DK1730277T3 - Kodning ved ligering under anvendelse af byggebloksoligonukleotider - Google Patents
Kodning ved ligering under anvendelse af byggebloksoligonukleotiderInfo
- Publication number
- DK1730277T3 DK1730277T3 DK05715120.1T DK05715120T DK1730277T3 DK 1730277 T3 DK1730277 T3 DK 1730277T3 DK 05715120 T DK05715120 T DK 05715120T DK 1730277 T3 DK1730277 T3 DK 1730277T3
- Authority
- DK
- Denmark
- Prior art keywords
- template
- oligonucleotide
- present
- chemical entities
- building block
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK2004/000195 WO2004083427A2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
US58500804P | 2004-07-06 | 2004-07-06 | |
DKPA200401067 | 2004-07-06 | ||
PCT/DK2005/000199 WO2005090566A2 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1730277T3 true DK1730277T3 (da) | 2010-03-01 |
Family
ID=40221922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05715120.1T DK1730277T3 (da) | 2004-03-22 | 2005-03-22 | Kodning ved ligering under anvendelse af byggebloksoligonukleotider |
Country Status (6)
Country | Link |
---|---|
US (1) | US7704925B2 (da) |
EP (1) | EP1730277B1 (da) |
AT (1) | ATE447020T1 (da) |
DE (1) | DE602005017370D1 (da) |
DK (1) | DK1730277T3 (da) |
WO (1) | WO2005090566A2 (da) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
IL163822A0 (en) | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
EP1539980B1 (en) * | 2002-08-01 | 2016-02-17 | Nuevolution A/S | Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules |
WO2004028682A2 (en) | 2002-09-27 | 2004-04-08 | Carlsberg A/S | Spatially encoded polymer matrix |
DK3299463T3 (da) | 2002-10-30 | 2020-12-07 | Nuevolution As | Enzymatisk kodning |
DE60330406D1 (de) | 2002-12-19 | 2010-01-14 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
DK1670939T3 (da) | 2003-09-18 | 2010-03-01 | Nuevolution As | Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser |
AU2004299145B2 (en) | 2003-12-17 | 2011-08-25 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
WO2005078122A2 (en) * | 2004-02-17 | 2005-08-25 | Nuevolution A/S | Method for enrichment involving elimination by mismatch hybridisation |
US7883848B2 (en) * | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
WO2007053358A2 (en) * | 2005-10-28 | 2007-05-10 | Praecis Pharmaceuticals, Inc. | Methods for identifying compounds of interest using encoded libraries |
LT3305900T (lt) | 2005-12-01 | 2021-11-10 | Nuevolution A/S | Fermentiniai kodavimo būdai didelių bibliotekų efektyviai sintezei |
KR101789216B1 (ko) | 2009-02-13 | 2017-10-23 | 엑스-켐, 인크. | Dna―코딩된 라이브러리의 생성 및 스크리닝 방법 |
WO2011127933A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
EP2748357B1 (en) | 2011-09-07 | 2018-04-04 | X-Chem, Inc. | Methods for tagging dna-encoded libraries |
JP5820320B2 (ja) * | 2012-03-27 | 2015-11-24 | 株式会社東芝 | 情報処理端末及び方法、並びに、情報管理装置及び方法 |
EA201992285A1 (ru) | 2012-07-13 | 2020-05-31 | Икс-Чем, Инк. | Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами |
WO2016074683A1 (en) | 2014-11-11 | 2016-05-19 | Lundorf Pedersen Materials Aps | Method for identification of molecules with desired characteristics |
CN106048736B (zh) * | 2015-04-14 | 2019-09-03 | 成都先导药物开发股份有限公司 | 一种固相合成dna编码化合物库的方法 |
GB201603789D0 (en) | 2016-03-04 | 2016-04-20 | Apta Biosciences Ltd | Oligonucleotides and methods for preparing |
SG10201911917WA (en) | 2016-05-02 | 2020-01-30 | Encodia Inc | Macromolecule analysis employing nucleic acid encoding |
CA3024875A1 (en) | 2016-06-16 | 2017-12-21 | Richard Edward Watts | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
EP3704246A4 (en) | 2017-10-31 | 2021-08-11 | Encodia, Inc. | PROCESSES AND KITS USING CODING AND / OR MARKING BY NUCLEIC ACIDS |
AU2018358057B2 (en) | 2017-10-31 | 2023-03-02 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
CA3120895A1 (en) | 2018-12-20 | 2020-06-25 | Sergey N. Krylov | Binder selection using capillary electrophoresis |
WO2020223000A1 (en) | 2019-04-30 | 2020-11-05 | Encodia, Inc. | Methods for preparing analytes and related kits |
EP3885437A1 (en) * | 2020-03-27 | 2021-09-29 | Technische Universität Dortmund | Dna-encoded chemical library, use thereof, and method to synthesize the library |
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US4822731A (en) * | 1986-01-09 | 1989-04-18 | Cetus Corporation | Process for labeling single-stranded nucleic acids and hybridizaiton probes |
US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
JPH04504651A (ja) | 1988-11-18 | 1992-08-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自然に存在しないアミノ酸をタンパク質に部位特異的に導入する方法 |
DE69032483T2 (de) | 1989-10-05 | 1998-11-26 | Optein, Inc., Seattle, Wash. | Zellfreie synthese und isolierung von genen und polypeptiden |
US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
WO1993003172A1 (en) | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
US5639603A (en) * | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
DK0604552T3 (da) * | 1991-09-18 | 1997-08-04 | Affymax Tech Nv | Fremgangsmåde til syntese af forskellige samlinger af oligomerer |
US5573905A (en) * | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
ATE246702T1 (de) | 1993-04-12 | 2003-08-15 | Univ Northwestern | Verfahren zur darstellung von oligonukleotiden |
US5681943A (en) * | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
US5473060A (en) | 1993-07-02 | 1995-12-05 | Lynx Therapeutics, Inc. | Oligonucleotide clamps having diagnostic applications |
US5571903A (en) * | 1993-07-09 | 1996-11-05 | Lynx Therapeutics, Inc. | Auto-ligating oligonucleotide compounds |
GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
US6165778A (en) * | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
GB2298863B (en) | 1993-11-02 | 1998-03-11 | Affymax Tech Nv | Apparatus and process for the synthesis of diverse compounds especially for generating and screening compound libraries |
US5503805A (en) * | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US5739386A (en) | 1994-06-23 | 1998-04-14 | Affymax Technologies N.V. | Photolabile compounds and methods for their use |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5843650A (en) * | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
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US5780613A (en) * | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
WO1998031700A1 (en) | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
WO1998054312A1 (en) * | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
US6969584B2 (en) | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
US20030004122A1 (en) * | 1997-11-05 | 2003-01-02 | Leonid Beigelman | Nucleotide triphosphates and their incorporation into oligonucleotides |
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WO1999054458A1 (en) * | 1998-04-17 | 1999-10-28 | Whitehead Institute For Biomedical Research | Use of a ribozyme to join nucleic acids and peptides |
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US7479472B1 (en) * | 1998-10-19 | 2009-01-20 | The Board Of Trustees Of The Leland Stanford Junior University | DNA-templated combinatorial library chemistry |
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EP1208219A1 (en) | 1999-04-08 | 2002-05-29 | Pavel Sergeev | Synthesis of biologically active compounds in cells |
ATE502117T1 (de) | 1999-06-25 | 2011-04-15 | Nanosphere Inc | Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen |
EP1196637B1 (en) * | 1999-07-27 | 2007-04-25 | Adnexus Therapeutics, Inc. | Peptide acceptor ligation methods |
EP1125945B1 (en) * | 1999-08-27 | 2003-05-21 | Japan Science and Technology Corporation | Reversible photocoupling nucleic acid and phosphoroamidite |
EP1832567A3 (en) * | 2001-03-19 | 2009-08-26 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2002102820A1 (en) | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Nucleoside derivatives for library preparation |
WO2004001042A2 (en) | 2002-06-20 | 2003-12-31 | Nuevolution A/S | Microarrays displaying encoded molecules |
RU2004101289A (ru) | 2001-06-20 | 2005-07-10 | Нуэволюшн А/С (Dk) | Способ синтеза молекулы на матрице |
CA2468733C (en) * | 2001-11-30 | 2013-06-11 | Biogen Idec Ma Inc. | Antibodies against monocyte chemotactic proteins |
IL163822A0 (en) | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
AU2003214032A1 (en) | 2002-03-15 | 2003-09-29 | Nuevolution A/S | A building block forming a c=c double bond upon reaction |
WO2003078627A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block capable of functional entity transfer to nucleophil |
WO2003078446A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c or a c-hetero atom bond upon reaction |
US20050221318A1 (en) | 2002-03-15 | 2005-10-06 | Gouliaev Alex H | Building block forming a c-c bond upon reaction |
WO2003082901A2 (en) | 2002-03-22 | 2003-10-09 | Emory University | Template-driven processes for synthesizing polymers and components related to such processes |
US20060099589A1 (en) | 2002-07-23 | 2006-05-11 | Nuevolution A/S | Gene shuffling by template switching |
EP1539980B1 (en) * | 2002-08-01 | 2016-02-17 | Nuevolution A/S | Library of complexes comprising small non-peptide molecules and double-stranded oligonucleotides identifying the molecules |
EP1540013B1 (en) * | 2002-08-19 | 2015-07-08 | The President and Fellows of Harvard College | Evolving new molecular function |
AU2003260291A1 (en) | 2002-09-12 | 2004-04-30 | Nuevolution A/S | Proximity-aided synthesis of templated molecules |
DK3299463T3 (da) | 2002-10-30 | 2020-12-07 | Nuevolution As | Enzymatisk kodning |
DE60330406D1 (de) * | 2002-12-19 | 2010-01-14 | Nuevolution As | Durch quasizufallsstrukturen und funktionen geführte synthesemethode |
US20060269920A1 (en) | 2003-02-21 | 2006-11-30 | Nuevolution A/S | Method for obtaining structural information about an encoded molecule |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
DK1608748T3 (da) * | 2003-03-20 | 2009-06-29 | Nuevolution As | Ligeringskodning af små molekyler |
EP1625230A2 (en) | 2003-05-09 | 2006-02-15 | Thorleif Möller | Selection and evolution of chemical libraries |
WO2004110964A2 (en) | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
WO2005003778A2 (en) | 2003-07-02 | 2005-01-13 | Nuevolution A/S | A method for identifying a synthetic molecule having affinity towards a target |
EP1533385A1 (en) | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Templated compounds for generation of encoded molecules and directional methods using such compounds |
DK1670939T3 (da) | 2003-09-18 | 2010-03-01 | Nuevolution As | Fremgangsmåde til opnåelse af strukturel information om et kodet molekyle og fremgangsmåde til udvælgelse af forbindelser |
NZ555698A (en) | 2004-11-08 | 2010-07-30 | Vipergen Aps | Structural nucleic acid guided chemical synthesis |
WO2006053571A2 (en) | 2004-11-22 | 2006-05-26 | Peter Birk Rasmussen | Template directed split and mix systhesis of small molecule libraries |
-
2005
- 2005-03-22 DK DK05715120.1T patent/DK1730277T3/da active
- 2005-03-22 US US10/593,868 patent/US7704925B2/en not_active Expired - Lifetime
- 2005-03-22 WO PCT/DK2005/000199 patent/WO2005090566A2/en active Application Filing
- 2005-03-22 AT AT05715120T patent/ATE447020T1/de not_active IP Right Cessation
- 2005-03-22 DE DE602005017370T patent/DE602005017370D1/de not_active Expired - Lifetime
- 2005-03-22 EP EP05715120A patent/EP1730277B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1730277B1 (en) | 2009-10-28 |
WO2005090566A2 (en) | 2005-09-29 |
ATE447020T1 (de) | 2009-11-15 |
DE602005017370D1 (de) | 2009-12-10 |
EP1730277A2 (en) | 2006-12-13 |
US7704925B2 (en) | 2010-04-27 |
US20090011957A1 (en) | 2009-01-08 |
WO2005090566A3 (en) | 2006-03-09 |
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