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DK168631B1 - Corticoidderivater, fremgangsmåde til fremstilling af corticoidderivaterne, farmaceutisk præparat indeholdende corticoidderivaterne samt mellemprodukter - Google Patents

Corticoidderivater, fremgangsmåde til fremstilling af corticoidderivaterne, farmaceutisk præparat indeholdende corticoidderivaterne samt mellemprodukter Download PDF

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Publication number
DK168631B1
DK168631B1 DK407384A DK407384A DK168631B1 DK 168631 B1 DK168631 B1 DK 168631B1 DK 407384 A DK407384 A DK 407384A DK 407384 A DK407384 A DK 407384A DK 168631 B1 DK168631 B1 DK 168631B1
Authority
DK
Denmark
Prior art keywords
methyl
fluoro
triol
pregnadiene
diol
Prior art date
Application number
DK407384A
Other languages
Danish (da)
English (en)
Other versions
DK407384D0 (da
DK407384A (da
Inventor
Issei Nitta
Kenichiro Nakao
Motoyoshi Miyake
Akira Maruyama
Junko Takashima
Hiroaki Ueno
Original Assignee
Mitsubishi Chem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58164772A external-priority patent/JPS6056997A/ja
Priority claimed from JP59120439A external-priority patent/JPS611698A/ja
Application filed by Mitsubishi Chem Ind filed Critical Mitsubishi Chem Ind
Publication of DK407384D0 publication Critical patent/DK407384D0/da
Publication of DK407384A publication Critical patent/DK407384A/da
Application granted granted Critical
Publication of DK168631B1 publication Critical patent/DK168631B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK407384A 1983-09-07 1984-08-24 Corticoidderivater, fremgangsmåde til fremstilling af corticoidderivaterne, farmaceutisk præparat indeholdende corticoidderivaterne samt mellemprodukter DK168631B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP58164772A JPS6056997A (ja) 1983-09-07 1983-09-07 新規な６−酸素化コルチコイド／７α−カ−ボネ−ト誘導体およびその製法
JP16477283 1983-09-07
JP59120439A JPS611698A (ja) 1984-06-12 1984-06-12 新規なコルチコイド誘導体およびその製法
JP12043984 1984-06-12

Publications (3)

Publication Number Publication Date
DK407384D0 DK407384D0 (da) 1984-08-24
DK407384A DK407384A (da) 1985-03-08
DK168631B1 true DK168631B1 (da) 1994-05-09

Family

ID=26458022

Family Applications (1)

Application Number Title Priority Date Filing Date
DK407384A DK168631B1 (da) 1983-09-07 1984-08-24 Corticoidderivater, fremgangsmåde til fremstilling af corticoidderivaterne, farmaceutisk præparat indeholdende corticoidderivaterne samt mellemprodukter

Country Status (9)

Country Link
EP (1) EP0136586B1 (de)
AT (1) ATE41013T1 (de)
AU (1) AU558725B2 (de)
DD (3) DD229135A5 (de)
DE (1) DE3476885D1 (de)
DK (1) DK168631B1 (de)
HU (2) HU201092B (de)
NO (1) NO843548L (de)
SU (2) SU1561827A3 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
WO1997041145A1 (en) 1996-05-01 1997-11-06 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services 21-substituted progesterone derivatives as new antiprogestational agents
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518179B1 (de) * 1964-10-07 1970-01-02 Warner Lambert Pharmaceutical Verfahren zur Herstellung von 17alpha-Acyloxy-20-keto-21-desoxy-steroiden
US3558675A (en) * 1969-06-30 1971-01-26 Merck & Co Inc Steroid carbonates and process
GB1440063A (en) * 1972-08-11 1976-06-23 Glaxo Lab Ltd 17alpha-esters of 17alpha,21-dihydroxy-20-oxo-steroids
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
DE3133082A1 (de) * 1981-08-18 1983-03-10 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue hydrocortison-derivate, ihre herstellung und verwendung

Also Published As

Publication number Publication date
DD229702A5 (de) 1985-11-13
AU3231184A (en) 1985-03-14
EP0136586B1 (de) 1989-03-01
DK407384D0 (da) 1984-08-24
EP0136586A2 (de) 1985-04-10
DD229135A5 (de) 1985-10-30
ATE41013T1 (de) 1989-03-15
DD232497A5 (de) 1986-01-29
EP0136586A3 (en) 1986-01-29
HUT37944A (en) 1986-03-28
AU558725B2 (en) 1987-02-05
HUT44040A (en) 1988-01-28
DE3476885D1 (en) 1989-04-06
NO843548L (no) 1985-03-08
HU201092B (en) 1990-09-28
DK407384A (da) 1985-03-08
SU1551250A3 (ru) 1990-03-15
SU1561827A3 (ru) 1990-04-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed