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DK172190B1 - Anvendelse af alfa-heterocyclisk substituerede tolunitriler og salte deraf til fremstilling af farmaceutiske præparater, nye forbindelser af denne klasse samt farmaceutisk præparat - Google Patents

Anvendelse af alfa-heterocyclisk substituerede tolunitriler og salte deraf til fremstilling af farmaceutiske præparater, nye forbindelser af denne klasse samt farmaceutisk præparat Download PDF

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Publication number
DK172190B1
DK172190B1 DK117687A DK117687A DK172190B1 DK 172190 B1 DK172190 B1 DK 172190B1 DK 117687 A DK117687 A DK 117687A DK 117687 A DK117687 A DK 117687A DK 172190 B1 DK172190 B1 DK 172190B1
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DK
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Prior art keywords
lower alkyl
alkyl
pyridyl
aryl
hydrogen
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Application number
DK117687A
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Danish (da)
English (en)
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DK117687A (da
DK117687D0 (da
Inventor
Robert Mathews Bowman
Ronald Edward Steele
Leslie Johnston Browne
Original Assignee
Ciba Geigy Ag
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25274596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK172190(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK117687D0 publication Critical patent/DK117687D0/da
Publication of DK117687A publication Critical patent/DK117687A/da
Application granted granted Critical
Publication of DK172190B1 publication Critical patent/DK172190B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK117687A 1986-03-07 1987-03-06 Anvendelse af alfa-heterocyclisk substituerede tolunitriler og salte deraf til fremstilling af farmaceutiske præparater, nye forbindelser af denne klasse samt farmaceutisk præparat DK172190B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83748986 1986-03-07
US06/837,489 US4749713A (en) 1986-03-07 1986-03-07 Alpha-heterocycle substituted tolunitriles

Publications (3)

Publication Number Publication Date
DK117687D0 DK117687D0 (da) 1987-03-06
DK117687A DK117687A (da) 1987-09-08
DK172190B1 true DK172190B1 (da) 1997-12-22

Family

ID=25274596

Family Applications (1)

Application Number Title Priority Date Filing Date
DK117687A DK172190B1 (da) 1986-03-07 1987-03-06 Anvendelse af alfa-heterocyclisk substituerede tolunitriler og salte deraf til fremstilling af farmaceutiske præparater, nye forbindelser af denne klasse samt farmaceutisk præparat

Country Status (36)

Country Link
US (1) US4749713A (pl)
EP (1) EP0236940B3 (pl)
JP (1) JPH0755930B2 (pl)
KR (1) KR910000482B1 (pl)
AT (1) ATE94873T1 (pl)
BG (4) BG45701A3 (pl)
CA (1) CA1316928C (pl)
CY (1) CY1905A (pl)
CZ (3) CZ279028B6 (pl)
DD (1) DD264432A5 (pl)
DE (2) DE19775016I2 (pl)
DK (1) DK172190B1 (pl)
DZ (1) DZ1055A1 (pl)
ES (1) ES2059317T3 (pl)
FI (1) FI91857C (pl)
HK (1) HK50296A (pl)
HU (1) HU202843B (pl)
IE (1) IE61101B1 (pl)
IL (1) IL81746A (pl)
LU (1) LU90128I2 (pl)
LV (1) LV5769B4 (pl)
MA (1) MA20888A1 (pl)
MC (1) MC1805A1 (pl)
MT (1) MTP998B (pl)
MX (1) MX5496A (pl)
MY (1) MY102428A (pl)
NL (1) NL970011I2 (pl)
NO (2) NO170277C (pl)
PH (1) PH24159A (pl)
PL (2) PL151490B1 (pl)
PT (1) PT84410B (pl)
RO (2) RO101533B1 (pl)
SK (3) SK736887A3 (pl)
SU (3) SU1470184A3 (pl)
TN (1) TNSN87033A1 (pl)
ZA (1) ZA871637B (pl)

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US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
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KR20030094415A (ko) 2001-05-16 2003-12-11 노파르티스 아게 Ν-｛5-[4-(4-메틸-피페라지노-메틸)-벤조일아미도]-2-메틸페닐｝-4-(3-피리딜)-2-피리미딘-아민 및 화학치료제를포함하는 배합물
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DZ1055A1 (fr) 2004-09-13
MTP998B (en) 1987-08-21
HK50296A (en) 1996-03-29
ZA871637B (en) 1987-10-28
LU90128I2 (fr) 1997-10-06
EP0236940B3 (en) 2011-03-23
PL151490B1 (en) 1990-09-28
EP0236940A2 (en) 1987-09-16
IE870575L (en) 1987-09-07
PT84410A (en) 1987-04-01
NO170277B (no) 1992-06-22
CA1316928C (en) 1993-04-27
RO101533B1 (en) 1992-06-25
IE61101B1 (en) 1994-10-05
FI870903A0 (fi) 1987-03-02
CS8707368A2 (en) 1991-02-12
MX5496A (es) 1993-12-01
BG46598A3 (en) 1990-01-15
NL970011I2 (nl) 1997-09-01
NO870937D0 (no) 1987-03-06
SU1470184A3 (ru) 1989-03-30
MY102428A (en) 1992-06-30
IL81746A0 (en) 1987-10-20
SU1577695A3 (ru) 1990-07-07
SK736787A3 (en) 1998-06-03
DE3787480T2 (de) 1994-02-24
TNSN87033A1 (fr) 1990-01-01
EP0236940A3 (en) 1989-10-18
US4749713A (en) 1988-06-07
DK117687A (da) 1987-09-08
RO101532B1 (en) 1992-11-03
BG45700A3 (en) 1989-07-14
AU6976887A (en) 1987-09-10
SK279102B6 (sk) 1998-06-03
PT84410B (pt) 1989-10-04
NO870937L (no) 1987-09-08
BG61204B2 (bg) 1997-02-28
LV5769A4 (lv) 1996-12-20
SK151287A3 (en) 1998-06-03
CS8701512A2 (en) 1991-02-12
CZ279028B6 (en) 1994-11-16
LV5769B4 (lv) 1997-04-20
NO1998010I1 (no) 1998-03-04
MC1805A1 (fr) 1987-12-22
ATE94873T1 (de) 1993-10-15
PL264460A1 (en) 1988-07-21
SK279101B6 (sk) 1998-06-03
SK279103B6 (sk) 1998-06-03
JPS62212369A (ja) 1987-09-18
DD264432A5 (de) 1989-02-01
ES2059317T3 (es) 1994-11-16
FI91857C (fi) 1994-08-25
DE3787480D1 (de) 1993-10-28
FI91857B (fi) 1994-05-13
SU1549478A3 (ru) 1990-03-07
PL152025B1 (en) 1990-10-31
KR870008851A (ko) 1987-10-21
CZ279026B6 (en) 1994-11-16
NO170277C (no) 1992-09-30
HU202843B (en) 1991-04-29
HUT43822A (en) 1987-12-28
DK117687D0 (da) 1987-03-06
CS8707367A2 (en) 1991-02-12
AU604011B2 (en) 1990-12-06
SK736887A3 (en) 1998-06-03
JPH0755930B2 (ja) 1995-06-14
DE19775016I2 (de) 2002-02-21
CY1905A (en) 1987-03-05
EP0236940B1 (en) 1993-09-22
PH24159A (en) 1990-03-22
FI870903A (fi) 1987-09-08
MA20888A1 (fr) 1987-10-01
NL970011I1 (nl) 1997-05-01
KR910000482B1 (ko) 1991-01-25
IL81746A (en) 1992-02-16
CZ279027B6 (en) 1994-11-16
BG45701A3 (en) 1989-07-14

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