DK168823B1 - Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor. - Google Patents

Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor. Download PDF

Info

Publication number: DK168823B1
Authority: DK; Denmark
Prior art keywords: plasmid; amino acid; fusion proteins; acid sequence; protein
Prior art date: 1985-12-21

Application number

DK619186A

Other languages

Danish (da)

English (en)

Other versions

DK619186D0 (da

DK619186A (da

Inventor

Paul Habermann

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-21

Filing date

1986-12-19

Publication date

1994-06-20

1986-12-19 Application filed by Hoechst Ag filed Critical Hoechst Ag

1986-12-19 Publication of DK619186D0 publication Critical patent/DK619186D0/da

1987-06-22 Publication of DK619186A publication Critical patent/DK619186A/da

1994-06-20 Application granted granted Critical

1994-06-20 Publication of DK168823B1 publication Critical patent/DK168823B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Microbiology (AREA)
Endocrinology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Plant Pathology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Sampling And Sample Adjustment (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK619186A 1985-12-21 1986-12-19 Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor. DK168823B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE3545565		1985-12-21
DE3545565		1985-12-21
DE19863636903 DE3636903A1 (de)	1985-12-21	1986-10-30	Fusionsproteine mit eukaryotischem ballastanteil
DE3636903		1986-10-30

Publications (3)

Publication Number	Publication Date
DK619186D0 DK619186D0 (da)	1986-12-19
DK619186A DK619186A (da)	1987-06-22
DK168823B1 true DK168823B1 (da)	1994-06-20

Family

ID=25839208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK619186A DK168823B1 (da)	1985-12-21	1986-12-19	Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor.

Country Status (16)

Country	Link
EP (1)	EP0229998B1 (fr)
JP (2)	JP2553058B2 (fr)
KR (1)	KR950000301B1 (fr)
AT (1)	ATE78296T1 (fr)
AU (1)	AU599943B2 (fr)
CA (1)	CA1339894C (fr)
DE (1)	DE3636903A1 (fr)
DK (1)	DK168823B1 (fr)
ES (1)	ES2033678T3 (fr)
FI (1)	FI93734C (fr)
GR (1)	GR3005985T3 (fr)
HU (1)	HU209747B (fr)
IE (1)	IE58935B1 (fr)
IL (1)	IL81018A (fr)
NO (1)	NO175003C (fr)
PT (1)	PT83973B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3545568A1 (de) *	1985-12-21	1987-07-16	Hoechst Ag	Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
DE3844211A1 (de) *	1988-12-29	1990-07-05	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
FR2643646B1 (fr) *	1989-02-27	1993-09-17	Pasteur Institut	Expression de sequences de nucleotides codant pour des vesicules a gaz
CU22222A1 (es) *	1989-08-03	1995-01-31	Cigb	Procedimiento para la expresion de proteinas heterologicas producidas de forma fusionada en escherichia coli, su uso, vectores de expresion y cepas recombinantes
DE3942580A1 (de) *	1989-12-22	1991-06-27	Basf Ag	Verfahren zur herstellung von hirudin
DE4105480A1 (de) *	1991-02-21	1992-08-27	Boehringer Mannheim Gmbh	Verbesserte aktivierung von rekombinanten proteinen
DE59711533D1 (de)	1996-07-26	2004-05-27	Aventis Pharma Gmbh	Insulinderivate mit erhöhter Zinkbindung
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
DE102006031955A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
US9526764B2 (en)	2008-10-17	2016-12-27	Sanofi-Aventis Deutschland Gmbh	Combination of an insulin and a GLP-1-agonist
WO2011058082A1 (fr)	2009-11-13	2011-05-19	Sanofi-Aventis Deutschland Gmbh	Composition pharmaceutique comprenant un agoniste de glp-1 et de la méthionine
HUE038147T2 (hu)	2009-11-13	2018-09-28	Sanofi Aventis Deutschland	GLP-1 agonistát, inzulint és metionint tartalmazó gyógyászati készítmény
WO2012028172A1 (fr)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Utilisation de lixisenatide pour fabrication de médicament pour traitement du diabète sucré de type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
HRP20230470T1 (hr)	2014-12-12	2023-07-21	Sanofi-Aventis Deutschland Gmbh	Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
KR20200080748A (ko)	2018-12-27	2020-07-07	주식회사 폴루스	음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
KR20200080747A (ko)	2018-12-27	2020-07-07	주식회사 폴루스	인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK108685A (da) *	1984-03-19	1985-09-20	Fujisawa Pharmaceutical Co	Vaekstfaktor i
EP0158198A1 (fr) *	1984-03-29	1985-10-16	Takeda Chemical Industries, Ltd.	ADN et son utilisation
GB8412517D0 (en) *	1984-05-16	1984-06-20	Nagai K	Recombinant fusion proteins

1986
- 1986-10-30 DE DE19863636903 patent/DE3636903A1/de not_active Withdrawn
- 1986-12-16 EP EP86117481A patent/EP0229998B1/fr not_active Expired - Lifetime
- 1986-12-16 AT AT86117481T patent/ATE78296T1/de not_active IP Right Cessation
- 1986-12-16 ES ES198686117481T patent/ES2033678T3/es not_active Expired - Lifetime
- 1986-12-18 IL IL81018A patent/IL81018A/xx not_active IP Right Cessation
- 1986-12-18 FI FI865187A patent/FI93734C/fi not_active IP Right Cessation
- 1986-12-19 IE IE333486A patent/IE58935B1/en not_active IP Right Cessation
- 1986-12-19 AU AU66760/86A patent/AU599943B2/en not_active Expired
- 1986-12-19 CA CA000525858A patent/CA1339894C/fr not_active Expired - Lifetime
- 1986-12-19 HU HU865354A patent/HU209747B/hu unknown
- 1986-12-19 DK DK619186A patent/DK168823B1/da not_active IP Right Cessation
- 1986-12-19 NO NO865192A patent/NO175003C/no not_active IP Right Cessation
- 1986-12-19 PT PT83973A patent/PT83973B/pt unknown
- 1986-12-20 KR KR1019860011010A patent/KR950000301B1/ko not_active Expired - Lifetime
- 1986-12-22 JP JP61306185A patent/JP2553058B2/ja not_active Expired - Lifetime
1992
- 1992-10-15 GR GR920402187T patent/GR3005985T3/el unknown
1995
- 1995-10-11 JP JP7263310A patent/JP2774260B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0229998B1 (fr)	1992-07-15
DK619186D0 (da)	1986-12-19
JP2774260B2 (ja)	1998-07-09
IL81018A0 (en)	1987-03-31
FI93734B (fi)	1995-02-15
GR3005985T3 (fr)	1993-06-07
IE58935B1 (en)	1993-12-01
NO865192L (no)	1987-06-22
HUT44614A (en)	1988-03-28
ATE78296T1 (de)	1992-08-15
IL81018A (en)	1992-03-29
CA1339894C (fr)	1998-06-02
AU6676086A (en)	1987-06-25
JPH08187089A (ja)	1996-07-23
EP0229998A3 (en)	1988-08-03
PT83973A (de)	1987-01-01
DK619186A (da)	1987-06-22
FI865187A0 (fi)	1986-12-18
JP2553058B2 (ja)	1996-11-13
KR870006187A (ko)	1987-07-09
NO175003C (no)	1994-08-17
HU209747B (en)	1994-10-28
ES2033678T3 (es)	1993-04-01
IE863334L (en)	1987-06-21
NO175003B (no)	1994-05-09
EP0229998A2 (fr)	1987-07-29
FI93734C (fi)	1995-05-26
KR950000301B1 (ko)	1995-01-13
PT83973B (pt)	1989-07-31
DE3636903A1 (de)	1987-07-02
AU599943B2 (en)	1990-08-02
NO865192D0 (no)	1986-12-19
JPS62167799A (ja)	1987-07-24
FI865187L (fi)	1987-06-22

Publication	Publication Date	Title
DK168823B1 (da)	1994-06-20	Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor.
DK172064B1 (da)	1997-10-06	Fusionsprotein, dets fremstilling og anvendelse, genstruktur, som koder for fusionsproteinet, vektor, som indeholder genstrukturen, og værtscelle, som indeholder vektoren
CA2089094C (fr)	2002-02-05	Expression de polypeptides recombinants et methode de purification amelioree
CA2438886C (fr)	2013-07-23	Proteine de fusion destinee a la secretion d'une proteine d'interet dans le surnageant de la culture bacterienne
US5496924A (en)	1996-03-05	Fusion protein comprising an interleukin-2 fragment ballast portion
NO175640B (fr)	1994-08-01
EP0470165A1 (fr)	1992-02-12	Proteines de fusion contenant des fragments n-terminaux de l'albumine serale humaine (hsa)
AU2002231784A1 (en)	2003-03-06	Fusion protein for the secretion of a protein of interest into the supernatant of the bacterial culture
AU700605B2 (en)	1999-01-07	Production of peptides using recombinant fusion protein constructs
Murphy Jr et al.	1998	Expression of human Interleukin-17 inPichia pastoris: purification and characterization
JPS63267278A (ja)	1988-11-04	インタ−フエロン結合体を暗号化する塩基配列
CN107108754A (zh)	2017-08-29	α‑1‑抗胰蛋白酶(A1AT)融合蛋白及其用途
Barthelemy et al.	1993	Production and secretion of human interleukin 6 into the periplasm of Escherichia coli: efficient processing of N-terminal variants of hIL6 by the E. coli signal peptidase
IE62522B1 (en)	1995-02-08	A process for the preparation of foreign proteins in streptomycetes
KR20190098689A (ko)	2019-08-22	융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-1 또는 이의 유사체를 생산하는 방법
Tokunaga et al.	1992	Characterization of Mouse α-Amylase Secreted from Saccharomyces cerevisiae by the pGKL 128 kDa Killer Secretion Signal
US6207798B1 (en)	2001-03-27	Modified PE40 toxin fusion proteins
FI97239B (fi)	1996-07-31	Menetelmä fuusioproteiinin valmistamiseksi
Han et al.	1998	Thioredoxin fusion/HIV‐1 protease coexpression system for production of soluble human IL6 in E. coli cytoplasm

Legal Events

Date	Code	Title	Description
1994-06-20	B1	Patent granted (law 1993)
2007-01-08	PUP	Patent expired