DK168294B1 - 6-alkyl-11-aminophenyløstran- og 6-alkyl-11-aminophenyl-19-norpregnanderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske midler indeholdende disse - Google Patents

6-alkyl-11-aminophenyløstran- og 6-alkyl-11-aminophenyl-19-norpregnanderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske midler indeholdende disse Download PDF

Info

Publication number: DK168294B1
Authority: DK; Denmark
Prior art keywords: group; alkyl; aminophenyl; solution; hydroxy
Prior art date: 1987-04-24

Application number

DK221888A

Other languages

Danish (da)

English (en)

Other versions

DK221888A (da

DK221888D0 (da

Inventor

Marinus Bernard Groen

Hendrik Paul De Jongh

Original Assignee

Akzo Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-24

Filing date

1988-04-22

Publication date

1994-03-07

1988-04-22 Application filed by Akzo Nv filed Critical Akzo Nv

1988-04-22 Publication of DK221888D0 publication Critical patent/DK221888D0/da

1988-10-25 Publication of DK221888A publication Critical patent/DK221888A/da

1994-03-07 Application granted granted Critical

1994-03-07 Publication of DK168294B1 publication Critical patent/DK168294B1/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK221888A 1987-04-24 1988-04-22 6-alkyl-11-aminophenyløstran- og 6-alkyl-11-aminophenyl-19-norpregnanderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske midler indeholdende disse DK168294B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8700970		1987-04-24
NL8700970		1987-04-24

Publications (3)

Publication Number	Publication Date
DK221888D0 DK221888D0 (da)	1988-04-22
DK221888A DK221888A (da)	1988-10-25
DK168294B1 true DK168294B1 (da)	1994-03-07

Family

ID=19849909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK221888A DK168294B1 (da)	1987-04-24	1988-04-22	6-alkyl-11-aminophenyløstran- og 6-alkyl-11-aminophenyl-19-norpregnanderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske midler indeholdende disse

Country Status (17)

Country	Link
US (1)	US4871724A (fi)
EP (1)	EP0289073B1 (fi)
JP (1)	JP2655676B2 (fi)
KR (1)	KR970005318B1 (fi)
CN (1)	CN1019978C (fi)
AT (1)	ATE69820T1 (fi)
AU (1)	AU608831B2 (fi)
CA (1)	CA1297472C (fi)
DE (1)	DE3866410D1 (fi)
DK (1)	DK168294B1 (fi)
ES (1)	ES2045082T3 (fi)
FI (1)	FI88396C (fi)
GR (1)	GR3003363T3 (fi)
IE (1)	IE60783B1 (fi)
NZ (1)	NZ224355A (fi)
PT (1)	PT87322B (fi)
ZA (1)	ZA882643B (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE172469T1 (de) *	1989-08-04	1998-11-15	Schering Ag	11 beta-aryl-gona-4,9-dien-3-one
US5407928A (en) *	1990-08-15	1995-04-18	Schering Aktiengesellschaft	11β-aryl-gona-4,9-dien-3-ones
ZA929315B (en) *	1991-12-20	1993-05-24	Akzo Nv	17-spirofuran-3'-ylidene steroids.
CA2100514C (en) *	1992-07-29	2005-03-29	Johannes A. M. Hamersma	17-spiromethylene steroids
DE4332283A1 (de) *	1993-09-20	1995-04-13	Jenapharm Gmbh	Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE4434488A1 (de)	1994-09-14	1996-03-21	Schering Ag	Steroidester und -amide, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5576310A (en) *	1994-09-20	1996-11-19	Jenapharm Gmbh	11-benzaldoxime-17β-methoxy-17α-methoxymethyl-estrasdiene derivatives, methods for their production and pharmaceuticals containing such compounds
ZA9510926B (en)	1994-12-23	1996-07-03	Schering Ag	Compounds with progesterone-antagonistic and antiestrogenic action to be used together for female contraception
US6020328A (en) *	1998-03-06	2000-02-01	Research Triangle Institute	20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US5962444A (en) *	1998-05-29	1999-10-05	Research Triangle Institute	17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6262042B1 (en)	1998-05-29	2001-07-17	Research Triangle Institute	17β-amino and hydroxylamino-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
CN1117759C (zh) *	1999-09-02	2003-08-13	上海中西药业股份有限公司	甾体化合物,其制备方法和其药物组合物及其应用
TW200531977A (en)	2004-03-25	2005-10-01	Akzo Nobel Nv	Progesterone receptor modulators
BRPI0717747A2 (pt)	2006-10-24	2013-10-22	Repros Therapeutics Inc	Composições e métodos de supressão da proliferação endometrial
TWI539953B (zh)	2008-04-28	2016-07-01	瑞波若斯治療學公司	用於治療乳癌之組成物和方法
MX2012010327A (es)	2010-03-22	2012-11-16	Repros Therapeutics Inc	Composiciones y metodos para la administracion no toxica de antiprogestinas.
US9096641B2 (en) *	2013-06-05	2015-08-04	Evestra, Inc.	Imidazolyl progesterone antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3424769A (en) *	1966-04-04	1969-01-28	Syntex Corp	Process for the preparation of novel 6alpha-methyl-delta4,9(10)- diene steroids
ZA8231B (en) *	1981-01-09	1982-11-24	Roussel Uclaf	New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
DE3461090D1 (en) *	1983-02-18	1986-12-04	Schering Ag	11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them
DE3347126A1 (de) *	1983-12-22	1985-07-11	Schering AG, 1000 Berlin und 4709 Bergkamen	11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
AU580843B2 (en) *	1985-02-07	1989-02-02	Schering Aktiengesellschaft	11``-phenyl-gonanes, their manufacture and pharmaceutical preparations containing them
US4678282A (en) *	1985-02-19	1987-07-07	Ovonic Imaging Systems, Inc.	Active display matrix addressable without crossed lines on any one substrate and method of using the same
GB8513723D0 (en) *	1985-05-31	1985-07-03	Erba Farmitalia	11-beta substituted steroids

1988
- 1988-04-12 EP EP88200689A patent/EP0289073B1/en not_active Expired - Lifetime
- 1988-04-12 ES ES88200689T patent/ES2045082T3/es not_active Expired - Lifetime
- 1988-04-12 DE DE8888200689T patent/DE3866410D1/de not_active Expired - Fee Related
- 1988-04-12 AT AT88200689T patent/ATE69820T1/de not_active IP Right Cessation
- 1988-04-14 ZA ZA882643A patent/ZA882643B/xx unknown
- 1988-04-14 IE IE113188A patent/IE60783B1/en not_active IP Right Cessation
- 1988-04-19 FI FI881826A patent/FI88396C/fi not_active IP Right Cessation
- 1988-04-20 CA CA000564606A patent/CA1297472C/en not_active Expired - Fee Related
- 1988-04-20 US US07/183,851 patent/US4871724A/en not_active Expired - Fee Related
- 1988-04-22 DK DK221888A patent/DK168294B1/da active IP Right Grant
- 1988-04-22 AU AU15072/88A patent/AU608831B2/en not_active Ceased
- 1988-04-22 JP JP63100010A patent/JP2655676B2/ja not_active Expired - Lifetime
- 1988-04-22 PT PT87322A patent/PT87322B/pt not_active IP Right Cessation
- 1988-04-22 NZ NZ224355A patent/NZ224355A/xx unknown
- 1988-04-23 KR KR1019880004653A patent/KR970005318B1/ko not_active IP Right Cessation
- 1988-04-23 CN CN88102416A patent/CN1019978C/zh not_active Expired - Fee Related
1991
- 1991-12-17 GR GR91402004T patent/GR3003363T3/el unknown

Also Published As

Publication number	Publication date
DK221888A (da)	1988-10-25
KR970005318B1 (ko)	1997-04-15
GR3003363T3 (en)	1993-02-17
KR880012637A (ko)	1988-11-28
NZ224355A (en)	1990-03-27
PT87322B (pt)	1992-08-31
DE3866410D1 (de)	1992-01-09
US4871724A (en)	1989-10-03
FI881826A (fi)	1988-10-25
AU1507288A (en)	1988-10-27
ES2045082T3 (es)	1994-01-16
JP2655676B2 (ja)	1997-09-24
EP0289073B1 (en)	1991-11-27
ZA882643B (en)	1988-10-04
FI881826A0 (fi)	1988-04-19
FI88396C (fi)	1993-05-10
JPS63280097A (ja)	1988-11-17
IE60783B1 (en)	1994-08-10
IE881131L (en)	1988-10-24
DK221888D0 (da)	1988-04-22
EP0289073A1 (en)	1988-11-02
FI88396B (fi)	1993-01-29
CA1297472C (en)	1992-03-17
ATE69820T1 (de)	1991-12-15
PT87322A (pt)	1988-05-01
CN88102416A (zh)	1988-12-14
CN1019978C (zh)	1993-03-03
AU608831B2 (en)	1991-04-18

Publication	Publication Date	Title
DK168294B1 (da)	1994-03-07	6-alkyl-11-aminophenyløstran- og 6-alkyl-11-aminophenyl-19-norpregnanderivater, fremgangsmåde til fremstilling heraf samt farmaceutiske midler indeholdende disse
EP0147361B1 (de)	1989-02-08	11 Beta-Aryl-Estradiene, deren Herstellung und diese enthaltende pharmazeutische Präparate
Colton et al.	1957	17-Alkyl-19-nortestosterones
DK168444B1 (da)	1994-03-28	7beta-methyl- eller 7beta-ethyl-11-aminophenylsteroidforbindelser, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse
EP0116974B1 (de)	1986-10-29	11-Beta-Aryl-Estradiene, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
EP0349481B1 (de)	1995-11-02	13-Alkyl-11Beta-phenylgonane
US5292878A (en)	1994-03-08	17-spirofuran-3'-ylidene steroids
AU8106887A (en)	1988-05-06	9-alpha-hydroxy steroids and process for their preparation
JPS61168029A (ja)	1986-07-29	１０位置に置換基を持つ新ステロイド、それらの製造法及びそれらの薬剤としての使用
HU210532A9 (en)	1995-04-28	19,11beta-bridged steroides, process for producing them and pharmaceutical compositions containing them
GB1569135A (en)	1980-06-11	Steroids
DE3410880A1 (de)	1985-10-03	17-substituierte estradiene und estratriene
US3381003A (en)	1968-04-30	3-keto-13beta-alkyl-17beta-acetyl-gona-4-ene-17alpha-ol compounds and processes of preparing them
CS203912B2 (en)	1981-03-31	Process for preparing derivatives of estradiene
US3032552A (en)	1962-05-01	1-methyl steroids of the androstane series
US3461118A (en)	1969-08-12	3beta-tetrahydrofuranyloxy - and 3beta-tetrahydropyranyloxyestra - 4,9(10) - dienes and -4,9(10),11-trienes,their preparation and intermediates thereof
HU177452B (en)	1981-10-28	Process for preparing new d-homo-steroids
JPS6321680B2 (fi)	1988-05-09
DE2855091C3 (fi)
DE2018055B2 (de)	1976-12-23	Verfahren zur herstellung von 17 alpha-propadienylsteroiden sowie einige 17 alpha-(3-substituierte-propinyl)- steroide
DE2755578A1 (de)	1979-06-13	C-homo-oestratriene
NO161499B (no)	1989-05-16	Analogifremgangsmaate for fremstilling av terapeutisk aktive 11beta-aryl-oestradiener.
NO136727B (fi)	1977-07-18
DE102006018869A1 (de)	2007-10-18	17alpha-substituierte 4-(3-Oxoestra-4,9-dien-11beta-yl)-benzoesäure, deren Derivate und Verfahren zu ihrer Herstellung
NO763545L (fi)	1977-05-12

Legal Events

Date	Code	Title	Description
1994-03-07	B1	Patent granted (law 1993)