[go: up one dir, main page]

DK1776339T3 - 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemet - Google Patents

3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemet

Info

Publication number
DK1776339T3
DK1776339T3 DK05779909T DK05779909T DK1776339T3 DK 1776339 T3 DK1776339 T3 DK 1776339T3 DK 05779909 T DK05779909 T DK 05779909T DK 05779909 T DK05779909 T DK 05779909T DK 1776339 T3 DK1776339 T3 DK 1776339T3
Authority
DK
Denmark
Prior art keywords
alkyl
halogen
carbon atom
hydrogen
derivatives
Prior art date
Application number
DK05779909T
Other languages
Danish (da)
English (en)
Inventor
Balazs Volk
Jozsef Barkeczy
Gyula Simig
Tibor Mezei
Dezsefi Rita Kapillerne
Endrene Flerian
Istvan Gacsalyi
Katalin Pallagi
Gabor Gigler
Gyoergy Levay
Krisztina Mericz
Csilla Leveleki
Nora Sziray
Gabor Szenasi
Andras Egyed
Laszlo Gabor Harsing
Original Assignee
Egis Gyogyszergyar Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0400957A external-priority patent/HU0400957D0/hu
Priority claimed from HU0500464A external-priority patent/HUP0500464A3/hu
Application filed by Egis Gyogyszergyar Nyrt filed Critical Egis Gyogyszergyar Nyrt
Application granted granted Critical
Publication of DK1776339T3 publication Critical patent/DK1776339T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK05779909T 2004-05-11 2005-05-11 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemet DK1776339T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0400957A HU0400957D0 (en) 2004-05-11 2004-05-11 Piperazinbe derivatives of dialkyl oxindoles
HU0500464A HUP0500464A3 (en) 2005-05-05 2005-05-05 Piperazine derivatives of dialkyl-oxindoles
PCT/HU2005/000052 WO2005109987A2 (fr) 2004-05-11 2005-05-11 Nouveaux derives piperazine d'oxindoles de dialkyle

Publications (1)

Publication Number Publication Date
DK1776339T3 true DK1776339T3 (da) 2009-11-02

Family

ID=89986001

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05779909T DK1776339T3 (da) 2004-05-11 2005-05-11 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-on-derivater og relaterede forbindelser til behandling af lidelser i centralnervesystemet

Country Status (24)

Country Link
US (1) US7786129B2 (fr)
EP (1) EP1776339B1 (fr)
JP (1) JP2007537229A (fr)
KR (1) KR20070011594A (fr)
AT (1) ATE435204T1 (fr)
AU (1) AU2005244389B2 (fr)
BG (1) BG109771A (fr)
CA (1) CA2565514A1 (fr)
CZ (1) CZ2006777A3 (fr)
DE (1) DE602005015223D1 (fr)
DK (1) DK1776339T3 (fr)
EA (1) EA014236B1 (fr)
ES (1) ES2329388T3 (fr)
HR (2) HRP20060404A2 (fr)
IL (1) IL179029A (fr)
MX (1) MXPA06013069A (fr)
NO (1) NO20065659L (fr)
NZ (1) NZ551547A (fr)
PL (1) PL1776339T3 (fr)
PT (1) PT1776339E (fr)
RS (1) RS20060623A (fr)
SI (1) SI1776339T1 (fr)
SK (1) SK51072006A3 (fr)
WO (1) WO2005109987A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007132841A1 (fr) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné et utilisation
WO2009063992A1 (fr) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited Dérivé de pyridine condensé et son utilisation
HUP0900071A2 (en) * 2009-02-06 2010-10-28 Egis Gyogyszergyar Nyilvanosan Optically active 3-[(phenyl-piperazin-1-yl)alkyl]-3-alkyl-oxindole derivatives influencing the central nervous system and pharmaceutical compositions containing them
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2635104B1 (fr) * 1988-08-03 1992-04-30 Synthelabo Derives d'indolone, leur preparation et leur application en therapeutique
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
WO1998008816A1 (fr) * 1996-08-26 1998-03-05 Meiji Seika Kaisha, Ltd. Derives d'indoxyle et psychotropes
JP2007537226A (ja) * 2004-05-11 2007-12-20 エギシュ ヂョヂセルヂャール エンニュ・エル・テー アルキルオキシンドールのピペラジン誘導体
PL1751138T3 (pl) * 2004-05-11 2008-05-30 Egis Gyogyszergyar Nyrt Pochodne indol-2-onu do leczenia chorób centralnego układu nerwowego, chorób układu pokarmowego oraz chorób układu krążenia

Also Published As

Publication number Publication date
IL179029A (en) 2011-11-30
RS20060623A (en) 2008-09-29
EP1776339A2 (fr) 2007-04-25
US7786129B2 (en) 2010-08-31
HRP20090504T1 (hr) 2009-10-31
WO2005109987A3 (fr) 2006-05-04
PL1776339T3 (pl) 2009-12-31
SK51072006A3 (sk) 2007-05-03
DE602005015223D1 (de) 2009-08-13
CZ2006777A3 (cs) 2007-03-14
JP2007537229A (ja) 2007-12-20
CA2565514A1 (fr) 2005-11-24
SI1776339T1 (sl) 2009-12-31
NO20065659L (no) 2007-01-29
PT1776339E (pt) 2009-09-16
BG109771A (bg) 2008-05-30
EP1776339B1 (fr) 2009-07-01
NZ551547A (en) 2010-06-25
ATE435204T1 (de) 2009-07-15
KR20070011594A (ko) 2007-01-24
MXPA06013069A (es) 2007-03-30
AU2005244389B2 (en) 2011-09-01
AU2005244389A1 (en) 2005-11-24
US20070232619A1 (en) 2007-10-04
IL179029A0 (en) 2007-03-08
WO2005109987A2 (fr) 2005-11-24
EA200602083A1 (ru) 2007-06-29
ES2329388T3 (es) 2009-11-25
HRP20060404A2 (en) 2007-04-30
WO2005109987A9 (fr) 2007-03-29
EA014236B1 (ru) 2010-10-29

Similar Documents

Publication Publication Date Title
NO20064579L (no) Bifenylforbindelser anvendelige som muskariniske receptorantagonister
DK1856045T3 (da) 1-eddikesyreindolderviater med PGD2-antagonisteffekt
MY156747A (en) Isoxazolo-pyridine derivatives
MX2007004699A (es) Derivados de indol y bencimidazol.
MX2010005299A (es) Derivados de bis-(sulfonilamino) en terapia 066.
EA200501585A1 (ru) Производные азетидинкарбоксамида и их применение при лечении нарушений, опосредованных св1 рецепторами
ATE449082T1 (de) (3,4-dihydro-chinazolin-2-yl)-(2-aryloxy-ethyl) amine mit aktivität am 5-ht-rezeptor
CY1116391T1 (el) Αιθινυλο παραγωγα ως θετικοι αλλοστερικοι ρυθμιστες του mglur5
MXPA06009475A (es) Derivados de quinazolina y usos terapeuticos de los mismos.
ATE374190T1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
NO20052730L (no) Aminoalkosyindoler som 5-HT6-reseptorligander for behandling av CNS-lidelser
NO20054135L (no) Kipolinon/benzoksazin derivater og anvendelser derav
TNSN07006A1 (en) Novel heterocyclic compounds
IL179029A0 (en) New piperazine derivatives of dialkyl oxindoles
NO20074622L (no) Metabolitter for NK-1 antagonister for brekninger
ATE396183T1 (de) Chromanderivate und ihre verwendung als liganden des 5-ht-rezeptors
NO20073330L (no) Sulfanylsubstituerte fenylmetanoner som glycintransportor 1 (glyt-1) inhibitorer for behandling av nevrologiske og nevropsykiatriske forstyrrelser
ATE465151T1 (de) 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren
NO20055257L (no) Ny fremgangsmate for syntesen av s-indolin-2-karboksylsyre og anvendelse derav i syntesen av perindopril
NO20070972L (no) Benzyloksyderivater som MAOB-inhibitorer
HUP0303025A2 (hu) Eljárás ariletanoldiaminok előállítására
NO20041704L (no) Substituerte alkylaminopyridazinonderivater, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger som inneholder disse
CY1114186T1 (el) Παραγωγα ιμιδαζολιου ως ανταγωνιστες mglur5
EA200602081A1 (ru) Пиридиновые производные алкилоксиндолов в качестве агентов, активных в отношении рецептора 5-нт7
IL179030A0 (en) Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders