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DK1616184T4 - Fremgangsmåde og kit til at påvise tidlig begyndelse af renal tubulær cellebeskadigelse - Google Patents

Fremgangsmåde og kit til at påvise tidlig begyndelse af renal tubulær cellebeskadigelse Download PDF

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Publication number
DK1616184T4
DK1616184T4 DK04758356.2T DK04758356T DK1616184T4 DK 1616184 T4 DK1616184 T4 DK 1616184T4 DK 04758356 T DK04758356 T DK 04758356T DK 1616184 T4 DK1616184 T4 DK 1616184T4
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ngal
antibody
renal
urine
complex
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DK04758356.2T
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DK1616184T3 (da
Inventor
Prased Devarajan
Jonathan M Barasch
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Childrens Hospital Med Ct
Univ Columbia
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (24)

1. Fremgangsmåde til påvisning af en renal tubulær cellebeskadigelse, som er en iskæmisk renal beskadigelse i en human patient, omfattende trinnene: 1) at bringe en urinprøve opnået fra en human patient i kontakt med et antistof for en biomarkør bestående af NGAL, som fremkommer inden for de første 24 timer efter starten af den iskæmiske renale beskadigelse, for at tillade dannelse af et kompleks af antistoffet og NGAL, og 2) at påvise antistof-NGAL-komplekset.
2. Fremgangsmåde ifølge krav 1, hvor flere urinprøver for patienten opnås med mellemrum.
3. Fremgangsmåde ifølge krav 2, hvor urinprøverne opnås kontinuert.
4. Fremgangsmåde ifølge krav 1, hvor trinnet med at påvise antistof-NGAL-komplekset omfatter at bringe komplekset i kontakt med et andet antistof til at påvise NGAL.
5. Fremgangsmåde ifølge krav 1 til yderligere at overvåge effektiviteten afen behandling af den renale tubulære cellebeskadigelse omfattende de yderligere trin: 3) at bringe mindst én urinprøve efter behandling fra den humane patient, som lider af renal tubulær cellebeskadigelse og får behandling derfor, i kontakt med et indfangningsantistof for NGAL for at tillade dannelse af et kompleks af antistoffet og NGAL, og 4) at påvise tilstedeværelsen af NGAL i urinprøven efter behandling ved påvisning af antistof-NGAL-komplekset.
6. Fremgangsmåde ifølge krav 5, hvor trin 4) med at påvise antistof-NGAL-komplekset omfatter trinnene: (4i) at adskille eventuelt ubundet materiale fra urinprøven fra indfangningsantistoffet-NGAL-komplekset, (4ii) at bringe ind-fangningsantistof-NGAL-komplekset i kontakt med et andet antistof til at påvise NGAL, for at tillade dannelse af et kompleks mellem NGAL og det andet antistof, (4iii) at adskille eventuelt ubundet andet antistof fra NGAL-andet antistofkomplekset, og (4iv) at påvise det andet antistof fra NGAL-andet antistofkomplekset.
7. Fremgangsmåde ifølge krav 5, hvor trin 3) omfatter trinnet at bringe urinprøven i kontakt med et medie, hvortil er fastgjort det første antistof.
8. Anvendelse af et kit omfattende: 1) midler til at opnå en kvantitet af en urinprøve fra den humane patient, 2) et medie hvorpå er fastgjort et indfangningsantistof i stand til at kompleksdanne med NGAL, 3) et assay til påvisning af et kompleks af NGAL og indfangningsantistoffet ved en fremgangsmåde ifølge krav 1.
9. Anvendelse ifølge krav 8, hvor midlerne til at opnå urinprøven er konstrueret til en mængde af urinprøven på mindre end 1 ml, mere typisk mindre end 10 μΙ.
10. Anvendelse ifølge krav 8, hvor opnåelsesmidlerne omfatter et redskab omfattende en overflade, hvor overfladen omfatter mediet.
11. Anvendelse ifølge krav 8, hvor opnåelsesmidlerne omfatter en beholder til at modtage urinprøven, hvor den urinkontaktende overflade af beholderen omfatter mediet.
12. Anvendelse ifølge krav 8, hvor assayet omfatter ELISA.
13. Anvendelse ifølge krav 8, hvor opnåelsesmidlerne omfatter et apparat omfattende en kassette indeholdende mediet.
14. Anvendelse ifølge krav 8, hvor kittet er et kit til tæt på patienten (point-of-care).
15. Anvendelse af point-of-care kit ifølge krav 14, hvor midlerne til at opnå urinprøven er konstrueret til en mængde af urinprøven på mindre end 1 ml, mere typisk mindre end 10 μΙ.
16. Anvendelse af point-of-care kit ifølge krav 15, hvor opnåelsesmidlerne omfatter et redskab omfattende en dyppepind, hvor dyppepindens overflade omfatter mediet.
17. Anvendelse af point-of-care kit ifølge krav 15, hvor assayet omfatter et kolo-rimetrisk dyppepinds-assay.
18. Anvendelse af et kit til konkurrerende enzymforbundet immunosorbentassay (ELISA) omfattende et antistof specifikt for NGAL, for at påvise dets tilstedeværelse i en urinprøve fra patienten ved en fremgangsmåde ifølge krav 1.
19. Anvendelse ifølge krav 18 beregnet til at assaye en urinprøve, som kan omfatte en væskemængde på ca. 1 ml eller mindre.
20. Fremgangsmåde til at identificere graden afen renal tubulær cellebeskadigelse, som er en iskæmisk renal beskadigelse forårsaget af en hændelse, omfattende trinnene: 1) at påvise i mindst én urinprøve opnået fra en human patient tilstedeværelsen afen biomarkør bestående af NGAL, som fremkommer inden for de første 24 timer efter starten af den iskæmiske renale beskadigelse, og 2) at bestemme graden af den renale tubulære cellebeskadigelse baseret på tidspunktet for starten af tilstedeværelsen af NGAL i urinprøven i forhold til tidspunktet for hændelsen.
21. Fremgangsmåde ifølge krav 1 omfattende trinnene: 1) at bringe en urinprøve omfattende op til 1 ml af den første urin fra patienten i kontakt med antistoffet for NGAL for at tillade dannelse af et kompleks af antistoffet og NGAL, og 2) at påvise antistof-NGAL-komplekset.
22. Fremgangsmåde ifølge krav 1 til påvisning af iskæmisk renal beskadigelse, hvor det urinale NGAL, målt inden for to timer efter nyretransplantation, er forudsigende for akut nyresvigt.
23. Fremgangsmåde ifølge krav 1 til påvisning af post-operativ akut nyresvigt hos humane patienter efter åben hjertekirurgi, hvor den urinale NGAL målt inden for to timer efter kirurgien er forudsigende for akut nyresvigt.
24. Fremgangsmåde ifølge krav 1, hvor urinprøven er en urinprøve inden for to timer efter den renale tubulære cellebeskadigelse.
DK04758356.2T 2003-03-27 2004-03-26 Fremgangsmåde og kit til at påvise tidlig begyndelse af renal tubulær cellebeskadigelse DK1616184T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45814303P 2003-03-27 2003-03-27
US48159603P 2003-11-04 2003-11-04
PCT/US2004/009191 WO2004088276A2 (en) 2003-03-27 2004-03-26 A method and kit for detecting the early onset of renal tubular cell injury

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DK1616184T3 DK1616184T3 (da) 2009-10-19
DK1616184T4 true DK1616184T4 (da) 2018-08-13

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DK10183320.0T DK2360475T3 (da) 2003-03-27 2004-03-26 Fremgangsmåde og kit til detektion af tidlig indtræden af renal tubulær celleskade

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US (11) US20040219603A1 (da)
EP (3) EP2083270B1 (da)
JP (2) JP5392980B2 (da)
CN (1) CN102183656B (da)
AT (1) ATE437371T1 (da)
AU (1) AU2004225472B2 (da)
BR (1) BRPI0408802B8 (da)
CA (1) CA2520658A1 (da)
DE (1) DE602004022150D1 (da)
DK (2) DK1616184T4 (da)
ES (3) ES2739463T3 (da)
MX (1) MXPA05010385A (da)
NZ (1) NZ543028A (da)
WO (1) WO2004088276A2 (da)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153660B2 (en) 2000-10-13 2006-12-26 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
DK1616184T4 (da) * 2003-03-27 2018-08-13 Childrens Hospital Med Ct Fremgangsmåde og kit til at påvise tidlig begyndelse af renal tubulær cellebeskadigelse
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
CA2565701A1 (en) * 2004-05-06 2005-11-17 Jonathan M. Barasch Ngal for reduction and amelioration of ischemic and nephrotoxic injuries
EP3208616B1 (en) * 2004-12-20 2018-09-26 Antibodyshop A/S Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
JP5006802B2 (ja) * 2005-02-18 2012-08-22 チルドレンズ メディカル センター コーポレイション 上皮由来の癌診断および予後診断のためのバイオマーカーとしてのＣｙｒ６１
US20070037232A1 (en) 2005-03-31 2007-02-15 Barasch Jonathan M Detection of NGAL in chronic renal disease
US20070087387A1 (en) * 2005-04-21 2007-04-19 Prasad Devarajan Method for the Early Detection of Renal Disease Using Proteomics
JP2009510478A (ja) * 2005-10-03 2009-03-12 バイオサイト インコーポレイテッド 全身性炎症反応症候群の診断および／または予後診断のための方法および組成物
US20080090304A1 (en) * 2006-10-13 2008-04-17 Barasch Jonathan Matthew Diagnosis and monitoring of chronic renal disease using ngal
US20100062537A1 (en) * 2005-11-30 2010-03-11 Harald Mischak Polypeptide Markers for the Diagnosis and Evaluation of Pelvi-Ureteric Junction Obstruction (PUJO)
US8372886B2 (en) * 2005-12-22 2013-02-12 Kiacta Sarl Treatment of renal disorders, diabetic nephropathy and dyslipidemias
CA2642833A1 (en) * 2006-02-17 2007-08-30 Children's Medical Center Corporation Free ngal as a biomarker for cancer
US7662578B2 (en) 2006-04-21 2010-02-16 Children's Hospital Medical Center Method and kit for the early detection of impaired renal status
US20080090765A1 (en) * 2006-05-25 2008-04-17 The Trustees Of Columbia University In The City Of New York Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage
US20090197280A1 (en) * 2006-05-30 2009-08-06 Kristian Bangert Methods and Devices for Rapid Assessment of Severity of Injury
US20100210031A2 (en) * 2006-08-07 2010-08-19 Antibodyshop A/S Diagnostic Test to Exclude Significant Renal Injury
GB0617429D0 (en) * 2006-09-05 2006-10-18 Electrophoretics Ltd Markers of renal transplant rejection and renal damage
US7842472B2 (en) 2006-11-14 2010-11-30 Alere International Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
US8524462B2 (en) * 2006-11-14 2013-09-03 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
CA2673022A1 (en) * 2006-12-22 2008-07-03 Bellus Health (International) Limited Methods, compounds, and compositions for treating metabolic disorders and diabetes
JP2010521694A (ja) * 2007-03-21 2010-06-24 バイオポルト・ダイアグノスティクス・アクティーゼルスカブ 腎傷害のための診断テスト
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
EP2125899B1 (en) * 2007-03-26 2012-11-14 Novartis AG Predictive renal safety biomarkers and biomarker signatures to monitor kidney function
US8846036B2 (en) 2007-10-19 2014-09-30 Abbott Laboratories Antibodies that bind to mammalian NGAL and uses thereof
WO2009059259A2 (en) * 2007-10-31 2009-05-07 Children's Hospital Medical Center Detection of worsening renal disease in subjects with systemic lupus erythematosus
ES2475990T5 (es) * 2007-11-15 2017-07-06 Bioporto Diagnostics A/S Uso diagnóstico de formas moleculares individuales de un biomarcador
EP2257813A4 (en) * 2008-03-12 2011-11-02 Univ Columbia NGAL WITH HIGH MOLECULAR WEIGHT AS BIOMARKER FOR CHRONIC KIDNEY DISEASE
US20090239242A1 (en) 2008-03-18 2009-09-24 Biotrin Intellectual Properties Limited Method for the early identification and prediction of kidney injury
US20090238812A1 (en) * 2008-03-18 2009-09-24 Biotrin Intellectual Properties Limited Method for the early indentification and prediction of an abrupt reduction in kidney function in a patient undergoing cardiothoracic surgery
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions
US20100122355A1 (en) * 2008-07-16 2010-05-13 Neal Paragas Transgenic Reporter Mouse and Method for Use
HUP0800448A2 (en) * 2008-07-21 2011-02-28 Pecsi Tudomanyegyetem Diagnosis of systemic diseases
US20120083421A1 (en) * 2008-10-16 2012-04-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose and monitor hiv-associated nephropathy (hivan)
US20100105150A1 (en) * 2008-10-24 2010-04-29 Abbott Laboratories Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal
EP2344526A1 (en) * 2008-11-05 2011-07-20 Abbott Laboratories Neutrophil gelatinase-associated lipocalin (ngal) protein isoforms enriched from urine and recombinant chinese hamster ovary (cho) cells and related compositions, antibodies, and methods of enrichment, analysis and use
WO2010057184A2 (en) * 2008-11-17 2010-05-20 The Brigham And Women's Hospital, Inc. Methods for detection of acute kidney injury in humans
WO2010058378A1 (en) * 2008-11-21 2010-05-27 Phadia Ab Methods, devices and kits for detecting or monitoring acute kidney injury
PT2391653E (pt) * 2009-01-28 2015-02-13 Ind Tech Res Inst Biomarcadores associados a nefropatia
US20100233739A1 (en) * 2009-02-12 2010-09-16 Jonathan Barasch Use of urinary ngal to diagnose unilateral and bilateral urinary obstruction
US20100233740A1 (en) * 2009-02-12 2010-09-16 Jonathan Barasch Use of urinary ngal to distinguish kidney disease and predict mortality in subjects with cirrhosis
EP2449385A1 (de) * 2009-07-02 2012-05-09 Mosaiques Diagnostics And Therapeutics AG Verfahren und marker zur diagnose eines akuten nierenversagens
WO2011025917A1 (en) * 2009-08-28 2011-03-03 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011053832A1 (en) * 2009-10-29 2011-05-05 The Trustees Of Columbia University In The City Of New York Use of urinary ngal to diagnose sepsis in very low birth weight infants
US20110229921A1 (en) 2010-03-18 2011-09-22 Abbott Laboratories METHODS OF ASSAYING URINARY NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (uNGAL) IN THE PROGNOSIS OF CADAVERIC KIDNEY TRANSPLANT FUNCTION IN A PATIENT, INCLUDING A PATIENT DIAGNOSED WITH DELAYED GRAFT FUNCTION (DGF), A METHOD OF ASSAYING uNGAL IN THE ASSESSMENT OF RISK OF DGF IN A PATIENT DIAGNOSED WITH EARLY GRAFT FUNCTION (EGF), AND RELATED KITS
ES2667066T3 (es) 2010-05-24 2018-05-09 The Trustees Of Columbia University In The City Of New York Proteínas NGAL mutantes y usos de las mismas
EP3339860B1 (en) 2010-06-23 2025-01-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US20130203074A1 (en) 2010-06-23 2013-08-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2899545B1 (en) * 2010-06-23 2018-08-22 Astute Medical, Inc. Methods for diagnosis and prognosis of renal injury and renal failure
WO2012068545A1 (en) * 2010-11-18 2012-05-24 Jonathan Barasch Ngal in acute kidney injury
NL2007112C2 (en) 2011-07-14 2013-01-15 Brainlabs B V Novel diagnostic method for diagnosing depression and monitoring therapy effectiveness.
US9387031B2 (en) * 2011-07-29 2016-07-12 Medtronic Ablation Frontiers Llc Mesh-overlayed ablation and mapping device
BR112014004389A2 (pt) * 2011-08-26 2017-03-28 Astute Medical Inc métodos e composições para diagnóstico de lesão renal e insuficiência renal
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
US10712349B2 (en) 2014-04-15 2020-07-14 The Brigham And Women's Hospital, Inc. Circulating KIM-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney
WO2018145117A1 (en) 2017-02-06 2018-08-09 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3736570A1 (en) 2019-05-09 2020-11-11 Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León Method for the diagnosis, sub-classification and prognosis of acute kidney injury by detecting cct7
CN112076309A (zh) * 2020-07-27 2020-12-15 南通大学 一种环状促红素衍生肽在肾损伤和环孢素a损伤保护中的应用
US20230384323A1 (en) * 2020-10-16 2023-11-30 Lmx Medtech Llc Method for Correction for Sample Volume
CN113083264A (zh) * 2021-04-16 2021-07-09 郑州大学 二氧化硅-金属有机骨架核壳型复合材料及其在硫醇小分子检测方面的应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US3635091A (en) * 1970-08-31 1972-01-18 Frederick D Linzer Midstream urine specimen and fractional fluid collectors
IT1074038B (it) * 1976-08-05 1985-04-17 Simes Esteri della epinina
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4357343A (en) * 1981-06-26 1982-11-02 Baxter Travenol Laboratories, Inc. Nutritional composition for management of renal failure
US4632901A (en) 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4731326A (en) * 1984-06-04 1988-03-15 Ortho Diagnostic Systems Inc. Disease diagnosis by detection of shed normal tissue antigens
US4640909A (en) * 1985-05-07 1987-02-03 J. T. Baker Chemical Company Bonded phase of silica and carboalkoxyalkyl silanes for solid phase extraction
IL85257A (en) * 1987-02-10 1993-02-21 Tanabe Seiyaku Co Pharmaceutical compositions containing 2-(4-methoxyphenyl) 3-acetoxy-5-- (2-(dimethylamino) ethyl) -8-chloro-2,3- dihydro-1,5-benzothiazepin -4 (5h)-one having renal function-improving effect and diuretic effect
US4900662A (en) * 1987-07-21 1990-02-13 International Immunoassay Laboratories, Inc. CK-MM myocardial infarction immunoassay
US4870007A (en) * 1987-12-18 1989-09-26 Eastman Kodak Company Immobilized biotinylated receptor in test device, kit and method for determining a ligand
US5273743A (en) * 1990-03-09 1993-12-28 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
JP2912413B2 (ja) * 1990-03-28 1999-06-28 東亜医用電子株式会社 粒度分布作成方法
US5405832A (en) * 1991-11-27 1995-04-11 Immtech International Inc. Method of treating non-streptococcal bacterial infections
EP0575906A2 (en) * 1992-06-19 1993-12-29 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. Sandwich immunoassay of beta-N-acetylglucosaminidase and monoclonal antibody used therein
SE9401351D0 (sv) * 1994-04-21 1994-04-21 Venge A method for diagnosis
US6348571B1 (en) * 1994-09-12 2002-02-19 Northwestern University Corticotropin release inhibiting factor and methods of using same
US5552313A (en) * 1994-11-21 1996-09-03 Kansas University DNA encoding mouse phosphotriesterase-related protein
US5814462A (en) * 1995-10-02 1998-09-29 The Trustees Of Columbia University In The City Of New York Biochemical markers of ischemia
US5750345A (en) * 1995-10-31 1998-05-12 Evanston Hospital Corporation Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
US5627034A (en) * 1995-12-05 1997-05-06 Wisconsin Alumni Research Foundation Assay for carcinoma proliferative status by measuring NGAL expression level
SI0907735T2 (sl) * 1996-05-24 2010-01-29 Biogen Idec Inc Modulatorji tkivne regeneracije
US5945294A (en) * 1996-11-26 1999-08-31 Heska Corporation Method to detect IgE
JP3334558B2 (ja) * 1997-04-23 2002-10-15 富士レビオ株式会社 酵素免疫測定方法及び試験片
KR100546223B1 (ko) * 1997-04-30 2006-01-26 마루하 주식회사 허혈성질환의 검출 또는 예지방법과 그 검출용키트
JP2001512668A (ja) * 1997-08-06 2001-08-28 ザイモジェネティクス，インコーポレイティド リポカリン相同体
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US6500627B1 (en) 1998-02-03 2002-12-31 The Trustees Of Columbia University In The City Of New York Methods for predicting pregnancy outcome in a subject by HCG assay
US6309888B1 (en) * 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
AUPP784398A0 (en) * 1998-12-21 1999-01-21 Monash University Kidney disease detection and treatment
US6114123A (en) * 1999-06-14 2000-09-05 Incyte Pharmaceuticals, Inc. Lipocalin family protein
AU5330200A (en) * 1999-06-18 2001-01-09 Michigan State University Method and apparatus for the detection of volatile products in a sample
US6762032B1 (en) * 1999-08-23 2004-07-13 Biocrystal, Ltd. Compositions, assay kits, and methods for use related to a disease condition comprising multiple sclerosis and/or a pro-MS immune response
US20020160495A1 (en) * 2000-09-20 2002-10-31 University Of Medicine And Dentistry Soluble ischemia activated protein
CA2424431A1 (en) * 2000-10-03 2002-04-11 Rowett Research Institute Method of assaying pyrrole-containing biological compounds
US7153660B2 (en) * 2000-10-13 2006-12-26 Children's Medical Center Corporation Non-invasive enzyme screen for tissue remodelling-associated conditions
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
ATE458199T1 (de) * 2001-05-04 2010-03-15 Biosite Inc Diagnostische marker der akuten koronaren syndrome und ihre verwendungen
WO2002094864A2 (en) * 2001-05-25 2002-11-28 Genset S.A. Human cdnas and proteins and uses thereof
US6847451B2 (en) * 2002-05-01 2005-01-25 Lifescan, Inc. Apparatuses and methods for analyte concentration determination
AU2003247303A1 (en) * 2002-07-17 2004-02-02 Index Pharmaceuticals Ab Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders
CN1220487C (zh) * 2003-03-26 2005-09-28 浙江大学 复方肾保护氨基酸组合物及其应用
DK1616184T4 (da) * 2003-03-27 2018-08-13 Childrens Hospital Med Ct Fremgangsmåde og kit til at påvise tidlig begyndelse af renal tubulær cellebeskadigelse
EP3208616B1 (en) * 2004-12-20 2018-09-26 Antibodyshop A/S Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders
US7977110B2 (en) * 2008-06-02 2011-07-12 Children's Hospital Medical Center Method for distinguishing between kidney dysfunctions

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