700073B1/ko active Active
- 2008-01-07 EP EP08700998.1A patent/EP2099826B1/en active Active
- 2008-01-07 ES ES08700998.1T patent/ES2439490T3/es active Active
- 2008-01-07 WO PCT/EP2008/000053 patent/WO2008081008A1/en not_active Ceased
- 2008-01-07 AU AU2008203703A patent/AU2008203703C1/en active Active
- 2008-01-07 DK DK11184418.9T patent/DK2426143T3/da active
- 2008-01-07 EP EP11184418.9A patent/EP2426143B1/en active Active
- 2008-01-07 PL PL11184418T patent/PL2426143T3/pl unknown
- 2008-01-07 KR KR1020167021950A patent/KR101735257B1/ko active Active
- 2008-01-07 CA CA2764852A patent/CA2764852C/en active Active
- 2008-01-07 KR KR1020127000738A patent/KR20120017469A/ko not_active Ceased
- 2008-01-07 EP EP11185486.5A patent/EP2436696B8/en active Active
- 2008-01-07 EA EA201201067A patent/EA029481B1/ru not_active IP Right Cessation
- 2008-01-07 MX MX2009007136A patent/MX2009007136A/es active IP Right Grant
-
2017
- 2017-08-08 CY CY20171100850T patent/CY1119197T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2099826T3 (da) | Anti-beta-amyloid-antistof og anvendelser deraf | |
| NO2023015I1 (no) | Benzovindiflupyr and Difenoconazole | |
| DK2209806T3 (da) | Anti-hepcidin-antistoffer og anvendelser deraf | |
| DK2059535T3 (da) | Prlr-specifikt antistof og anvendelser deraf | |
| DK2118140T3 (da) | Humancytomegalovirus-neutraliserende antistoffer og anvendelse deraf | |
| DK2068887T3 (da) | SP35-antistoffer og anvendelser heraf | |
| DK2108006T3 (da) | Bindemidler og materialer lavet dermed | |
| DK3124497T3 (da) | Rationelt designede syntetiske antistofbiblioteker og anvendelser deraf | |
| DK1994055T3 (da) | Anti-5t4-antistoffer og anvendelser deraf | |
| DK2328931T3 (da) | Selektive anti-hepcidin-25-antistoffer og anvendelser deraf | |
| BRPI0812367A2 (pt) | Dispositivos interoclusais e respectivos métodos de fabrico | |
| DK2170827T3 (da) | Indolin-2-oner og aza-indolin-2-oner | |
| DK2139490T3 (da) | Diazo-bicykliske smac-mimetiske stoffer og anvendelser deraf | |
| CY2015013I1 (el) | Αντι-μολυσματικες πυραμιδινες και χρησεις αυτων | |
| DK3091034T3 (da) | Anti-CD40-antistoffer og anvendelser deraf | |
| BRPI0816789A2 (pt) | Goji e inflamação | |
| DK2147096T3 (da) | Modificerede faktor-VII-polypeptider og anvendelser deraf | |
| DK1904104T3 (da) | SP35-antistoffer og anvendelser heraf | |
| DK3339323T3 (da) | Anti-n3pglu-amyloid-beta-peptid-antistoffer og anvendelser deraf | |
| BRPI0809677A2 (pt) | Anticorpos anti-ige | |
| CR10556A (es) | Humanized antibody against amyloid beta | |
| EP1913800A4 (en) | NANOELECTROMECHANICAL AND MICROELECTROMECHANICAL SENSORS AND ANALYZERS | |
| BRPI0821110A2 (pt) | Anticorpo anti nr-10 e uso do mesmo | |
| HUE038501T2 (hu) | Antitest készítmények | |
| DK2388266T3 (da) | Fusionsmolekyler og IL-15-varianter |