DK1658047T3 - Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitet - Google Patents
Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitetInfo
- Publication number
- DK1658047T3 DK1658047T3 DK04764317T DK04764317T DK1658047T3 DK 1658047 T3 DK1658047 T3 DK 1658047T3 DK 04764317 T DK04764317 T DK 04764317T DK 04764317 T DK04764317 T DK 04764317T DK 1658047 T3 DK1658047 T3 DK 1658047T3
- Authority
- DK
- Denmark
- Prior art keywords
- storage stability
- residual moisture
- excellent storage
- amorphous powder
- low residual
- Prior art date
Links
- 239000000843 powder Substances 0.000 title abstract 4
- 239000007921 spray Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Detergent Compositions (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10339197A DE10339197A1 (de) | 2003-08-22 | 2003-08-22 | Sprühgetrocknete amorphe Pulver mit geringer Restfeuchte und guter Lagerstabilität |
PCT/EP2004/009333 WO2005020953A1 (de) | 2003-08-22 | 2004-08-20 | Sprühgetrocknete amorphe pulver mit geringer restfeuchte und guter lagerstabilität |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1658047T3 true DK1658047T3 (da) | 2008-06-16 |
Family
ID=34202048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04764317T DK1658047T3 (da) | 2003-08-22 | 2004-08-20 | Spraytörret amorft pulver med en lav resterende fugtighed og udmærket lagerstabilitet |
Country Status (11)
Country | Link |
---|---|
US (1) | US20070298116A1 (es) |
EP (1) | EP1658047B1 (es) |
JP (1) | JP2007503380A (es) |
KR (1) | KR20070054590A (es) |
AT (1) | ATE388688T1 (es) |
CA (1) | CA2536319A1 (es) |
DE (2) | DE10339197A1 (es) |
DK (1) | DK1658047T3 (es) |
ES (1) | ES2302021T3 (es) |
TW (1) | TW200517142A (es) |
WO (1) | WO2005020953A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
GB0327723D0 (en) | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
US7611709B2 (en) * | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
DE102006023770A1 (de) * | 2006-05-20 | 2007-11-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Treibgasfreie Aerosolformulierung für die Inhalation |
DE102006030164A1 (de) * | 2006-06-29 | 2008-01-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Pulver |
DE102006030166A1 (de) * | 2006-06-29 | 2008-01-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Tempern |
DE102006053375A1 (de) * | 2006-11-10 | 2008-05-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Mischung von Pulvern |
PT103743B (pt) * | 2007-05-16 | 2013-01-15 | Hovione Farmaciencia S A | Processo para preparar derivados de 21-disódio fosfato de pregnanos. |
GB0716026D0 (en) * | 2007-08-16 | 2007-09-26 | Norton Healthcare Ltd | An inhalable medicament |
EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
JP6078217B2 (ja) * | 2008-01-15 | 2017-02-08 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 粉末化されたタンパク質組成物及びその作製方法 |
EP2172190A1 (en) * | 2008-10-02 | 2010-04-07 | Laboratorios Liconsa, S.A. | Inhalable particles comprising tiotropium |
JP2012509922A (ja) * | 2008-11-27 | 2012-04-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規粉末化結晶質吸入薬 |
JP5671001B2 (ja) * | 2009-03-26 | 2015-02-18 | パルマトリックス,インコーポレイテッド | 肺疾患を治療するための乾燥粉末製剤および方法 |
EP2662472B1 (de) | 2009-03-31 | 2019-02-27 | Boehringer Ingelheim International Gmbh | Verfahren zur Beschichtung einer Oberfläche eines Bauteils |
KR20100123240A (ko) * | 2009-05-15 | 2010-11-24 | 포항공과대학교 산학협력단 | 호흡기 염증성 질환의 치료 또는 예방을 위한 호흡기내 투여용 약학 제제 및 상기 질환의 치료 또는 예방 방법 |
EP2432531B1 (de) | 2009-05-18 | 2019-03-06 | Boehringer Ingelheim International GmbH | Adapter, inhalationseinrichtung und zerstäuber |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
WO2011064163A1 (en) | 2009-11-25 | 2011-06-03 | Boehringer Ingelheim International Gmbh | Nebulizer |
KR101782306B1 (ko) | 2009-11-25 | 2017-09-27 | 베링거 인겔하임 인터내셔날 게엠베하 | 분무기 |
WO2011160932A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
EP2694220B1 (de) | 2011-04-01 | 2020-05-06 | Boehringer Ingelheim International GmbH | Medizinisches gerät mit behälter |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
ES2775104T5 (es) | 2011-11-18 | 2023-06-08 | Regeneron Pharma | Método de fabricación de una formulación farmacéutica de liberación prolongada que comprende micropartículas de proteínas recubiertas de polímero utilizando secado por pulverización |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
WO2013152894A1 (de) | 2012-04-13 | 2013-10-17 | Boehringer Ingelheim International Gmbh | Zerstäuber mit kodiermitteln |
DE202013012829U1 (de) | 2012-06-14 | 2020-03-04 | Glycom A/S | Verbesserung der Stabilität und Reinheit sowie Erhöhung der Bioverfügbarkeit von menschlichen Milch-Oligosacchariden oder Vorläufern oder Mischungen davon |
ITMI20130571A1 (it) | 2013-04-10 | 2014-10-11 | Zambon Spa | Composizione farmaceutica contenente budesonide e formoterolo |
PL2835146T3 (pl) | 2013-08-09 | 2021-04-06 | Boehringer Ingelheim International Gmbh | Nebulizator |
WO2015018904A1 (en) | 2013-08-09 | 2015-02-12 | Boehringer Ingelheim International Gmbh | Nebulizer |
DK3139979T3 (da) | 2014-05-07 | 2023-10-09 | Boehringer Ingelheim Int | Enhed, forstøver og fremgangsmåde |
HUE055604T2 (hu) | 2014-05-07 | 2021-12-28 | Boehringer Ingelheim Int | Porlasztó |
MX380824B (es) | 2014-05-07 | 2025-03-12 | Boehringer Ingelheim Int | Nebulizador y recipiente. |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
EP3212212B1 (en) | 2014-10-31 | 2020-09-23 | Monash University | Powder formulation |
AU2016369557B2 (en) * | 2015-12-16 | 2022-10-20 | Regeneron Pharmaceuticals, Inc. | Compositions and methods of manufacturing protein microparticles |
WO2019012461A1 (en) | 2017-07-12 | 2019-01-17 | Glycom A/S | AMORPHOUS MIXTURE COMPRISING A NEUTRAL MONO- OR OLIGOSACCHARIDE AND A NON-GLUCIDIC ACID COMPONENT |
KR20240104926A (ko) | 2022-12-28 | 2024-07-05 | 씨제이제일제당 (주) | 발효 제품 제조 방법 |
TW202440065A (zh) * | 2022-12-28 | 2024-10-16 | 日商中外製藥股份有限公司 | 包含分散對象物質的固體分散體、包含其之醫藥組合物及其製造方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
IT1265240B1 (it) * | 1993-11-30 | 1996-10-31 | Ekita Investments Nv | Compressa farmaceutica a rilascio controllato, di forma lenticolare |
PL319600A1 (en) * | 1994-09-29 | 1997-08-18 | Andaris Ltd | Spray-dried microparticles as therapeutic carriers |
US6165463A (en) * | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
US6258341B1 (en) * | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
US6309671B1 (en) * | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
US5855913A (en) * | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
US5976574A (en) * | 1996-12-31 | 1999-11-02 | Inhale Therapeutic Systems | Processes for spray drying hydrophobic drugs in organic solvent suspensions |
CA2277801C (en) * | 1997-01-16 | 2002-10-15 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
US6284282B1 (en) * | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
WO2000010541A1 (en) * | 1998-08-25 | 2000-03-02 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
TWI310688B (en) * | 1999-10-29 | 2009-06-11 | Nektar Therapeutics | Dry powder compositions having improved dispersivity |
GB0004827D0 (en) * | 2000-02-29 | 2000-04-19 | Quadrant Holdings Cambridge | Compositions |
US20020120228A1 (en) * | 2000-06-08 | 2002-08-29 | Yuh-Fun Maa | Powder compositions |
CN1438874A (zh) * | 2000-06-08 | 2003-08-27 | 宝德杰克特疫苗有限公司 | 粉末组合物 |
DE60127175T2 (de) * | 2000-12-21 | 2007-11-08 | Nektar Therapeutics, San Carlos | Lagerstabile pulverzusammensetzungen mit interleukin-4 rezeptor |
WO2002101412A2 (en) * | 2001-06-08 | 2002-12-19 | Powderject Vaccines, Inc. | Spray freeze-dried compositions |
US20030186271A1 (en) * | 2001-11-19 | 2003-10-02 | Robin Hwang | Pharmaceutical compositions in particulate form |
MXPA04009673A (es) * | 2002-04-03 | 2005-01-11 | Solvay Pharm Bv | Formulacion de cannabinoide natural estabilizado. |
AU2003221888B2 (en) * | 2002-04-11 | 2008-11-06 | Medimmune, Llc | Preservation of bioactive materials by spray drying |
-
2003
- 2003-08-22 DE DE10339197A patent/DE10339197A1/de not_active Ceased
-
2004
- 2004-08-10 US US10/915,298 patent/US20070298116A1/en not_active Abandoned
- 2004-08-20 TW TW093125236A patent/TW200517142A/zh unknown
- 2004-08-20 KR KR1020067003664A patent/KR20070054590A/ko not_active Ceased
- 2004-08-20 CA CA002536319A patent/CA2536319A1/en not_active Abandoned
- 2004-08-20 DE DE502004006512T patent/DE502004006512D1/de not_active Expired - Lifetime
- 2004-08-20 DK DK04764317T patent/DK1658047T3/da active
- 2004-08-20 JP JP2006523610A patent/JP2007503380A/ja active Pending
- 2004-08-20 WO PCT/EP2004/009333 patent/WO2005020953A1/de active IP Right Grant
- 2004-08-20 ES ES04764317T patent/ES2302021T3/es not_active Expired - Lifetime
- 2004-08-20 AT AT04764317T patent/ATE388688T1/de active
- 2004-08-20 EP EP04764317A patent/EP1658047B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR20070054590A (ko) | 2007-05-29 |
WO2005020953A1 (de) | 2005-03-10 |
CA2536319A1 (en) | 2005-03-10 |
US20070298116A1 (en) | 2007-12-27 |
TW200517142A (en) | 2005-06-01 |
EP1658047A1 (de) | 2006-05-24 |
DE10339197A1 (de) | 2005-03-24 |
JP2007503380A (ja) | 2007-02-22 |
DE502004006512D1 (de) | 2008-04-24 |
ES2302021T3 (es) | 2008-07-01 |
EP1658047B1 (de) | 2008-03-12 |
ATE388688T1 (de) | 2008-03-15 |
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