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DK1628749T3 - Anordninger og fremgangsmåder til biomateriel produktion - Google Patents

Anordninger og fremgangsmåder til biomateriel produktion Download PDF

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Publication number
DK1628749T3
DK1628749T3 DK04753608.1T DK04753608T DK1628749T3 DK 1628749 T3 DK1628749 T3 DK 1628749T3 DK 04753608 T DK04753608 T DK 04753608T DK 1628749 T3 DK1628749 T3 DK 1628749T3
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DK
Denmark
Prior art keywords
methods
devices
biomaterial production
biomaterial
production
Prior art date
Application number
DK04753608.1T
Other languages
English (en)
Inventor
Henry Hebel
Sriram Ramakrishnan
Hugo Gonzalez
Jeff Darnell
Original Assignee
Vgxi Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1628749(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vgxi Inc filed Critical Vgxi Inc
Application granted granted Critical
Publication of DK1628749T3 publication Critical patent/DK1628749T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/406—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles with gas supply only at the bottom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C12N1/066—Lysis of microorganisms by physical methods
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03D—FLOTATION; DIFFERENTIAL SEDIMENTATION
    • B03D2203/00—Specified materials treated by the flotation agents; Specified applications
    • B03D2203/003—Biotechnological applications, e.g. separation or purification of enzymes, hormones, vitamins, viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Sustainable Development (AREA)
  • Virology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DK04753608.1T 2003-05-30 2004-05-27 Anordninger og fremgangsmåder til biomateriel produktion DK1628749T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47474903P 2003-05-30 2003-05-30
PCT/US2004/016806 WO2004108260A2 (en) 2003-05-30 2004-05-27 Devices and methods for biomaterial production

Publications (1)

Publication Number Publication Date
DK1628749T3 true DK1628749T3 (da) 2019-09-16

Family

ID=33511626

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04753608.1T DK1628749T3 (da) 2003-05-30 2004-05-27 Anordninger og fremgangsmåder til biomateriel produktion
DK10075640.2T DK2364769T3 (da) 2003-05-30 2004-05-27 Apparater og fremgangsmåder til biomaterialeproduktion

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10075640.2T DK2364769T3 (da) 2003-05-30 2004-05-27 Apparater og fremgangsmåder til biomaterialeproduktion

Country Status (7)

Country Link
US (1) US7238522B2 (da)
EP (2) EP2364769B1 (da)
CA (1) CA2567324C (da)
DK (2) DK1628749T3 (da)
ES (1) ES2748130T3 (da)
TW (1) TWI303275B (da)
WO (1) WO2004108260A2 (da)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7248938B2 (en) 2003-12-31 2007-07-24 Vigilistics, Inc. Method and system for monitoring batch product manufacturing
DE102004052254A1 (de) * 2004-05-03 2005-12-01 Plasmid Factory Gmbh & Co. Kg Verfahren zum Aufschluss von Zellen und zur Abtrennung von Zellbestandteilen
US7846720B2 (en) * 2005-01-26 2010-12-07 Vgx Pharmaceuticals, Inc. Optimized high yield synthetic plasmids
AT501380B1 (de) * 2005-02-07 2007-11-15 Vitali Dipl Ing Dshemelinski Verfahren zur reinigung der dna/rna von proteinen und zellulären reststoffen im zellenlysat
JP5439183B2 (ja) 2006-10-17 2014-03-12 ヴィージーエックス ファーマシューティカルズ，インコーポレイテッド 哺乳動物の細胞の電気穿孔のための電気穿孔装置および該電気穿孔装置を使用する方法
WO2008148010A1 (en) * 2007-05-23 2008-12-04 Vgx Pharmaceuticals, Inc. Composition comprising high concentration of biologically active molecules and processes for preparing the same
US20080299621A1 (en) * 2007-05-31 2008-12-04 Ge Healthcare Uk Limited Miniprep system for simple and rapid plasmid dna extraction
AU2008256411B2 (en) 2007-06-01 2013-08-22 F. Hoffmann-La Roche Ag Immunoglobulin purification
US7989615B2 (en) * 2007-07-13 2011-08-02 The Penn State Research Foundation Separation of different isoforms of plasmid DNA using ultrafiltration
WO2009073330A2 (en) * 2007-11-12 2009-06-11 The Trustees Of The University Of Pennsylvania Novel vaccines against multiple subtypes of influenza virus
WO2009065032A1 (en) * 2007-11-14 2009-05-22 Vgx Pharmaceuticals, Inc. Antibody production elicited by a dna vaccine delivered by electroporation
EP2234624B1 (en) 2008-01-11 2018-06-20 Inovio Pharmaceuticals, Inc. Novel vaccines against multiple subtypes of dengue virus
EP2088196A1 (en) * 2008-02-08 2009-08-12 Boehringer Ingelheim RCV GmbH & Co KG Methods and devices for producing biomolecules
CN102083457B (zh) 2008-05-28 2018-05-08 Vgx制药有限公司 天花dna疫苗及其引起免疫应答的抗原
BRPI0921359A2 (pt) 2008-11-17 2015-08-25 Inovio Pharmaceuticals Inc Antígenos que induzem a resposta imunológica contra flavivírus e métodos de uso dos mesmos
AU2010313132B2 (en) 2009-11-02 2015-01-15 Inovio Pharmaceuticals, Inc. Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
WO2011097640A1 (en) 2010-02-08 2011-08-11 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same
CN110195069A (zh) 2010-09-27 2019-09-03 宾夕法尼亚大学托管会 共有抗原构建体和由其制备的疫苗以及使用所述疫苗治疗疟疾的方法
KR102131276B1 (ko) 2010-11-12 2020-07-08 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 공통 전립선 항원, 이것을 암호화하는 핵산 분자, 그리고 이것을 포함하는 백신 및 용도
CA2826199A1 (en) 2011-01-31 2012-08-09 The Trustees Of The University Of Pennsylvania Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
EP3760227A1 (en) 2011-02-11 2021-01-06 The Trustees of the University of Pennsylvania Nucleic acid molecule encoding hepatitis b virus core protein and vaccine comprising the same
AU2012321315B2 (en) 2011-07-11 2016-04-14 Inovio Pharmaceuticals, Inc Cross-protective arenavirus vaccines and their method of use
JP6158819B2 (ja) * 2011-11-10 2017-07-05 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 分取カラムクロマトグラフィシステム
US9750795B2 (en) 2011-12-12 2017-09-05 The Trustees Of The University Of Pennsylvania Proteins comprising MRSA PBP2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat MRSA infections
MX354986B (es) 2011-12-12 2018-03-28 Univ Pennsylvania Composiciones que comprenden construcciones geneticas y vacunas de il-12 mejoradas, agentes inmunoterapeuticos y metodos para su uso.
JP2015514132A (ja) 2012-04-10 2015-05-18 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ヒト呼吸器合胞体ウイルスコンセンサス抗原、核酸構築物、およびそれらから作製されるワクチン、ならびにその使用方法
CA3194125A1 (en) 2012-04-12 2013-10-17 The Trustees Of The University Of Pennsylvania Filovirus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
CN102854052B (zh) * 2012-08-08 2015-01-07 长春迪瑞医疗科技股份有限公司 一种气泡混匀方法及其控制系统
BR112015013004B1 (pt) 2012-12-13 2022-09-06 The Trustees Of The University Of Pennsylvania Molécula de ácido nucleico isolada, proteína e seus usos, bem como composição e vacina
US9556427B2 (en) * 2013-02-27 2017-01-31 Syngenta Participations Ag Methods and compositions for preparation of nucleic acids
KR20230062666A (ko) 2013-03-15 2023-05-09 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 구제역 바이러스 (fmdv) 공통 단백질, 그에 대한 코딩 서열 및 그로부터 제조된 백신
WO2014144885A2 (en) 2013-03-15 2014-09-18 The Trustees Of The University Of Pennsylvania Cancer vaccines and methods of treatment using the same
SG11201604719WA (en) 2013-12-13 2016-07-28 Univ Pennsylvania Dna antibody constructs and method of using same
ES2626963T3 (es) * 2014-07-25 2017-07-26 Vito Nv (Vlaamse Instelling Voor Technologisch Onderzoek Nv) Método y aparato para la disrupción de células de biomasa
US11278619B2 (en) 2014-12-01 2022-03-22 The Trustees Of The University Of Pennsylvania DNA antibody constructs and method of using same
CN106884011B (zh) * 2015-12-16 2020-11-17 固安鼎泰海规生物科技有限公司 一种规模化质粒纯化的联合液相层析分离方法
KR102742526B1 (ko) 2016-02-05 2024-12-18 이노비오 파마수티컬즈, 인크. 암 백신 및 이를 이용하는 치료 방법
US10774322B2 (en) 2016-12-29 2020-09-15 Shoreline Biome, Llc Combined lysis protocol for comprehensive cell lysis
US11149246B2 (en) 2016-12-29 2021-10-19 Shoreline Biome, Llc Methods for cell lysis and preparation of high molecular weight DNA from modified cells
CN111479585A (zh) 2017-12-13 2020-07-31 艾诺奥医药品有限公司 靶向boris的癌症疫苗和其用途
US11235044B2 (en) 2017-12-13 2022-02-01 Inovio Pharmaceuticals, Inc. Cancer vaccines targeting MUC16 and uses thereof
RU2021115092A (ru) 2017-12-13 2022-01-24 Иновио Фармасьютикалз, Инк. Противораковые вакцины нацеленные на prame и их применения
KR20240024366A (ko) 2017-12-13 2024-02-23 이노비오 파마수티컬즈, 인크. 메소텔린을 표적으로 하는 암 백신 및 이의 용도
CN108298626A (zh) * 2018-01-15 2018-07-20 天津科创复兴科技咨询有限公司 一种废水曝气净化装置
CA3101009A1 (en) * 2018-05-31 2019-12-05 Vgxi Inc. Lysis coil apparatus and uses thereof for isolation and purification of polynucleotides
EP3594338A1 (en) * 2018-07-12 2020-01-15 Kaneka Eurogentec SA Method and apparatus for the purification of extra-chromosomal nucleic acid sequences
EP3887041A1 (en) * 2018-11-27 2021-10-06 Specialty Electronic Materials Netherlands BV Fluid treatment vessel
CN112940061B (zh) 2019-12-10 2024-05-03 财团法人工业技术研究院 核酸萃取装置
CN111073885A (zh) * 2019-12-31 2020-04-28 江苏耀海生物制药有限公司 一种应用于双链dna片段的纯化方法
CN111662807A (zh) * 2020-07-14 2020-09-15 漳州卫生职业学院 染色体自动收获装置及其自动收获方法
CN111979109A (zh) * 2020-09-01 2020-11-24 深圳普瑞金生物药业有限公司 质粒载体连续裂解装置
CN114164113A (zh) * 2020-09-10 2022-03-11 西比曼生物科技（香港）有限公司 一种封闭式的菌体裂解工艺
CN114381355B (zh) * 2020-10-19 2024-07-30 艾棣维欣(苏州)生物制品有限公司 用于提取细菌中质粒dna的气泡发生装置
CN114181931B (zh) * 2020-10-19 2023-12-26 艾棣维欣(苏州)生物制品有限公司 一种从细菌中提取质粒dna的方法
CN115404232A (zh) * 2021-05-10 2022-11-29 艾棣维欣(苏州)生物制品有限公司 用于提取细菌中质粒dna的方法
WO2022271955A1 (en) 2021-06-23 2022-12-29 Musc Foundation For Research Development Novel targeted shrna nanoparticles for cancer therapy
CN114561273A (zh) * 2022-04-02 2022-05-31 北京沃森创新生物技术有限公司 一种制备质粒的连续碱裂解系统以及质粒的制备方法
WO2024086213A2 (en) * 2022-10-19 2024-04-25 Abec, Inc. Cell lysis and plasmid isolation system
WO2024188449A1 (de) * 2023-03-13 2024-09-19 Hombrechtikon Systems Engineering Ag Mischungsvorrichtung und verfahren zur bereitstellung eines gemisches
CN117431149B (zh) * 2023-12-22 2024-03-08 北京艺妙神州医药科技有限公司 一种菌体的洗涤方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH453316A (de) * 1964-11-10 1968-06-14 Inventa Ag Verfahren zur Herstellung von Hydroxylamin durch katalytische Hydrierung von Stickoxyd und Vorrichtung zur Durchführung dieses Verfahrens
US4533123A (en) 1984-05-07 1985-08-06 Betz Laboratories, Inc. Liquid mixing device
US5438128A (en) 1992-02-07 1995-08-01 Millipore Corporation Method for rapid purifiction of nucleic acids using layered ion-exchange membranes
EP0555798B1 (en) 1992-02-13 1999-05-06 Becton, Dickinson and Company Hydrated celite and purification of DNA
US5591841A (en) 1993-01-14 1997-01-07 Ji; Huamin Rapid purification of circular DNA by triplex-mediated affinity capture
US5482836A (en) 1993-01-14 1996-01-09 The Regents Of The University Of California DNA purification by triplex-affinity capture and affinity capture electrophoresis
AU689815B2 (en) 1993-08-30 1998-04-09 Promega Corporation Nucleic acid purification compositions and methods
US5438127A (en) 1993-09-27 1995-08-01 Becton Dickinson And Company DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane
US5561064A (en) 1994-02-01 1996-10-01 Vical Incorporated Production of pharmaceutical-grade plasmid DNA
US5990301A (en) 1994-02-07 1999-11-23 Qiagen Gmbh Process for the separation and purification of nucleic acids from biological sources
GB9411572D0 (en) 1994-06-09 1994-08-03 Amersham Int Plc Magnetic bead precipitation method
US6197553B1 (en) 1994-07-15 2001-03-06 Merck & Co., Inc. Method for large scale plasmid purification
US5625053A (en) 1994-08-26 1997-04-29 Board Of Regents For Northern Illinois Univ. Method of isolating purified plasmid DNA using a nonionic detergent, solution
US5705628A (en) 1994-09-20 1998-01-06 Whitehead Institute For Biomedical Research DNA purification and isolation using magnetic particles
US5837529A (en) 1994-10-17 1998-11-17 Genzyme Corporation Method for lysing cells
US5981735A (en) 1996-02-12 1999-11-09 Cobra Therapeutics Limited Method of plasmid DNA production and purification
FR2746412B1 (fr) 1996-03-21 1998-06-12 Rhone Poulenc Rorer Sa Purification d'adn plasmidique de qualite pharmaceutique
US7026468B2 (en) 1996-07-19 2006-04-11 Valentis, Inc. Process and equipment for plasmid purification
US7807822B2 (en) 1996-08-01 2010-10-05 Robert Bridenbaugh Methods for purifying nucleic acids
US6011148A (en) 1996-08-01 2000-01-04 Megabios Corporation Methods for purifying nucleic acids
US5707812A (en) 1996-08-06 1998-01-13 Vical Incorporated Purification of plasmid DNA during column chromatography
US5843731A (en) 1996-09-05 1998-12-01 Asahi Kogaku Kogyo Kabushiki Kaisha Method for purifying plasmid DNA on calcium phosphate compound
EP0853123A1 (de) 1997-01-10 1998-07-15 Roche Diagnostics GmbH Reinigung von DNA durch Cross-Flow-Filtration
US5986085A (en) 1997-04-25 1999-11-16 Transgenomic, Inc. Matched ion polynucleotide chromatography (MIPC) process for separation of polynucleotide fragments
SE9703532D0 (sv) 1997-09-30 1997-09-30 Pharmacia Biotech Ab A process for the purification of plasmid DNA
GB2338236B (en) 1998-06-13 2003-04-09 Aea Technology Plc Microbiological cell processing
DE19900681B4 (de) 1999-01-04 2007-04-12 Sartorius Ag Verwendung von Anionaustauschermembranen zur Entfernung von Endotoxinen aus Nukleinsäure-haltigen Lösungen
ATE253976T1 (de) 1999-03-11 2003-11-15 Cobra Therapeutics Ltd Mischgefäss für zelllysaten
GB9905646D0 (en) 1999-03-11 1999-05-05 Cobra Therapeutics Ltd A vessel for mixing a cell lysate
EP1290158B1 (en) 2000-06-02 2006-12-06 Pall Corporation Processing of plasmid-containing fluids
WO2004024283A2 (en) 2002-09-13 2004-03-25 Valentis, Inc. Apparatus and method for preparative scale purification of nucleic acids

Also Published As

Publication number Publication date
CA2567324A1 (en) 2004-12-16
EP2364769A1 (en) 2011-09-14
TW200504207A (en) 2005-02-01
CA2567324C (en) 2012-01-03
EP2364769B1 (en) 2016-01-13
TWI303275B (en) 2008-11-21
WO2004108260A2 (en) 2004-12-16
EP1628749A2 (en) 2006-03-01
EP1628749B1 (en) 2019-07-31
WO2004108260A3 (en) 2005-05-12
US7238522B2 (en) 2007-07-03
DK2364769T3 (da) 2016-04-11
ES2748130T3 (es) 2020-03-13
US20050014245A1 (en) 2005-01-20

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