DK159683C - 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel - Google Patents

9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel

Info

Publication number: DK159683C
Authority: DK; Denmark
Prior art keywords: hydroxybutyl; medicine; compound; preparation; guanine derivative
Prior art date: 1983-12-20

Application number

DK362585A

Other languages

Danish (da)

English (en)

Other versions

DK159683B (da

DK362585D0 (da

DK362585A (da

Inventor

Karl Nils-Gunnar Johansson

Bjoern Gunnar Lindborg

Jan-Olof Noren

Original Assignee

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-20

Filing date

1985-08-09

Publication date

1991-04-15

1983-12-20 Priority claimed from SE8307051A external-priority patent/SE8307051D0/xx

1983-12-20 Priority claimed from SE8307052A external-priority patent/SE8307052D0/xx

1985-08-09 Application filed by Medivir Ab filed Critical Medivir Ab

1985-08-09 Publication of DK362585D0 publication Critical patent/DK362585D0/da

1985-08-09 Publication of DK362585A publication Critical patent/DK362585A/da

1990-11-19 Publication of DK159683B publication Critical patent/DK159683B/da

1991-04-15 Application granted granted Critical

1991-04-15 Publication of DK159683C publication Critical patent/DK159683C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1787—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings and having unsaturation outside the aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK362585A 1983-12-20 1985-08-09 9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel DK159683C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
SE8307051		1983-12-20
SE8307051A SE8307051D0 (sv)	1983-12-20	1983-12-20	Novel derivatives of alkyl guanine novel derivatives of alkyl guanine
SE8307052		1983-12-20
SE8307052A SE8307052D0 (sv)	1983-12-20	1983-12-20	Novel derivatives of guanine novel derivatives of guanine
PCT/SE1984/000426 WO1985002845A1 (en)	1983-12-20	1984-12-13	Novel derivatives of guanine
SE8400426		1984-12-13

Publications (4)

Publication Number	Publication Date
DK362585D0 DK362585D0 (da)	1985-08-09
DK362585A DK362585A (da)	1985-08-09
DK159683B DK159683B (da)	1990-11-19
DK159683C true DK159683C (da)	1991-04-15

Family

ID=26658599

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK362585A DK159683C (da)	1983-12-20	1985-08-09	9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel

Country Status (20)

Country	Link
US (1)	US4798833A (fi)
EP (2)	EP0146516A3 (fi)
JP (1)	JPH0667939B2 (fi)
KR (1)	KR910010048B1 (fi)
AU (1)	AU586415B2 (fi)
CA (1)	CA1285560C (fi)
DE (1)	DE3477568D1 (fi)
DK (1)	DK159683C (fi)
ES (3)	ES8609325A1 (fi)
FI (1)	FI80885C (fi)
GB (1)	GB2151622B (fi)
GR (1)	GR82499B (fi)
HU (1)	HU193595B (fi)
IE (1)	IE57913B1 (fi)
IL (1)	IL73682A (fi)
IS (1)	IS1507B (fi)
MY (1)	MY102565A (fi)
PH (1)	PH21410A (fi)
PT (1)	PT79714B (fi)
WO (1)	WO1985002845A1 (fi)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0141927B1 (en) *	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives
US5684153A (en)	1984-08-16	1997-11-04	Beecham Group Plc	Process for the preparation of purine derivatives
CA1288098C (en) *	1984-08-24	1991-08-27	Richard L. Tolman	4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
SE8406538D0 (sv) *	1984-12-21	1984-12-21	Astra Laekemedel Ab	Novel derivatives of purine
DE3671227D1 (de) *	1985-07-27	1990-06-21	Beecham Group Plc	9-substituierte guaninmonohydrate.
EP0219838A3 (en) *	1985-10-22	1988-04-06	Takeda Chemical Industries, Ltd.	Carbocyclic purine nucleosides, their production and use
US5066655A (en) *	1987-04-24	1991-11-19	Whitby Research, Inc.	N6-substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5565566A (en) *	1987-04-24	1996-10-15	Discovery Therapeutics, Inc.	N6 -substituted 9-methyladenines: a new class of adenosine receptor antagonists
US5175288A (en) *	1987-08-01	1992-12-29	Beecham Group P.L.C.	Process for preparing purine derivatives and intermediates thereof
US4935427A (en) *	1987-12-31	1990-06-19	The United States Of America As Represented By The Department Of Health And Human Services	Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US5284837A (en) *	1988-05-06	1994-02-08	Medivir Ab	Derivatives of purine, process for their preparation and a pharmaceutical preparation
SE8801729D0 (sv) *	1988-05-06	1988-05-06	Astra Ab	Purine derivatives for use in therapy
GB8817607D0 (en) *	1988-07-23	1988-09-01	Beecham Group Plc	Novel process
GB8822236D0 (en) *	1988-09-21	1988-10-26	Beecham Group Plc	Chemical process
CA2009109A1 (en) *	1989-02-02	1990-08-02	John Hannah	Antiviral acyclonucleosides and acyclonucleotides
GB8904855D0 (en) *	1989-03-03	1989-04-12	Beecham Group Plc	Pharmaceutical treatment
GB8917959D0 (en) *	1989-08-05	1989-09-20	Beecham Group Plc	Pharmaceutical formulation
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process
GB9001886D0 (en) *	1990-01-26	1990-03-28	Beecham Group Plc	Pharmaceutical formulation
US5674869A (en) *	1990-07-07	1997-10-07	Beecham Group Plc	Pharmaceutical treatment
ATE178605T1 (de) *	1993-06-23	1999-04-15	Merrell Pharma Inc	Carbo-acyclische nukleosidderivate als antivirale und antineoplastische mittel
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US5869493A (en) *	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
GB9615253D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
GB9615276D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
PT102030B (pt) *	1996-07-20	1999-04-30	Smithkline Beecham Plc	Processo para a apreparacao dos compostos penciclovir ou famciclovir que sao utesi como agentes antivirais
GB9807114D0 (en)	1998-04-02	1998-06-03	Smithkline Beecham Plc	Novel process
US20230218644A1 (en)	2020-04-16	2023-07-13	Som Innovation Biotech, S.A.	Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4347360A (en) *	1980-09-16	1982-08-31	Ens Bio Logicals Inc.	Ring open nucleoside analogues
IL64501A (en) *	1980-12-22	1985-07-31	Astra Laekemedel Ab	9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4355032B2 (en) *	1981-05-21	1990-10-30		9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
DK154561C (da) *	1981-08-11	1989-04-24	Wellcome Found	Analogifremgangsmaade til fremstilling af antivirale 9-substituerede 2-aminopurinderivater eller fysiologisk acceptable salte eller estere deraf
NZ201662A (en) *	1981-08-26	1986-07-11	Merck & Co Inc	9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
AU564576B2 (en) *	1981-09-24	1987-08-20	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Purine derivatives
US5250535A (en) *	1982-02-01	1993-10-05	Syntex Inc.	Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
SE8203855D0 (sv) *	1982-06-21	1982-06-21	Astra Laekemedel Ab	Novel derivatives of guanine i
SE8203856D0 (sv) *	1982-06-21	1982-06-21	Astra Laekemedel Ab	Novel derivatives of guanine ii
EP0141927B1 (en) *	1983-08-18	1991-10-30	Beecham Group Plc	Antiviral guanine derivatives
DE3671227D1 (de) *	1985-07-27	1990-06-21	Beecham Group Plc	9-substituierte guaninmonohydrate.

1984
- 1984-11-29 IL IL73682A patent/IL73682A/xx not_active IP Right Cessation
- 1984-12-13 HU HU84807A patent/HU193595B/hu unknown
- 1984-12-13 AU AU37873/85A patent/AU586415B2/en not_active Expired
- 1984-12-13 WO PCT/SE1984/000426 patent/WO1985002845A1/en active IP Right Grant
- 1984-12-13 DE DE8585900247T patent/DE3477568D1/de not_active Expired
- 1984-12-13 JP JP60500231A patent/JPH0667939B2/ja not_active Expired - Lifetime
- 1984-12-13 EP EP84850390A patent/EP0146516A3/en active Pending
- 1984-12-13 KR KR1019850700161A patent/KR910010048B1/ko not_active IP Right Cessation
- 1984-12-13 EP EP85900247A patent/EP0165289B1/en not_active Expired
- 1984-12-17 PH PH31589A patent/PH21410A/en unknown
- 1984-12-18 GB GB08431910A patent/GB2151622B/en not_active Expired
- 1984-12-18 GR GR82499A patent/GR82499B/el unknown
- 1984-12-18 ES ES538721A patent/ES8609325A1/es not_active Expired
- 1984-12-19 PT PT79714A patent/PT79714B/pt unknown
- 1984-12-19 IE IE3261/845A patent/IE57913B1/en not_active IP Right Cessation
- 1984-12-19 CA CA000470490A patent/CA1285560C/en not_active Expired - Lifetime
- 1984-12-19 IS IS2966A patent/IS1507B/is unknown
1985
- 1985-08-09 DK DK362585A patent/DK159683C/da not_active IP Right Cessation
- 1985-08-19 FI FI853171A patent/FI80885C/fi active IP Right Grant
- 1985-09-12 ES ES546916A patent/ES8704170A1/es not_active Expired
1986
- 1986-04-30 ES ES554546A patent/ES8800946A1/es not_active Expired
1987
- 1987-02-06 US US07/015,481 patent/US4798833A/en not_active Expired - Lifetime
- 1987-10-01 MY MYPI87002765A patent/MY102565A/en unknown

Also Published As

Publication number	Publication date
ES8704170A1 (es)	1987-03-16
PT79714A (en)	1985-01-01
ES538721A0 (es)	1986-09-01
DK159683B (da)	1990-11-19
KR850700136A (ko)	1985-10-25
GB2151622A (en)	1985-07-24
GR82499B (en)	1985-04-19
GB8431910D0 (en)	1985-01-30
EP0165289B1 (en)	1989-04-05
AU586415B2 (en)	1989-07-13
IS1507B (is)	1992-09-29
MY102565A (en)	1992-07-31
US4798833A (en)	1989-01-17
EP0146516A2 (en)	1985-06-26
DK362585D0 (da)	1985-08-09
EP0146516A3 (en)	1985-08-14
CA1285560C (en)	1991-07-02
ES8800946A1 (es)	1987-12-01
FI853171A0 (fi)	1985-08-19
IS2966A7 (is)	1985-06-21
IE57913B1 (en)	1993-05-19
IL73682A0 (en)	1985-02-28
ES546916A0 (es)	1987-03-16
HU193595B (en)	1987-11-30
IE843261L (en)	1985-06-20
HUT37619A (en)	1986-01-23
FI853171L (fi)	1985-08-19
JPH0667939B2 (ja)	1994-08-31
PH21410A (en)	1987-10-15
AU3787385A (en)	1985-07-12
DK362585A (da)	1985-08-09
KR910010048B1 (ko)	1991-12-12
IL73682A (en)	1991-08-16
ES8609325A1 (es)	1986-09-01
ES554546A0 (es)	1987-12-01
PT79714B (en)	1986-12-30
DE3477568D1 (en)	1989-05-11
WO1985002845A1 (en)	1985-07-04
FI80885B (fi)	1990-04-30
GB2151622B (en)	1988-05-11
FI80885C (fi)	1990-08-10
EP0165289A1 (en)	1985-12-27
JPS61500730A (ja)	1986-04-17

Publication	Publication Date	Title
DK159683C (da)	1991-04-15	9-(4-hydroxybutyl)-guaninderivat, farmaceutisk praeparat indeholdende en saadan forbindelse og anvendelse af den til fremstilling af et laegemiddel
DK156376C (da)	1990-01-02	Anvendelse af ibogain til fremstilling af et laegemiddel til behandling af narkotikamisbrug
DK407588D0 (da)	1988-07-21	Oxadiazolforbindelse, farmaceutisk praeparat indeholdende en saadan forbindelse, anvendelse af forbindelsen til fremstilling af et laegemiddel samt fremgangsmaade til fremstilling af en saadan forbindelse
DK163959C (da)	1992-09-21	Farmaceutisk praeparat til oral indgift indeholdende cimetidin
DK349387D0 (da)	1987-07-07	Nitrofuranderivater samt fremgangsmaade til fremstilling deraf og anvendelse af forbindelserne som laegemiddel
DK181586A (da)	1986-10-23	2,5-diaryltetrahydrofuran, farmaceutisk praeparat indeholdendeen saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK615988A (da)	1989-05-06	Fremgangsmaade til fremstilling af et afsvovlingsmiddel
DK645788D0 (da)	1988-11-18	Anvendelse af ergolinderivater til fremstilling af et farmaceutisk praeparat
DK127588A (da)	1988-09-10	Beta-aminoethylsubstituerede phenylforbindelser, farmaceutiske praeparater indeholdende samme og fremgangsmaader til fremstilling af saadanne forbindelser
DK102990D0 (da)	1990-04-26	Thieno-triazolodiazepinderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DK335782A (da)	1983-06-15	Thixotrop vaeske, fremgangsmaade til fremstilling deraf og anvendelse deraf til indgift af et veterinaert laegemiddel
DK473088A (da)	1989-02-26	Anvendelse af 2-amino-6-trifluormethoxybenzothiazol til fremstilling af et laegemiddel
DK159683A (da)	1984-10-13	Tyverisikringsanlaeg, navnlig til butiksarealer
DK635988A (da)	1989-05-20	1,3-butandiolacetoacetat-derivater og anvendelse af 1,3-butandiolacetoacetat-forbindelser til fremstilling af farmaceutiske praeparater
DK473288A (da)	1989-02-26	Anvendelse af 2-amino-6-trifluormethoxybenzothiazol til fremstilling af et laegemiddel
DK612788A (da)	1989-05-05	Alkoxyderivater af ginkolider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende saadanne forbindelser
DK347789A (da)	1989-07-13	Cysteinderivater, fremgangsmaade til fremstilling af dem og farmaceutiske praeparater indeholdende saadanne forbindelser
DK711988D0 (da)	1988-12-21	Methyltetrahydropyridyloxadiazol, farmaceutisk praeparat indeholdende en saadan forbindelse og fremgangsmaade til fremstilling af en saadan forbindelse
DK701588D0 (da)	1988-12-16	N-hydroxy-5-phenyl-2-furancarboximidamider og anvendelse heraf til fremstilling af farmceutiske praeparater
DK155682A (da)	1982-10-08	Fremgangsmaade til fremstilling af et psykotropt laegemiddel
DK365087A (da)	1988-01-16	1,3,5-trithianderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
DK164771C (da)	1992-12-28	Fremgangsmaade til fremstilling af et nasalt farmaceutisk praeparat indeholdende ergot-cycliske peptidalkaloider
DK489084D0 (da)	1984-10-12	Fremgangsmaade til udvinding af beta-elemonsyre og farmaceutisk praeparat indeholdende beta-elemonsyre
DK473188D0 (da)	1988-08-24	Anvendelse af 2-amino-6-trifluormethoxybenzothiazol til fremstilling af et laegemiddel
DK176888D0 (da)	1988-03-30	Thieno-imidazo(2,1-b)thiazolderivater, fremgangsmaade til fremstilling af saadanne derivater og laegemiddel indeholdende disse

Legal Events

Date	Code	Title	Description
2005-01-03	PUP	Patent expired