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DK158307C - Analogifremgangsmaade til fremstilling af 4-(fenylalkyl)-imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Analogifremgangsmaade til fremstilling af 4-(fenylalkyl)-imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK158307C
DK158307C DK304382A DK304382A DK158307C DK 158307 C DK158307 C DK 158307C DK 304382 A DK304382 A DK 304382A DK 304382 A DK304382 A DK 304382A DK 158307 C DK158307 C DK 158307C
Authority
DK
Denmark
Prior art keywords
compounds
preparation
phenylalkyl
analogue
acid addition
Prior art date
Application number
DK304382A
Other languages
Danish (da)
English (en)
Other versions
DK158307B (da
DK304382A (da
Inventor
Arto Johannes Karjalainen
Kauko Oiva Antero Kurkela
Esko Kalervo Pohjala
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Oy filed Critical Farmos Oy
Publication of DK304382A publication Critical patent/DK304382A/da
Publication of DK158307B publication Critical patent/DK158307B/da
Application granted granted Critical
Publication of DK158307C publication Critical patent/DK158307C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK304382A 1981-07-10 1982-07-07 Analogifremgangsmaade til fremstilling af 4-(fenylalkyl)-imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf DK158307C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB08121333A GB2101114B (en) 1981-07-10 1981-07-10 Substituted imidazole derivatives and their preparation and use
GB8121333 1981-07-10

Publications (3)

Publication Number Publication Date
DK304382A DK304382A (da) 1983-01-11
DK158307B DK158307B (da) 1990-04-30
DK158307C true DK158307C (da) 1990-10-08

Family

ID=10523160

Family Applications (2)

Application Number Title Priority Date Filing Date
DK304382A DK158307C (da) 1981-07-10 1982-07-07 Analogifremgangsmaade til fremstilling af 4-(fenylalkyl)-imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK630486A DK160610C (da) 1981-07-10 1986-12-29 Analogifremgangsmaade til fremstilling af 4-fenylalkyl- eller 4-fenylalkenylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK630486A DK160610C (da) 1981-07-10 1986-12-29 Analogifremgangsmaade til fremstilling af 4-fenylalkyl- eller 4-fenylalkenylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (23)

Country Link
US (3) US4544664A (hu)
EP (1) EP0072615B1 (hu)
JP (1) JPS5818365A (hu)
KR (1) KR860001864B1 (hu)
AT (1) ATE17121T1 (hu)
AU (1) AU554125B2 (hu)
BG (1) BG60763B2 (hu)
CA (1) CA1184559A (hu)
DD (1) DD207713A1 (hu)
DE (1) DE3268111D1 (hu)
DK (2) DK158307C (hu)
FI (1) FI77858C (hu)
GB (1) GB2101114B (hu)
HK (1) HK8289A (hu)
HU (1) HU187773B (hu)
IE (1) IE53244B1 (hu)
IL (1) IL66271A (hu)
NO (1) NO160439C (hu)
NZ (1) NZ201176A (hu)
SG (1) SG65388G (hu)
SU (1) SU1241990A3 (hu)
UA (1) UA5557A1 (hu)
ZA (1) ZA824875B (hu)

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GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
US4482723A (en) * 1983-04-11 1984-11-13 Pfizer Inc. Process for preparation of 4-acetyl-2-substituted-imidazoles
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US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
US4661508A (en) * 1984-06-18 1987-04-28 Eli Lilly And Company Aromatase inhibiting α,α-diphenyl-4(5)imidazole-methanes or -ethanes
FI844786A0 (fi) * 1984-12-04 1984-12-04 Farmos Oy Terapeutiskt utnyttjbar foerening.
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FI864570A0 (fi) * 1986-11-11 1986-11-11 Farmos Oy Terapeutiskt anvaendbar foerening.
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
GB2210875B (en) * 1987-10-09 1991-05-29 Farmos Oy Aromatase inhibiting 4(5)-imidazoles
GB2215206B (en) 1988-02-29 1991-07-03 Farmos Oy 4-substituted imidazole derivatives useful in perioperative care
GB8810067D0 (en) 1988-04-28 1988-06-02 Ucb Sa Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
US5439928A (en) * 1989-03-30 1995-08-08 Orion-Yhtyma Oy Aromatase inhibiting 4(5)-imidazoles
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CN107613977A (zh) 2015-05-06 2018-01-19 I-技术有限公司 用于控制鱼上寄生甲壳纲动物的美托咪定
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AU2018208422B2 (en) 2017-01-10 2021-11-11 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
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CN108872431B (zh) * 2018-07-09 2021-03-23 成都倍特药业股份有限公司 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法
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CN111217756B (zh) * 2019-12-11 2022-03-11 南京亿华药业有限公司 一种盐酸右美托咪定的制备方法
CN113896684A (zh) * 2020-07-06 2022-01-07 复旦大学 一种美托咪定的制备方法
CN117295718A (zh) 2022-03-22 2023-12-26 维科-兹多洛夫希沃特尼赫有限责任公司 美托咪定及其衍生物的制备方法
CN114671811A (zh) * 2022-04-14 2022-06-28 南京正科医药股份有限公司 一种右美托咪定拆分副产物的外消旋化回收方法

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GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use

Also Published As

Publication number Publication date
NO160439B (no) 1989-01-09
DE3268111D1 (en) 1986-02-06
FI77858B (fi) 1989-01-31
SU1241990A3 (ru) 1986-06-30
DK158307B (da) 1990-04-30
AU8562882A (en) 1983-01-13
JPH0372621B2 (hu) 1991-11-19
CA1184559A (en) 1985-03-26
DK160610C (da) 1991-09-02
NO160439C (no) 1989-04-19
FI822140A0 (fi) 1982-06-15
DK630486A (da) 1986-12-29
GB2101114B (en) 1985-05-22
GB2101114A (en) 1983-01-12
DK630486D0 (da) 1986-12-29
FI822140L (fi) 1983-01-11
DK304382A (da) 1983-01-11
EP0072615B1 (en) 1985-12-27
KR840000507A (ko) 1984-02-22
SG65388G (en) 1989-06-16
IE53244B1 (en) 1988-09-14
JPS5818365A (ja) 1983-02-02
KR860001864B1 (ko) 1986-10-24
US4639464A (en) 1987-01-27
DD207713A1 (de) 1984-03-14
BG60763B2 (bg) 1996-02-29
UA5557A1 (uk) 1994-12-28
AU554125B2 (en) 1986-08-07
ATE17121T1 (de) 1986-01-15
IL66271A0 (en) 1982-11-30
ZA824875B (en) 1983-05-25
DK160610B (da) 1991-04-02
US4544664A (en) 1985-10-01
US4826864A (en) 1989-05-02
NO822183L (no) 1983-01-11
NZ201176A (en) 1985-08-16
IL66271A (en) 1987-02-27
HK8289A (en) 1989-02-03
EP0072615A1 (en) 1983-02-23
FI77858C (fi) 1989-05-10
HU187773B (en) 1986-02-28

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