DK161092C - Antibiotisk stof, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende det og mikroorganismestamme til brug ved fremstilling af det - Google Patents

Antibiotisk stof, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende det og mikroorganismestamme til brug ved fremstilling af det

Info

Publication number: DK161092C
Authority: DK; Denmark
Prior art keywords: antibiotic; factor; procedures; preparing; pharmaceutical preparation
Prior art date: 1984-10-11

Application number

DK457385A

Other languages

Danish (da)

English (en)

Other versions

DK457385D0 (da

DK457385A (da

DK161092B (da

Inventor

Enrico Selva

Luciano Gastaldo

Grazia Beretta

Angelo Borghi

Beth P Goldstein

Vittorio Arioli

Giovanni Cassani

Francesco Parenti

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-11

Filing date

1985-10-08

Publication date

1991-11-18

1985-10-08 Application filed by Lepetit Spa filed Critical Lepetit Spa

1985-10-08 Publication of DK457385D0 publication Critical patent/DK457385D0/da

1986-04-12 Publication of DK457385A publication Critical patent/DK457385A/da

1991-05-27 Publication of DK161092B publication Critical patent/DK161092B/da

1991-11-18 Application granted granted Critical

1991-11-18 Publication of DK161092C publication Critical patent/DK161092C/da

Links

239000000126 substance Substances 0.000 title abstract 5
230000003115 biocidal effect Effects 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
244000005700 microbiome Species 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
BEVDFPMXVNOQBI-AXNWEOKVSA-N (19R,22R,34S,37R,40R,52S)-64-[(2S,3R,4R,5S,6S)-3-amino-6-carboxy-4,5-dihydroxyoxan-2-yl]oxy-5,32-dichloro-2,26,31,49-tetrahydroxy-22-(methylamino)-21,35,38,54,56,59-hexaoxo-47-[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-7,13,28-trioxa-20,36,39,53,55,58-hexazaundecacyclo[38.14.2.23,6.214,17.219,34.18,12.123,27.129,33.141,45.010,37.046,51]hexahexaconta-3,5,8,10,12(64),14(63),15,17(62),23(61),24,26,29(60),30,32,41,43,45(57),46(51),47,49,65-henicosaene-52-carboxylic acid Chemical compound CN[C@@H]1c2ccc(O)c(Oc3cc(O)c(Cl)c(c3)[C@@H]3NC(=O)[C@@H](Cc4ccc(Oc5cc6cc(Oc7ccc(cc7Cl)C(O)C7NC(=O)[C@H](NC(=O)[C@@H]6NC3=O)c3cccc(c3)-c3c(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)cc(O)cc3[C@H](NC7=O)C(O)=O)c5O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3N)C(O)=O)cc4)NC1=O)c2 BEVDFPMXVNOQBI-AXNWEOKVSA-N 0.000 abstract 6
102000003712 Complement factor B Human genes 0.000 abstract 2
108090000056 Complement factor B Proteins 0.000 abstract 2
241000187361 Actinomadura sp. Species 0.000 abstract 1
208000035473 Communicable disease Diseases 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/03—Actinomadura

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Virology (AREA)
Mycology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK457385A 1984-10-11 1985-10-08 Antibiotisk stof, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende det og mikroorganismestamme til brug ved fremstilling af det DK161092C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8425685		1984-10-11
GB848425685A GB8425685D0 (en)	1984-10-11	1984-10-11	Antibiotic a 40926 complex

Publications (4)

Publication Number	Publication Date
DK457385D0 DK457385D0 (da)	1985-10-08
DK457385A DK457385A (da)	1986-04-12
DK161092B DK161092B (da)	1991-05-27
DK161092C true DK161092C (da)	1991-11-18

Family

ID=10568022

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK457385A DK161092C (da)	1984-10-11	1985-10-08	Antibiotisk stof, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende det og mikroorganismestamme til brug ved fremstilling af det

Country Status (22)

Country	Link
US (1)	US4935238A (ja)
EP (1)	EP0177882B1 (ja)
JP (2)	JPH0637508B2 (ja)
KR (1)	KR940009280B1 (ja)
AT (1)	ATE49215T1 (ja)
AU (1)	AU599308B2 (ja)
CA (1)	CA1317900C (ja)
DE (1)	DE3575145D1 (ja)
DK (1)	DK161092C (ja)
ES (1)	ES8609352A1 (ja)
FI (1)	FI81117C (ja)
GB (1)	GB8425685D0 (ja)
GR (1)	GR852442B (ja)
HU (1)	HU194317B (ja)
IE (1)	IE58708B1 (ja)
IL (1)	IL76596A (ja)
MY (1)	MY100880A (ja)
NO (1)	NO164111C (ja)
NZ (1)	NZ213775A (ja)
PH (1)	PH23013A (ja)
PT (1)	PT81288B (ja)
ZA (1)	ZA857697B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8531846D0 (en) *	1985-12-30	1986-02-05	Lepetit Spa	Antibiotic a 40926 mannosyl aglycon
GB8608809D0 (en) *	1986-04-11	1986-05-14	Lepetit Spa	Antibiotic
GB8608798D0 (en) *	1986-04-11	1986-05-14	Lepetit Spa	Recovery of glycopeptide antibiotics from aqueous solutions
DK363587A (da) *	1986-07-30	1988-01-31	Smithkline Beckman Corp	Antibiotika og fremstilling heraf under anvendelseaf actinomadura parvosata
GB8621912D0 (en) *	1986-09-11	1986-10-15	Lepetit Spa	Increasing ratio of components of anti-biotic complex
GR871488B (en) *	1986-10-10	1987-11-12	Lepetit Spa	New antibiotics
US5135857A (en) *	1987-07-03	1992-08-04	Gruppo Lepetit S.P.A.	Process for the preparation of de-mannosyl teicoplanin derivatives
PH27266A (en) *	1989-03-14	1993-05-04	Fujisawa Pharmaceutical Co	WS7622, A,B,C and D substances and pharmaceutical composition containing same
JPH06503306A (ja) *	1990-12-05	1994-04-14	グルポ・レペチツト・エス・ピー・エイ	テイコプラニン抗生物質の３８−デカルボキシ−３８−ヒドロキシメチル誘導体およびそれらの製造方法
EP0578644B1 (en)	1991-03-27	1996-12-04	GRUPPO LEPETIT S.p.A.	Antibiotic a 40926 ester derivatives
US5606036A (en) *	1991-03-27	1997-02-25	Gruppo Lepetit Spa	Antibiotic A 40926 ester derivatives
US5750509A (en) *	1991-07-29	1998-05-12	Gruppo Lepetit S.P.A.	Amide derivatives of antibiotic A 40926
US5939523A (en) *	1995-07-05	1999-08-17	Gruppo Lepetit Spa	Purification of dalbaheptide antibiotics by isoelectric focusing
JP2000508671A (ja)	1996-04-23	2000-07-11	バイオサーチ・イタリア・ソチエタ・ペル・アチオニ	抗生物質ａ４０９２６のアミド誘導体の改善された化学的製造法
RU2124895C1 (ru) *	1998-05-28	1999-01-20	Головкина Любовь Павловна	Противопаразитарная мазь "авермектиновая"
EP1413626A1 (en) *	2002-10-23	2004-04-28	Vicuron Pharmaceuticals, Inc.	Genes and proteins for the biosynthesis of the glycopeptide antibiotic A40926
US7119061B2 (en)	2002-11-18	2006-10-10	Vicuron Pharmaceuticals, Inc.	Dalbavancin compositions for treatment of bacterial infections
KR20120056310A (ko) *	2002-11-18	2012-06-01	비큐론 파마세티컬스 인코포레이티드	박테리아 감염 치료를 위한 달바반신 투여 방법
US20060074014A1 (en)	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
CN110183519B (zh) *	2019-05-06	2023-04-11	大邦(湖南)生物制药有限公司	一种达巴万星关键中间体a40926的分离纯化方法
CN110156876A (zh) *	2019-05-25	2019-08-23	聊城大学	一种适合工业化生产的高纯度a40926b0制备方法
CN113993879A (zh) *	2019-06-13	2022-01-28	瑞泽恩制药公司	在多级色谱过程期间去除非期望的组分的方法
CN110940763B (zh) *	2019-12-19	2022-07-26	宜昌东阳光生化制药有限公司	分离纯化达巴万星前体a40926的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4195079A (en) *	1979-01-31	1980-03-25	Pfizer Inc.	New polycyclic ether antibiotic
CA1183789A (en) *	1981-08-04	1985-03-12	Kiyoshi Isono	Antibiotic 76-11, process for the production thereof, anticoccidiosis agent and domestic animals growth accelerator comprising the same as an effective ingredient
US4578271A (en) *	1982-05-24	1986-03-25	Fujisawa Pharmaceutical Co., Ltd.	Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions
GR78648B (ja) *	1982-07-26	1984-09-27	Bristol Myers Co

1984
- 1984-10-11 GB GB848425685A patent/GB8425685D0/en active Pending
1985
- 1985-10-01 AT AT85112406T patent/ATE49215T1/de not_active IP Right Cessation
- 1985-10-01 DE DE8585112406T patent/DE3575145D1/de not_active Expired - Lifetime
- 1985-10-01 EP EP85112406A patent/EP0177882B1/en not_active Expired - Lifetime
- 1985-10-02 AU AU48195/85A patent/AU599308B2/en not_active Expired
- 1985-10-06 IL IL76596A patent/IL76596A/xx not_active IP Right Cessation
- 1985-10-07 ZA ZA857697A patent/ZA857697B/xx unknown
- 1985-10-08 DK DK457385A patent/DK161092C/da not_active IP Right Cessation
- 1985-10-08 FI FI853914A patent/FI81117C/fi not_active IP Right Cessation
- 1985-10-08 GR GR852442A patent/GR852442B/el unknown
- 1985-10-09 US US06/785,930 patent/US4935238A/en not_active Expired - Lifetime
- 1985-10-10 CA CA000492682A patent/CA1317900C/en not_active Expired - Lifetime
- 1985-10-10 HU HU853936A patent/HU194317B/hu not_active IP Right Cessation
- 1985-10-10 ES ES547766A patent/ES8609352A1/es not_active Expired
- 1985-10-10 NZ NZ213775A patent/NZ213775A/xx unknown
- 1985-10-10 NO NO854018A patent/NO164111C/no not_active IP Right Cessation
- 1985-10-10 PT PT81288A patent/PT81288B/pt unknown
- 1985-10-10 IE IE248985A patent/IE58708B1/en not_active IP Right Cessation
- 1985-10-11 JP JP60226671A patent/JPH0637508B2/ja not_active Expired - Fee Related
- 1985-10-11 PH PH32922A patent/PH23013A/en unknown
- 1985-10-11 KR KR1019850007474A patent/KR940009280B1/ko not_active Expired - Lifetime
1987
- 1987-04-24 MY MYPI87000539A patent/MY100880A/en unknown
1993
- 1993-09-30 JP JP5265554A patent/JP2572937B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HUT39480A (en)	1986-09-29
PT81288A (en)	1985-11-01
AU599308B2 (en)	1990-07-19
FI853914L (fi)	1986-04-12
PH23013A (en)	1989-03-03
DK457385D0 (da)	1985-10-08
ES8609352A1 (es)	1986-09-01
JP2572937B2 (ja)	1997-01-16
NZ213775A (en)	1989-03-29
ES547766A0 (es)	1986-09-01
IE852489L (en)	1986-04-11
EP0177882A3 (en)	1987-05-27
NO164111C (no)	1990-08-29
KR940009280B1 (ko)	1994-10-06
HU194317B (en)	1988-01-28
CA1317900C (en)	1993-05-18
FI81117C (fi)	1990-09-10
IL76596A0 (en)	1986-02-28
AU4819585A (en)	1986-04-17
FI853914A0 (fi)	1985-10-08
EP0177882B1 (en)	1990-01-03
PT81288B (pt)	1987-10-20
NO854018L (no)	1986-04-14
KR860003342A (ko)	1986-05-23
JPH06225757A (ja)	1994-08-16
US4935238A (en)	1990-06-19
ZA857697B (en)	1986-07-30
GB8425685D0 (en)	1984-11-14
IE58708B1 (en)	1993-11-03
IL76596A (en)	1992-05-25
GR852442B (ja)	1986-02-03
ATE49215T1 (de)	1990-01-15
DE3575145D1 (de)	1990-02-08
JPS61148188A (ja)	1986-07-05
MY100880A (en)	1991-05-16
JPH0637508B2 (ja)	1994-05-18
NO164111B (no)	1990-05-21
FI81117B (fi)	1990-05-31
DK457385A (da)	1986-04-12
DK161092B (da)	1991-05-27
EP0177882A2 (en)	1986-04-16

Publication	Publication Date	Title
DK161092C (da)	1991-11-18	Antibiotisk stof, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende det og mikroorganismestamme til brug ved fremstilling af det
FR12C0065I1 (ja)	2012-12-14
EP0379395A3 (en)	1991-10-02	Antibiotic l53-18a and process for preparation thereof
DK161150C (da)	1991-11-18	Antibiotikum sb 22484, fremgangsmaade til fremstilling deraf og mikroorganisme til brug ved fremgangsmaaden
ATE17582T1 (de)	1986-02-15	Antibiotikum s/433, verfahren zu dessen herstellung und dessen verwendung als antitumor- mittel.
ES479116A1 (es)	1980-01-16	Procedimiento para la obtencion de una mezcla de antibioti- cos bm782 alfaii, bm782 alfa 2 y bm782 alfa ia.
JPS5462393A (en)	1979-05-19	Preparation of antibiotic substance, verdamicin

Legal Events

Date	Code	Title	Description
2005-10-24	PUP	Patent expired