DK2015736T3 - Sfæriske eller ikke-sfæriske mikrokapsler omfattende GLP1-peptider, deres fremstilling og anvendelse - Google Patents
Sfæriske eller ikke-sfæriske mikrokapsler omfattende GLP1-peptider, deres fremstilling og anvendelseInfo
- Publication number
- DK2015736T3 DK2015736T3 DK07724702.1T DK07724702T DK2015736T3 DK 2015736 T3 DK2015736 T3 DK 2015736T3 DK 07724702 T DK07724702 T DK 07724702T DK 2015736 T3 DK2015736 T3 DK 2015736T3
- Authority
- DK
- Denmark
- Prior art keywords
- spherical
- diseases
- conditions associated
- microcapsules
- preparation
- Prior art date
Links
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 title abstract 3
- 239000003094 microcapsule Substances 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 108091016366 Histone-lysine N-methyltransferase EHMT1 Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 2
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 229920006037 cross link polymer Polymers 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003248 secreting effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
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- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0653—Adipocytes; Adipose tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/0602—Vertebrate cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
- A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06009678A EP1854455B1 (en) | 2006-05-10 | 2006-05-10 | Spherical microcapsules comprising GLP-1 peptides, their production and use |
PCT/EP2007/003775 WO2007128443A2 (en) | 2006-05-10 | 2007-04-27 | Spherical or non-spherical microcapsules comprising glp-i peptides, their production and use |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2015736T3 true DK2015736T3 (da) | 2011-06-14 |
Family
ID=37773605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07724702.1T DK2015736T3 (da) | 2006-05-10 | 2007-04-27 | Sfæriske eller ikke-sfæriske mikrokapsler omfattende GLP1-peptider, deres fremstilling og anvendelse |
Country Status (13)
Country | Link |
---|---|
US (2) | US8790705B2 (da) |
EP (3) | EP1854455B1 (da) |
JP (1) | JP5209608B2 (da) |
CN (1) | CN101489539A (da) |
AT (2) | ATE444741T1 (da) |
AU (1) | AU2007247511B2 (da) |
CA (1) | CA2649902A1 (da) |
DE (2) | DE602006009631D1 (da) |
DK (1) | DK2015736T3 (da) |
ES (1) | ES2363810T3 (da) |
PL (1) | PL2015736T3 (da) |
PT (1) | PT2015736E (da) |
WO (1) | WO2007128443A2 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1767545T3 (da) | 2005-09-22 | 2010-03-15 | Biocompatibles Uk Ltd | GLP-1 (Glucagon-lignende peptid-1)-fusionspolypeptider med forøget peptidaseresistens |
DE602006009631D1 (de) * | 2006-05-10 | 2009-11-19 | Biocompatibles Uk Ltd | GLP-1 Peptide enthaltende kugelförmige Mikrokapseln, deren Produktion und deren Verwendung |
EP1972349A1 (en) * | 2007-03-21 | 2008-09-24 | Biocompatibles UK Limited | GLP-1 fusion peptides conjugated to polymer(s), their production and use |
EP1975176A1 (en) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Novel glp-1 fusion peptides, their production and use |
US20100226976A1 (en) * | 2007-07-11 | 2010-09-09 | Marcelle Machluf | Encapsulated mesenchymal stem cells and uses thereof |
EP2163243A1 (en) * | 2008-09-12 | 2010-03-17 | Biocompatibles UK Limited | Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof |
EP2251028A1 (en) * | 2009-05-12 | 2010-11-17 | Biocompatibles Uk Ltd. | Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor |
US20120020931A1 (en) | 2010-06-02 | 2012-01-26 | Rutgers, The State University Of New Jersey | Therapeutic encapsulated embryonic stem cells and mesenchymal stromal cells |
US20140004201A1 (en) * | 2010-09-15 | 2014-01-02 | Biocompatibles Uk Ltd. | Treatment of Vascular Diseases Using Encapsulated Cells Encoding and Secreting GLP-1, or a Fragment or Variant Thereof |
CN103582463B (zh) | 2011-01-19 | 2018-02-13 | 弗拉克泰尔实验室公司 | 用于组织处理的装置与方法 |
US20140017304A1 (en) * | 2011-03-29 | 2014-01-16 | Myriam Bosmans | Method for encapsulated therapeutic products and uses thereof |
EP2709634B1 (en) * | 2011-05-19 | 2020-09-09 | Mesoblast, Inc. | Methods for treating obesity and/or metabolic syndrome |
KR101335176B1 (ko) * | 2011-12-12 | 2013-11-29 | 테고사이언스 (주) | 상처 치유용 드레싱재제 |
KR102086184B1 (ko) | 2012-02-27 | 2020-03-06 | 프랙틸 래브러토리스 인코포레이티드 | 조직의 치료를 위한 열 절제 시스템,장치 및 방법 |
EP2838598B1 (en) | 2012-04-19 | 2020-01-15 | Fractyl Laboratories, Inc. | Tissue expansion devices |
EP3714826A1 (en) | 2012-07-30 | 2020-09-30 | Fractyl Laboratories, Inc. | Electrical energy ablation systems and devices for the treatment of tissue |
EP2882362B1 (en) | 2012-08-09 | 2024-01-03 | Fractyl Health, Inc. | Ablation systems, devices and methods for the treatment of tissue |
WO2014055997A1 (en) | 2012-10-05 | 2014-04-10 | Fractyl Laboratories Inc. | Methods, systems and devices for performing multiple treatments on a patient |
EP3003461B1 (en) | 2013-06-04 | 2019-05-01 | Fractyl Laboratories, Inc. | Systems and devices for reducing the luminal surface area of the gastrointestinal tract |
EP3043732B1 (en) | 2013-09-12 | 2021-04-07 | Fractyl Laboratories, Inc. | Systems and devices for treatment of target tissue |
JP6603660B2 (ja) * | 2013-11-22 | 2019-11-06 | フラクティル ラボラトリーズ インコーポレイテッド | 消化管における治療制約の生成のためのシステム、デバイスおよび方法 |
CN104805058A (zh) * | 2014-01-23 | 2015-07-29 | 上海欧易生物医学科技有限公司 | 一种稳定表达外源性glp-1基因的人脐带源间充质干细胞株 |
US10959774B2 (en) | 2014-03-24 | 2021-03-30 | Fractyl Laboratories, Inc. | Injectate delivery devices, systems and methods |
EP3169260B1 (en) | 2014-07-16 | 2019-09-25 | Fractyl Laboratories, Inc. | System for treating diabetes and related diseases and disorders |
US9757535B2 (en) | 2014-07-16 | 2017-09-12 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
US11185367B2 (en) | 2014-07-16 | 2021-11-30 | Fractyl Health, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
TWI726889B (zh) * | 2015-06-10 | 2021-05-11 | 英商梅迪繆思有限公司 | 蛋白酶抗性之脂化肽 |
ES2968038T3 (es) | 2015-12-23 | 2024-05-06 | Univ Johns Hopkins | Agonista GLP-1R de acción prolongada como terapia de afecciones neurológicas y neurodegenerativas |
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- 2006-05-10 EP EP06009678A patent/EP1854455B1/en not_active Not-in-force
- 2006-05-10 AT AT06009678T patent/ATE444741T1/de not_active IP Right Cessation
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2007
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- 2007-04-27 AU AU2007247511A patent/AU2007247511B2/en not_active Ceased
- 2007-04-27 CA CA002649902A patent/CA2649902A1/en not_active Abandoned
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- 2007-04-27 US US12/300,087 patent/US8790705B2/en not_active Expired - Fee Related
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- 2007-04-27 PL PL07724702T patent/PL2015736T3/pl unknown
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Also Published As
Publication number | Publication date |
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ATE444741T1 (de) | 2009-10-15 |
JP5209608B2 (ja) | 2013-06-12 |
EP2015736A2 (en) | 2009-01-21 |
CA2649902A1 (en) | 2007-11-15 |
EP1854455B1 (en) | 2009-10-07 |
PT2015736E (pt) | 2011-05-30 |
AU2007247511B2 (en) | 2012-12-06 |
DE602007013385D1 (de) | 2011-05-05 |
WO2007128443A2 (en) | 2007-11-15 |
DE602006009631D1 (de) | 2009-11-19 |
US8790705B2 (en) | 2014-07-29 |
AU2007247511A1 (en) | 2007-11-15 |
US20140105991A1 (en) | 2014-04-17 |
EP2015736B1 (en) | 2011-03-23 |
EP1854455A1 (en) | 2007-11-14 |
EP2174655A1 (en) | 2010-04-14 |
JP2009536166A (ja) | 2009-10-08 |
CN101489539A (zh) | 2009-07-22 |
US20100068289A1 (en) | 2010-03-18 |
PL2015736T3 (pl) | 2011-09-30 |
WO2007128443A3 (en) | 2008-05-22 |
ATE502628T1 (de) | 2011-04-15 |
ES2363810T3 (es) | 2011-08-17 |
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